CN104523216B - A kind of hysteroscope system based on optical coherence tomography and its implementation - Google Patents
A kind of hysteroscope system based on optical coherence tomography and its implementation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
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Abstract
The invention discloses a kind of hysteroscope system based on optical coherence tomography and its implementation, wherein, the described hysteroscope system based on optical coherence tomography comprises: hysteroscope main mirror, optical coherence tomography module and imaging main frame.Compared with existing hysteroscope, the hysteroscope system based on optical coherence tomography of the present invention can realize common white photoimaging and degree of depth tomography two kinds of patterns simultaneously.Degree of depth tomography provides the organizational information in the uterine epidermal 2-3mm degree of depth, detectablely occurs in subcutaneous early carcinomatous change, and the early stage disease for uterus carcinoma is disconnected provides important means.In addition, owing to adopting ultra-wideband light source, imaging depth can reach 2-3mm.Owing to adopting wide field interference mode, simplify the imaging photoconduction of the band scanning element needed for general optical fault chromatography imaging technique, namely the existing imaging optical fiber bundle in market can be used as imaging and leads, without the need to design probe, this design is easy to produce, and has good marketing application prospect.
Description
Technical field
The present invention relates to endoscopic technique field, in particular a kind of hysteroscope system based on optical coherence tomography and its implementation.
Background technology
Hysteroscope is new, an invasive gynecological Clinics, for checking in cavity of uterus and a kind of fiber light source endoscope for the treatment of, be mainly used in the lower symptom of diagnosis: foreign body in abnormal uterine bleeding, infertility or habitual aborter, uterine cavity, submucous myoma excision, endometrial polyp excision, intrauterine adhesion, uterine septum excise, carcinoma of endometrium.
Cervix uteri mirror imaging system comprises hysteroscope, energy resource system, light-source system, perfusion system and imaging system; It utilizes the front portion of mirror body to enter uterine cavity, adopt white-light illuminating, and color high-definition has enlarge-effect to observed position, intuitively, accurately to become the first-selected inspection method of gynecology hemorrhagic disease and Intrauterine pathologies.Hysteroscope directly can inspect Intrauterine pathologies, can make rapidly accurate diagnosis to most of intrauterine disease.
But, because uterus early carcinomatous change often occurs in below mucous layer, although cervix uteri mirror can obtain the grown form of uterine mucosa epithelium, but owing to using white-light illuminating, the penetration depth of white light to tissue is limited, cannot check profound level tissue, and therefore diagnostic accuracy is not enough.Also there is no a kind of instrument carrying out Depth Imaging diagnosis for uterine mucosa fine structure at present.
Optical coherence tomography (Opticalcoherencetomography, OCT) be the ultimate principle utilizing weak coherent light interferometer, biological tissue's different depth aspect can be detected to the back-reflection of incident weak coherent light or scattered signal several times, by scanning, biological tissue's two dimension or three dimensional structure image can be obtained, contactless, the Noninvasive fault imaging of live body ocular tissue microscopic structure can be realized.Optical coherence tomography is ultrasonic optical analog product, but its axial resolution depends on the coherence of light source, can reach 10um, and can reach the penetration depth of about 3mm in biological tissues.Spot scan is adopted in traditional Optical coherence tomography, wide field optical coherence tomography system once can carry out interference imaging to a plane, quick realtime imaging has very high potential, and simultaneously owing to not needing scanning element, probe designs and production are simplified.
In view of this, how wide field optical coherence tomography and hysteroscope are organically combined and use, realize preparing when biological tissue positioning and qualitative and detailed inspection is carried out to uterine mucosa or infantile tumour become one of current research direction.
Summary of the invention
The object of the present invention is to provide a kind of hysteroscope system based on optical coherence tomography and its implementation, be intended to solve the problems such as diagnostic accuracy that existing cervix uteri mirror exists is not enough.
