CN104522657A - Health food capable of supplementing multiple mineral substances - Google Patents
Health food capable of supplementing multiple mineral substances Download PDFInfo
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- CN104522657A CN104522657A CN201410801503.9A CN201410801503A CN104522657A CN 104522657 A CN104522657 A CN 104522657A CN 201410801503 A CN201410801503 A CN 201410801503A CN 104522657 A CN104522657 A CN 104522657A
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Abstract
The invention discloses a health food capable of supplementing multiple mineral substances. The health food comprises the following components in percentage by weight: 5-25% of calcium hydrophosphate, 5-25% of calcium L-threonate, 3-12% of zinc glycinate, 2-6% of manganese gluconate, 0.5-3% of magnesium gluconate, 0.5-3% of ferrous fumarate, 3-12% of selenium-enriched edible mushroom powder and the balance of auxiliary materials, wherein the ratio of additions of calcium hydrophosphate to calcium L-threonate is 1:1. Since the mineral substances added in the health food exist in an organic substance chelated or amino acid chelated form, the mineral substances can be rapidly decomposed, the bioavailability of the mineral substances is greatly improved; the additions of calcium L-threonate and calcium hydrophosphate are same so as to ensure that the ration of calcium to phosphorus is 2:1, and the health food is more suitable for a human body to absorb. The health food has the advantages of reasonable component, scientific proportion, good taste feeling, reliable effect and no toxicity and side effects and can be administrated in a long term.
Description
Technical field
The present invention relates to health products exploitation and preparing technical field, especially a kind of health food of supplementary several mineral materials.
Background technology
We know, have confirmed as the indispensable essential trace element of maintenance normal activities at present and have had 14 kinds, i.e. iron, copper, zinc, iodine, selenium, manganese, cobalt, chromium, molybdenum, nickel, silicon, tin, vanadium and fluorine.The effect of various different minerals confrontation human body is very large, and wherein, calcium is that human body must obtain important mineral element, supplements appropriate edible calcium, can reduce bone loss, the generation of delaying osteoporosis; Iron is a kind of essential trace element that body burden is maximum, and iron deficiency can cause anaemia, causes hypoferric anemia, and make people's fatiguability, trick is sent out cool, and immunity and anti-infection ability reduce; Zinc is that various zinc relies on the necessary material of enzyme, and be also RNA polymerase simultaneously, archaeal dna polymerase activates necessary element, scarce zinc can cause parageusia, appetite declines, some appearance allotriophagys, impact property function, increase the weight of stagnation of growing, also can occur epithelial damage; Selenium is the trace element of needed by human, is to form paddy to look into the distance sweet peptide peroxidase (GSH-Px), can Cell protection and tissue avoid damaging by peroxide, particularly Cell protection film and organelle mitochondria, microsome and lysosomal film; Manganese deficiency can affect fecundity, can make offspring's congenital abnormality, and the abnormal and impaired glucose tolerance of the formation of bone and cartilage, causes the reduction of insulin synthesis and secretion, affect glycometabolism, also can cause neurasthenia syndrome, affect intelligence development; Magnesium belongs to the one in human nutrition element-mineral matter element, belong to the macroelement class of mineral matter, as the activator of enzyme, participate in the enzymatic reaction of more than 300 kinds, also can involved in sugar glycolysis, fatty acid oxidation, protein synthesis, nucleic acid metabolism etc., in addition, promote that the formation of bone has important function.And these mineral matters can not generate in vivo, must be obtained by external environment.Due to some trace element in vivo, its physiological action is minimum, and effective dose and toxic dose are extremely close, and therefore insufficiency of intake or Excess free enthalpy are not only unhelpful is harmful on the contrary, therefore necessary science during condensed food interpolation trace element, all should meet science requirements to enhancement vector and strengthening dosage.
At present, relevant report is had to mineral composition, if application number is refer in " a kind of minerals and vitamins nutritious supplementary pharmaceutical " of 201210011296.2 to adopt chromium picolinate, selenide of carragheen, magnesium citrate, vitamin B1, vitamin B2, vitamin B6, polydextrose is that primary raw material is made.Although this combination has effect of supplementary mineral matter, mainly supplement chromium, selenium, these three kinds of mineral matters of magnesium, supplementary function is not had to the calcium in the present invention, zinc, manganese, this several mineral matter of iron.In above-mentioned disclosed mineral composition, great majority are all select inorganic matter as carrier, and nutrient is single, and proportioning is science not, and easily causing is mineral matter insufficiency of intake or excessive, greatly have impact on absorption and the utilization of mineral matter, cause the wasting of resources.
