CN104491728B - It is a kind of to treat retention of damp-heat in the interior, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer - Google Patents
It is a kind of to treat retention of damp-heat in the interior, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer Download PDFInfo
- Publication number
- CN104491728B CN104491728B CN201410815663.9A CN201410815663A CN104491728B CN 104491728 B CN104491728 B CN 104491728B CN 201410815663 A CN201410815663 A CN 201410815663A CN 104491728 B CN104491728 B CN 104491728B
- Authority
- CN
- China
- Prior art keywords
- volatile oil
- vinegar
- stir
- immature fruit
- citron orange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000008280 blood Substances 0.000 title claims abstract description 33
- 208000008469 Peptic Ulcer Diseases 0.000 title claims abstract description 26
- 208000011906 peptic ulcer disease Diseases 0.000 title claims abstract description 25
- 239000008187 granular material Substances 0.000 title claims abstract description 19
- 230000014759 maintenance of location Effects 0.000 title claims abstract description 15
- 239000000341 volatile oil Substances 0.000 claims abstract description 59
- 235000021419 vinegar Nutrition 0.000 claims abstract description 54
- 239000000052 vinegar Substances 0.000 claims abstract description 54
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 37
- 240000004307 Citrus medica Species 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 241001078983 Tetradium ruticarpum Species 0.000 claims abstract description 31
- 239000002775 capsule Substances 0.000 claims abstract description 28
- 238000011282 treatment Methods 0.000 claims abstract description 27
- 241001313857 Bletilla striata Species 0.000 claims abstract description 25
- 241000576429 Forsythia suspensa Species 0.000 claims abstract description 25
- 239000000284 extract Substances 0.000 claims abstract description 25
- 241000218176 Corydalis Species 0.000 claims abstract description 24
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 23
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 23
- 239000009636 Huang Qi Substances 0.000 claims abstract description 23
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 22
- 239000007864 aqueous solution Substances 0.000 claims abstract description 22
- 241000245665 Taraxacum Species 0.000 claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 239000003921 oil Substances 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000004821 distillation Methods 0.000 claims description 4
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 claims 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 claims 1
- 235000021286 stilbenes Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 48
- 208000002193 Pain Diseases 0.000 abstract description 18
- 230000036407 pain Effects 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 17
- 235000013305 food Nutrition 0.000 abstract description 16
- 208000024891 symptom Diseases 0.000 abstract description 16
- 235000019658 bitter taste Nutrition 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 10
- 239000002253 acid Substances 0.000 abstract description 9
- 206010067171 Regurgitation Diseases 0.000 abstract description 7
- 230000001114 myogenic effect Effects 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 4
- 230000001105 regulatory effect Effects 0.000 abstract description 4
- 230000007812 deficiency Effects 0.000 abstract description 3
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 description 47
- 231100000397 ulcer Toxicity 0.000 description 47
- 210000002784 stomach Anatomy 0.000 description 25
- 210000004369 blood Anatomy 0.000 description 16
- 201000010099 disease Diseases 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 16
- 230000006870 function Effects 0.000 description 13
- 210000004185 liver Anatomy 0.000 description 9
- 210000001156 gastric mucosa Anatomy 0.000 description 8
- 206010030113 Oedema Diseases 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 7
- 230000035876 healing Effects 0.000 description 7
- 210000000952 spleen Anatomy 0.000 description 7
- 208000011580 syndromic disease Diseases 0.000 description 7
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 6
- 206010007247 Carbuncle Diseases 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 210000004051 gastric juice Anatomy 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 208000007107 Stomach Ulcer Diseases 0.000 description 5
- 230000001684 chronic effect Effects 0.000 description 5
- 230000004087 circulation Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 201000005917 gastric ulcer Diseases 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 210000004400 mucous membrane Anatomy 0.000 description 5
- 231100001274 therapeutic index Toxicity 0.000 description 5
- 240000009138 Curcuma zedoaria Species 0.000 description 4
- 238000002575 gastroscopy Methods 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 3
- 208000007882 Gastritis Diseases 0.000 description 3
- 206010020565 Hyperaemia Diseases 0.000 description 3
- 230000035508 accumulation Effects 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000000767 anti-ulcer Effects 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 230000001079 digestive effect Effects 0.000 description 3
- 206010013781 dry mouth Diseases 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 229940055726 pantothenic acid Drugs 0.000 description 3
