CN104524126A - Traditional Chinese medicine for treating randomized stagnation of phlegm type dizziness and preparation method - Google Patents
Traditional Chinese medicine for treating randomized stagnation of phlegm type dizziness and preparation method Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine for treating randomized stagnation of phlegm type dizziness and a preparation method. The traditional Chinese medicine comprises the crude drugs of mica, cladonia fallax abbayes, piny flowers, welted thistle, apocynum venetum, trillium tschonoskii maxim, trifoliate oranges, amur lilac seeds, lacebark pine cone, snakegourd peel, wild ginger, polemonium laxiflorum, glycosmis pentaphylla, asarum splendens, fortune eupatorium herbs, pogostemon cablin and orange peel. The traditional Chinese medicine has the advantages of being capable of having the definite curative effect on the randomized stagnation of phlegm type dizziness, high in pertinence, quick in effect taking, small in toxic and side effect and low in relapse rate.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating the dizzy Chinese medicine of stagnation of turbid phlegm in middle-JIAO type and preparation method.
Background technology
Dizzy be human body to the orientation of spatial relationship or para equilibrium, be a kind of self or outdoor scene illusion of movement or hallucination.During outbreak, most of patients sensation surrounding is in rotation, and swinging depending on thing or rocking (his innervation is dizzy) appears in small number of patients; Also can have from rotating, toppling over, rise and fall or rocking in certain plane (from dynamic dizzy).Can be divided into patients with vestibular system vertigo (true vertigo) and non-patients with vestibular system vertigo (giddy) clinically, the cause of disease is more complicated.
The traditional Chinese medical science is thought, dizzyly can be caused by wind, expectorant, void, therefore has the saying such as " calm do not do dizzy ", " dizziness must be caused by phlegm ", " dizziness must be due to deficiency ".Dizzyly refer to blurring of vision or dark and dim eyesight; Swoon and refer to self-induction health or external scene rotary oscillation, astasia.The two often occurs simultaneously, therefore is referred to as dizzy.Slight dizzy person closes order and namely stops.The dizzy person of severe as boat by bus, or with nausea and vomiting, nervously to perspire, even limbs deflection is for the symptom such as falling.Dizzy is the common a kind of symptom of middle-aged and elderly people.It can be caused by the various diseases in modern medicine, as Menieres disease, vestibulum auris internae and lost infection, vestibulum auris internae neuritis, hypertension, hypotension, anemia, diabetes, leukopenia, cerebral arteriosclerosis, neurosis etc.
At present, be usually used in the dizzy medicine for the treatment of and mainly contain the medicines such as phenothiazines, antihistaminic class, hyoscyami class, ubiquity can not symptomatic treatment, and effective percentage is low, and take effect slow, side effect is many, easily the shortcoming such as recurrence.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind ofly to treat the dizzy Chinese medicine of stagnation of turbid phlegm in middle-JIAO type and preparation method, and Chinese medicine of the present invention has definite curative effect to stagnation of turbid phlegm in middle-JIAO type is dizzy, with strong points, instant effect, toxic and side effects are little and relapse rate is low.
