CN104491744A - Traditional Chinese medicine composition for treating myelofibrosis caused by qi stagnation and blood stasis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating myelofibrosis caused by qi stagnation and blood stasis. The composition is characterized by being prepared from the following medicinal materials in parts by weight: 6-9 parts of curcuma zedoary, 12-15 parts of bauhinia seeds, 9-12 parts of undulata hand.-mazz, 15-18 parts of Chinese astilbe rhizome, 12-15 parts of kadsura coccinea, 6-9 parts of leeches, 15-20 parts of cantonese speranskia, 6-9 parts of vanieria thorn, 3-6 parts of fructus polygoni orientalis, 5-8 parts of trogopterus dung, 6-9 parts of Chinese ivy fruits, 1-3 parts of Piper sarmentosum Roxb, 3-6 parts of goldhair grmnopteris herb rhizome, 10-15 parts of Chinese ixora flower roots, 1-3 parts of citrus aurantium, 15-20 parts of ciliate leucas, 5-10 parts of semen aesculi and 5-7 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention for treating myelofibrosis caused by qi stagnation and blood stasis is high in effective rate and reliable in curative effect, and myelofibrosis cured does not relapse.

Description

A kind of Chinese medicine composition for the treatment of qi stagnation and blood stasis type myelofibrosis

Technical field

The present invention relates to a kind of Chinese medicine, particularly a kind of Chinese medicine composition being used for the treatment of qi stagnation and blood stasis type myelofibrosis.

Background technology

Myelofibrosis belongs to " asthenia blood deficiency ", " gathering " category of the traditional Chinese medical science.Cause the reason of myelofibrosis mainly contain following some: 1., depressed rage impairing the liver, functional activity of QI being not smooth, qi depression to blood stasis, with the passing of time injures Liver and kidney, no resource of generating and transforming QI and blood, and the deficiency of YIN is raw interior-heat then.2., ponder over the easy impairment of the spleen, dysfunction of the spleen in transportation, retention of water-damp in the body, extremity lose supports, or kidney-yang deficiency, and blood deficiency can not go up flourish women's head-ornaments.3., spleen is source of generating QI and blood, and the biochemical weary source of insufficiency of the spleen then QI and blood, cause QI and blood deficiency, the heart is become homeless foster, or insufficiency of the spleen transporting mistake department.Qi as the commander of blood, blood being the mother of qi, and with the passing of time the deficiency of vital energy, then causes qi depression to blood stasis, stops in blood stasis, and venation is obstructed, and long-pending in bulk, causes pain due to blood stasis for a long time.4., internal injury caused by excess of seven emotions, cause depression of liver-QI, catharsis mistake department, functional activity of QI being not smooth, the stagnation of QI is blood stasis then, stagnation of blood stasis, for a long time long-pending in bulk, and venation is obstructed, stagnation of QI and blood may bring about pain; Or liver-QI transversely invading the stomach, stomach-QI being unable to descend normally.Primary disease main manifestations is that skin mucosa is pale, purpura, the fatigue and weak engendered, becomes thin weak, and hepatosplenomegaly, Progressive symmetric erythrokeratodermia anemia, some patients has bone joint pain, renal colic, heating, left epigastric discomfort, heavy constriction or pain.At present, the myelofibrosis cause of disease, pathogenesis are not clear, and doctor trained in Western medicine lacks effectively treatment.Mainly with suiting the medicine to the illness, transfusing blood the treatments such as support, androgen, chemotherapy, interferon, partial row splenectomy, these treatment general curative effects are poor, and toxic and side effects is large, fundamentally can not cure this disease.Chinese medicine both can improve clinical symptoms, again by replenishing QI and blood, invigorating the liver and kidney, improved hematopoieticmicroenviron-ment, promoted the recovery of hemopoietic function, fundamentally cured this disease.The different times of the myelofibrosis that the traditional Chinese medical science causes according to different reason and progression of disease, carries out Coryza Treated by Syndrome Differentiation in conjunction with clinical practice, is divided into by primary disease: liver-kidney yin deficiency, yang deficiency of spleen and stomache, QI and blood deficiency folder stasis of blood type, qi stagnation and blood stasis type.At present, the Chinese medicine for the treatment of myelofibrosis has multiple, but the Chinese patent medicine being directed to qi stagnation and blood stasis type myelofibrosis there is no report.