- 235000019161 pantothenic acid Nutrition 0.000 description 3
- 239000011713 pantothenic acid Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 206010061926 Purulence Diseases 0.000 description 2
- 240000001949 Taraxacum officinale Species 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000001262 anti-secretory effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 238000001839 endoscopy Methods 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 239000002398 materia medica Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- LVRVABPNVHYXRT-BQWXUCBYSA-N 52906-92-0 Chemical compound C([C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)C1=CC=CC=C1 LVRVABPNVHYXRT-BQWXUCBYSA-N 0.000 description 1
- 208000010470 Ageusia Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 241001313855 Bletilla Species 0.000 description 1
- 102100034279 Calcium-binding mitochondrial carrier protein Aralar2 Human genes 0.000 description 1
- ZVMJXSJCBLRAPD-ZFWWWQNUSA-N Curzerenone Chemical compound C1[C@@](C=C)(C)[C@@H](C(=C)C)C(=O)C2=C1OC=C2C ZVMJXSJCBLRAPD-ZFWWWQNUSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- ZVMJXSJCBLRAPD-UHFFFAOYSA-N Epicurzerenone Natural products C1C(C=C)(C)C(C(=C)C)C(=O)C2=C1OC=C2C ZVMJXSJCBLRAPD-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000033469 Gastrooesophageal heterotopia Diseases 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 244000060234 Gmelina philippensis Species 0.000 description 1
- 241000577951 Hydnum Species 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000010728 Meckel diverticulum Diseases 0.000 description 1
- 102000002419 Motilin Human genes 0.000 description 1
- 101800002372 Motilin Proteins 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 230000018199 S phase Effects 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 244000178320 Vaccaria pyramidata Species 0.000 description 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 description 1
- 206010066969 Vitello-intestinal duct remnant Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 239000000464 adrenergic agent Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000001062 anti-nausea Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 239000010242 baoji Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- 108010084210 citrin Proteins 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- QUQIBYMETMROHZ-UHFFFAOYSA-N curzerenone Natural products CCC1(C)Cc2occ(C)c2C(=O)C1C(C)C QUQIBYMETMROHZ-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000007937 eating Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 208000015419 gastrin-producing neuroendocrine tumor Diseases 0.000 description 1
- 201000000052 gastrinoma Diseases 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940074869 marquis Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 210000002954 meckel diverticulum Anatomy 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- LGZXYFMMLRYXLK-UHFFFAOYSA-N mercury(2+);sulfide Chemical compound [S-2].[Hg+2] LGZXYFMMLRYXLK-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- VBUNOIXRZNJNAD-UHFFFAOYSA-N ponazuril Chemical compound CC1=CC(N2C(N(C)C(=O)NC2=O)=O)=CC=C1OC1=CC=C(S(=O)(=O)C(F)(F)F)C=C1 VBUNOIXRZNJNAD-UHFFFAOYSA-N 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- -1 production Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 208000037921 secondary disease Diseases 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to treatment retention of damp-heat in the interior, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer, effectively solve treatment peptic ulcer, and eliminate pain, turgor, receive poor deficiency of food, it is glutted after food, general acid regurgitation water, belch frequency is made, the medication problem for the symptom such as bitter taste is sticky, method is, by the 220g of vinegar corydalis tuber 180, the 450g of the capsule of weeping forsythia 350, the 700g of dandelion 500, the 220g of stir-baked RHIIZOMA CURCUMAE with vinegar 180, the 200g of the coptis 160, the 70g of evodia rutaecarpa 50 processed, the 260g of the dried immature fruit of citron orange 220, the raw 220g of the Radix Astragali 180, the 330g of the bletilla striata 270 is made, stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed, add water distillating extracting oil, the another device of the aqueous solution after volatile oil is extracted to preserve；The dregs of a decoction after volatile oil are extracted to mix with vinegar corydalis tuber, the capsule of weeping forsythia, dandelion, the coptis, the raw Radix Astragali, the bletilla striata, add water to cook, decocting liquid merges with extracting the aqueous solution after volatile oil, is concentrated under reduced pressure into the medicinal extract that 80 DEG C of relative densities are 1.35, granulation, dry, volatile oil is added, scientific formula of the present invention, with clearing away heat and eliminating dampeness, regulating qi to disperse stagnation, the inverse relieving haperacidity of drop, Tuoli myogenic function, good effect.
Description
Technical field
The present invention relates to medicine, be it is a kind of treat retention of damp-heat in the interior, stagnation of QI-blood type peptic ulcer Chinese medicinal granule (also known as
The profound even particle of compound).
