CN104497348B - A kind of submissiveization Processes and apparatus of poly- polysaccharide freeze-drying sponge dressing - Google Patents
A kind of submissiveization Processes and apparatus of poly- polysaccharide freeze-drying sponge dressing Download PDFInfo
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- CN104497348B CN104497348B CN201410855893.8A CN201410855893A CN104497348B CN 104497348 B CN104497348 B CN 104497348B CN 201410855893 A CN201410855893 A CN 201410855893A CN 104497348 B CN104497348 B CN 104497348B
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- 238000004108 freeze drying Methods 0.000 title claims abstract description 44
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 33
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 33
- 150000004676 glycans Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title description 12
- 230000008569 process Effects 0.000 title description 8
- 239000007788 liquid Substances 0.000 claims abstract description 37
- 239000003595 mist Substances 0.000 claims abstract description 32
- 239000007921 spray Substances 0.000 claims abstract description 30
- 238000003860 storage Methods 0.000 claims abstract description 16
- 230000015654 memory Effects 0.000 claims abstract description 13
- 239000000126 substance Substances 0.000 claims abstract description 13
- 238000005213 imbibition Methods 0.000 claims abstract description 5
- 150000004804 polysaccharides Chemical class 0.000 claims description 31
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- 238000007789 sealing Methods 0.000 claims description 12
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 7
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 7
- 239000004571 lime Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 229920001661 Chitosan Chemical class 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- 238000000465 moulding Methods 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 238000005520 cutting process Methods 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 230000011218 segmentation Effects 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
- 235000011054 acetic acid Nutrition 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000000783 alginic acid Substances 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229960001126 alginic acid Drugs 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 150000004781 alginic acids Chemical class 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- 235000013922 glutamic acid Nutrition 0.000 claims description 2
- 235000011167 hydrochloric acid Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 238000009434 installation Methods 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000012545 processing Methods 0.000 abstract description 4
- 230000000704 physical effect Effects 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 238000009833 condensation Methods 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000012797 qualification Methods 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000628997 Flos Species 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention provides the submissive chemical industry skills that sponge dressing is lyophilized in a kind of poly- polysaccharide, using ultrasonic wave transducer oscillator, the object liquid to be atomized of storage is manufactured into fine liquid droplet using the physical action of high-frequency vibration, and it is discharged into the spray chamber connected according to certain speed by wind-power, sponge block is put into fog, sponge block and mist come into full contact with and gradually imbibition mist, carries out submissiveization processing；The present invention is also corresponding to provide a kind of submissiveization equipment, including interconnected liquid storage cylinder and spray chamber, is mounted on the ultrasonic ultrasonic delay line memory that liquid storage cylinder bottom is used for atomized liquid, and the fixture in spray chamber, sponge block is clamped by fixture；Submissiveization processing is carried out to freeze-drying sponge using submissive chemical industry skill provided by the invention, it can be made that density is high, hole is small, large specific surface area, humid stability are good, and the sponge dressing with preferable resilience and compliance, device structure is simple, and the product qualified rate of production is high.
Description
Technical field
The present invention relates to the submissiveization Processes and apparatus that sponge dressing is lyophilized in a kind of poly- polysaccharide, belong to medical sponge production and add
Work technical field.
Background technology
At present in field of medical technology, either the hemostasis in surgical operation and clean operation or postoperative wound or its
Healing nursing of his surface of a wound etc. still all be unable to do without the participation of all kinds of medical dressing, and the further development of modern medical service technology is then
More stringent requirements are proposed for the practical performance to the physics and chemistry of medical dressing or biologically again.
Poly- polysaccharide sponge material because its raw material sources are easy to get, good biocompatibility, liquid absorption capacity are strong,
Processing and forming such as facilitates at the series of advantages, and possibility is provided for its application on novel high-performance medical dressing.It was molded already
Such product also obtained comparable approval after the application of a certain range of market, be one in dressing technical field not
The developing direction that can be neglected.
However, being conventionally used to the sponge material generally use crosslinked foaming of dressing, primary or secondary freeze drying legal system
Standby to form, the poly- polysaccharide sponge density obtained through such method is relatively low, compliance is poor, lacks flexibility, and part quality is hard
It lacking flexibility, resulting problem is that the lower sponge of density, general aperture is larger, and water suction and water-retaining property are poor, and
Specific surface area is smaller, it is difficult to have the medical dressing field of special requirement, such as hemostasis (general specific surface area for comparing surface area
Higher, haemostatic effect is better)；However sponge density is higher, hardness is accordingly higher, poor compliance, is especially led in medical dressing
Domain, it is difficult to fitting wound skin, especially some joint motion positions well.