In order to solve the problems of the technologies described above, the invention provides and a kind ofly treat the dizzy Chinese medicine of stagnation of turbid phlegm in middle-JIAO type, each raw medicinal material of described Chinese medicine comprises: Muscovitum, Cladonia fallax Abbayes, Flos pini, Herba Cardui Crispi, Herba Apocyni veneti, Rhizoma Trillii Tschonoskii, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Cortex Syringae, Strobilus Pini, the fruit-rind of Chinese trichosanthes, Herba Asari Forbesii, Radix Polemonii Liniflori, Radix Glycosmidis Citrifoliae, Herba Asari Maximi, Herba Eupatorii, Herba Pogostemonis and Pericarpium citri sinensis.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: 10 ~ 20 parts, Muscovitum, Cladonia fallax Abbayes 20 ~ 30 parts, Flos pini 30 ~ 40 parts, Herba Cardui Crispi 10 ~ 20 parts, Herba Apocyni veneti 30 ~ 40 parts, Rhizoma Trillii Tschonoskii 5 ~ 15 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 ~ 30 parts, Cortex Syringae 10 ~ 20 parts, Strobilus Pini 20 ~ 30 parts, the fruit-rind of Chinese trichosanthes 15 ~ 25 parts, Herba Asari Forbesii 5 ~ 15 parts of, Radix Polemonii Liniflori 10 ~ 20 parts, Radix Glycosmidis Citrifoliae 10 ~ 20 parts, Herba Asari Maximi 5 ~ 15 parts, Herba Eupatorii 20 ~ 30 parts, Herba Pogostemonis 10 ~ 20 parts and Pericarpium citri sinensis 10 ~ 20 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: 15 ~ 20 parts, Muscovitum, Cladonia fallax Abbayes 20 ~ 25 parts, Flos pini 30 ~ 35 parts, Herba Cardui Crispi 10 ~ 15 parts, Herba Apocyni veneti 35 ~ 40 parts, Rhizoma Trillii Tschonoskii 5 ~ 10 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 ~ 25 parts, Cortex Syringae 10 ~ 15 parts, Strobilus Pini 25 ~ 30 parts, the fruit-rind of Chinese trichosanthes 20 ~ 25 parts, Herba Asari Forbesii 10 ~ 15 parts of, Radix Polemonii Liniflori 10 ~ 15 parts, Radix Glycosmidis Citrifoliae 15 ~ 20 parts, Herba Asari Maximi 5 ~ 10 parts, Herba Eupatorii 25 ~ 30 parts, Herba Pogostemonis 15 ~ 20 parts and Pericarpium citri sinensis 10 ~ 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: 18 parts, Muscovitum, Cladonia fallax Abbayes 22 parts, Flos pini 31 parts, Herba Cardui Crispi 13 parts, Herba Apocyni veneti 36 parts, Rhizoma Trillii Tschonoskii 8 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 24 parts, Cortex Syringae 12 parts, Strobilus Pini 28 parts, the fruit-rind of Chinese trichosanthes 21 parts, Herba Asari Forbesii 11 parts of, Radix Polemonii Liniflori 14 parts, Radix Glycosmidis Citrifoliae 16 parts, Herba Asari Maximi 8 parts, Herba Eupatorii 27 parts, Herba Pogostemonis 17 parts and Pericarpium citri sinensis 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: 16 parts, Muscovitum, Cladonia fallax Abbayes 24 parts, Flos pini 33 parts, Herba Cardui Crispi 12 parts, Herba Apocyni veneti 40 parts, Rhizoma Trillii Tschonoskii 7 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 21 parts, Cortex Syringae 14 parts, Strobilus Pini 26 parts, the fruit-rind of Chinese trichosanthes 23 parts, Herba Asari Forbesii 13 parts of, Radix Polemonii Liniflori 12 parts, Radix Glycosmidis Citrifoliae 18 parts, Herba Asari Maximi 7 parts, Herba Eupatorii 28 parts, Herba Pogostemonis 15 parts and Pericarpium citri sinensis 13 parts.
Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by Muscovitum, Cladonia fallax Abbayes, Flos pini, Herba Cardui Crispi, Herba Apocyni veneti, Rhizoma Trillii Tschonoskii, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Cortex Syringae, Strobilus Pini and fruit-rind of Chinese trichosanthes mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 60% ~ 80% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, decocts 2 ~ 4 hours, filters; Again filtering residue is added relative to filtering residue 2 ~ 4 times of water gagings, decoct 1 ~ 3 hour, filter; Twice filtrate merges, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and starch is 1: 0.03 ~ 0.05; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles, described Pulvis Talci and described magnesium stearate is 100: 2 ~ 4: 0.2 ~ 0.4.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to stagnation of turbid phlegm in middle-JIAO type is dizzy, with strong points, instant effect, toxic and side effects are little and relapse rate is low.