Summary of the invention

Object of the present invention aims to provide a kind of Chinese medicine composition for the treatment of qi stagnation and blood stasis type myelofibrosis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing qi stagnation and blood stasis type myelofibrosis.

For achieving the above object, the present invention by the following technical solutions: a kind of Chinese medicine composition for the treatment of qi stagnation and blood stasis type myelofibrosis, is characterized in that being made up of the medical material of following weight proportion:

Rhizoma Curcumae 6-9 part, Semen Bauhiniae championii 12-15 part, Radix Araliae undulatae 9-12 part, Radix astilbes chinensis (Rhizoma Astilbes Chinensis) 15-18 part, Caulis Kadsurae Coccineae 12-15 part, Hirudo 6-9 part, Herba speranskiae cantonensis 15-20 part, Spina Cudraniae Cochinchinensis 6-9 part, Fructus Polygoni Orientalis 3-6 part, Oletum Trogopterori 5-8 part, the sub-1-3 part of Fructus hederae sinensis 6-9 part, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Radix seu Herba Gymnopteris vestitae 3-6 part, Radix Ixorae Chinensis 10-15 part, Citrus aurantium L. var. amara Engl. 1-3 part, Herba leucadis ciliatae 15-20 part, Semen Aesculi 5-10 part, Radix Glycyrrhizae 5-7 part.

Source and the function of medical material involved in formula cure mainly as follows:

Rhizoma Curcumae [source] medical material Ji Yuan: be the rhizome of zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary and RADIX CURCUMAE.[nature and flavor] acrid in the mouth; Bitter; [return through] warm in nature returns liver, spleen channel [function cures mainly] circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Main vim and vigour are pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; Lump in the abdomen tumor mass in the abdomen; Traumatic injury.

Semen Bauhiniae championii [source] medical material Ji Yuan: be the seed of leguminous plant Caulis Bauhihiae Championii.[nature and flavor] toil; Temperature [return through] liver; Stomach is through [function cures mainly] promoting the circulation of QI to relieve pain; Blood circulation promoting and blood stasis dispelling.Main distending pain over the hypochondrium, gastric abscess, traumatic injury.

Radix Araliae undulatae [source] medical material Ji Yuan: be the root of Araliaceae Radix Araliae undulatae.[nature and flavor] bitter in the mouth; Pungent; [function cures mainly] cool in nature blood circulation promoting and blood stasis dispelling; Inducing menstruation to relieve menalgia; Expelling wind and removing dampness.Main traumatic injury; Fracture; Mass in the abdomen; Amenorrhea; Dysmenorrhea; Impairment caused by overstrain pain; Rheumatalgia.

The rhizome that Radix astilbes chinensis (Rhizoma Astilbes Chinensis) [source] is saxifragaceae plant Herba astilbes chinensis etc.Summer, autumn adopt, removing fibrous root, scale, fine hair, using fresh herb or dry.[nature and flavor] are warm in nature, puckery.[function cures mainly] blood circulation promoting and blood stasis dispelling, pain relieving, removing toxic substances.Control traumatic injury, joint bones and muscles pain, stomachache, postoperative pain.

Caulis Kadsurae Coccineae [source] medical material Ji Yuan: be root and the viticula of Schisandraceae Plant Kadsura coccinea (Lem.) A.C. Smith.[nature and flavor] are pungent; Micro-hardship; Warm in nature.[function cures mainly] promoting the circulation of QI to relieve pain; Dissipating blood stasis dredging collateral.Cure mainly gastric and duodenal ulcers; Chronic gastritis; Acute gastroenteritis; Rheumatic arthralgia; Traumatic injury; Fracture; Dysmenorrhea; Postnatal blood stasis is suffered from abdominal pain; Colicky.

