CN104502314A - Biochemical sensor for coupling optical microcavity molecule - Google Patents
Biochemical sensor for coupling optical microcavity molecule Download PDFInfo
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- CN104502314A CN104502314A CN201410795206.8A CN201410795206A CN104502314A CN 104502314 A CN104502314 A CN 104502314A CN 201410795206 A CN201410795206 A CN 201410795206A CN 104502314 A CN104502314 A CN 104502314A
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- microcavity
- miniflow
- microflow
- biochemical sensor
- transmission spectrum
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Abstract
The invention relates to a biochemical sensor for a coupling optical microcavity molecule. The biochemical sensor comprises a fused optic fiber, one light microflow microcavity and one external packaging polymer, wherein the fused optic fiber mainly comprises a silicon dioxide optical fiber, has the diameter of 3-5mu m and is taken on the microflow microcavity; a main component of the microflow microcavity is silicon dioxide, the diameter of the microflow microcavity is 100-500mu m, and the wall thickness of the microflow microcavity is 2-20mu m; an encapsulation polymer is mainly a low refractive index material, has refractive index of 1-1.4, and is used for fixing relative position of the fused optic fiber and the microflow microcavity. The biochemical sensor has the advantages of compact structure, small dimension, strong external vibration resistance, good stability, low detection limit, simple production, low cost and the like.
Description
Technical field
The invention belongs to sensor technical field, be specifically related to a kind of biochemical sensor of coupled micro-cavity photon molecule.
Background technology
In chemical-biological field, people often need to analyze the sample of trace.Because the environment of biology interior is very complicated, and useful information is often only included in a wherein very little part or in being difficult to the composition discovered, although so biosensor technique is of a great variety, development rapidly, but in the face of the work of this " looking for a needle in a haystack ", ability or limited.So develop new Photonics Technology means, explore new senser element and just have great significance.
For in the photonic device of bio-sensing, optical microcavity is most characteristic numerous, is also of most potentiality.Optical microcavity is the optical resonator of yardstick in micron dimension, and light field local in chamber, makes photon repeatedly shake in chamber by it, is equivalent to the number of times adding light-matter interaction.It carrys out the existence of perception analysis thing by the change of detection own optical pattern, therefore may be used for the virgin state of detecting analytes.The Q value of Whispering-gallery-mode microcavity is the highest, and photon lifetime is the longest, so in echo wall mode optical micro-cavity sensor, photon is the strongest with the interaction analyzing thing, is conducive to obtaining higher detection sensitivity; And Q value is higher, optical mode live width is narrower, is conducive to obtaining lower detection limit.Current optical microcavity is considered to the effective means studied at the particle of nanometer scale yardsticks such as nucleic acid, protein, viruses.
But traditional optical micro-cavity sensors is often by passive way, namely realize by pyrometric cone coupling means such as the micro-ring core chamber of microballoon or microtubule, sensing characteristics is given a shock the impact on optical fiber and microcavity coupling space greatly, integration and stability are had a greatly reduced quality, therefore just need a kind of new sensor, improve stability and the sensitivity of this kind of device.
Summary of the invention
The object of the invention is to the biochemical sensor proposing a kind of coupled micro-cavity photon molecule, make up the deficiency that optical bio chemical sensor in the past exists.
The present invention includes one section of melting cone fiber, a light miniflow microcavity and an outer enclosure polymkeric substance, melting cone fiber principal ingredient is silicon dioxide, and diameter is 3-5 μm, rides against on miniflow microcavity; Miniflow microcavity principal ingredient is silicon dioxide, and diameter is 100-500 μm, and wall thickness is 2-20 μm; Encapsulation polymkeric substance is mainly low-index material, refractive index between 1-1.4, for the relative position relation of fixing melting cone fiber and miniflow microcavity; The transmission spectrum of one or more optical mode can be observed from the transmission spectrum of melting cone fiber, these optical modes often have different sensitivity, by just detecting biological sample the relative change between the change of device single mode transmission spectrum wavelength or multiple pattern.
The present invention has compact conformation, and size is little, and anti-extraneous vibration ability is strong, good stability, and detection limit is low, the fairly simple and low cost and other advantages of manufacture craft.
