CN104498266A - Yellow rice wine suitable for autumn and winter invigoration, and preparation method thereof - Google Patents

Yellow rice wine suitable for autumn and winter invigoration, and preparation method thereof Download PDF

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Publication number
CN104498266A
CN104498266A CN201410679343.5A CN201410679343A CN104498266A CN 104498266 A CN104498266 A CN 104498266A CN 201410679343 A CN201410679343 A CN 201410679343A CN 104498266 A CN104498266 A CN 104498266A
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China
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wine
storehouse
storehouse body
cylinder
yellow rice
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CN201410679343.5A
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周丕煌
吴春艳
庄松娟
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QINGDAO NINE GREAT RICE WINE Co Ltd
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QINGDAO NINE GREAT RICE WINE Co Ltd
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Priority to CN201410679343.5A priority Critical patent/CN104498266A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12GWINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00Preparation of other alcoholic beverages
    • C12G3/02Preparation of other alcoholic beverages by fermentation

Abstract

The invention provides yellow rice wine suitable for autumn and winter invigoration. The yellow rice wine comprises following ingredients, by weight, 70 to 75% of broomcorn millet, 5.0 to 6.0% of red date, 2 to 2.5% of matrimony vine, 1 to 1.5% of donkey-hide gelatin, 4 to 10% of rock sugar, 4.0 to 5.0% of raw wheat koji, 10 to 20% of softened water, 0.05% of glucoamylase (50 thousand units), and 0.02% of alcohol active dry yeast. 1 to 5% of a traditional Chinese medicine extract and 1 to 5% of a functional additive are added. The yellow rice wine can be produced at the four seasons; the preparation method is simple; the yellow rice wine is convenient for preparing, is capable of relaxing muscles and tendons, stimulating the circulation of the blood, and improving immunity, and is especially suitable for autumn and winter invigoration.

Description

The yellow rice wine that a kind of applicable autumn and winter nourish and manufacture method thereof
technical field:
The present invention relates to the technical field of the preparation of wine, particularly relate to yellow rice wine and manufacture method thereof that a kind of applicable autumn and winter nourish.
Background technology
Yellow rice wine is invigorated blood circulation dispelling cold, and clearing and activating the channels and collaterals effect, especially in autumn and winter, drinking yellow rice wine should drink.Add in yellow rice wine after several ginger splices boil and drink, dispelling cold of both can having invigorated blood circulation, clearing and activating the channels and collaterals, the stimulation that can also effectively keep out the cold, preventing cold.Although it should be noted that yellow rice wine alcoholic strength is low, also want appropriate when drinking, be generally advisable with l00-200 gram of often eating.Yellow rice wine effect: anti-ageingly protect the heart.In " Four Great families " that beer, grape wine, yellow rice wine, white wine form, when several yellow rice wine nutritive value is the highest, and its ethanol content is only l5% ~ l6%, is genuine delicious low alcohol.As the alcoholic drink that China is the most ancient, the content of its protein is higher, and house has 21 seed amino acids and a large amount of b vitamin, and it is anti-ageing comparatively suitable often to drink women's beauty treatment, the elderly.We know, the inorganic salt in human body form body tissue and safeguard that normal physiological function is necessary, and the inorganic salt detected in yellow rice wine have more than l8 kind, comprise major element and iron, copper, zinc, the selenium and other trace elements such as calcium, magnesium, potassium, phosphorus.Wherein magnesium is sugar in human body, fat, protein metabolism and the indispensable cofactor of cellular respiration enzyme system.Also be safeguard myoneural excitability and heart normal function, protection cardiovascular systems is necessary.During human body magnesium deficiency, easily there is the disease such as arteriosclerosis, cardiac damage.And the effect of selenium is mainly eliminated in body and is produced too much active oxygen radical, thus have improve immunity of organisms, anti-ageing, anticancer, protect cardiovascular and that cardiac muscle is healthy effect.Existing achievement in research shows, it is all relevant with scarce selenium that the Keshan disease, cancer, cardiovascular and cerebrovascular diseases, diabetes, infertility etc. more than 40 of human body plants illness.Therefore, drink yellow rice wine in right amount, have provide protection to heart.The fat-reducing of yellow rice wine effect, beauty treatment, anti-ageing, the heat of yellow rice wine is very high, and having drunk too much, it is fat to be certain to.But suitable drinking can accelerate blood circulation and metabolism, also helps fat-reducing.Containing a large amount of sugar, organic acid, the acid of oxygen base and various VITAMIN in yellow rice wine, there is higher nutritive value.Be take rice as raw material due to yellow rice wine, make through long saccharification, fermentation, the starch in raw material and protein are decomposed into micromolecular material by enzyme, easily digested, and therefore, people are also classified as yellow rice wine as nutritional drink wine.The number of degrees of yellow rice wine are lower, and taste is popular, especially to women's beauty treatment, the elderly is anti-ageing certain effect, is relatively applicable to daily drinking.Such as, but also will control, the number of degrees are at the yellow rice wine of about 15 degree, and every day, the amount of drinking was not more than 8 liang; The number of degrees are at about 17 degree, and the amount of drinking is not more than 6 liang every day.