Detailed description of the invention
The invention provides and a kind ofly treat the dizzy Chinese medicine of stagnation of turbid phlegm in middle-JIAO type, its raw medicinal material comprises: Muscovitum, Cladonia fallax Abbayes, Flos pini, Herba Cardui Crispi, Herba Apocyni veneti, Rhizoma Trillii Tschonoskii, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Cortex Syringae, Strobilus Pini, the fruit-rind of Chinese trichosanthes, Herba Asari Forbesii, Radix Polemonii Liniflori, Radix Glycosmidis Citrifoliae, Herba Asari Maximi, Herba Eupatorii, Herba Pogostemonis and Pericarpium citri sinensis.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Muscovitum: be silicates mineral white Muscovitum.[nature and flavor] are sweet; Temperature.[return through] heart; Liver; Lung; Spleen; Urinary bladder channel.[function cures mainly] calms the nerves relieving convulsion; Arresting bleeding and healing up ulcer.Main cardiopalmus; Insomnia; Dizzy; Epilepsy; Chronic diarrhea; Leukorrhagia; Traumatic hemorrhage; Eczema.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Cladonia fallax Abbayes: the Herb of lichens Cladoniaceae Cladonia plant tophus stamen Cladonia fallax Abbayes.Summer gathers, and decontamination dries.[nature and flavor] are bitter, flat.[function cures mainly] is calm, pain relieving, convergence.For neurasthenia, epilepsy, schizophrenia, the vertigo, traumatic injury; Burn and scald is controlled in external.[extracts] " national Chinese herbal medicine compilation "
Flos pini: be the pollen of pinaceae plant Pinus massoniana Lamb, Pinus tabuliformis, Pinus densiflora, Pollen pini thunbergii etc.[nature and flavor] are sweet; Warm in nature.[return through] liver; Stomach warp.[function cures mainly] dispels the wind; QI invigorating; Removing dampness; Hemostasis.Main headache is dizzy; To have loose bowels dysentery; Eczema eczema; Wound hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Herba Cardui Crispi: be feverfew silk hair Herba Cardui Crispi and the herb or the root that save hair Herba Cardui Crispi.[nature and flavor] mildly bitter flavor; Cool in nature.[function cures mainly] dispels the wind; Heat clearing away; Dampness removing; Cooling blood for hemostasis; Promoting blood circulation and detumescence.Main cold cough; Have a headache dizzy; Urinary system infection; Chyluria; Leucorrhea; Jaundice; Rheumatic arthralgia; Spit blood; Epistaxis; Hematuria; Menorrhagia; Dysfunctional uterine hemorrhage; Traumatic injury; Furuncle furuncle and phyma; Swelling and pain of hemorrhoid; Burn.[extracts] " China's book on Chinese herbal medicine "
Herba Apocyni veneti: be the leaf of apocynaceae plant Herba Apocyni veneti.[nature and flavor] are sweet; Micro-hardship; Cool in nature.[function cures mainly] heat clearing away suppressing the hyperactive liver; Inducing diuresis to remove edema.Main hypertension; Dizzy; Headache; Cardiopalmus; Insomnia; Edema urine water.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Trillii Tschonoskii: be the rhizome of liliaceous plant Trillium tschonoskii Maxim and Jilin Trillium tschonoskii Maxim.[nature and flavor] are sweet; Micro-pungent; Temperature; Slightly poisonous.[function cures mainly] is calm; Pain relieving; Invigorate blood circulation; Hemostasis.Main hypertension; Neurasthenia; Dizziness and headache; Lumbago and skelalgia; Menoxenia; Metrorrhagia; Traumatic hemorrhage; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus): be rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) young fruit or immature fruit.[nature and flavor] acrid in the mouth; Bitter; Warm in nature.[return through] liver; Stomach warp.[function cures mainly] dispersing the stagnated liver-QI for regulating the stomach; Regulating QI to relieve pain; Removing food stagnancyization is stagnant.Main fullness and distention in the chest and hypochondrium; Abdominal distention; Breast lumps; Hernia pain; Painful and swollen testis; Traumatic injury; Food stagnation; Constipation; Uterine prolapse.[extracts] " China's book on Chinese herbal medicine "
Cortex Syringae: be the bark of Oleaceae plants syringa reticulata var mandshurica.[nature and flavor] are bitter; Pungent; Slightly warm in nature.[return through] lung meridian.[function cures mainly] dispersing lung-QI and dissipating phlegm; Relieving cough and asthma; Diuretic.Main chronic bronchitis; Asthma; Sudden cardiac edema.[extracts] " China's book on Chinese herbal medicine "