Summary of the invention
Have that nutrient element is single, the unscientific deficiency of proportioning to overcome existing mineral composition, the object of this invention is to provide a kind ofly to form rationally, proportioning science, bioavailability are high, absorption of human body good, the health food of supplementary several mineral materials that has no side effect.
The present invention solves the scheme that its technical problem adopts: a kind of health food of supplementary several mineral materials, it is characterized in that: it is made up of the component of following weight percents: calcium monohydrogen phosphate 5 ~ 25%, l threonic acid 5 ~ 25%, glycine zine 3 ~ 12%, manganese gluconate 2 ~ 6%, magnesium gluconate 0.5 ~ 3%, ferrous fumarate 0.5 ~ 3%, selenium-enriched edible mushroom powder 3 ~ 12%, all the other are auxiliary material, the percentage by weight sum of each component is 100%, and described calcium monohydrogen phosphate and the addition of l threonic acid are 1 ︰ 1.
Further, described auxiliary material is made up of beeswax, phosphatide and olive oil, and wherein, the percentage by weight of described beeswax is 3 ~ 8%, and the percentage by weight of described phosphatide is 3 ~ 8%, and the percentage by weight of described olive oil is 30 ~ 60%.
Precedence technique scheme of the present invention is: the percentage by weight of described each component is: calcium monohydrogen phosphate 11%, l threonic acid 11%, glycine zine 4%, manganese gluconate 3%, magnesium gluconate 1%, ferrous fumarate 0.7%, selenium-enriched edible mushroom powder 3.3%, auxiliary material 66%, wherein, in described auxiliary material, the percentage by weight of beeswax is 6%, the percentage by weight of phosphatide is 6%, and the percentage by weight of olive oil is 54%.
The health food of supplementary several mineral materials of the present invention can be made into soft capsule, be made up of flexible glue utricule and the content be encapsulated in flexible glue utricule, its content makes suspendible feed liquid, again through capsule material making, pelleting, drying, wash the operations such as ball and make soft capsule, produce the health care soft capsule that content content is the supplementary several mineral materials of 500 mg ~ 1000mg/ grains.Described flexible glue utricule is by the ratio preparation routinely of gelatin, glycerine, water.The concrete preparation technology of its soft capsule belongs to prior art, repeats no more.
Usage of the present invention and consumption are: adult's recommended amounts every day is 1g.Be every day 2 times by human body recommended intake, each 1, can long-term taking.
Calcium monohydrogen phosphate chosen by the health food of supplementary several mineral materials of the present invention, l threonic acid, glycine zine, manganese gluconate, magnesium gluconate, ferrous fumarate, selenium-enriched edible mushroom powder are raw material, wherein, calcium monohydrogen phosphate is a kind of phosphate of calcium, calcium exists with the form of ion after entering human body, is more conducive to absorption of human body; L threonic acid is the moderate complex compound of a kind of molecular size, both water-soluble, dissolves in grease again.It is easily by intestinal mucosa identification, and directly can be absorbed with the form of complex molecules, absorptivity is high; Its pH value of water solution, close to neutral, to stomach without any excitant, do not need vitamin D reinforcing in absorption process, does not consume hydrochloric acid in gastric juice; Glycine zine is a kind of food zinc enhancer, and have important effect to the intelligence of human body and body development, assimilation effect is better than inorganic zinc; Manganese in manganese gluconate can activate a large amount of enzymes in human body, participates in organism metabolism movable, promotes growth in humans and normal osteogenic action; Magnesium gluconate is dissociated into magnesium ion and gluconic acid in vivo, participate in energetic supersessions all in body, the formation of the platelet aggregation that prevention human body causes because of magnesium deficiency and coronary artery thrombus, enhances metabolism, improves cytotrophy, improves a poor appetite and nutrition, help are grown; Ferrous fumarate infiltration rate is fast, participates in the generation of multiple enzyme in body, has activation, enhanced machine body immunity function; In the several times of the suitable ferrous sulfate of the absorptivity of enteron aisle, do not disturb the absorption of other element, good with various nutriment, antibiotic compatibility, there is synergy; Selenium-enriched edible mushroom powder gathers selenium ability by force, and