There is a kind of medical hemostatic prepared using freeze-drying poly- polysaccharide freeze-drying sea on the market in unresolved problem above
Silk floss (CN201210545888：A kind of preparation method of styptic sponge for dressing), the sponge density is high, hole is small, compares table
Area is big, solves the problems, such as that dressing sponge density is small, but obtained sponge quality is harder, and resilience is poor, poor compliance, application
When wound hemostasis, it is easier to phenomenon of rupture occur, to limit its scope of application.
To prepare large specific surface area and the good dressing sponge of elasticity, part producing person add in the initial formulation of sponge
The dressing sponge compliance of submissiveization additive, production is good, but due to being added to submissiveization additive, affects dressing sponge
Biocompatibility, therefore limit its Clinical practice range.
Invention content
It is an object of the invention to solve the deficiencies in the prior art, and provide a kind of for improving poly- polysaccharide sponge compliance
Technique and equipment that is swift to operate and being easy to regulation and control, it is upper and apply upper requirement in production to adapt to dressing sponge.
Technical solution is used by realizing the object of the invention, a kind of submissive chemical industry skill of poly- polysaccharide freeze-drying sponge dressing,
Include the following steps：
(1) by poly- polysaccharide freeze-drying sponge carry out rough segmentation cut, obtain freeze-drying sponge block, be lyophilized sponge block length be 10 ㎝~
40 ㎝, width are the ㎝ of 10 ㎝~40；
(2) object liquid mist to be atomized is turned into fine liquid droplet using ultrasonic ultrasonic delay line memory, collects fine liquid mist
Drop forms mist, and mist is passed through sealing device, mist is made to be circulated with sealing device in ultrasonic ultrasonic delay line memory；
(3) freeze-drying sponge block is put into the sealing device full of mist and handle 0.5~30 minute, make freeze-drying sponge block and
Mist comes into full contact with and gradually up to obtaining, extensibility is 1.0N/cm~20.0N/cm to imbibition mist and permanent deformation is not more than
10% submissiveization sponge；
(4) submissiveization sponge is subjected to cutting according to the size of application requirements, obtains submissiveization sponge dressing.
The poly- polysaccharide freeze-drying sponge is determined by the aqueous solution mixing acidic materials and medical bactericide of poly- polysaccharide by mold
Type, freezing and freeze-drying molding are prepared.
The poly- polysaccharide is alginic acid, water soluble polyamide, chitosan or chitosan derivatives.
The acidic materials are glutamic acid, lactic acid, hydrochloric acid, acetic acid or glycolic.
The object liquid to be atomized is pure water or medical.
The also corresponding submissiveization equipment for providing poly- polysaccharide freeze-drying sponge dressing of the present invention, including interconnected liquid storage cylinder
And spray chamber, it is mounted on the ultrasonic ultrasonic delay line memory that liquid storage cylinder bottom is used for atomized liquid, and the fixture in spray chamber；
The fixture includes the strut of fixed plate and 2~100 mounted in pairs in fixed plate, and the fixed plate is strip square column,
Fixed plate is horizontally fixed on spray chamber bottom surface, and each strut is alternately fixed in fixed plate successively along fixed plate long side, the branch
Bar is L-shaped, including horizon bar and tilting bar, and the angle between tilting bar and horizon bar is 95 °~135 °, and the horizon bar of strut is worn
Cross fixed plate and can in fixed plate where horizon bar linear reciprocation slide.
The top of the spray chamber is the head cover being flexibly connected with spray chamber, and head cover is transparent panel, and the lower surface of head cover is
The angle of inclined surface, head cover lower surface and horizontal direction is 10 °~45 °.
Liquid storage cylinder is connected to spray chamber by admission line and outlet pipe, and fan is equipped between liquid storage cylinder and spray chamber,
Fan is mounted in admission line.
The bottom of spray chamber is equipped with the lime set overflow port with valve.
Submissive chemical industry skill provided by the invention uses ultrasonic wave transducer oscillator, will be stored using the physical action of high-frequency vibration
Object liquid to be atomized be manufactured into fine liquid droplet, and discharged according to certain speed to being connected by wind-power
Spray chamber in；From effect, the comfort index of poly- polysaccharide sponge --- stretching in 2004 standards of YY/T0471.4-
Malleability and set resistant --- can through this technique be improved significantly, and can be adjusted in a wider range,
The improvement of middle extensibility is the most apparent, and existing poly- polysaccharide sponge material lacks measurable comfort index because quality itself is harder
(i.e. for material with regard to being broken before deformation reaches 20%, break-draw power is 0.1MPa), is handled by this technique submissiveization
After 0.5~30 minute, extensibility can arbitrarily adjust in the range of 1.0N/cm~20.0N/cm, be permanently deformed and can control
Within system 10%, the sponge of submissiveization can meet the requirement in clinical application to medical supplies product comfort.