The pharmaceutical use of yellow rice wine effect: efficacy-enhancing ingredient be priming return through be commonly called as, refer to that some drugs can guide the efficacy of a drug of other medicines to arrive diseased region or a certain passages through which vital energy circulates, play " guide " and carry out immunotherapy targeted autoantibody.They not only coordinate with decoction, apply together with broadly matching with patent medicine.In addition, " medicine efficacy enhancing ingredient " heighten the effect of a treatment in addition, detoxify, the effect such as flavoring, protection gi tract.In a prescription, need not medicine efficacy enhancing ingredient be needed, be determined according to the state of an illness by doctor, generally not need oneself deallocation system of patient and his family.The effective constituent of medicine can not only be dissolved out by yellow rice wine, is easy to absorption of human body, can also arrive the position needing treatment so as to guiding drug effect.In the Tang Dynasty, China the-portion pharmacopeia " Xinxiu Bencao " defines rice wine and is used as medicine.LI Shi-Zhen is said in Compendium of Material Medica: " all wine alcohol Li are different, and only rice wine enters medicinal ".Namely rice wine be yellow rice wine, and it has promoting blood circulation, stomach, moistens skin, supports board gas, holds up liver, except therapeutic actions such as gas under wind.It can thus be appreciated that always people make wine base with yellow rice wine and make health and medical wine of curing the disease, and illustrate that yellow rice wine and Chinese drugs agentia have and a kind ofly natural mix the factor or affinity.Though white wine is better to Chinese medicine solute effect, stimulates comparatively large when drinking, be not good at alcohol user and easily occur the phenomenons such as diarrhoea, itch.Beer then alcoholic strength is too low, is unfavorable for the stripping of Effective Component of Chinese Medicine.And yellow rice wine alcoholic strength is moderate, it is ideal medicine efficacy enhancing ingredient.In addition, yellow rice wine brewage or in old storage process, [rush cylinder operation (namely add water, mixed song, inoculation yeast bacterium) → primary fermentation operation (not higher than 28 DEG C, 12 hours) → Primary Fermentation operation is not (higher than 26 DEG C, 4 days) → secondary fermentation operation (not higher than 25 DEG C, 16 days) → squeezing → aftertreatment → old storage filters (temperature range 5-28 DEG C)] the suitable consumption temperature of yellow rice wine be temperature is at about 35 DEG C.Scald at yellow rice wine in the process of heat, the organic compound such as methyl alcohol, aldehyde, ethers that the denier contained in yellow rice wine is unhelpful to HUMAN HEALTH, can raise along with temperature and vapor away, meanwhile, lipid fragrant substance be then rising along with the rising of temperature, causes yellow rice wine spoiled.Equally, in the fermentation and old storage process of yellow rice wine, must strictly control to store sth. in a cellar temperature variation, especially in summer, temperature is easy to exceed 35 degrees Celsius, adds top fermentation storehouse sultry, usually cause rotten (leavening temperature, old storing temperature as above) that yellow rice wine is batch, for factory causes massive losses.Current terms of settlement is, or configures temperature equipment in fermentation storehouse, as air-conditioning system, or water-cooled air cooling system etc., or stop production clear-cut summer, spring and autumn is produced in overtime work.In above-mentioned terms of settlement, use temperature equipment to substantially increase production cost, also result in energy dissipation; The words that summer stops production then can bring about great losses.
Therefore, the present invention is intended to the function of yellow rice wine as efficacy-enhancing ingredient in traditional medicine, further interpolation relative medicine, it is made to circulate in overall Yellow rice wine preparation technology, especially be suitable for nourishing winter, all producible a kind of technique is simple throughout the year, easily manufactured, the yellow rice wine that applicable autumn and winter of strengthening immunity of stimulating the circulation of the blood and cause the muscles and joints to relax nourish and manufacture method thereof.
summary of the invention:
The object of the invention is to overcome the shortcoming existed in prior art, provide a kind of all producible throughout the year a kind of technique being suitable for nourishing winter simple, easily manufactured, the yellow rice wine that applicable autumn and winter of strengthening immunity of stimulating the circulation of the blood and cause the muscles and joints to relax nourish and manufacture method thereof.
To achieve these goals, the invention provides the yellow rice wine that a kind of applicable autumn and winter nourish, wherein, comprise the component of following weight percent units:
Milled glutinous broomcorn millet 70-75%, red date 5.0-6.0%, matrimony vine 2%-2.5%, donkey-hide gelatin 1-1.5%, rock sugar 4-10%, raw wheat koji 4.0-5.0%, softening water 10-20%, saccharifying enzyme (50,000 unit) 0.5 ‰, alcohol active dried yeast 0.2 ‰.
Be added with the following component of weight percent units further:
Chinese medicine extract 1-5%.
Be added with the following component of weight percent units further:
Functional additive 1-5%.
Described Chinese medicine extract extracts certainly: Yanhusuo, Semen Vaccariae, turmeric, the root of three-nerved spicebush, the dried immature fruit of citron orange, monkshood, pyrrosia lingua, Semen Coicis, sophora flower, shepherd's purse, the wind-weed, golden cypress, radix scrophulariae, levisticum, the root of fangji, root tuber of aromatic turmeric, the bighead atractylodes rhizome, the Radix Astragali, Medcinal Evodia Fruit, Radix Glycyrrhizae.
Functional additive is chitin, any one in oligochitosan or alginates.