selenium content exceeds nearly thousand times than the selenium content of common plant, and wherein Organic Selenium is up to more than 99% in total Se content, and its bioavailability exceeds 28% than inorganic selenium; Except containing except abundant Organic Selenium, also contain the trace element of abundant polypeptide, polysaccharide, vitamin and multiple needed by human body.The mineral matter that the health food of supplementary several mineral materials of the present invention adds exists mainly with the form of organic matter chelating or chelating amino acids, can decompose rapidly in vivo, drastically increase the bioavailability of mineral matter, and l threonic acid is identical with the addition of calcium monohydrogen phosphate, can ensure that in component, calcium-phosphorus ratio is 2:1 like this, be more suitable for absorption of human body; Ferrous fumarate absorptivity is high, can not disturb the absorption of other element in vivo, cannot antagonism with other metallic element; It also added powder of edible fungus, promotes the absorption of mineral matter in enteron aisle and utilization.Show through zoopery, its effect is reliable, has no side effect.Compared with prior art, the present invention forms rationally, proportioning science, bioavailability are high, absorption of human body good, taking convenience, mouthfeel are good, has supplementary mineral matter, improves the effect of immunity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Raw materials usedly in the present embodiment be commercial products, wherein,
Calcium monohydrogen phosphate is auspicious general purchased from Zhengzhou, and its content is >=99%.Calcium monohydrogen phosphate is a kind of phosphate of calcium, and calcium exists with the form of ion after entering human body, is more conducive to absorption of human body.
L threonic acid praises occasion purchased from Shanghai, and its content is >=99%.L threonic acid is ascorbic deep processed product, is the moderate complex compound of a kind of molecular size, both water-soluble, dissolves in grease again.It directly can be absorbed with the form of complex molecules easily by intestinal mucosa identification, thus be reached high absorptivity.L threonic acid pH value of water solution, close to neutral, to stomach without any excitant, do not need vitamin D reinforcing in absorption process, does not consume hydrochloric acid in gastric juice.This product is different from other calcium agent on mechanism of absorption, be a class is dominant absorption process with Passive diffusion, has bioactive calcium source.
Glycine zine is purchased from Dong Huajinlong, and its content is >=99%.It is a kind of well food zinc enhancer, and have important effect to the intelligence of human body and body development, assimilation effect is better than inorganic zinc.
Manganese gluconate is purchased from the huge victory in Hubei, and its content is >=99%.Manganese in manganese gluconate can activate a large amount of enzymes in human body, participates in organism metabolism movable, and promoting growth in humans and normal osteogenic action, is good food additive.
Magnesium gluconate is auspicious general purchased from Zhengzhou, and its content is >=99%.Magnesium gluconate is dissociated into magnesium ion and gluconic acid in vivo, participates in energetic supersessions all in body, can activate or catalysis more than 300 enzyme system.The platelet aggregation that human body can be prevented to cause because of magnesium deficiency and the formation of coronary artery thrombus, have the anti-and membrane stabilizing action of calcium knot, can enhance metabolism, improve cytotrophy, improve a poor appetite and nutrition, help are grown.
Ferrous fumarate is encouraged into purchased from Shanghai, and wherein iron content is >=99%.Ferrous fumarate infiltration rate is fast, participates in the generation of multiple enzyme in body, has activation, enhanced machine body immunity function, improves anti-stress ability and resistance against diseases; In the several times of the suitable ferrous sulfate of the absorptivity of enteron aisle, do not disturb the absorption of other element, with other metallic element without antagonism; Good with various nutriment, antibiotic compatibility, there is synergy.
Selenium-enriched edible mushroom powder gathers selenium ability by force, and selenium content exceeds nearly thousand times than the selenium content of common plant; Wherein Organic Selenium in total Se content up to more than 99%; Its bioavailability exceeds 28% than inorganic selenium; Except containing except abundant Organic Selenium, also contain the trace element of abundant polypeptide, polysaccharide, vitamin and multiple needed by human body.