Hirudo [source] this product is the dry body of Hirudinidae animal whitmania Whitmania pigra Whitman, Hirudo Hirudo nipponica Whitman or Folium Salicis Babylonicae Hirudo Whit-mania acranulata Whitman.[nature and flavor] are salty, bitter, flat; Slightly poisonous.[return through] returns Liver Channel.[function cures mainly] removing blood stasis, removing blood stasis, stimulates the menstrual flow.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.

Herba speranskiae cantonensis [source] medical material Ji Yuan: be the herb of euphorbia plant Guangdong speranskia tuberculata.[nature and flavor] are bitter; Flat [return through] lung; Liver; Large intestine channel [function cures mainly] wind-damp dispelling; The meridian dredging; Removing blood stasis with potent drugs pain relieving.Main air pain of dampness syndrome; Lump in the abdomen; Scrofula; Furuncle swelling toxin; Traumatic injury.

Spina Cudraniae Cochinchinensis [source] medical material Ji Yuan: be moraceae plants cudrania cochinchinensis Spina jujubae.[nature and flavor] are bitter; Slightly warm in nature [function cures mainly] blood stasis dispelling removing food stagnancy.Gather in main abdomen; Mass in the abdomen.

Fructus Polygoni Orientalis [source] medical material Ji Yuan: be the fruit of the thin knotweed of polygonaceae plant.[nature and flavor] are salty; [return through] cool in nature liver; Spleen channel [function cures mainly] promoting blood circulation to remove stagnancy; Invigorating spleen to remove dampness; Heat-clearing and toxic substances removing; Improving eyesight.Main flank disease is amassed; Dropsy; Gastric abscess; Lack of appetite abdominal distention; Acute catarrhal conjunctivitis; Skin ulcer swells; Scrofula.

Oletum Trogopterori [source] medical material Ji Yuan: be the dry feces of flying squirrel section animal trogopterus xanthipes Milne-Edwards.[nature and flavor] bitter in the mouth; Sweet; [return through] warm in nature liver; Spleen channel [function cures mainly] promoting blood circulation and stopping pain; Removing stasis to stop bleeding; Removing food stagnancy detoxifies.The all pains of main trusted subordinate's vim and vigour; Women's amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Metrostaxis; Infantile malnutrition; Snakes and scorpions centipete bite.

Fructus hederae sinensis [source] medical material Ji Yuan: be the fruit of Araliaceae Caulis Hederae Sinensis.[nature and flavor] sweet in the mouth; Bitter; [function cures mainly] warm in nature invigorating the liver and kidney; Strong waist knee joint, promoting the circulation of QI to relieve pain.Main body void is frail; Soreness of the waist and knees, arthralgia due to stagnation of blood; Coldness and pain in the epigastrium.

Radix Piperis sarmentosi (Herba Piperis Sarmentosi) [source] medical material Ji Yuan: be the fruit ear of Piperaceae plant Radix Piperis sarmentosi (Herba Piperis Sarmentosi) PipersarmentosumRoxb..[nature and flavor] are pungent; Temperature [function cures mainly] warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Removing dampness is subsided a swelling.Main abdominal distention; Cold-damp is suffered from diarrhoea; Rheumatic arthralgia; Colicky; Toothache; Edema.

Radix seu Herba Gymnopteris vestitae [source] medical material Ji Yuan: be herb or the rhizome of Hemionitidaceae plant gold hair psilophyton.[nature and flavor] are pungent; Bitter; Cool [return through] lung; Stomach is through [function cures mainly] heat-clearing and toxic substances removing; Promoting the circulation of QI to relieve pain.The high heat of main typhoid fever; Arthralgia; Stomachache.

Radix Ixorae Chinensis [source] medical material Ji Yuan: be the root of dicotyledon medicine Maguireothamnus speciosus Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati).[nature and flavor] are bitter; Micro-puckery; Cool [return through] lung; Stomach is through [function cures mainly] clearing away heat and cooling blood; Promoting blood circulation and stopping pain.Main cough; Spitting of blood; Rheumatic arthritis; Stomachache; Women's amenorrhea; Skin infection swells and ache; Traumatic injury.