Object to better implement the present invention, the invention also discloses the preparation method of the yellow rice wine that a kind of applicable autumn and winter nourish, wherein, comprises the steps:
Raw material:
Milled glutinous broomcorn millet: milled glutinous broomcorn millet shells, faint yellow, full grains, without mould grain, has normal meter Xiang; Moisture≤14.0%, impurity≤2.0%;
Red date: fruit shape is full, and head is even, meat is plump, has the due color and luster of this product, without going rotten;
Matrimony vine: class fusiform is slightly flat, and fruit is scarlet, without mildew and rot, impurity;
Donkey-hide gelatin: chocolate, glossy, matter is hard and crisp, and section light, fragment is looked in brown translucent illumination.Gas is micro-, and taste is micro-sweet;
Milled glutinous broomcorn millet, red date, matrimony vine are put into respectively stainless cylinder of steel or Porcelain Jar puts into clear water by impurities and dust rinsed clean;
Boiling
The milled glutinous broomcorn millet cleaned, red date, matrimony vine are loaded food steamer, builds the compacting of lid surrounding, open steam boiling;
Timing steam off after 40 minutes when crossing vapour, simmer 10-15 minute, uncapping, it is well-done to check whether, well-donely takes the dish out of the pot;
Cooling
The softening water of 10-20% can be added in the process that takes the dish out of the pot;
Open fan for cooling to 58--60 DEG C;
Saccharification
By boiling water cooling (, to 52-58 DEG C, yeast is to 30-35 DEG C for saccharifying enzyme), within 15 minutes, respectively saccharifying enzyme, alcohol active dried yeast are activated in advance; The usage quantity of saccharifying enzyme (saccharogenic power is 50000 units) is 0.5 ‰, and alcohol active dried yeast usage quantity is 0.2 ‰;
Add wheat koji, saccharifying enzyme and material to stir, closing heap insulation saccharification 10-15 minute, the usage quantity of wheat koji is 4.0-5.0%;
Lower the temperature into cylinder
Add the alcohol active dried yeast yeast activated after continuing to be cooled to 38-40 DEG C and mix even blanking, must not below or above this temperature;
Cylinder (tank) first by clean water clean (comprise cylinder along, outer wall), must bail out before use, then sprays cylinder edge and inwall and bottom with 75% alcohol;
The material entering cylinder, to be as the criterion from cylinder along 25-30cm, builds cylinder cap, will enter the cylinder date to fill and paste on cylinder outer wall;
Be placed in by jar fermenter after entering cylinder in semi-underground fermentation storehouse, the structure in semi-underground yellow wine fermentation storehouse, comprises storehouse body and Ku Ding, the body side of being, storehouse body shape structure, and top, storehouse is fixed on the top of the storehouse body of Fang Tizhuan, lower part of storehouse body is embedded in and is positioned at underground, upper part of storehouse body exposes to above earth's surface, the joining place of lower part of storehouse body and upper part of storehouse body is fixedly installed collar tie beam, the sidewall of upper part of storehouse body is provided with vent window, the height of lower part of storehouse body is 1.5-2.2m, the height of upper part of storehouse body is 1.8-2.5m, the inwall on storehouse body and top, storehouse is provided with rustproof layer, the outer wall on storehouse body and top, storehouse is provided with thermal insulation layer, thermal insulation layer, rustproof layer and storehouse body, storehouse is fixedly connected with between top, the bottom of storehouse body is provided with multiple spacing groove, spacing groove with bottom the body of storehouse between be fixedly connected with, in spacing groove, jar fermenter is installed, the rectangular array-like of spacing groove, spacing between adjacent two jar fermenters is 1-2m.Storehouse body one sidewall is provided with wine inlet pipe and water inlet pipe, and wine inlet pipe and water inlet pipe extend to the inside of storehouse body, and the bottom of storehouse body is provided with blow-off pipe, and blow-off pipe is positioned at the below of wine inlet pipe, water inlet pipe.Between vent window with storehouse body, gemel connection or slideway are connected, and described thermal insulation layer is benzene plate or rock cotton board, and described rustproof layer is aluminium foil layer or plastic plate;
Primary fermentation (enter cylinder before 48 hours sections)
Enter cylinder and measure karusen temperature in 24 hours, when temperature reaches 39 DEG C, carry out first time and drive rake,
Enter cylinder 44--48 hour and measure karusen temperature, when temperature reaches 42 DEG C, carry out second time and drive rake,
Drive rake to require: operate light and slow, prevent mash from spilling, by next for rolling up of bottom, surrounding is pushed away central authorities.
Secondary fermentation (enter cylinder after 48 hours time period);
Enter cylinder to carry out third time after 48 hours and drive rake, then build cylinder cap standing for fermentation, secondary fermentation time 10-15 days;
Squeeze wine
Fermentation ends, pumps into pressure filter and carries out press filtration by karusen, early stage, pressurization did not allow wine naturally flow out, and pressurizeed, added and be pressed in more than 10 hours, wine liquid is pooled to settling tank after wine flow velocity slows down;
Chinese medicine extract or function additive (optional) is added in this step
Filter
Extract supernatant liquor to be used for filtering (wine pin uses in extraction after collecting clarification together), carry out blending between batch wine according to standard, sampling detects, and filters after product is qualified;
Diatomite adopts 500# model, dilutes with a small amount of wine liquid, and filter adds diatomite after sucking again, carries out circulating filtration and observes visor, squeeze into disinfection tank after wine liquid is limpid;
Allotment
Quantity according to wine liquid calculates the donkey-hide gelatin adding 1.0-1.5%, first donkey-hide gelatin is used grinder mill powdering, add 2-3 doubly filter after yellow rice wine dilute, then pour in disinfection tank.Quantity according to wine liquid calculates the rock sugar taking 4.0-8.0% and directly adds in disinfection tank;
Sterilization, colloidal sol, filling
Open steam and heat-sterilization is carried out to the wine liquid in disinfection tank, make donkey-hide gelatin dissolve further simultaneously, make it to merge with wine body, steam off when temperature reaches 85-90 DEG C, standing 10 minutes, then carry out filling and sealing.