The submissiveization process selection be lyophilized sponge be submissiveization object, the freeze-drying sponge by poly- polysaccharide aqueous solution mixed acid
Property substance and fungicide, be prepared by mould shape, freezing and freeze-drying molding, have that density is high, hole is small, specific surface area
Big and good humid stability advantage has preferable resilience and compliance after submissiveization process；It can be according to clinic
Actual needs selects pure water or drug as object liquid to be atomized so that submissiveization sponge dressing effect diversification of preparation,
Clinically it is widely used；The submissive chemical industry skill to the post-processing for being molded sponge by realizing submissiveization, and so there is no need to sponge
Initial formulation does being specifically designed on comfort, to eliminate the trouble using all kinds of submissiveization additives, avoids to each
The risk that the biocompatibility of kind sponge products is reappraised, therefore the submissive chemical industry skill is particularly suitable for formula sensitivity
Poly- polysaccharide sponge medical supplies.
For submissiveization equipment provided by the invention by specific adjustable fixture clamping freeze-drying sponge block, fixture includes solid
The strut of fixed board and 2~100 mounted in pairs in fixed plate, can be on demand in 5cm~10cm per the spacing of a pair of strut
Between adjust, it can be achieved that different sizes be lyophilized sponge block submissiveization handle；The lime set overflow port of spray chamber bottom can be by mist
To change the lime set discharge in room, prevents freeze-drying sponge block from being drenched, transparent head cover is convenient for observing spray chamber inner case at any time, and
When discharge lime set.
Anti-condensation pollution structure at two is devised in the equipment, first, having between the tilting bar and horizon bar of fixture strut
95 °~135 ° of angle, opposite two tilting bars are with the use of clamping freeze-drying sponge block, two tilting bars and freeze-drying sponge block
Edge be line contact, therefore can avoid tilting bar on condensation drench freeze-drying sponge block key position；Second is that atomization ceiling
The lower surface of lid has 10 °~45 ° of angle with horizontal direction, forms one along the sagging surface of cabinet wall, ensures head cover
The condensation at place will not drop onto on the freeze-drying sponge block in processing；Anti-condensation pollution design, ensure that submissiveization place above two
The product qualification rate of the submissiveization sponge dressing of reason, qualification rate is up to 99%.
Description of the drawings
Fig. 1 is submissiveization process flow chart provided by the invention.
Fig. 2 is the structural schematic diagram of submissiveization equipment provided by the invention.
Wherein, 1- spray chambers, 2- lime set overflow ports, 3- ultrasonic ultrasonic delay line memories, 4- liquid storage cylinders, 5- admission lines, 6- fans,
7- outlet passageways, 8- head covers, 9- fixed plates, 10- struts.
Specific implementation mode
The present invention is illustrated in detail with reference to the accompanying drawings and examples.
Embodiment 1：
The submissive chemical industry skill of poly- polysaccharide freeze-drying sponge dressing provided by the invention, technological process is as shown in Figure 1, including such as
Lower step：
(1) poly- polysaccharide freeze-drying sponge block raw material is carried out rough segmentation to cut, obtains freeze-drying sponge block, the length that sponge block is lyophilized is
10 ㎝, width are 10 ㎝, and aqueous solution mixing acetic acid and medical bactericide of the sponge by chitosan is lyophilized in the poly- polysaccharide, by mould
Tool sizing, freezing and freeze-drying molding are prepared；
(2) use ultrasonic ultrasonic delay line memory will it is purity water atomised be fine liquid droplet, collect fine liquid droplet formation mist,
Mist is passed through sealing device, mist is made to be circulated with sealing device in ultrasonic ultrasonic delay line memory；
(3) freeze-drying sponge block is put into the sealing device full of mist and is handled 0.5 minute, make freeze-drying sponge block and mist
It comes into full contact with and gradually imbibition mist is 1.0N/cm~20.0N/cm and is permanently deformed no more than 10% until obtaining extensibility
Submissiveization sponge；
(4) submissiveization sponge is subjected to cutting according to the size of application requirements, obtains submissiveization sponge dressing.