Accompanying drawing explanation
Fig. 1 is encapsulation type biochemical sensor structural representation;
Fig. 2 is encapsulation type biochemical sensor cross-sectional structure schematic diagram;
Fig. 3 is the measurement result figure of transmission spectrum stability in time;
Fig. 4 is in microcavity one, second mode mode distributions figure;
Fig. 5 is to microcavity quality factor measure result figure;
Fig. 6 measures microcavity internal liquid refraction index changing and system transmission spectrum graph of a relation;
Fig. 7 measures microcavity resonance wavelength relative changes and internal liquid index of refraction relationship figure.
Embodiment
Below in conjunction with accompanying drawing, the present invention is described in further detail.
The encapsulation type light microfluidic biological chemical sensor based on microvesicle resonator cavity that the present invention proposes, is combined successively by such as lower part and forms: one section of melting cone fiber, 1, light miniflow microcavity 2 and an outer enclosure polymkeric substance 3, as depicted in figs. 1 and 2.
The principle of the invention is as follows: first, for the microcavity of Whispering-gallery-mode, when sample refractive index changes or the Echo Wall has a granular absorption near it, can cause the change of resonance wavelength.And for micro-bubble resonator cavity, because its light field is distributed in microcavity microchannel in a large number, and there is little model volume, therefore the effect of light and material can be very strong, is easy to obtain highly sensitive sensor.Melting cone fiber principal ingredient is silicon dioxide, and diameter is 3-5 μm, rides against on miniflow microcavity; Miniflow microcavity principal ingredient is silicon dioxide, and diameter is 100-500 micrometer range, and wall thickness is 2-20 μm; Encapsulating material is mainly low-index material, and refractive index can between 1-1.4, for the relative position relation of fixing melting cone fiber and miniflow microcavity.The transmission spectrum of one or more optical mode can be observed from the transmission spectrum of melting cone fiber, these optical modes often have different sensitivity, by just detecting sample the relative change between the change of device single mode transmission spectrum wavelength or multiple pattern.
In the present invention, the relative position relation of melting cone fiber and miniflow microcavity is fixed by low-index material, and therefore the factor such as external shock excites impact very little on optical mode in microcavity.
In the present invention, miniflow microcavity inwall can apply the ligands specific of corresponding detection thing thus carry out specificity detection to tested biological sample.
In the present invention, the self-reference technique such as pattern splitting or mode differential can be adopted further to suppress the noise of signal further, improve detection limit.
Example: utilize this encapsulation type light microfluidic biological chemical sensor to detect aqueous phase body refractive index liquid
1, the measurement wavelength adopted is near 1550nm.
2, melting cone fiber diameter is 3 microns, and rides against on miniflow microcavity, and namely its coupling space is 0 μm.
3, microcavity is micro-bubble microcavity, and as shown in Figure 2, be 400 μm with reference to microcavity diameters, wall thickness is 5 μm.
4, encapsulating material adopts MY133 polymkeric substance, and owing to have employed encapsulation technology, device stability is in time better, can transmission spectrum degree of depth stiffness of coupling etc. change minimum more than 100 hours, as shown in Figure 3.
5, owing to adopting encapsulation refractive index lower, so light field distributes in the polymer, less (Fig. 4) is so its microcavity quality factor still can again 10
6above, as shown in Figure 5.
6, when in microcavity, refractive index changes, system transmission spectrum changes with the change of refringence, as shown in Figure 6; Meanwhile, due to not same order pattern mould field, distribution proportion is different in a liquid, and its sensitivity is also different, and the sensitivity of second mode can reach 5 nm/RIU, as shown in Figure 7.
7, the common film noise of employing self-reference effect sensor can be suppressed further, will neither same order pattern (, second mode) with the mutual reference of change of refractive index, system noise is reduced greatly, simultaneously because First-Order Mode sensitivity is lower, so its total sensitivity still can remain near 5 nm/RIU.