Advantage of the present invention is: all producible throughout the year a kind of technique being suitable for nourishing winter is simple, and easily manufactured, the applicable autumn and winter of strengthening immunity of stimulating the circulation of the blood and cause the muscles and joints to relax nourish, and are specially:
1, give full play to yellow rice wine effect as medicine efficacy enhancing ingredient, add corresponding traditional Chinese medicinal components, prepare functional type yellow rice wine;
2, add Chinese medicine extract or functional additive in wine liquid, make it possess health-care effect.
3, all can produce throughout the year, utilize the temperature of underground wall body internal stability to regulate the temperature in warehouse on the one hand, thus achieve the energy-conservation object in fermentation storehouse, no matter how extraneous weather changes, and the indoor environment temperature in fermentation storehouse does not have a greater change; The heat preserving mode that storehouse body divides and storehouse is pushed up is utilized to reduce Changes in weather to the impact of storehouse storehouse temperature on the other hand on the ground.The present invention is under the temperature in summer is 25 degrees Celsius, and the temperature in winter is on 15 degree of setting, and range of temperature is less than 10 degrees Celsius, meets the processing requirement that yellow wine fermentation is throughout the year produced completely.Meanwhile, because the wine industry that wine inlet pipe is come in is high temperature, usually produce steam, so, antirust treatment is made to storehouse body inwall, considerably increases the work-ing life of storehouse body.
accompanying drawing explanation:
Fig. 1 is that the present invention is fermented the structural representation in storehouse.
Fig. 2 is that the present invention is fermented the cross-sectional schematic in storehouse.
Fig. 3 is process flow sheet of the present invention.
accompanying drawing identifies:
1, jar fermenter 2, storehouse body 3, collar tie beam
4, thermal insulation layer 5, rustproof layer 6, Ku Ding
7, vent window 8, wine inlet pipe 9, water inlet pipe
10, blow-off pipe 11, spacing groove
embodiment:
Example 1
Be suitable for the yellow rice wine that the autumn and winter nourish,
Milled glutinous broomcorn millet 70%, red date 5.0%, matrimony vine 2%, donkey-hide gelatin 1%, rock sugar 4%, raw wheat koji 4.0%, softening water 13.93%, saccharifying enzyme (50,000 unit) 0.5 ‰, alcohol active dried yeast 0.2 ‰.
immunizing power compares:
Select 10 small white mouse feeding foodstuffs,
Select 10 small white mouse feeding 3-5ml of the present invention.
Be compared as follows:
Wherein, the absorption of comparative group calcium and mineral substance is fast, and propagation bifidus bacillus, milk-acid bacteria number are many, low compared with control group of the index of blood fat, blood sugar, cholesterol regulating.Repeatedly be placed in dark environment and exposure environment in 3-5 day, control group catches an illness probability greatly, so comparative group immunizing power is strong.
Example 2
Be suitable for the yellow rice wine that the autumn and winter nourish,
Milled glutinous broomcorn millet 72%, red date 5%, matrimony vine 2.5%, donkey-hide gelatin 1.5%, rock sugar 4%, raw wheat koji 4%, softening water 10.93%, saccharifying enzyme (50,000 unit) 0.5 ‰, alcohol active dried yeast 0.2 ‰.
Mouse experiment, selects 10 mouse to be divided into experimental group and control group two groups, often organizes 5, and 10 mouse legs are sprained to silt blue or green red and swollen, the present invention of experimental group feeding, each 3-5ml, control group is feeding not.Observe after 7 days, the mouse silt green grass or young crops of experimental group is disappeared, detumescence, hinder limb and can land walking, and control group is red and swollen, dare not land.Have this to confirm, the present invention has good effect promoting blood circulation and removing obstruction in channels.
Example 3
Milled glutinous broomcorn millet 71%, red date 5.0%, matrimony vine 2%, donkey-hide gelatin 1%, rock sugar 4%, raw wheat koji 4.0%, softening water 11%, saccharifying enzyme (50,000 unit) 0.5 ‰, alcohol active dried yeast 0.2 ‰, Chinese medicine extract: 1.93%.
Chinese medicine extract is taken from: Yanhusuo, Semen Vaccariae, turmeric, the root of three-nerved spicebush, the dried immature fruit of citron orange, monkshood, pyrrosia lingua, Semen Coicis, sophora flower, shepherd's purse, the wind-weed, golden cypress, radix scrophulariae, levisticum, the root of fangji, root tuber of aromatic turmeric, the bighead atractylodes rhizome, the Radix Astragali, Medcinal Evodia Fruit, Radix Glycyrrhizae.
Use flooding mode to extract Chinese medicine extract, after adding correctives, filter to obtain traditional Chinese medicine liquid, join in yellow rice wine, can obvious strengthening immunity, improve effect promoting blood circulation and removing obstruction in channels.
Mouse experiment: with 20 small white mouses for laboratory animal, the rear thigh of 20 small white mouses is hurt the wound of long 3mm, dark 1mm, respectively smear mercurochrome and wrap gauze, then every 10 is one group, 1st group is each 3-5ml of experimental group feeding the present invention, does not feed as a control group for second group.After 3 weeks, gross specimen observation, Biomechanics test are carried out to wound, gross specimen observations: experimental group wound heals completely, naturally falls scab; Control group heals substantially, does not fall scab.Biomechanics test result is as following table:
In the present invention, Chinese medicine composition is for the pharmacy mechanism evidence promoting wound healing:
1, lower HIF-1 alpha levels, raise the expression level of VEGF, histocyte can be induced and be produced HIF-1 (hypoxia-inducible factor-1 under hypoxic-ischemic environment, HIF-1, comprise HIF-1 α and HIF-1 β two kinds), wherein HIF-1 α can modulating vascular endothelial cell growth factor (ECGF) (vascular endothelial growth factor, VEGF), the expression of endothelin-1, erythropoietin etc., promote formation and the vascular remodeling of new vessel, thus start wound repair mechanism.The impact of diabetes skin ulcer Rats Exposed To Hypoxia inducible factor-1 and vascular endothelial growth factor is promoted by observing benefiting qi and removing blood stasis Chinese medicine, result shows that benefiting qi and removing blood stasis Chinese medicine is by lowering the expression level of HIF-1 α, raising the expression level of VEGF, improve ischemic hypoxia state, impel angiogenesis, thus wound healing.