Citrus aurantium L. var. amara Engl. [source] medical material Ji Yuan: be the alabastrum of rutaceae Citrus aurantium L. var. amara Engl..[nature and flavor] are pungent; Sweet; Micro-hardship; Property flat [function cures mainly] to regulate the flow of vital energy the chest stuffiness relieving; Stomach function regulating preventing or arresting vomiting.It is main that painful abdominal mass is vexed in the heart; Abdominal distention; Anorexia; Nausea and vomiting.

Herba leucadis ciliatae [source] medical material Ji Yuan: be the herb of labiate Herba leucadis ciliatae.[nature and flavor] bitter in the mouth; Pungent; Property flat [function cures mainly] dispersing liver and promoting blood circulation; By wind improving eyesight; Removing toxic substances.Housewife female's blood stasis amenorrhea; The pain over the hypochondriac region; Night blindness in children; Optic atrohic blindness cataracta; Swollen ulcer drug; Syphilis of the bone; Scabies; Erythra.

Semen Aesculi [source] medical material Ji Yuan: be the fruits and seeds of Hippocastanaceae plant Aesculus chinensis Bunge, Radix Aesculi or Aesculus.[nature and flavor] sweet in the mouth; [return through] warm in nature liver; Stomach is soothing the liver through [function cures mainly]; Regulate the flow of vital energy; Alleviating distention in middle-JIAO; Pain relieving.The main breast side of body; Distending pain of the breast; Dysmenorrhea; Gastric abscess.

Radix Glycyrrhizae [source] this product is the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..[nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

In the process of tcm syndrome differentiation and treatment, we are usually in conjunction with auxiliary facilities, then do Skeletal X-ray or histopathological inspection, lab testing, bone marrow radioisotope scan inspection further, determine the course of disease of patient further, can be divided into for three phases by the order of severity:

Early stage complete blood cell hyperplasia accompanied is slight the myelofibrosis phase: medullary cell is the hypertrophy of degree varies.Red, all hypertrophy such as grain, megakaryocytic series are the most obvious with megalokaryocyte.Fat vacuole disappears, and reticular fiber increases, but does not still affect the normal configuration of bone marrow.Hematopoietic cell accounts for more than 70%.Bone marrow matrix increases to master with soluble collagen.

Mid-term bone marrow suppression and fibrosis phase: proliferation of fibrous tissue is given prominence to, and account for the 40%-60% of bone marrow, hematopoietic cell accounts for 30%, and megalokaryocyte is hypertrophy still.Bone trabecula increases, it is thick to increase, and has new bone formation with bone marrow adjacent regions.Each is dispersed in parallel pencil that hemopoietic region formed by reticular fiber, collagen fiber, plasma cell and stromal cell or helical form material is separated.

Late period myelofibrosis and osteosclerosis phase: myelofibrosis whole latter stage.Based on the bone trabecula hypertrophy of sclerotin, account for the 30-40% of bone marrow.All significantly hypertrophy is organized in fiber and osteosclerosis, and pulp cavity is narrow, and except megalokaryocyte still can be regarded sb. as an outsider, other hematopoietic cells significantly reduce.In this phase bone marrow matrix composition, polymeric protein is main, main manifestations fibronectin, and outer connection albumen distribution increases.