The mineral matter that the health food of supplementary several mineral materials of the present invention adds exists mainly with the form of organic matter chelating or chelating amino acids, can decompose rapidly in vivo, drastically increase the bioavailability of mineral matter, and l threonic acid is identical with the addition of calcium monohydrogen phosphate, can ensure that in component, calcium-phosphorus ratio is 2:1 like this, be more suitable for absorption of human body; Ferrous fumarate absorptivity is high, can not disturb the absorption of other element in vivo, cannot antagonism with other metallic element; It also added powder of edible fungus, promotes the absorption of mineral matter in enteron aisle and utilization.The main component of adding in auxiliary material is olive oil, and olive oil can protect cardiovascular system from many aspects, can prevent artery sclerosis and atherosclerotic syndromes, hypertension, heart disease, heart failure, kidney failure, cerebral hemorrhage; Effectively can reduce the generation of cholecystitis and gall stone and effect of prevention diabetes.
embodiment 1
A kind of health food of supplementary several mineral materials, it is made up of the component of following weight percents: calcium monohydrogen phosphate 11%, l threonic acid 11%, glycine zine 4.2%, manganese gluconate 3.0%, magnesium gluconate 1.0%, ferrous fumarate 0.7%, selenium-enriched edible mushroom powder 3.3%, auxiliary material 66%, wherein, auxiliary material is made up of beeswax, phosphatide and olive oil, the percentage by weight of beeswax is 6%, and the percentage by weight of phosphatide is 6%, and the percentage by weight of olive oil is 54%.
The health food composition of the supplementary several mineral materials that the present embodiment provides rationally, proportioning science, bioavailability are high, absorption of human body good, taking convenience, mouthfeel are good, effect is reliable, has no side effect.
embodiment 2
A kind of health food of supplementary several mineral materials, it is made up of the component of following weight percents: calcium monohydrogen phosphate 5%, l threonic acid 5%, glycine zine 12%, manganese gluconate 2%, magnesium gluconate 3%, ferrous fumarate 3%, selenium-enriched edible mushroom powder 12%, auxiliary material 58%, wherein, auxiliary material is made up of beeswax, phosphatide and olive oil, the percentage by weight of beeswax is 8%, and the percentage by weight of phosphatide is 8%, and the percentage by weight of olive oil is 42.
The health food composition of the supplementary several mineral materials that the present embodiment provides rationally, proportioning science, bioavailability are high, absorption of human body good, taking convenience, mouthfeel are good, effect is reliable, have no side effect.
embodiment 3
A kind of health food of supplementary several mineral materials, it is made up of the component of following weight percents: calcium monohydrogen phosphate 25%, l threonic acid 25%, glycine zine 3%, manganese gluconate 2%, magnesium gluconate 0.5%, ferrous fumarate 0.5%, selenium-enriched edible mushroom powder 8%, auxiliary material 36%, wherein, auxiliary material is made up of beeswax, phosphatide and olive oil, the percentage by weight of beeswax is 3%, and the percentage by weight of phosphatide is 3%, and the percentage by weight of olive oil is 30%.
The health food composition of the supplementary several mineral materials that the present embodiment provides rationally, proportioning science, bioavailability are high, absorption of human body good, taking convenience, mouthfeel are good, effect is reliable, have no side effect.
embodiment 4
A kind of health food of supplementary several mineral materials, it is made up of the component of following weight percents: calcium monohydrogen phosphate 7%, l threonic acid 7%, glycine zine 6%, manganese gluconate 6%, magnesium gluconate 2%, ferrous fumarate 1%, selenium-enriched edible mushroom powder 3%, auxiliary material 68%, wherein, auxiliary material is made up of beeswax, phosphatide and olive oil, the percentage by weight of beeswax is 4%, and the percentage by weight of phosphatide is 4%, and the percentage by weight of olive oil is 60%.
The health food composition of the supplementary several mineral materials that the present embodiment provides rationally, proportioning science, bioavailability are high, absorption of human body good, taking convenience, mouthfeel are good, effect is reliable, have no side effect.