2, the acceptor RTK strengthened in wound healing is active in the process of wound healing, somatomedin plays an important role, somatomedin is then by receptor tyrosine kinase (receptor tyrosine kinase, RTK) mediated cell external stimulus signal, the function such as propagation, differentiation of regulating cell.Observe the impact of Chinese medicine on soft-tissue trauma healing receptor tyrosine kinase activity, result shows that the RTK that Chinese medicine can strengthen in soft-tissue trauma healing is active.
3, promote the propagation of new capillary vessel, promote that granulation tissue growth improves the permeability of surface of a wound blood vessel and the regeneration of blood vessel, the blood confession of affected part can be improved, promote granulation tissue growth, accelerate the immediate union of the surface of a wound.Herbal mixture promotes the experimental study of rabbit skin wound healing, and result shows that this herbal mixture has significant effect in wound healing, can promote that wound blood vessels is rebuild, and reduces the infiltration of inflammatory cell, accelerates collagen fiber hyperplasia and forms scar, prevent wound infection.
4, rising transforming growth factor-beta 1 (the transforming growth factor-β 1 that TGF-β 1 expresses is promoted, TGF-β 1) Main Function be regulate the growth and differ entiation of cell, the synthesis of inducing cell epimatrix and apoptosis, thus the healing promoting wound.By the observation to transforming growth factor-beta and wound healing, result shows that TGF-β 1 expresses at early metaphase and raises, to the synthesis of promotion inoblast collagen protein, proteoglycan, fibre asphalt mixture and integral protein, enhancing migration of epithelial cells and inoblast synthetic cell epimatrix have key effect, are importances of its wound healing.
Example 4
Milled glutinous broomcorn millet 71%, red date 5.0%, matrimony vine 2%, donkey-hide gelatin 1%, rock sugar 4%, raw wheat koji 4.0%, softening water 11%, saccharifying enzyme (50,000 unit) 0.5 ‰, alcohol active dried yeast 0.2 ‰, chitin: 1.93%.
The effect of the chitin that the present invention adds is as follows:
Trauma hemostasis
1, the chitin of thrombocyte in blood is combined, and can improve the adhesive power of wound tissue, make local vasoconstriction fast, reduces hemorrhage quantity.2, improve the new histiocytic propagation of speed of wound healing, form the basic substance being badly in need of volume, hyaluronic acid is important material.Crust mass-energy increases hyaluronic quantity in tissue, promotes the formation of cytolemma.And in active cells process, produce a large amount of collegen filament, and form compact substance skin rapidly, can not scar.3, chitin can prevent and treat wound face infect to be used in wound local outside chitin can bacteria growing inhibiting, domestic and foreign literature report chitin applies wound in vitro can suppress gram-positive microorganism and Candida albicans growth, and 5 mg/ml bacteriostasis rates reach 75 ~ 100%; The wound cytophagous quantity in local and activity can be increased; Timely elimination necrotic tissue, promotes the formation of granulation tissue.Form this three large key element of wound wound healing, complement each other and comprehensively work.4, the application chitin of chitin on Orthopeadic Surgery is as Cranial defect portion weighting material, accelerate aggegation owing to helping platelet adhesion reaction and show good anastalsis, assemble phagocytic cell, the scavenger cell of volume around chitinous, the effect suppressing the invasion and attack of local pathogenic bacteria to have obvious accelerated bone to repair.
The flow process of above-mentioned example, as shown in Figure 3.
Raw material:
Milled glutinous broomcorn millet: milled glutinous broomcorn millet shells, faint yellow, full grains, without mould grain, has normal meter Xiang; Moisture≤14.0%, impurity≤2.0%;
Red date: fruit shape is full, and head is even, meat is plump, has the due color and luster of this product, without going rotten;
Matrimony vine: class fusiform is slightly flat, and fruit is scarlet, without mildew and rot, impurity;
Donkey-hide gelatin: chocolate, glossy, matter is hard and crisp, and section light, fragment is looked in brown translucent illumination.Gas is micro-, and taste is micro-sweet;
Milled glutinous broomcorn millet, red date, matrimony vine are put into respectively stainless cylinder of steel or Porcelain Jar puts into clear water by impurities and dust rinsed clean;
Boiling
The milled glutinous broomcorn millet cleaned, red date, matrimony vine are loaded food steamer, builds the compacting of lid surrounding, open steam boiling;
Timing steam off after 40 minutes when crossing vapour, simmer 10-15 minute, uncapping, it is well-done to check whether, well-donely takes the dish out of the pot;
Cooling
The softening water of 10-20% can be added in the process that takes the dish out of the pot;
Open fan for cooling to 58--60 DEG C;
Saccharification
By boiling water cooling (, to 52-58 DEG C, yeast is to 30-35 DEG C for saccharifying enzyme), within 15 minutes, respectively saccharifying enzyme, alcohol active dried yeast are activated in advance; The usage quantity of saccharifying enzyme (saccharogenic power is 50000 units) is 0.5 ‰, and alcohol active dried yeast usage quantity is 0.2 ‰;