The clinical manifestation of qi stagnation and blood stasis type myelofibrosis is distension and fullness in the abdomen, has block under rib, soft and not hard, does not fixingly move, or pain, pain in fixed position, and there is ecchymosis on the dark red or tongue limit of tongue, and tongue is white, stringy and tense pulse or puckery.Therapeutic Principle is blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.The present invention adopts formula and the proportioning of science, and the Rhizoma Curcumae adopted in formula has effect of circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving; Semen Bauhiniae championii has effect of promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling; Radix Araliae undulatae has effect of blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, expelling wind and removing dampness; Radix astilbes chinensis (Rhizoma Astilbes Chinensis) has effect of blood circulation promoting and blood stasis dispelling, pain relieving, removing toxic substances; Caulis Kadsurae Coccineae has effect of promoting the circulation of QI to relieve pain, dissipating blood stasis dredging collateral; Hirudo has removing blood stasis, removing blood stasis, the effect of stimulating the menstrual flow; Herba speranskiae cantonensis has effect of wind-damp dispelling, the meridian dredging, removing blood stasis with potent drugs pain relieving; Spina Cudraniae Cochinchinensis has effect of blood stasis dispelling removing food stagnancy; Fructus Polygoni Orientalis has effect of promoting blood circulation to remove stagnancy, invigorating spleen to remove dampness, heat-clearing and toxic substances removing, improving eyesight; Oletum Trogopterori has effect of promoting blood circulation and stopping pain, removing stasis to stop bleeding, removing food stagnancy removing toxic substances; Fructus hederae sinensis has effect of invigorating the liver and kidney, strong waist knee joint, promoting the circulation of QI to relieve pain; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) has effect of warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, removing dampness detumescence; Radix seu Herba Gymnopteris vestitae has effect of heat-clearing and toxic substances removing, promoting the circulation of QI to relieve pain; Radix Ixorae Chinensis has effect of clearing away heat and cooling blood, promoting blood circulation and stopping pain; Citrus aurantium L. var. amara Engl. has effect of the chest stuffiness relieving of regulating the flow of vital energy, stomach function regulating preventing or arresting vomiting; Herba leucadis ciliatae has dispersing liver and promoting blood circulation, by effect of wind improving eyesight, removing toxic substances; Semen Aesculi have soothing the liver, regulate the flow of vital energy, alleviating distention in middle-JIAO, pain relieving effect; Radix Glycyrrhizae has effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cooperatively interact between each medicine in formula, synergism, made Chinese medicine has effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, can effectively treat qi stagnation and blood stasis type myelofibrosis, over 4 years, by showing the use of 80 routine patients, effective percentage reaches 96.2%, therapeutic effect is good, follows up a case by regular visits to and no longer recur for 1 year after healing.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:

1, sampling approach

Be diagnosed as the patient of qi stagnation and blood stasis type myelofibrosis from my unit over nearly 5 years, the routine patient of random selecting 160, wherein, man 80 example, female 80 example, age 38-78 year, be divided into matched group and treatment group at random, often organize each 80 people.The data there was no significant differences such as two groups of ages, have comparability.

2, test method

2.1 matched group patients use Busulfan, and by specification is taken, 10 weeks courses for the treatment of.

The oral the present invention of 2.2 treatment group according to the obtained Chinese medicinal granule of specific embodiment 1, early, middle and late each once.10 weeks courses for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterions of therapeutical effect:

Clinical recovery: clinical asymptomatic, spleen reduces and reaches under rib within 2 cm, hemocyte quantity in normal range, without inmature grain, erythroneocytosis; Myelosis degree is normal; Bone marrow biopsy hypertrophy fiber absorbs; More than 1 year without recurrence.Effective: clinical asymptomatic, spleen reduces and reaches 1/2 or more; Hemocyte quantity in normal range, without inmature grain, erythroneocytosis; Myelosis degree is normal; Bone marrow biopsy hypertrophy pars fibrosa absorbs.Effective: clinical symptoms has clear improvement; Spleen reduces before comparatively treating, but does not reach 1/2; At least one item of blood cell count reaches normal range, and inmature grain, erythroneocytosis comparatively treat front minimizing 1/2 or more.Invalid: the person that do not reach at criterion of progress.

3.2 treatment statistical results are in table 1.

Table 1 liang group comparitive study

As can be seen here, the medicine adopting prescription of the present invention obtained can safe and effective treatment qi stagnation and blood stasis type myelofibrosis.

Detailed description of the invention

Below in conjunction with the concrete example implemented, further detailed description is done to the present invention.

Embodiment 1

Take Rhizoma Curcumae 9 grams, Semen Bauhiniae championii 15 grams, Radix Araliae undulatae 12 grams, Radix astilbes chinensis (Rhizoma Astilbes Chinensis) 18 grams, Caulis Kadsurae Coccineae 15 grams, Hirudo 9 grams, Herba speranskiae cantonensis 20 grams, Spina Cudraniae Cochinchinensis 9 grams, Fructus Polygoni Orientalis 6 grams, Oletum Trogopterori 8 grams, Fructus hederae sinensis 9 grams of, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 3 grams, Radix seu Herba Gymnopteris vestitae 6 grams, Radix Ixorae Chinensis 15 grams, Citrus aurantium L. var. amara Engl. 3 grams, Herba leucadis ciliatae 20 grams, Semen Aesculi 10 grams, 7 grams, Radix Glycyrrhizae.Various medical material grinding is become end, then uses conventional method " whole part " to extract and make instant Chinese medicine granule, carry out subpackage according to every pouch 10 grams, airtight, preserve in shady and cool, dry place.

