CN104524015A

CN104524015A - Anaesthesia pain-relieving paste used for controlling cancer pain

Info

Publication number: CN104524015A
Application number: CN201410690555.3A
Authority: CN
Inventors: 王雪晴; 范广法
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-11-17
Filing date: 2014-11-17
Publication date: 2015-04-22

Abstract

The invention discloses an anaesthesia pain-relieving paste used for controlling cancer pain. Traditional Chinese medicine theory considers that people feels pain when the body circulation is blocked, otherwise, people is not painful, and generation of pain is associated with qi and blood obstruction. The anaesthesia pain-relieving paste employs traditional Chinese medicines all-grass of Beautiful spotflower, seed of whiteflower cacalia, root of Ilex corallina Franch., root of cherry elaeagnus, ardisia faberi Hemsl., root of Chinese trumpetcreeper, lysimachia circaeoides Heml., herb of creeping violet, bigleaf beautyberry leaf and root of yellowfruit raspberry which have efficacy of activating blood, freeing the collateral vessels and resolving accumulation, and the paste is prepared according to a conventional method. Through clinic tests, the anaesthesia pain-relieving paste has the total effective rate of 95%, and is substantial in curative effect and free of side effect.

Description

A kind of anesthesia analgesic paste for controlling cancerous pain

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relating to a kind of anesthesia analgesic paste for controlling cancerous pain.

Background technology

Cancerous pain (abbreviation cancer pain) is one of the most common symptom be subject to the most unbearably of malignant tumor patient, and it reduces the life quality of patient from many aspects such as psychology, physiology, spirit.Therefore analgesia is one of major measure of Therapeutic cancer.WHO using effective treatment of cancer pain as one of four emphasis in cancer unified plan.Though third order convergence is internationally recognized Pain Treatment method, but still fail to control all cancer pains ideally.And opioid drug has the untoward reaction such as additive, toleration.Through years of researches and practice, the effect of Chinese medicine in Pain Treatment gets the nod, as motherland's medical science important component part, external treatment of Chinese medicine compares with Western medicine, it is reliable that pain relieving has curative effect, use safety, and toxic and side effects is few, and without the advantage such as additive and withdrawal, be widely used clinically.Part cancer patient spleen and stomach function is poor, and it is bad that effect digested and assimilated by Chinese medicine for oral administration, now uses external treatment can to compensate its defect part.Plaster is the conventional dosage forms of Chinese medicine external, and it sticks in the corresponding body surface of local tumor or sore spot body surface, utilizes drug effect, reaches reducing swelling and alleviating pain, presses down the object of cancer contracting tumor.

Summary of the invention

The object of this invention is to provide a kind of anesthesia analgesic paste for controlling cancerous pain.Theory of Chinese medical science is thought: " pain is then obstructed, and general rule is not bitterly ", generation and the QI and blood of pain block obstructed relevant, should use promoting blood circulation to remove obstruction in the collateral addiction medicine.

The object of the invention is to be achieved through the following technical solutions, this anesthesia analgesic paste being used for controlling cancerous pain is made up of the Chinese medicine of following weight portion: Herba Spilanthis callimorphae 10-15 part, Semen Caesalpiniae Minacis 5-8 part, Ilex sp. 8-12 part, Radix Elaeagni Multiflorae 15-25 part, Herba Ardisiae Pusillae 3-9 part, Radix campsis 5-9 part, Herba Lysimachiae Circaeoidis 4-9 part, Herba Violae Serpentis 8-10 part, Folium Callicarpae Macrophyllae 30-40 part, Radix rubi Xanthocarpi 5-10 part.

Preferably, Herba Spilanthis callimorphae 13 parts, Semen Caesalpiniae Minacis 6 parts, Ilex sp. 10 parts, Radix Elaeagni Multiflorae 20 parts, Herba Ardisiae Pusillae 6 parts, Radix campsis 7 parts, 6 parts, Herba Lysimachiae Circaeoidis, Herba Violae Serpentis 9 parts, Folium Callicarpae Macrophyllae 35 parts, Radix rubi Xanthocarpi 7 parts.

Preparation method decocts after adding appropriate distilled water, and totally twice, merge medical filtration, adding ethanol makes its alcohol content reach 75%, carries out precipitate with ethanol process, leaves standstill and filters, reclaim ethanol, make concentration of liquid medicine to paste after waving most alcohol taste, add the antiseptic of 2%, stir, vessel port seals, and after autoclaving, places room temperature, refrigerated storage, for subsequent use.

Fang Zhong: Herba Spilanthis callimorphae's blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Semen Caesalpiniae Minacis eliminating stasis to stop pain, clearing heat and expelling damp; Ilex sp. promoting blood circulation and stopping pain; Radix Elaeagni Multiflorae is invigorated blood circulation, circulation of qi promoting, tonifying deficiency; Herba Ardisiae Pusillae promoting blood circulation to remove obstruction in the collateral; Radix campsis clots absorbing, dispel the wind, removing heat from blood; Herba Lysimachiae Circaeoidis detumescence and promoting granulation, eliminating stasis to stop pain, cooling blood for hemostasis; Herba Violae Serpentis heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Folium Callicarpae Macrophyllae hemostasis, pain relieving, dissipating blood stasis for subsidence of swelling; Radix rubi Xanthocarpi anti-inflammatory analgetic.