Add wheat koji, saccharifying enzyme and material to stir, closing heap insulation saccharification 10-15 minute, the usage quantity of wheat koji is 4.0-5.0%;
Lower the temperature into cylinder
Add the alcohol active dried yeast yeast activated after continuing to be cooled to 38-40 DEG C and mix even blanking, must not below or above this temperature;
Cylinder (tank) first by clean water clean (comprise cylinder along, outer wall), must bail out before use, then sprays cylinder edge and inwall and bottom with 75% alcohol;
The material entering cylinder, to be as the criterion from cylinder along 25-30cm, builds cylinder cap, will enter the cylinder date to fill and paste on cylinder outer wall;
Be placed in by jar fermenter after entering cylinder in semi-underground fermentation storehouse, the structure in semi-underground yellow wine fermentation storehouse, comprises storehouse body and Ku Ding, the body side of being, storehouse body shape structure, and top, storehouse is fixed on the top of the storehouse body of Fang Tizhuan, lower part of storehouse body is embedded in and is positioned at underground, upper part of storehouse body exposes to above earth's surface, the joining place of lower part of storehouse body and upper part of storehouse body is fixedly installed collar tie beam, the sidewall of upper part of storehouse body is provided with vent window, the height of lower part of storehouse body is 1.5-2.2m, the height of upper part of storehouse body is 1.8-2.5m, the inwall on storehouse body and top, storehouse is provided with rustproof layer, the outer wall on storehouse body and top, storehouse is provided with thermal insulation layer, thermal insulation layer, rustproof layer and storehouse body, storehouse is fixedly connected with between top, the bottom of storehouse body is provided with multiple spacing groove, spacing groove with bottom the body of storehouse between be fixedly connected with, in spacing groove, jar fermenter is installed, the rectangular array-like of spacing groove, spacing between adjacent two jar fermenters is 1-2m.Storehouse body one sidewall is provided with wine inlet pipe and water inlet pipe, and wine inlet pipe and water inlet pipe extend to the inside of storehouse body, and the bottom of storehouse body is provided with blow-off pipe, and blow-off pipe is positioned at the below of wine inlet pipe, water inlet pipe.Between vent window with storehouse body, gemel connection or slideway are connected, and described thermal insulation layer is benzene plate or rock cotton board, and described rustproof layer is aluminium foil layer or plastic plate;
Primary fermentation (enter cylinder before 48 hours sections)
Enter cylinder and measure karusen temperature in 24 hours, when temperature reaches 39 DEG C, carry out first time and drive rake,
Enter cylinder 44--48 hour and measure karusen temperature, when temperature reaches 42 DEG C, carry out second time and drive rake,
Drive rake to require: operate light and slow, prevent mash from spilling, by next for rolling up of bottom, surrounding is pushed away central authorities.
Secondary fermentation (enter cylinder after 48 hours time period);
Enter cylinder to carry out third time after 48 hours and drive rake, then build cylinder cap standing for fermentation, secondary fermentation time 10-15 days;
Squeeze wine
Fermentation ends, pumps into pressure filter and carries out press filtration by karusen, early stage, pressurization did not allow wine naturally flow out, and pressurizeed, added and be pressed in more than 10 hours, wine liquid is pooled to settling tank after wine flow velocity slows down;
Chinese medicine extract or function additive (optional) is added in this step
Filter
Extract supernatant liquor to be used for filtering (wine pin uses in extraction after collecting clarification together), carry out blending between batch wine according to standard, sampling detects, and filters after product is qualified;
Diatomite adopts 500# model, dilutes with a small amount of wine liquid, and filter adds diatomite after sucking again, carries out circulating filtration and observes visor, squeeze into disinfection tank after wine liquid is limpid;
Allotment
Quantity according to wine liquid calculates the donkey-hide gelatin adding 1.0-1.5%, first donkey-hide gelatin is used grinder mill powdering, add 2-3 doubly filter after yellow rice wine dilute, then pour in disinfection tank.Quantity according to wine liquid calculates the rock sugar taking 4.0-8.0% and directly adds in disinfection tank;
Sterilization, colloidal sol, filling
Open steam and heat-sterilization is carried out to the wine liquid in disinfection tank, make donkey-hide gelatin dissolve further simultaneously, make it to merge with wine body, steam off when temperature reaches 85-90 DEG C, standing 10 minutes, then carry out filling and sealing.
As Figure 1-Figure 2, Fig. 1 is that the present invention is fermented the structural representation in storehouse.Fig. 2 is that the present invention is fermented the cross-sectional schematic in storehouse.