Technical scheme of the present invention is as follows:
Based on a hysteroscope system for optical coherence tomography, wherein, comprising:
One hysteroscope main mirror, it comprises further: imaging probe, for white light imaging interface, for the image camera of white light imaging and lighting source; The white light that lighting source sends obtains corresponding white light imaging image information be back to image camera after imaging probe after;
One optical coherence tomography module, it comprises further: an imaging optical fiber bundle, a wide field optical coherence tomography light path and a ultra-wideband light source; The infrared light that ultra-wideband light source sends is linked into hysteroscope main mirror through wide field optical coherence tomography light path by imaging optical fiber bundle, obtains corresponding infrared wide field image-forming information;
One imaging main frame, it connects hysteroscope main mirror and optical coherence tomography module respectively;
Wherein, described infrared wide field image-forming information and white light imaging image information are sent into imaging main frame simultaneously and are carried out signal processing, and export corresponding testing result.
Preferably, the described hysteroscope system based on optical coherence tomography, wherein, the imaging probe of described hysteroscope main mirror comprises: the white light hysteroscope camera lens independently arranged and infrared light hysteroscope camera lens.
Preferably, the described hysteroscope system based on optical coherence tomography, wherein, described optical coherence tomography light path comprises a Michelson formula optical interference circuit and double precision optical delay line platform;
Wherein, double precision optical delay line platform is made up of a piezoelectric ceramics and motor; During imaging, ultra-wideband light source launch infrared light be divided into two bundles by one 50/50 beam splitters: a branch of be conveyed into the double precision optical delay line platform be made up of piezoelectric ceramics and motor after, be reflected back beam splitter through reflecting mirror again, another Shu Zuowei infrared illumination exports through the output interface of ultra-wideband light source.
Preferably, described wide field optical coherence tomography module can adopt sweep method to realize, and concrete plant modification is, ultra-wideband light source adopts infrared swept light source to substitute, described double precision optical delay line adopts and only uses piezoelectric ceramics micro-displacement platform, and algorithm also does corresponding change.
An implementation method for the above-mentioned hysteroscope system based on optical coherence tomography, wherein, said method comprising the steps of:
After S1, imaging probe are inserted, the white light that lighting source sends obtains corresponding white light imaging image information be back to image camera after imaging probe after;
The infrared light that S2, ultra-wideband light source send is linked into hysteroscope main mirror through wide field optical coherence tomography light path by imaging optical fiber bundle, obtains corresponding infrared wide field image-forming information;
S3, described infrared wide field image-forming information and white light imaging image information are sent into imaging main frame simultaneously and are carried out signal processing, and export corresponding testing result.
Preferably, the implementation method of the described hysteroscope system based on optical coherence tomography, wherein, is characterized in that, described step S2 comprises further:
During imaging, ultra-wideband light source launch infrared light be divided into two bundles by one 50/50 beam splitters: a branch of be conveyed into the double precision optical delay line platform be made up of piezoelectric ceramics and motor after, be reflected back beam splitter through reflecting mirror again, another Shu Zuowei infrared illumination exports through the output interface of ultra-wideband light source.
Preferably, the implementation method of the described hysteroscope system based on optical coherence tomography, wherein, in step S3, imaging main frame carries out signal processing and specifically comprises:
By four step substep phase shift algorithm, structure chart reconstruction is carried out to the information collected, obtains the image information of sample.
Compared with prior art, the hysteroscope system based on optical coherence tomography provided by the present invention and its implementation have the following advantages:
(1) hysteroscope described in this patent, compared with existing hysteroscope, can realize common white photoimaging and degree of depth tomography two kinds of patterns simultaneously.Degree of depth tomography provides the organizational information in the uterine epidermal 2-3mm degree of depth, detectablely occurs in subcutaneous early carcinomatous change, provides important means to the early stage disease of uterus carcinoma is disconnected.
(2) this patent the scheme of optical fault chromatography imaging technique that adopts be wide field infrared optics tomography.Compare with existing optical fault chromatography imaging technique, owing to adopting ultra-wideband light source, imaging depth can reach 2-3mm.Owing to adopting wide field interference mode, simplify the scanheads needed for general optical fault chromatography imaging technique, existing imaging optical fiber bundle can use, and without the need to design probe, is easy to produce.
(3) combination of optical fault chromatography imaging technique and existing hysteroscope: because the imaging of optical fault chromatography imaging technique adopts imaging optical fiber bundle, biopsy channel can be utilized to carry out imaging, is convenient to reequip on existing hysteroscope basis.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the embodiment of the hysteroscope system based on optical coherence tomography of the present invention.
Fig. 2 is the schematic diagram of hysteroscope main mirror in the embodiment of the hysteroscope system based on optical coherence tomography of the present invention.