Strobilus Pini: be the cone of pinaceae plant lacebark pine.[nature and flavor] are bitter; Warm in nature.[function cures mainly] eliminates the phlegm; Cough-relieving; Relieving asthma.Main chronic tracheitis; Cough; Breathe hard; To foam at the mouth expectorant.[extracts] " China's book on Chinese herbal medicine "
The fruit-rind of Chinese trichosanthes: be the peel of cucurbitaceous plant Fructus Trichosanthis and Chinese Fructus Trichosanthis.[nature and flavor] sweet in the mouth; Micro-hardship; Cold in nature.[return through] returns lung; Stomach warp.[function cures mainly] removing heat from the lung and dissipating phlegm; Promoting the circulation of QI relieving stuffiness of the chest by dispersing aggregation of pathogens.Main cough due to lung-heat; Breast side of body painful abdominal mass pain, laryngopharynx swelling and pain; Nodules of the breast acute mastitis.[extracts] " China's book on Chinese herbal medicine "
Herba Asari Forbesii: be the rhizome of aristolochiaceae plant Herba Asari Forbesii and root or herb.[nature and flavor] are pungent; Temperature; Mild toxicity.[return through] lung; Liver; Kidney; Urinary bladder channel.[function cures mainly] expelling wind and cold; Expectorant diuretic; Promoting blood circulation and stopping pain.Main anemofrigid cold; Phlegm retention is breathed with cough; Edema; Anemofrigid-damp arthralgia; Traumatic injury; Headache; Toothache; Stomachache; Eruptive disease is suffered from abdominal pain; Scrofula; Toxic swelling; Venom.[extracts] " China's book on Chinese herbal medicine "
Radix Polemonii Liniflori: is the root of Radix Polemonii Liniflori section vegetable silk Hua Radix Polemonii Liniflori and rhizome.[nature and flavor] are bitter; Flat.[return through] lung; The heart; Liver; Spleen; Stomach warp.[function cures mainly] reduces phlegm; Calm the nerves; Hemostasis.Main cough with copious phlegm; Epilepsy; Insomnia; Spitting of blood; Nosebleed is bent; Spit blood; Have blood in stool; Menorrhagia.[extracts] " China's book on Chinese herbal medicine "
Radix Glycosmidis Citrifoliae: be root and the leaf of rutaceae Radix Glycosmidis Citrifoliae.[nature and flavor] are bitter; Flat.[return through] lung; Stomach; Liver Channel.[function cures mainly] expelling pathogenic wind from the body surface; Preventing phlegm from forming and stopping coughing; To regulate the flow of vital energy removing food stagnancy; Dissipating blood stasis for subsidence of swelling.Main cold cough; Dyspepsia is indigestion and loss of appetite; Abdominal pain due to retention of food; Colicky; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Asari Maximi: be the root of aristolochiaceae plant Qincheng city Herba Asari, rhizome or herb.[nature and flavor] are pungent; Temperature; Slightly poisonous.[return through] lung; Spleen; Liver Channel.[function cures mainly] cold expelling dispels the wind; Subduing swelling and detoxicating; Blood-activating analgetic.Main anemofrigid cold; Phlegm retention is breathed with cough; Carbuncle on the nape; Scrofula; Toothache; Headache; Rheumatic arthralgia; Serpentis lyssodexis.[extracts] " China's book on Chinese herbal medicine "
Herba Eupatorii: be the dry aerial parts of feverfew Herba Eupatorii Eupatorium fortunei Turcz..[nature and flavor] are pungent, flat.[return through] returns spleen, stomach, lung meridian.[function cures mainly] removing dampness by means of aromatics, appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.[extracts] " Chinese Pharmacopoeia "
Herba Pogostemonis: be the dry aerial parts of labiate Herba Pogostemonis Pogostemon cablin (Blanco) Benth..By the place of production difference point Stone steles Herba Pogostemonis and Pogostemon cablin Benth.[nature and flavor] are pungent, tepor.[return through] returns spleen, stomach, lung meridian.[function cures mainly] eliminating turbid pathogen with aromatics, appetizing preventing or arresting vomiting, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, and heat-damp in summer asthenia is not uncomfortable in chestly relaxed, and cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.[extracts] " Chinese Pharmacopoeia "