Embodiment 2：
The submissive chemical industry skill of poly- polysaccharide freeze-drying sponge dressing provided by the invention, technological process is as shown in Figure 1, including such as
Lower step：
(1) poly- polysaccharide freeze-drying sponge block raw material is carried out rough segmentation to cut, obtains freeze-drying sponge block, the length that sponge block is lyophilized is
40 ㎝, width are 40 ㎝, and aqueous solution mixing acetic acid and medical bactericide of the sponge by chitosan is lyophilized in the poly- polysaccharide, by mould
Tool sizing, freezing and freeze-drying molding are prepared；
(2) it is fine liquid droplet to use ultrasonic ultrasonic delay line memory to be atomized hemostatic agent, collects fine liquid droplet and is formed
Mist is passed through sealing device, mist is made to be circulated with sealing device in ultrasonic ultrasonic delay line memory by mist；
(3) freeze-drying sponge block is put into the sealing device full of mist and is handled 30 minutes, make freeze-drying sponge block and mist
It comes into full contact with and gradually imbibition mist is 1.0N/cm~20.0N/cm and is permanently deformed no more than 10% until obtaining extensibility
Submissiveization sponge；
(4) submissiveization sponge is subjected to cutting according to the size of application requirements, obtains submissiveization sponge dressing.
The also corresponding submissiveization equipment for providing poly- polysaccharide freeze-drying sponge dressing of the present invention, structure is as shown in Fig. 2, include
Interconnected liquid storage cylinder 4 and spray chamber 1 is mounted on the ultrasonic ultrasonic delay line memory 3 that 4 bottom of liquid storage cylinder is used for atomized liquid, and
Fixture in spray chamber, liquid storage cylinder 4 are connected to spray chamber 1 by admission line 5 and outlet pipe 7, liquid storage cylinder 4 and mist
Change to be equipped between room 1 and mist be blown into the fan 6 in spray chamber, fan 6 is mounted in admission line, the top of spray chamber be with
The head cover 8 of spray chamber flexible connection, head cover are transparent panel, and the lower surface of head cover is inclined surface, head cover lower surface and horizontal direction
Angle be 10 °~45 °, the bottom of spray chamber is equipped with the lime set overflow port 2 with valve；The fixture include fixed plate 9 and 2~
Strut 10 of 100 mounted in pairs in fixed plate, the fixed plate 9 are strip square column, and fixed plate is horizontally fixed on atomization
On 1 bottom surface of room, each strut 10 is alternately fixed in fixed plate successively along fixed plate long side, and the strut is L-shaped, including horizon bar
And tilting bar, the angle between tilting bar and horizon bar are 95 °~135 °, the horizon bar of strut passes through fixed plate and can be solid
Along linear reciprocation sliding where horizon bar in fixed board.
Claims (4)
1. a kind of submissive chemical industry skill of poly- polysaccharide freeze-drying sponge dressing, which is characterized in that include the following steps：
(1) poly- polysaccharide freeze-drying sponge is carried out rough segmentation to cut, obtains freeze-drying sponge block, the length that sponge block is lyophilized is 10 ㎝~40
㎝, width are the ㎝ of 10 ㎝~40, and aqueous solution mixing acidic materials and Medical sterilization of the sponge by poly- polysaccharide are lyophilized in the poly- polysaccharide
Agent is prepared by mould shape, freezing and freeze-drying molding；
(2) object liquid mist to be atomized is turned into fine liquid droplet using ultrasonic ultrasonic delay line memory, collects fine liquid droplet shape
At mist, mist is passed through sealing device, mist is made to be circulated with sealing device in ultrasonic ultrasonic delay line memory, it is described to be atomized
Object liquid is pure water or medical；
(3) freeze-drying sponge block is put into the sealing device full of mist and is handled 0.5~30 minute, make freeze-drying sponge block and mist
It comes into full contact with and gradually imbibition mist is 1.0N/cm~20.0N/cm and is permanently deformed no more than 10% until obtaining extensibility
Submissiveization sponge；
(4) submissiveization sponge is subjected to cutting according to the size of application requirements, obtains submissiveization sponge dressing.
2. the submissive chemical industry skill of poly- polysaccharide freeze-drying sponge dressing according to claim 1, it is characterised in that：The poly- polysaccharide
For alginic acid, chitosan or chitosan derivatives.
3. the submissive chemical industry skill of poly- polysaccharide freeze-drying sponge dressing according to claim 1, it is characterised in that：The acid
Matter is glutamic acid, lactic acid, hydrochloric acid, acetic acid or glycolic.