Finished product involved by the embodiment of the present invention 1 ~ 4, can be prepared into soft capsule by following process steps:
A () suspendible material is produced: weigh beeswax, phosphatide, olive oil heating by weight ratio, dissolve, make suspension;
(b) grinding, degassed: to weigh calcium monohydrogen phosphate by weight ratio, l threonic acid, glycine zine, manganese gluconate, magnesium gluconate, ferrous fumarate, selenium-enriched edible mushroom powder be placed in colloid mill grinding three times, cross 100 mesh sieves, add in suspension, stir, obtain content material; Content material is placed in vacuum kettle degassed;
C the making of () capsule material: by gelatin, water, glycerine in 100: 100: 40 ratio weighings, in being shipped to glue tank, stirs and is warming up to 60 DEG C ~ 75 DEG C, treat that gelatin all melts, decompression vacuum pumping, insulation is for subsequent use;
(d) pelleting: the content material that capsule body filtrate step (c) obtained and step (b) obtain is sent in pellet press according to the ratio of weight ratio 1: 2, suppresses soft capsule, and drying, packaging, finished product.
carry out zoopery with the given health food supplementing several mineral materials of embodiment 1 below, further illustrate the present invention and there is the effect improving immunity.
1), materials and methods
1.1), sample: according to the embodiment of the present invention 1 provide preparation method to prepare the soft capsule of 500mg.Human oral's recommended amounts is every day 1 time, each 2, and adult's body weight press 60kg calculating, amounts to dosage 0.167g/kg.bw.
1.2), animal used as test and grouping: body weight is the SPF level Kunming kind female mice 50 of 18g-22g, is provided by Henan Province's Experimental Animal Center.Be divided into control group, experimental group at random.Experimental group is amounted to dosage per os with the sample given by embodiment 1 and is given, and control group is with isodose starch feeding.
1.3), experimental situation condition: experiment condition is barrier environment, temperature 22 DEG C-24 DEG C, humidity 52%-54%.
1.4), experimental technique:
1.4.1), the mouse lymphocyte transformation experiment (mtt assay) of ConA induction: asepticly get spleen, make cell suspension, Hank ' s liquid washes 2 times, and adjustment cell concentration is 3 × 106/ml.Join in 24 well culture plates by a cell suspension point holes, every hole 1ml, a hole adds 75ulConA liquid (7.5ug/ml), and another hole is contrast, puts 5% carbon dioxide, cultivates 72h for 37 DEG C.Cultivation terminates front 4h, and every hole sucks supernatant 0.7ml, adds 0.7ml not containing the RPMI1640 nutrient solution of calf serum, adds MTT (5mg/ml) 50ul/ hole simultaneously, continues to cultivate 4h.After cultivation terminates, every hole adds 1ml acid isopropyl alcohol, and piping and druming mixing, makes purple crystal dissolve completely, measures OD value with 570nm wavelength.
1.4.2), antibody-producting cell detect (Jerne improves slide method): get sheep blood brine 3 times, hematocrit SRBC physiological saline be made into 2%(v/v) cell suspension, every mouse lumbar injection 0.2ml.Immunity 5 days after, put to death mouse, get spleen, 200 eye mesh screens filter, washing, centrifugal 2 times, finally cell is suspended in 8mlHanks liquid.Adjustment cell concentration is 5 × 106/ml.By top layer culture medium heating for dissolving, mix with equivalent 2 times of concentration Hanks liquid, packing small test tube, often pipe 0.5ml, add 50ul10%SRBC, 20ul splenocyte suspension, mixing, reviewing, incubation 1.5h in CO2gas incubator, add the complement (1: 8) with the dilution of SA liquid, continue incubation 1.5h, counting hemolysis plaque number.
1.4.3), the mensuration (determination of lactate dehydrogenase method) of NK cytoactive: test mice cervical dislocation is put to death, and asepticly gets spleen, and make splenocyte suspension, Hank ' s liquid washes 2 times, and adjustment cell concentration is 2 × 107/ml.Get target cell and each 100ul of effector cell (effect target is than 50: 1), add U-shaped 96 well culture plates, target cell Spontaneous release hole adds target cell and each 100ul of nutrient solution, the maximum release aperture of target cell adds target cell and each 100ul of 2.5%Triton, all establish three parallel holes, in 37 DEG C, cultivate 4h in 5%CO2 incubator, in 96 well culture plates at the bottom of the Aspirate supernatant 100ul horizontalization of every hole, add LDH matrix liquid 100ul simultaneously, reaction 3min-10min, every hole adds the HCl30ul of 1mol/L, measures optical density (OD) at ELIASA 490nm place.Wherein,
NK cytoactive=[(reacting hole OD-Spontaneous release hole OD)/(maximum release aperture OD-Spontaneous release hole OD)] × 100%.