Pericarpium citri sinensis: be the peel of rutaceae fragrant citrus Citurs junos Tanaka.[nature and flavor] are bitter; Pungent; Temperature.[return through] spleen; Lung meridian.[function cures mainly] fast diarrhea due to disorder of QI every; Eliminating phlegm and lowering adverse QI; Help digestion stomach function regulating; Relieve the effect of alcohol; Kill fish Eriocheir sinensis poison.The main chest and diaphragm stagnation of QI; Cough with copious phlegm; Diet does not disappear; Nausea and vomiting; Drunk.[extracts] " China's book on Chinese herbal medicine "
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: 10 ~ 20 parts, Muscovitum, Cladonia fallax Abbayes 20 ~ 30 parts, Flos pini 30 ~ 40 parts, Herba Cardui Crispi 10 ~ 20 parts, Herba Apocyni veneti 30 ~ 40 parts, Rhizoma Trillii Tschonoskii 5 ~ 15 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 ~ 30 parts, Cortex Syringae 10 ~ 20 parts, Strobilus Pini 20 ~ 30 parts, the fruit-rind of Chinese trichosanthes 15 ~ 25 parts, Herba Asari Forbesii 5 ~ 15 parts of, Radix Polemonii Liniflori 10 ~ 20 parts, Radix Glycosmidis Citrifoliae 10 ~ 20 parts, Herba Asari Maximi 5 ~ 15 parts, Herba Eupatorii 20 ~ 30 parts, Herba Pogostemonis 10 ~ 20 parts and Pericarpium citri sinensis 10 ~ 20 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: 15 ~ 20 parts, Muscovitum, Cladonia fallax Abbayes 20 ~ 25 parts, Flos pini 30 ~ 35 parts, Herba Cardui Crispi 10 ~ 15 parts, Herba Apocyni veneti 35 ~ 40 parts, Rhizoma Trillii Tschonoskii 5 ~ 10 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 ~ 25 parts, Cortex Syringae 10 ~ 15 parts, Strobilus Pini 25 ~ 30 parts, the fruit-rind of Chinese trichosanthes 20 ~ 25 parts, Herba Asari Forbesii 10 ~ 15 parts of, Radix Polemonii Liniflori 10 ~ 15 parts, Radix Glycosmidis Citrifoliae 15 ~ 20 parts, Herba Asari Maximi 5 ~ 10 parts, Herba Eupatorii 25 ~ 30 parts, Herba Pogostemonis 15 ~ 20 parts and Pericarpium citri sinensis 10 ~ 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: 18 parts, Muscovitum, Cladonia fallax Abbayes 22 parts, Flos pini 31 parts, Herba Cardui Crispi 13 parts, Herba Apocyni veneti 36 parts, Rhizoma Trillii Tschonoskii 8 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 24 parts, Cortex Syringae 12 parts, Strobilus Pini 28 parts, the fruit-rind of Chinese trichosanthes 21 parts, Herba Asari Forbesii 11 parts of, Radix Polemonii Liniflori 14 parts, Radix Glycosmidis Citrifoliae 16 parts, Herba Asari Maximi 8 parts, Herba Eupatorii 27 parts, Herba Pogostemonis 17 parts and Pericarpium citri sinensis 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: 16 parts, Muscovitum, Cladonia fallax Abbayes 24 parts, Flos pini 33 parts, Herba Cardui Crispi 12 parts, Herba Apocyni veneti 40 parts, Rhizoma Trillii Tschonoskii 7 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 21 parts, Cortex Syringae 14 parts, Strobilus Pini 26 parts, the fruit-rind of Chinese trichosanthes 23 parts, Herba Asari Forbesii 13 parts of, Radix Polemonii Liniflori 12 parts, Radix Glycosmidis Citrifoliae 18 parts, Herba Asari Maximi 7 parts, Herba Eupatorii 28 parts, Herba Pogostemonis 15 parts and Pericarpium citri sinensis 13 parts.
Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by Muscovitum, Cladonia fallax Abbayes, Flos pini, Herba Cardui Crispi, Herba Apocyni veneti, Rhizoma Trillii Tschonoskii, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Cortex Syringae, Strobilus Pini and fruit-rind of Chinese trichosanthes mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 60% ~ 80% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, decocts 2 ~ 4 hours, filters; Again filtering residue is added relative to filtering residue 2 ~ 4 times of water gagings, decoct 1 ~ 3 hour, filter; Twice filtrate merges, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and starch is 1: 0.03 ~ 0.05; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles, described Pulvis Talci and described magnesium stearate is 100: 2 ~ 4: 0.2 ~ 0.4.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Muscovitum 160g, Cladonia fallax Abbayes 240g, Flos pini 330g, Herba Cardui Crispi 120g, Herba Apocyni veneti 400g, Rhizoma Trillii Tschonoskii 70g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 210g, Cortex Syringae 140g, Strobilus Pini 260g, fruit-rind of Chinese trichosanthes 230g, Herba Asari Forbesii 130g, Radix Polemonii Liniflori 120g, Radix Glycosmidis Citrifoliae 180g, Herba Asari Maximi 70g, Herba Eupatorii 280g, Herba Pogostemonis 150g and Pericarpium citri sinensis 130g.