4. a kind of equipment for the poly- polysaccharide freeze-drying submissive chemical industry skill of sponge dressing described in claim 1, it is characterised in that：Including
Interconnected liquid storage cylinder and spray chamber is mounted on the ultrasonic ultrasonic delay line memory that liquid storage cylinder bottom is used for atomized liquid, and installation
Fixture in spray chamber, liquid storage cylinder is connected to spray chamber by admission line and outlet pipe, between liquid storage cylinder and spray chamber
Equipped with fan, fan is mounted in admission line, and the top of the spray chamber is the head cover being flexibly connected with spray chamber, and head cover is
Transparent panel, the lower surface of head cover are inclined surface, and the angle of head cover lower surface and horizontal direction is 10 °~45 °, the bottom of spray chamber
Equipped with the lime set overflow port with valve；The fixture includes the strut of fixed plate and 2~100 mounted in pairs in fixed plate,
The fixed plate is strip square column, and fixed plate is horizontally fixed on spray chamber bottom surface, and each strut is handed over successively along fixed plate long side
For being fixed in fixed plate, the strut is L-shaped, including horizon bar and tilting bar, and the angle between tilting bar and horizon bar is
95 °~135 °, the horizon bar of strut passes through fixed plate and can the linear reciprocation sliding where horizon bar in fixed plate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410855893.8A CN104497348B (en) | 2014-12-31 | 2014-12-31 | A kind of submissiveization Processes and apparatus of poly- polysaccharide freeze-drying sponge dressing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410855893.8A CN104497348B (en) | 2014-12-31 | 2014-12-31 | A kind of submissiveization Processes and apparatus of poly- polysaccharide freeze-drying sponge dressing |
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| Publication Number | Publication Date |
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| CN104497348A CN104497348A (en) | 2015-04-08 |
| CN104497348B true CN104497348B (en) | 2018-10-26 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887358A (en) * | 2006-07-14 | 2007-01-03 | 青岛博益特生物材料有限公司 | Medical chitosan dressing and its application |
| US20070083137A1 (en) * | 2004-12-23 | 2007-04-12 | Hemcon Medical Technologies, Inc. | Supple tissue dressing assemblies, systems, and methods formed from softened hydrophilic polymer sponge structures such as chitosan |
| CN101613512A (en) * | 2009-07-16 | 2009-12-30 | 中国科学院长春应用化学研究所 | A kind of rapid-imbibing foamed material with antibacterial property and preparation method thereof |
| CN103027788A (en) * | 2013-01-05 | 2013-04-10 | 吴斌 | Absorbable medical dressing and preparation method thereof |
| CN103028135A (en) * | 2012-12-14 | 2013-04-10 | 武汉奥绿新生物科技有限公司 | Method for preparing hemostatic sponge for dressing |
-
2014
- 2014-12-31 CN CN201410855893.8A patent/CN104497348B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070083137A1 (en) * | 2004-12-23 | 2007-04-12 | Hemcon Medical Technologies, Inc. | Supple tissue dressing assemblies, systems, and methods formed from softened hydrophilic polymer sponge structures such as chitosan |
| CN1887358A (en) * | 2006-07-14 | 2007-01-03 | 青岛博益特生物材料有限公司 | Medical chitosan dressing and its application |
| CN101613512A (en) * | 2009-07-16 | 2009-12-30 | 中国科学院长春应用化学研究所 | A kind of rapid-imbibing foamed material with antibacterial property and preparation method thereof |
| CN103028135A (en) * | 2012-12-14 | 2013-04-10 | 武汉奥绿新生物科技有限公司 | Method for preparing hemostatic sponge for dressing |
| CN103027788A (en) * | 2013-01-05 | 2013-04-10 | 吴斌 | Absorbable medical dressing and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN104497348A (en) | 2015-04-08 |
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Denomination of invention: Softening technology and equipment for polysaccharides lyophilized sponge dressing Effective date of registration: 20200513 Granted publication date: 20181026 Pledgee: Guanggu Branch of Wuhan Rural Commercial Bank Co.,Ltd. Pledgor: WUHAN GREENOVO BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020420000017 |
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Denomination of invention: Softening process and equipment of a kind of polysaccharide freeze-dried sponge dressing Effective date of registration: 20210517 Granted publication date: 20181026 Pledgee: Guanggu Branch of Wuhan Rural Commercial Bank Co.,Ltd. Pledgor: WUHAN GREENOVO BIOTECHNOLOGY Co.,Ltd. Registration number: Y2021420000023 |
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