1.5), experimental data statistics: carry out statistical analysis with Spss11.0 software.
2), result
2.1), sample is on the impact of cell transformation capacity
Table 1 sample is on the impact of mouse lymphocyte conversion capability
| Group | Number of animals | Lymphopoiesis ability (OD difference) | |
| (only) | `x±s | P value | |
| Control group | 10 | 0.017±0.012 | - |
| Experimental group | 10 | 0.038±0.025 | 0.036 |
From table 1, per os gives the sample 30 days of embodiment 1, and experimental group can increase mouse lymphocyte conversion capability, has conspicuousness (P<0.05) with control group comparing difference.
2.2), sample is on the impact of humoral immunity
Table 2 sample is on the impact of mouse antibodies cellulation number
| Group | Number of animals | Hemolysis plaque number | |
| (only) | (individual/10 6Individual splenocyte) `x ± s | P value | |
| Control group | 10 | 111±43 | - |
| Experimental group | 10 | 159±34 | 0.017 |
As shown in Table 2, per os gives the sample 30 days of mouse embodiment 1, and experimental group can increase mouse antibodies cellulation number, has conspicuousness (P<0.05) with control group comparing difference.
2.3), sample is on the impact of NK cells in mice activity
Table 3 sample is on the impact of NK cells in mice activity
| Group | Number of animals | NK cytoactive | NK cytoactive | |
| (only) | `x±s（%） | Square root arcsine conversion value `x ± s | P value | |
| Control group | 10 | 28.7±12.4 | 18.1±9.1 | - |
| Experimental group | 10 | 35.4±13.6 | 32.1±7.6 | 0.017 |
From table 3, per os gives the sample 30 days of mouse embodiment 1, and experimental group can increase NK cells in mice activity, has conspicuousness (P<0.05) with control group comparing difference.
As can be seen from experimental data, in laboratory conditions, per os gives the sample 30 days that mouse embodiment 1 provides, experimental group can increase Mice Mice lymphocyte transformation ability, antibody-producting cell number, NK cells in mice activity, there is conspicuousness (P<0.05) with control group comparing difference, illustrate that the present invention has effect of develop immunitypty.
Claims (3)
1. the health food of a supplementary several mineral materials, it is characterized in that: it is made up of the component of following weight percents: calcium monohydrogen phosphate 5 ~ 25%, l threonic acid 5 ~ 25%, glycine zine 3 ~ 12%, manganese gluconate 2 ~ 6%, magnesium gluconate 0.5 ~ 3%, ferrous fumarate 0.5 ~ 3%, selenium-enriched edible mushroom powder 3 ~ 12%, all the other are auxiliary material, the percentage by weight sum of each component is 100%, and described calcium monohydrogen phosphate and the addition of l threonic acid are 1 ︰ 1.
2. the health food of a kind of supplementary several mineral materials according to claim 1, it is characterized in that: described auxiliary material is made up of beeswax, phosphatide and olive oil, wherein, the percentage by weight of described beeswax is 3 ~ 8%, the percentage by weight of described phosphatide is 3 ~ 8%, and the percentage by weight of described olive oil is 30 ~ 60%.
3. the health food of a kind of supplementary several mineral materials according to claim 2, it is characterized in that: the percentage by weight of described each component is: calcium monohydrogen phosphate 11%, l threonic acid 11%, glycine zine 4%, manganese gluconate 3%, magnesium gluconate 1%, ferrous fumarate 0.7%, selenium-enriched edible mushroom powder 3.3%, auxiliary material 66%; Wherein, in described auxiliary material, the percentage by weight of beeswax is 6%, and the percentage by weight of phosphatide is 6%, and the percentage by weight of olive oil is 54%.
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Application publication date: 20150422 |