Its preparation method comprises the following steps:
The first step, by Muscovitum, Cladonia fallax Abbayes, Flos pini, Herba Cardui Crispi, Herba Apocyni veneti, Rhizoma Trillii Tschonoskii, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Cortex Syringae, Strobilus Pini and fruit-rind of Chinese trichosanthes mixing, add relative to mixture 7 times amount determining alcohol be 70% alcohol reflux 3 times, each 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.31, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, decocts 3 hours, filters; Again filtering residue is added relative to filtering residue 3 times of water gagings, decoct 2 hours, filter; Twice filtrate merges, and being concentrated into 70 DEG C of relative densities is the mastic of 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and starch is 1: 0.045; Mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of mastic compound particles, Pulvis Talci and magnesium stearate is 100: 3.4: 0.36.
Embodiment 2: powder
Get Muscovitum 180g, Cladonia fallax Abbayes 220g, Flos pini 310g, Herba Cardui Crispi 130g, Herba Apocyni veneti 360g, Rhizoma Trillii Tschonoskii 80g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 240g, Cortex Syringae 120g, Strobilus Pini 280g, fruit-rind of Chinese trichosanthes 210g, Herba Asari Forbesii 110g, Radix Polemonii Liniflori 140g, Radix Glycosmidis Citrifoliae 160g, Herba Asari Maximi 80g, Herba Eupatorii 270g, Herba Pogostemonis 170g and Pericarpium citri sinensis 150g.
Its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 6 times is the ethanol of 85%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 3 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step: add the starch relative to its quality 2.8 times in the micropowders obtained by second step, mixing, obtains powder.
Toxicity test
Acute toxicity testing: application mice 80, male and female half and half, body weight 24 ~ 32g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 7.30g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.5 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>36.5 crude drug/kg, every day, maximum dosage-feeding was 73.0 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 28g) oral administration gavage Chinese medicine of the present invention is 682 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention presses 13.12,19.03 and 37.45g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 88 routine cases are my Out-patient Department or inpatient, male 41 people, women 47 people, 28 ~ 70 years old age.Wherein, Menieres disease 17 example, vertebro-basilar artery insufficiency 10 example, disease of inner ear 16 example, 26 Patients with Hypertension, hypotension 10 example, neurosis 9 example is accompanied.
Be divided into treatment group and matched group at random, wherein treatment group 44 people, male 21 people, women 23 people, 29 ~ 70 years old age; Wherein, Menieres disease 9 example, vertebro-basilar artery insufficiency 5 example, disease of inner ear 9 example, hypertension 12 example, hypotension 4 example, neurosis 5 example is accompanied.
Matched group 44 people, male 20 people, women 24 people, 28 ~ 70 years old age; Wherein, Menieres disease 8 example, vertebro-basilar artery insufficiency 5 example, disease of inner ear 7 example, hypertension 14 example, hypotension 6 example, neurosis 4 example is accompanied.Two groups of ages, sex, the course of disease, diseased region, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).
Diagnostic criteria:
The diagnosis of all patients meets diagnostic criteria dizzy in doctor trained in Western medicine " neurological ", determine diagnostic criteria with reference to State Administration of Traditional Chinese Medicine's " disease of tcm Standardization of diagnosis and curative effect ": 1, have a dizzy spell, rotate depending on thing, the lighter closes order and namely stops simultaneously, severe one, as ship by bus, very then holds down; 2, nausea and vomiting can be accompanied, nystagmus, Hiccough and deaf, sweating, pale complexion etc.; 3, chronic onset increases the weight of gradually, or Acute onset, or recurrent exerbation; 4, measuring blood pressure, pigment of having a blood test, red blood cell count(RBC), electric audiometry, brainstem evoked potential, sheet taken the photograph by electronystagmogram and cervical vertebra x line, and all patients all check through the necessity such as electrocardiogram, CT, MRI; 5, should note getting rid of tumor, serious blood disease and increased intracranial pressure disease etc.
Stagnation of turbid phlegm in middle-JIAO type patient in the present invention, needs through the further typing of following Syndrome Differentiation of Traditional Chinese Medicine standard.Stagnation of turbid phlegm in middle-JIAO type: disease is seen dizzy, heaviness of the head as being covered, uncomfortable in chest nauseating, vomiting sputum, lack of appetite drowsirness, how fat body is, and light red tongue is fat, and tongue is greasy in vain, and soft pulse is sliding.
Therapeutic Method:
Treatment group: give the embodiment of the present invention 1 tablet every day 3 times, each 51 week was 1 course for the treatment of, took 2 courses for the treatment of continuously;
Matched group: give lignocaine and to add in 5% Glucose Liquid 250ml quiet by 2mg/kg, 1 time/d, Xiao Xuan Shan Lang delays each a slice (10mg) of alkali sheet (6542), and every day 3 times, 7 days was 1 course for the treatment of, was used in conjunction 2 courses for the treatment of.