Fig. 3 is the schematic diagram of the first embodiment based on optical coherence tomography module in the hysteroscope system of optical coherence tomography of the present invention.
Fig. 4 is the schematic diagram of the second embodiment based on optical coherence tomography module in the hysteroscope system of optical coherence tomography of the present invention.
Fig. 5 is the flow chart of the implementation method of the hysteroscope system based on optical coherence tomography of the present invention.
Detailed description of the invention
The invention provides a kind of hysteroscope system based on optical coherence tomography and its implementation, for making object of the present invention, technical scheme and effect clearly, clearly, the present invention is described in more detail below.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Refer to Fig. 1, it is the schematic diagram of the embodiment of the hysteroscope system based on optical coherence tomography of the present invention.As shown in the figure, the described hysteroscope system based on optical coherence tomography comprises: hysteroscope main mirror, optical coherence tomography module and imaging main frame 3; Wherein, described hysteroscope main mirror comprise imaging probe 1-1, for the fluid intake 1-2 of perfusion and outlet 1-3, for insert biopsy tweezer biopsy channel 1-4, for white light imaging interface 1-5 with for the image camera 1-6 of white light imaging and lighting source 1-7.Described optical coherence tomography module comprises: the imaging optical fiber bundle 2-1 of one ruler cun accessible hysteroscope biopsy channel, a wide field optical coherence tomography light path are (in figure, represent with 2-2 to 2-8, can describe in detail below) and a ultra-wideband light source 2-9.
See also Fig. 2, in the present embodiment, main mirror comprises imaging probe 1-1, for fluid intake 1-2 and the outlet 1-3 of perfusion, for inserting the biopsy channel 1-4 of biopsy tweezer, for white light imaging interface 1-5.During imaging, patient empties's bladder, gets lithotomy position, uses local anesthesia, after cervical clamps clamping labium anterius, detects uterine cavity size, and expands palace with intra-uterine dilator.First inject a little swollen palace liquid as 5% must, and hysteroscope camera lens 1-1 is inserted.Inject swollen palace liquid by the pressure needed for different medium and speed by 1-2 (outlet of the corresponding 1-2 of 1-1-2) afterwards, uterine cavity is filled, and becomes clear in the visual field.White-light illuminating is exported through 1-3 (outlet of the corresponding 1-3 of 1-1-3) by light, and White-light image is back to image camera 1-6 through 1-1-1 and gathers.Rotatable mirror body during collection, and make complete observation in order, obtain the inner white light imaging result of uterine cavity thus.
Please continue to refer to Fig. 3, optical coherence tomography light path comprises a Michelson formula optical interference circuit and double precision optical delay line platform, and optical delay line platform is made up of a piezoelectric ceramics 2-4 and motor 2-5.During imaging, the infrared light that ultra-wideband light source 2-9 launches is divided into two bundles by one piece of 50/50 beam splitter 2-6, a branch of be conveyed into the double precision optical delay line platform be made up of piezoelectric ceramics 2-4 and motor 2-5 after, be reflected back beam splitter 2-6 through reflecting mirror 2-3 again, another Shu Zuowei infrared illumination exports through ultra-wideband light source output interface 2-2.Uterine mucosa is thrown light on by hysteroscope camera lens 1-1-4 by imaging optical fiber bundle 2-1, infrared beam can realize to the uterine cancer cell observed the irradiation that penetration depth is 2-3mm, reflected light is still gathered by imaging port 1-1-4, and passes infrared wide field optical coherence tomography module (i.e. optical coherence tomography module) back by imaging optical fiber bundle 2-1.The folded light beam passed back by the port 2-2 of infrared wide field optical coherence tomography module is with uterine cancer cell information, interfere at beam splitting chip 2-6 and the reference beam through optical delay line platform, obtain the face interference light signal of the corresponding degree of depth of reflection place, white light source reflected light signal and described face interference light signal transfer to described imaging main frame 3.
Should be understood that, the thinking that described employing hysteroscope biopsy channel does optical fault tomography can be used for other all there is the endoscope of biopsy channel.As rectoscope, gastroscope etc.Corresponding imaging optical fiber bundle can be selected according to endoscopic biopsy channel size.