Comprise storehouse body 2 and top, storehouse 6, storehouse body 2 is in square body shape structure, and top, storehouse 6 is fixed on the top of the storehouse body 2 of Fang Tizhuan, lower part of storehouse body 2 is embedded in and is positioned at underground, upper part of storehouse body 2 exposes to above earth's surface, the joining place of lower part of storehouse body 2 and upper part of storehouse body 2 is fixedly installed collar tie beam 3, collar tie beam 3 is bar construction, storehouse body 2 is concrete structure, collar tie beam 3 arranges reinforcing bar, reinforcing bar extends along the vertical direction of storehouse body, one end extends to top, storehouse, the other end extends to the below bottom the body of storehouse, greatly increase the soundness of storehouse body, the sidewall of upper part of storehouse body 2 is provided with vent window 7, wherein, the height of lower part of storehouse body 2 is 1.5-2.2m, the height of upper part of storehouse body 2 is 1.8-2.5m, the inwall on storehouse body 2 and top, storehouse 6 is provided with rustproof layer 5, the outer wall on storehouse body 2 and top, storehouse 6 is provided with thermal insulation layer 4, thermal insulation layer 4, rustproof layer 5 and storehouse body 2, be fixedly connected with between top, storehouse 6, the bottom of storehouse body 2 is provided with multiple spacing groove 11, spacing groove 11 with bottom storehouse body 2 between be fixedly connected with, be fixedly connected with specifically by flange, jar fermenter 1 is installed in spacing groove 11, the rectangular array-like of spacing groove 11, spacing between adjacent two jar fermenters is 1-2m.For ensureing ferment effect, need spacing between jar fermenter comparatively large, the heat radiation of the wine with temperature facilitating wine inlet pipe to pour into, after going out cylinder, clear up jar fermenter, often cause ornaments change in location, said spacing groove is set, keeps this distance, and then keep yellow rice wine quality.Storehouse body 2 one sidewall is provided with wine inlet pipe 8 and water inlet pipe 9, wine inlet pipe 8 and water inlet pipe 9 extend to the inside of storehouse body 2, and the bottom of storehouse body 2 is provided with blow-off pipe 10, and blow-off pipe 10 is positioned at the below of wine inlet pipe 8, water inlet pipe 9.Between vent window 7 with storehouse body 2, gemel connection or slideway are connected, and thermal insulation layer 4 is benzene plate or rock cotton board, and rustproof layer 5 is aluminium foil layer or plastic plate.
fermentation storehouse of the present invention result of use is as follows:
Contrast experiment is carried out in two fermentation storehouses that Wine Co., Ltd is contained in Qingdao nine, existing common fermentation storehouse (building above earth's surface) 400 ㎡, air-conditioning fermentation storehouse (building above earth's surface) 400 ㎡, build the present invention (semi-underground fermentation storehouse) 400 ㎡, temperature variation is compared as follows shown in table:
product quality indicator of the present invention:

Claims (6)

1. the yellow rice wine of nourishing of applicable autumn and winter, is characterized in that, comprise the component of following weight percent units:
Milled glutinous broomcorn millet 70-75%, red date 5.0-6.0%, matrimony vine 2%-2.5%, donkey-hide gelatin 1-1.5%, rock sugar 4-10%, raw wheat koji 4.0-5.0%, softening water 10-20%, saccharifying enzyme (50,000 unit) 0.5 ‰, alcohol active dried yeast 0.2 ‰.
2. be applicable to the autumn and winter yellow rice wine of nourishing according to claim 1, it is characterized in that, be added with the following component of weight percent units further:
Chinese medicine extract 1-5%.
3. be applicable to the autumn and winter yellow rice wine of nourishing according to claim 1, it is characterized in that, be added with the following component of weight percent units further:
Functional additive 1-5%.
4. be applicable to the autumn and winter yellow rice wine of nourishing according to claim 2, it is characterized in that, described Chinese medicine extract to extract from Yanhusuo, Semen Vaccariae, turmeric, the root of three-nerved spicebush, the dried immature fruit of citron orange, monkshood, pyrrosia lingua, Semen Coicis, sophora flower, shepherd's purse, the wind-weed, golden cypress, radix scrophulariae, levisticum, the root of fangji, root tuber of aromatic turmeric, the bighead atractylodes rhizome, the Radix Astragali, Medcinal Evodia Fruit, Radix Glycyrrhizae.
5. be applicable to the autumn and winter yellow rice wine of nourishing according to claim 3, it is characterized in that, functional additive is chitin, any one in oligochitosan or alginates.
6. be applicable to a preparation method for the yellow rice wine that the autumn and winter nourish as described in as arbitrary in claim 1-5, it is characterized in that, comprise the steps:
Raw material:
Milled glutinous broomcorn millet: milled glutinous broomcorn millet shells, faint yellow, full grains, without mould grain, has normal meter Xiang; Moisture≤14.0%, impurity≤2.0%;
Red date: fruit shape is full, and head is even, meat is plump, has the due color and luster of this product, without going rotten;
Matrimony vine: class fusiform is slightly flat, and fruit is scarlet, without mildew and rot, impurity;
Donkey-hide gelatin: chocolate, glossy, matter is hard and crisp, section light, and fragment is looked in brown translucent to illumination; Gas is micro-, and taste is micro-sweet;
Milled glutinous broomcorn millet, red date, matrimony vine are put into respectively stainless cylinder of steel or Porcelain Jar puts into clear water by impurities and dust rinsed clean;
Boiling
The milled glutinous broomcorn millet cleaned, red date, matrimony vine are loaded food steamer, builds the compacting of lid surrounding, open steam boiling;
Timing steam off after 40 minutes when crossing vapour, simmer 10-15 minute, uncapping, it is well-done to check whether, well-donely takes the dish out of the pot;
Cooling
The softening water of 10-20% can be added in the process that takes the dish out of the pot;
Open fan for cooling to 58--60 DEG C;
Saccharification
By boiling water cooling (, to 52-58 DEG C, yeast is to 30-35 DEG C for saccharifying enzyme), within 15 minutes, respectively saccharifying enzyme, alcohol active dried yeast are activated in advance; The usage quantity of saccharifying enzyme (saccharogenic power is 50000 units) is 0.5 ‰, and alcohol active dried yeast usage quantity is 0.2 ‰;