Curative effect judging standard: with reference to State Administration of Traditional Chinese Medicine " Chinese medical disease Standardization of diagnosis and curative effect ".Recovery from illness: vertigo symptoms and relevant sign disappear, and auxiliary examination is normal, follows up a case by regular visits to and does not recur for 1 year; Take a turn for the better: vertigo symptoms is obviously alleviated, and auxiliary examination is improved, and follows up a case by regular visits to and has slight onset of vertigo half a year; Invalid: vertigo symptoms is without improvement, and auxiliary examination is without improvement.
Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.As can be seen from Table 1, adopt treatment by Chinese herbs stagnation of turbid phlegm in middle-JIAO type of the present invention dizzy, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs stagnation of turbid phlegm in middle-JIAO type of the present invention dizzy, relative to Western medicine, treatment the course for the treatment of on significantly shorten.
A table 1 liang group treats two groups of comparitive study (example) after 2 weeks respectively:
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Effectively total |
| Treatment group | 44 | 26 | 15 | 3 | 41(93.18％) |
| Matched group | 44 | 17 | 21 | 6 | 38(86.36％) |
Number and cure rate comparative example (%) is cured stage by stage after a table 2 liang group treats 2 weeks respectively
| Group | Treat 5 days | Treat 10 days | Treat 14 days |
| Treatment group (cure rate) | 3(6.82％) | 20(45.45％) | 26(59.09％) |
| Matched group (cure rate) | 1(2.27％) | 11(25％) | 17(38.64％) |
According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect and the advantage that not easily recurs.
Over the course for the treatment of, there is not any untoward reaction in treatment group; There are 5 example drowsiness, 2 routine muscular tremors, 3 routine respiration inhibition, 9 routine xerostomias in matched group, 4 examples are flushing and the untoward reaction such as 2 routine palpitating speeds, and therefore relative to Western medicine, Chinese medicine of the present invention also has the advantage that safety is high and have no side effect.
Concrete case: Zhao, women, 42 years old.Because having a dizzy spell, headache, rotates depending on thing, is admitted to hospital, through various inspections such as CT, is diagnosed as dizzy with nausea and vomiting.According to traditional Chinese medical science classical symptom: disease is seen dizzy, heaviness of the head as being covered, uncomfortable in chest nauseating, vomiting sputum, lack of appetite drowsirness, how fat body is, and light red tongue is fat, and tongue is greasy in vain, and soft pulse is sliding, is diagnosed as stagnation of turbid phlegm in middle-JIAO type further dizzy.Give Chinese medicine embodiment 1 tablet of the present invention every day 3 times, each 5, treat after 6 days, vertigo symptoms and relevant sign disappear, and follow up a case by regular visits to and do not recur for 1 year, recovery from illness.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat the dizzy Chinese medicine of stagnation of turbid phlegm in middle-JIAO type for one kind, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Muscovitum, Cladonia fallax Abbayes, Flos pini, Herba Cardui Crispi, Herba Apocyni veneti, Rhizoma Trillii Tschonoskii, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Cortex Syringae, Strobilus Pini, the fruit-rind of Chinese trichosanthes, Herba Asari Forbesii, Radix Polemonii Liniflori, Radix Glycosmidis Citrifoliae, Herba Asari Maximi, Herba Eupatorii, Herba Pogostemonis and Pericarpium citri sinensis.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: 10 ~ 20 parts, Muscovitum, Cladonia fallax Abbayes 20 ~ 30 parts, Flos pini 30 ~ 40 parts, Herba Cardui Crispi 10 ~ 20 parts, Herba Apocyni veneti 30 ~ 40 parts, Rhizoma Trillii Tschonoskii 5 ~ 15 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 ~ 30 parts, Cortex Syringae 10 ~ 20 parts, Strobilus Pini 20 ~ 30 parts, the fruit-rind of Chinese trichosanthes 15 ~ 25 parts, Herba Asari Forbesii 5 ~ 15 parts of, Radix Polemonii Liniflori 10 ~ 20 parts, Radix Glycosmidis Citrifoliae 10 ~ 20 parts, Herba Asari Maximi 5 ~ 15 parts, Herba Eupatorii 20 ~ 30 parts, Herba Pogostemonis 10 ~ 20 parts and Pericarpium citri sinensis 10 ~ 20 