Further, as shown in Figure 4, optical coherence tomography light path of the present invention can also adopt other modes to realize: changing ultra-wideband light source is infrared swept light source, meanwhile, only uses a reflecting mirror 2-3 and piezoelectric ceramics 2-4 (saving motor 2-5).
Further, the information being input to imaging main frame 3 comprises the interferogram information that infrared camera collects, abundant informations such as comprising intensity, phase place, frequency is carried owing to relating to figure information, but interferogram itself directly can not reflect the structure of sample, need to reduce sample structure image by phase modulation and phase shift restructing algorithm, specifically, need sample or reference mirror to move specific or equal step-length, then calculate intensity and phase information with the interferogram obtained after such control phase.The present invention applies four step substep phase shift algorithm and carries out structure chart reconstruction.
By a concrete example, the present invention illustrates how its four steps substep phase shift algorithm realizes.
Interference signal is expressed as
Wherein I0 is DC terms, and A is interference signal amplitude, the strength information namely required, φ is the initial phase relevant with sample,
it is the phase-shift phase of modulation.Infrared camera gathers four width images within each phase shift cycle, T=1/f, does not need specific 90 degree of phase-shift phases here, only needs the interval that each phase shift keeps equal, also can increase and gather phase shifted images width number N to improve the signal to noise ratio of interference image.
Can derive intensity amplitude is thus
The phase-shift phase of modulation is
The phase information of sample can be calculated according to this:
Formula 1 and formula 4 are the intensity and phase information that each pixel four-step phase-shifting of infrared camera obtains.The image information of sample can be obtained by restructuring pixel distribution.Certainly, the signal of above-mentioned camera collection can also access installation medical monitor and carry out processes and displays, and medical monitor is connected to form by processing host, display and operating control keyboard, completes optical coherence tomography three-dimensional reconstruction structure in main frame.
Present invention also offers a kind of implementation method of the hysteroscope system based on optical coherence tomography, as shown in Figure 5, said method comprising the steps of:
After S100, imaging probe are inserted, the white light that lighting source sends obtains corresponding white light imaging image information be back to image camera after imaging probe after;
The infrared light that S200, ultra-wideband light source send is linked into hysteroscope main mirror through wide field optical coherence tomography light path by imaging optical fiber bundle, obtains corresponding infrared wide field image-forming information;
S300, described infrared wide field image-forming information and white light imaging image information are sent into imaging main frame simultaneously and are carried out signal processing, and export corresponding testing result.
Further, described step S2 comprises further:
During imaging, ultra-wideband light source launch infrared light be divided into two bundles by one 50/50 beam splitters: a branch of be conveyed into the double precision optical delay line platform be made up of piezoelectric ceramics and motor after, be reflected back beam splitter through reflecting mirror again, another Shu Zuowei infrared illumination exports through the output interface of ultra-wideband light source.In addition, in step S3, imaging main frame carries out signal processing and specifically can also comprise:
By four step substep phase shift algorithm, structure chart reconstruction is carried out to the information collected, obtains the image information of sample.
In sum, the hysteroscope system based on optical coherence tomography provided by the invention and its implementation, wherein, the described hysteroscope system based on optical coherence tomography comprises: hysteroscope main mirror, optical coherence tomography module and imaging main frame.Compared with existing hysteroscope, the hysteroscope system based on optical coherence tomography of the present invention can realize common white photoimaging and degree of depth tomography two kinds of patterns simultaneously.Degree of depth tomography provides the organizational information in the uterine epidermal 2-3mm degree of depth, detectablely occurs in subcutaneous early carcinomatous change, provides important means to the early stage disease of uterus carcinoma is disconnected.In addition, owing to adopting ultra-wideband light source, imaging depth can reach 2-3mm.Owing to adopting wide field interference mode, simplify the scanheads needed for general optical fault chromatography imaging technique, existing imaging optical fiber bundle can use, and without the need to design probe, is easy to produce, has good marketing application prospect.
Should be understood that, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection domain that all should belong to claims of the present invention.