Add wheat koji, saccharifying enzyme and material to stir, closing heap insulation saccharification 10-15 minute, the usage quantity of wheat koji is 4.0-5.0%;
Lower the temperature into cylinder
Add the alcohol active dried yeast yeast activated after continuing to be cooled to 38-40 DEG C and mix even blanking, must not below or above this temperature;
Cylinder (tank) first by clean water clean (comprise cylinder along, outer wall), must bail out before use, then sprays cylinder edge and inwall and bottom with 75% alcohol;
The material entering cylinder, to be as the criterion from cylinder along 25-30cm, builds cylinder cap, will enter the cylinder date to fill and paste on cylinder outer wall;
Be placed in by jar fermenter after entering cylinder in semi-underground fermentation storehouse, the structure in semi-underground yellow wine fermentation storehouse, comprises storehouse body and Ku Ding, the body side of being, storehouse body shape structure, and top, storehouse is fixed on the top of the storehouse body of Fang Tizhuan, lower part of storehouse body is embedded in and is positioned at underground, upper part of storehouse body exposes to above earth's surface, the joining place of lower part of storehouse body and upper part of storehouse body is fixedly installed collar tie beam, the sidewall of upper part of storehouse body is provided with vent window, the height of lower part of storehouse body is 1.5-2.2m, the height of upper part of storehouse body is 1.8-2.5m, the inwall on storehouse body and top, storehouse is provided with rustproof layer, the outer wall on storehouse body and top, storehouse is provided with thermal insulation layer, thermal insulation layer, rustproof layer and storehouse body, storehouse is fixedly connected with between top, the bottom of storehouse body is provided with multiple spacing groove, spacing groove with bottom the body of storehouse between be fixedly connected with, in spacing groove, jar fermenter is installed, the rectangular array-like of spacing groove, spacing between adjacent two jar fermenters is 1-2m,
Storehouse body one sidewall is provided with wine inlet pipe and water inlet pipe, and wine inlet pipe and water inlet pipe extend to the inside of storehouse body, and the bottom of storehouse body is provided with blow-off pipe, and blow-off pipe is positioned at the below of wine inlet pipe, water inlet pipe;
Between vent window with storehouse body, gemel connection or slideway are connected, and described thermal insulation layer is benzene plate or rock cotton board, and described rustproof layer is aluminium foil layer or plastic plate;
Primary fermentation (enter cylinder before 48 hours sections)
Enter cylinder and measure karusen temperature in 24 hours, when temperature reaches 39 DEG C, carry out first time and drive rake,
Enter cylinder 44--48 hour and measure karusen temperature, when temperature reaches 42 DEG C, carry out second time and drive rake,
Drive rake to require: operate light and slow, prevent mash from spilling, by next for rolling up of bottom, surrounding is pushed away central authorities;
Secondary fermentation (enter cylinder after 48 hours time period);
Enter cylinder to carry out third time after 48 hours and drive rake, then build cylinder cap standing for fermentation, secondary fermentation time 10-15 days;
Squeeze wine
Fermentation ends, pumps into pressure filter and carries out press filtration by karusen, early stage, pressurization did not allow wine naturally flow out, and pressurizeed, added and be pressed in more than 10 hours, wine liquid is pooled to settling tank after wine flow velocity slows down;
Chinese medicine extract or function additive (optional) is added in this step
Filter
Extract supernatant liquor to be used for filtering (wine pin uses in extraction after collecting clarification together), carry out blending between batch wine according to standard, sampling detects, and filters after product is qualified;
Diatomite adopts 500# model, dilutes with a small amount of wine liquid, and filter adds diatomite after sucking again, carries out circulating filtration and observes visor, squeeze into disinfection tank after wine liquid is limpid;
Allotment
Quantity according to wine liquid calculates the donkey-hide gelatin adding 1.0-1.5%, first donkey-hide gelatin is used grinder mill powdering, add 2-3 doubly filter after yellow rice wine dilute, then pour in disinfection tank;
Quantity according to wine liquid calculates the rock sugar taking 4.0-8.0% and directly adds in disinfection tank;
Sterilization, colloidal sol, filling
Open steam and heat-sterilization is carried out to the wine liquid in disinfection tank, make donkey-hide gelatin dissolve further simultaneously, make it to merge with wine body, steam off when temperature reaches 85-90 DEG C, standing 10 minutes, then carry out filling and sealing.
CN201410679343.5A 2013-11-27 2014-11-24 Yellow rice wine suitable for autumn and winter invigoration, and preparation method thereof Pending CN104498266A (en)

Priority Applications (1)

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Application Number Priority Date Filing Date Title
CN201310611860 2013-11-27
CN2013106118604 2013-11-27
CN201410679343.5A CN104498266A (en) 2013-11-27 2014-11-24 Yellow rice wine suitable for autumn and winter invigoration, and preparation method thereof

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104893936A (en) * 2015-06-30 2015-09-09 青岛浩大海洋保健食品有限公司 Chitosan compound wine with effect of delaying senescence
CN106544215A (en) * 2016-10-26 2017-03-29 刘炳兴 A kind of manufacture method of Hakka yellow rice wine
CN107099424A (en) * 2017-06-30 2017-08-29 青岛河澄知识产权有限公司 A kind of preparation method of alcohol based composition for beautifying face and moistering lotion
CN107118905A (en) * 2017-06-30 2017-09-01 青岛河澄知识产权有限公司 A kind of alcohol based composition for beautifying face and moistering lotion

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104893936A (en) * 2015-06-30 2015-09-09 青岛浩大海洋保健食品有限公司 Chitosan compound wine with effect of delaying senescence
CN106544215A (en) * 2016-10-26 2017-03-29 刘炳兴 A kind of manufacture method of Hakka yellow rice wine
CN107099424A (en) * 2017-06-30 2017-08-29 青岛河澄知识产权有限公司 A kind of preparation method of alcohol based composition for beautifying face and moistering lotion
CN107118905A (en) * 2017-06-30 2017-09-01 青岛河澄知识产权有限公司 A kind of alcohol based composition for beautifying face and moistering lotion

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Application publication date: 20150408