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: 15 ~ 20 parts, Muscovitum, Cladonia fallax Abbayes 20 ~ 25 parts, Flos pini 30 ~ 35 parts, Herba Cardui Crispi 10 ~ 15 parts, Herba Apocyni veneti 35 ~ 40 parts, Rhizoma Trillii Tschonoskii 5 ~ 10 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 ~ 25 parts, Cortex Syringae 10 ~ 15 parts, Strobilus Pini 25 ~ 30 parts, the fruit-rind of Chinese trichosanthes 20 ~ 25 parts, Herba Asari Forbesii 10 ~ 15 parts of, Radix Polemonii Liniflori 10 ~ 15 parts, Radix Glycosmidis Citrifoliae 15 ~ 20 parts, Herba Asari Maximi 5 ~ 10 parts, Herba Eupatorii 25 ~ 30 parts, Herba Pogostemonis 15 ~ 20 parts and Pericarpium citri sinensis 10 ~ 15 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: 18 parts, Muscovitum, Cladonia fallax Abbayes 22 parts, Flos pini 31 parts, Herba Cardui Crispi 13 parts, Herba Apocyni veneti 36 parts, Rhizoma Trillii Tschonoskii 8 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 24 parts, Cortex Syringae 12 parts, Strobilus Pini 28 parts, the fruit-rind of Chinese trichosanthes 21 parts, Herba Asari Forbesii 11 parts of, Radix Polemonii Liniflori 14 parts, Radix Glycosmidis Citrifoliae 16 parts, Herba Asari Maximi 8 parts, Herba Eupatorii 27 parts, Herba Pogostemonis 17 parts and Pericarpium citri sinensis 15 parts.
5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: 16 parts, Muscovitum, Cladonia fallax Abbayes 24 parts, Flos pini 33 parts, Herba Cardui Crispi 12 parts, Herba Apocyni veneti 40 parts, Rhizoma Trillii Tschonoskii 7 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 21 parts, Cortex Syringae 14 parts, Strobilus Pini 26 parts, the fruit-rind of Chinese trichosanthes 23 parts, Herba Asari Forbesii 13 parts of, Radix Polemonii Liniflori 12 parts, Radix Glycosmidis Citrifoliae 18 parts, Herba Asari Maximi 7 parts, Herba Eupatorii 28 parts, Herba Pogostemonis 15 parts and Pericarpium citri sinensis 13 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, by Muscovitum, Cladonia fallax Abbayes, Flos pini, Herba Cardui Crispi, Herba Apocyni veneti, Rhizoma Trillii Tschonoskii, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Cortex Syringae, Strobilus Pini and fruit-rind of Chinese trichosanthes mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 60% ~ 80% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, decocts 2 ~ 4 hours, filters; Again filtering residue is added relative to filtering residue 2 ~ 4 times of water gagings, decoct 1 ~ 3 hour, filter; Twice filtrate merges, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and starch is 1: 0.03 ~ 0.05; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles, described Pulvis Talci and described magnesium stearate is 100: 2 ~ 4: 0.2 ~ 0.4.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, by Muscovitum, Cladonia fallax Abbayes, Flos pini, Herba Cardui Crispi, Herba Apocyni veneti, Rhizoma Trillii Tschonoskii, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Cortex Syringae, Strobilus Pini and fruit-rind of Chinese trichosanthes mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 60% ~ 80% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, decocts 2 ~ 4 hours, filters; Again filtering residue is added relative to filtering residue 2 ~ 4 times of water gagings, decoct 1 ~ 3 hour, filter; Twice filtrate merges, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and starch is 1: 0.03 ~ 0.05; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles, described Pulvis Talci and described magnesium stearate is 100: 2 ~ 4: 0.2 ~ 0.4.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
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| CN1765409A (en) * | 2005-09-29 | 2006-05-03 | 李亚萍 | Chinese herbal decoction for treating turbid phlegm stagnation pattern dizziness and preparation method |
| CN103655980A (en) * | 2013-12-25 | 2014-03-26 | 孙斌 | Traditional Chinese medicine for treating randomized stagnation of phlegm type auditory vertigo |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1765409A (en) * | 2005-09-29 | 2006-05-03 | 李亚萍 | Chinese herbal decoction for treating turbid phlegm stagnation pattern dizziness and preparation method |
| CN103655980A (en) * | 2013-12-25 | 2014-03-26 | 孙斌 | Traditional Chinese medicine for treating randomized stagnation of phlegm type auditory vertigo |
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Application publication date: 20150422 |