Claims (6)
1. based on a hysteroscope system for optical coherence tomography, it is characterized in that, comprising:
One hysteroscope main mirror, it comprises further: imaging probe, the interface for white light imaging, the image camera for white light imaging and lighting source; The white light that lighting source sends obtains corresponding white light imaging image information be back to image camera after imaging probe after;
One optical coherence tomography module, it comprises further: an imaging optical fiber bundle, a wide field optical coherence tomography light path and a ultra-wideband light source; The infrared light that ultra-wideband light source sends is linked into hysteroscope main mirror through wide field optical coherence tomography light path by imaging optical fiber bundle, obtains corresponding infrared wide field image-forming information;
One imaging main frame, it connects hysteroscope main mirror and optical coherence tomography module respectively;
Wherein, described infrared wide field image-forming information and white light imaging image information are sent into imaging main frame simultaneously and are carried out signal processing, and export corresponding testing result;
Described wide field optical coherence tomography light path comprises a Michelson formula optical interference circuit and double precision optical delay line platform;
Wherein, double precision optical delay line platform is made up of a piezoelectric ceramics and motor; During imaging, ultra-wideband light source launch infrared light be divided into two bundles by one 50/50 beam splitters: a branch of be conveyed into the double precision optical delay line platform be made up of piezoelectric ceramics and motor after, be reflected back beam splitter through reflecting mirror again, another Shu Zuowei infrared illumination exports through the output interface of ultra-wideband light source.
2. the hysteroscope system based on optical coherence tomography according to claim 1, is characterized in that, the imaging probe of described hysteroscope main mirror comprises: the white light hysteroscope camera lens independently arranged and infrared light hysteroscope camera lens.
3. the hysteroscope system based on optical coherence tomography according to claim 1, is characterized in that, described ultra-wideband light source adopts infrared swept light source to substitute, and described double precision optical delay line platform adopts and only uses piezoelectric ceramics micro-displacement platform.
4. an implementation method for the hysteroscope system based on optical coherence tomography according to claim 1, is characterized in that, said method comprising the steps of:
After S1, imaging probe are inserted, the white light that lighting source sends obtains corresponding white light imaging image information be back to image camera after imaging probe after;
The infrared light that S2, ultra-wideband light source send is linked into hysteroscope main mirror through wide field optical coherence tomography light path by imaging optical fiber bundle, obtains corresponding infrared wide field image-forming information;
S3, described infrared wide field image-forming information and white light imaging image information are sent into imaging main frame simultaneously and are carried out signal processing, and export corresponding testing result.
5. the implementation method of the hysteroscope system based on optical coherence tomography according to claim 4, is characterized in that, described step S2 comprises further:
During imaging, ultra-wideband light source launch infrared light be divided into two bundles by one 50/50 beam splitters: a branch of be conveyed into the double precision optical delay line platform be made up of piezoelectric ceramics and motor after, be reflected back beam splitter through reflecting mirror again, another Shu Zuowei infrared illumination exports through the output interface of ultra-wideband light source.
6. the implementation method of the hysteroscope system based on optical coherence tomography according to claim 5, is characterized in that, in step S3, imaging main frame carries out signal processing and specifically comprises:
By four step substep phase shift algorithm, structure chart reconstruction is carried out to the information collected, obtains the image information of sample.
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| CN113273968A (en) * | 2021-05-24 | 2021-08-20 | 汤姆飞思（香港）有限公司 | Detection method, device and system for directly applying noninvasive OCT (optical coherence tomography) to endometrium |
| CN113854949A (en) * | 2021-11-10 | 2021-12-31 | 福建师范大学 | Hysteroscope-based photoacoustic imaging system and working method thereof |
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| CN201055372Y (en) * | 2007-07-20 | 2008-05-07 | 浙江大学 | Rigid pipe type common-path type endoscopic OCT parallel imaging system |
| CN202821285U (en) * | 2012-09-04 | 2013-03-27 | 无锡微奥科技有限公司 | Composite endoscopic imaging system based on optical coherence tomography |
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Address after: 528253 Room 503, Floor 5, Building A, Jingu Zhichuang Industrial Community, No. 2, Yong'an North Road, Dawu Community, Guicheng Street, Nanhai District, Foshan City, Guangdong Province (residence declaration) Patentee after: Guangdong Oupu Mandi Technology Co.,Ltd. Address before: 528251 504, block a, Jingu optoelectronics, No.1, Yong'an North Road, Nanhai District, Foshan City, Guangdong Province Patentee before: GUANGDONG OPTOMEDIC TECHNOLOGY CO.,LTD. |
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