Be used for the treatment of qi stagnation and blood stasis type myelofibrosis.Oral, every bu is taken for early, middle and late three times.

Specific embodiment 2

Take Rhizoma Curcumae 6 grams, Semen Bauhiniae championii 12 grams, Radix Araliae undulatae 9 grams, Radix astilbes chinensis (Rhizoma Astilbes Chinensis) 15 grams, Caulis Kadsurae Coccineae 12 grams, Hirudo 6 grams, Herba speranskiae cantonensis 15 grams, Spina Cudraniae Cochinchinensis 6 grams, Fructus Polygoni Orientalis 3 grams, Oletum Trogopterori 5 grams, Fructus hederae sinensis 6 grams of, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 1 gram, Radix seu Herba Gymnopteris vestitae 3 grams, Radix Ixorae Chinensis 10 grams, Citrus aurantium L. var. amara Engl. 1 gram, Herba leucadis ciliatae 15 grams, Semen Aesculi 5 grams, 5 grams, Radix Glycyrrhizae.Various medical material grinding is become end, then uses conventional method " whole part " to extract and make instant Chinese medicine granule, carry out subpackage according to every pouch 10 grams, airtight, preserve in shady and cool, dry place.

Be used for the treatment of qi stagnation and blood stasis type myelofibrosis.Oral, every bu is taken for early, middle and late three times.

Specific embodiment 3

Take Rhizoma Curcumae 8 grams, Semen Bauhiniae championii 13 grams, Radix Araliae undulatae 10 grams, Radix astilbes chinensis (Rhizoma Astilbes Chinensis) 17 grams, Caulis Kadsurae Coccineae 13 grams, Hirudo 8 grams, Herba speranskiae cantonensis 16 grams, Spina Cudraniae Cochinchinensis 8 grams, Fructus Polygoni Orientalis 5 grams, Oletum Trogopterori 7 grams, Fructus hederae sinensis 8 grams of, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 2 grams, Radix seu Herba Gymnopteris vestitae 5 grams, Radix Ixorae Chinensis 11 grams, Citrus aurantium L. var. amara Engl. 2 grams, Herba leucadis ciliatae 16 grams, Semen Aesculi 8 grams, 6 grams, Radix Glycyrrhizae.Various medical material grinding is become end, then uses conventional method " whole part " to extract and make instant Chinese medicine granule, carry out subpackage according to every pouch 10 grams, airtight, preserve in shady and cool, dry place.

Be used for the treatment of qi stagnation and blood stasis type myelofibrosis.Oral, every bu is taken for early, middle and late three times.

Claims (1)

1. treat a Chinese medicine composition for qi stagnation and blood stasis type myelofibrosis, it is characterized in that being made up of the medical material of following weight proportion:

Rhizoma Curcumae 6-9 part, Semen Bauhiniae championii 12-15 part, Radix Araliae undulatae 9-12 part, Radix astilbes chinensis (Rhizoma Astilbes Chinensis) 15-18 part, Caulis Kadsurae Coccineae 12-15 part, Hirudo 6-9 part, Herba speranskiae cantonensis 15-20 part, Spina Cudraniae Cochinchinensis 6-9 part, Fructus Polygoni Orientalis 3-6 part, Oletum Trogopterori 5-8 part, the sub-1-3 part of Fructus hederae sinensis 6-9 part, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Radix seu Herba Gymnopteris vestitae 3-6 part, Radix Ixorae Chinensis 10-15 part, Citrus aurantium L. var. amara Engl. 1-3 part, Herba leucadis ciliatae 15-20 part, Semen Aesculi 5-10 part, Radix Glycyrrhizae 5-7 part.