Clinical data

1, physical data observes case is 60 routine tumor patients in May, 2009 ~ 2010 2 months sections, is my institute oncology hospitalization patient.Wherein pulmonary carcinoma 23 example, esophageal carcinoma 5 example, gastric cancer 8 example, intestinal cancer 9 example, hepatocarcinoma 9 example, cancer of pancreas 2 example, breast carcinoma 4 example.Inclusive criteria: (1) age: 18 ~ 70 years old; (2) moderate and severe pain patient; (3) without obvious cardio-pulmonary function obstacle, KPS >=30 point, estimate the inpatient of life cycle more than 1 month; (4) informed consent, the good person of compliance; (5) without drug dependence and allergy sufferers.

2, treatment and care method patient use Chinese drug anesthesia ZHITONG GAO of the present invention, take Herba Spilanthis callimorphae 13g, Semen Caesalpiniae Minacis 6g, Ilex sp. 10g, Radix Elaeagni Multiflorae 20g, Herba Ardisiae Pusillae 6g, Radix campsis 7g, Herba Lysimachiae Circaeoidis 6g, Herba Violae Serpentis 9g, Folium Callicarpae Macrophyllae 35g, Radix rubi Xanthocarpi 7g.Decoct after adding appropriate distilled water, totally twice, merge medical filtration, adding ethanol makes its alcohol content reach 75%, carries out precipitate with ethanol process, leaves standstill and filters, reclaim ethanol, make concentration of liquid medicine to paste after waving most alcohol taste, add the antiseptic of 2%, stir, vessel port seals, and after autoclaving, places room temperature, refrigerated storage, for subsequent use.During use, to be coated in about 0.5cm on cotton paper thick by flat for ZHITONG GAO, stick in the most violent position of patient pain, or react on the pain sensitivity district of body surface, the extensive obfuscator in patient pain position, can choose point-application around sore spot, size is about 10cm × 5cm, applies ointment or plaster every day 6 to 10 hours, change 1 every day, being used in conjunction 10 days was 1 course for the treatment of.

3, criterion of therapeutical effect is effective: pain score decline more than 50%, A level total score decline 85%, B level total score decline >=70%, < 85%, C level total score decline >=50%, < 70%; Effective: total score declines 50% or following, A level total score decline >=40%, < 50%, B level total score decline >=30%, < 40%, C level total score decline < 30%; Invalid: total score is without decline.

4, therapeutic outcome sees the following form:

According to therapeutic outcome, Chinese drug anesthesia ZHITONG GAO of the present invention is total effective rate 95% in control cancer pain, evident in efficacy.All patients before the treatment after, breathing, heart rate, pulse frequency, blood pressure, blood, urine, stool routine, hepatic and renal function and the change of electrocardiogram equal Non Apparent Abnormality, all there is not untoward reaction in viewing duration.

Detailed description of the invention

Embodiment one: take Herba Spilanthis callimorphae 13g, Semen Caesalpiniae Minacis 6g, Ilex sp. 10g, Radix Elaeagni Multiflorae 20g, Herba Ardisiae Pusillae 6g, Radix campsis 7g, Herba Lysimachiae Circaeoidis 6g, Herba Violae Serpentis 9g, Folium Callicarpae Macrophyllae 35g, Radix rubi Xanthocarpi 7g, decoct after adding appropriate distilled water, twice totally, merge medical filtration, adding ethanol makes its alcohol content reach 75%, carry out precipitate with ethanol process, leave standstill and filter, reclaim ethanol, make concentration of liquid medicine to paste after waving most alcohol taste, add the antiseptic of 2%, stir, vessel port seals, after autoclaving, place room temperature, refrigerated storage, for subsequent use.

Embodiment two: take Herba Spilanthis callimorphae 15g, Semen Caesalpiniae Minacis 8g, Ilex sp. 8g, Radix Elaeagni Multiflorae 25g, Herba Ardisiae Pusillae 3g, Radix campsis 9g, Herba Lysimachiae Circaeoidis 4g, Herba Violae Serpentis 10g, Folium Callicarpae Macrophyllae 40g, Radix rubi Xanthocarpi 10g, preparation method is with embodiment one.

Embodiment three: take Herba Spilanthis callimorphae 10g, Semen Caesalpiniae Minacis 5g, Ilex sp. 12g, Radix Elaeagni Multiflorae 15g, Herba Ardisiae Pusillae 9g, Radix campsis 5g, Herba Lysimachiae Circaeoidis 9g, Herba Violae Serpentis 8g, Folium Callicarpae Macrophyllae 30g, Radix rubi Xanthocarpi 5g, preparation method is with embodiment one.

Claims

1. for controlling an anesthesia analgesic paste for cancerous pain, it is characterized in that this anesthesia analgesic paste is made up of the Chinese medicine of following weight portion: Herba Spilanthis callimorphae 10-15 part, Semen Caesalpiniae Minacis 5-8 part, Ilex sp. 8-12 part, Radix Elaeagni Multiflorae 15-25 part, Herba Ardisiae Pusillae 3-9 part, Radix campsis 5-9 part, Herba Lysimachiae Circaeoidis 4-9 part, Herba Violae Serpentis 8-10 part, Folium Callicarpae Macrophyllae 30-40 part, Radix rubi Xanthocarpi 5-10 part.

2. a kind of anesthesia analgesic paste for controlling cancerous pain according to claim 1, is characterized in that this anesthesia analgesic paste is made up of the Chinese medicine of following weight portion: Herba Spilanthis callimorphae 13 parts, Semen Caesalpiniae Minacis 6 parts, Ilex sp. 10 parts, Radix Elaeagni Multiflorae 20 parts, Herba Ardisiae Pusillae 6 parts, Radix campsis 7 parts, 6 parts, Herba Lysimachiae Circaeoidis, Herba Violae Serpentis 9 parts, Folium Callicarpae Macrophyllae 35 parts, Radix rubi Xanthocarpi 7 parts.