Claims (2)
1. the biochemical sensor of coupled micro-cavity photon molecule, comprises one section of melting cone fiber, a light miniflow microcavity and an outer enclosure polymkeric substance, it is characterized in that: melting cone fiber principal ingredient is silicon dioxide, and diameter is 3-5 μm, ride against on miniflow microcavity; Miniflow microcavity principal ingredient is silicon dioxide, and diameter is 100-500 μm, and wall thickness is 2-20 μm; Encapsulation polymkeric substance is mainly low-index material, refractive index between 1-1.4, for the relative position relation of fixing melting cone fiber and miniflow microcavity; The transmission spectrum of one or more optical mode can be observed from the transmission spectrum of melting cone fiber, these optical modes often have different sensitivity, by just detecting biological sample the relative change between the change of device single mode transmission spectrum wavelength or multiple pattern.
2. biochemical sensor according to claim 1, is characterized in that: miniflow microcavity inwall can apply the ligands specific of corresponding detection thing thus carry out specificity detection to tested biological sample.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410795206.8A CN104502314A (en) | 2014-12-18 | 2014-12-18 | Biochemical sensor for coupling optical microcavity molecule |
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| CN201410795206.8A CN104502314A (en) | 2014-12-18 | 2014-12-18 | Biochemical sensor for coupling optical microcavity molecule |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107121156A (en) * | 2017-04-03 | 2017-09-01 | 复旦大学 | The encapsulation type light miniflow microcavity biochemical sensor of radial direction higher order mode can be retained |
| CN108896512A (en) * | 2018-07-18 | 2018-11-27 | 清华-伯克利深圳学院筹备办公室 | The detection device and method of microfluid |
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| CN1566938A (en) * | 2003-06-11 | 2005-01-19 | 中国科学院电子学研究所 | Multiple parameter micro sensor |
| CN101386403A (en) * | 2008-09-13 | 2009-03-18 | 中北大学 | Micro optical fibre voltage sensor based on ring micro-cavity |
| CN101419161A (en) * | 2008-10-24 | 2009-04-29 | 中北大学 | Gas detecting method and gas sensor based on plane annular micro-cavity |
| CN101435808A (en) * | 2008-12-22 | 2009-05-20 | 博奥生物有限公司 | Method for preparing three-dimensional micro-pipe or cavity and application thereof |
| CN101957478A (en) * | 2010-07-27 | 2011-01-26 | 中北大学 | Packaging structure and method for optical microcavity coupling system |
| CN102841054A (en) * | 2012-09-27 | 2012-12-26 | 复旦大学 | Biochemical sensor of coupled micro-cavity photon molecule |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1566938A (en) * | 2003-06-11 | 2005-01-19 | 中国科学院电子学研究所 | Multiple parameter micro sensor |
| CN101386403A (en) * | 2008-09-13 | 2009-03-18 | 中北大学 | Micro optical fibre voltage sensor based on ring micro-cavity |
| CN101419161A (en) * | 2008-10-24 | 2009-04-29 | 中北大学 | Gas detecting method and gas sensor based on plane annular micro-cavity |
| CN101435808A (en) * | 2008-12-22 | 2009-05-20 | 博奥生物有限公司 | Method for preparing three-dimensional micro-pipe or cavity and application thereof |
| CN101957478A (en) * | 2010-07-27 | 2011-01-26 | 中北大学 | Packaging structure and method for optical microcavity coupling system |
| CN102841054A (en) * | 2012-09-27 | 2012-12-26 | 复旦大学 | Biochemical sensor of coupled micro-cavity photon molecule |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107121156A (en) * | 2017-04-03 | 2017-09-01 | 复旦大学 | The encapsulation type light miniflow microcavity biochemical sensor of radial direction higher order mode can be retained |
| WO2018184402A1 (en) * | 2017-04-03 | 2018-10-11 | 复旦大学 | Package-type opto-fluidic microcavity biochemical sensor capable of retaining high-order radial mode |
| CN107121156B (en) * | 2017-04-03 | 2019-10-15 | 复旦大学 | The encapsulation type light miniflow microcavity biochemical sensor of radial higher order mode can be retained |
| CN108896512A (en) * | 2018-07-18 | 2018-11-27 | 清华-伯克利深圳学院筹备办公室 | The detection device and method of microfluid |
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Application publication date: 20150408 |