Background technology
Peptic ulcer (peptic ulcer, PU) is clinical common, multiple disease of digestive system, and most data are shown
About 10%~12% people can suffer from the disease in life.At present, due to the continuous aggravation of social competition, increase in thought of people pressure
Greatly, nervous, a series of undesirable elements such as irregular, eating and drinking without temperance, the change of diet structure, habits of smoking and alcohol drinking of living stimulations
Under, the incidence of disease for causing this sick constantly rises, although with Western medicine H2The antisecretory such as receptor antagonist and proton pump inhibitor
Extensive use, its recent cure rate up to 90% or so, but generally observation show, its Ulcer cicatrization quality (QOUH) is poor, answer
Hair rate height is clinical still unsolved problem.According to relevant statistics, after ulcer healing the natural recurrence rate of 1 year for 50~
60%, and the recurrence rate in 2 years is then up to more than 60~90%, therefore Ulcer cicatrization quality is improved, prevent the recurrence after healing
It is the emphasis that should be studied from now on.So far, increasing expert thinks：" healing of ulcer does not refer to merely filling for mucomembranous defect
Fill out and repair, with greater need for the reconstruction of mucosal tissue structure." simple acid suppression, relieving haperacidity is only to improve Stomach duodenum chamber
PH value, but not change ulcer natural history, and on evidence prompting Acidinhibitor it is stronger, its be discontinued after ulcer recurrence when
Between it is more early, then improve the healing quality of ulcer, improve the structure of callus, strengthen its ability for damaging again of resistance so that
Effectively prevent recurrence from then seeming to be even more important.
Find that, with the Peptic Ulcers of Chinese medicine, recurrence rate is substantially reduced, very according to substantial amounts of clinical observation
To there is for many years not recidivist, some patients take Chinese herb on the prevention, then entirely prevented in advance in the autumn and winter easily recurred or at the end of winter and the beginning of spring
The recurrence of ulcer, result, it is believed that further investigation Chinese medicine is promoting Ulcer cicatrization quality, prevents in terms of ulcer recurrence, has
Good prospect.It is clinically how dialectical with tradition at present with Chinese medicine peptic ulcer, according to the different interpretation of the cause, onset and process of an illness and card type,
Different prescriptions are imposed respectively, and for various reasons, it is used and unsatisfactory existing Chinese medicine prescription, and particularly patient takes medicine
Inconvenience, some Chinese patent drugs for treatment peptic ulcer adaptive surfaces are narrower, can not meet the reality to treating digestive ulcer medicament
Need, therefore, strengthen the rules for the treatment of prescription research that traditional Chinese medicine promotes Ulcer cicatrization quality and antiulcer recurrence, in specification case mark
On the premise of the accurate, course for the treatment of and efficacy evaluation, find and adapt to wide, late result is consolidated, and convenient to take, effect is good, without any poison
The medicine of side effect, is urgent problem to be solved.
The content of the invention
For above-mentioned situation, to overcome the defect of prior art, the purpose of the present invention is just to provide one kind and treated in damp and hot
Accumulate, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer, can effectively solve to treat peptic ulcer, and eliminate pain, turgor is received
Glutted after poor deficiency of food, food, general acid regurgitation water, belch frequency is made, the medication problem for the symptom such as bitter taste is sticky.
The technical scheme that the present invention is solved is that the Chinese medicine is by weight meter：Vinegar corydalis tuber 180-220g, capsule of weeping forsythia 350-
450g, dandelion 500-700g, stir-baked RHIIZOMA CURCUMAE with vinegar 180-220g, the coptis 160-200g, evodia rutaecarpa 50-70g processed, dried immature fruit of citron orange 220-260g,
Raw Radix Astragali 180-220g, bletilla striata 270-330g are made, wherein, stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed add water to submerge, heating is steamed
Extraction volatile oil is evaporated, volatile oil is standby, extract the another device of the aqueous solution after volatile oil and save backup；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and Wu Zhu processed
Cornel extracts the dregs of a decoction after volatile oil and mixed with vinegar corydalis tuber, the capsule of weeping forsythia, dandelion, the coptis, the raw Radix Astragali, the bletilla striata, adds water to submerge every time,
Decoct three times, 1.5h, second and third each pan-fried 1h are decocted for the first time, merge three decocting liquids, filtration, after said extracted volatile oil
The aqueous solution merges, and is concentrated under reduced pressure into the medicinal extract that 80 DEG C of relative densities are 1.35, pelletizes, dries, and adds above-mentioned volatile oil and mixes, i.e.,
Into the Chinese medicinal granule of the present invention.
Prepared by scientific formula of the present invention, easily abundant raw material, production, medicine is mutually propped up by monarch, minister, the principles of formulating prescriptions helped, made
Hold, with clearing away heat and eliminating dampeness, regulating qi to disperse stagnation, the inverse relieving haperacidity of drop, Tuoli myogenic function.It is normal that clinic is mainly used in treatment peptic ulcer
The retention of damp-heat in the interior seen, stagnation of QI-blood type patient.Good effect, it is cheap, take easy to carry, be treatment digestive ulcer medicament
On innovation.
Embodiment
The embodiment to the present invention elaborates with reference to embodiments.
The present invention can be provided in specific implementation by following examples.
Embodiment 1
The present invention, can also be by weight meter in specific implementation：Vinegar corydalis tuber 190-210g, the capsule of weeping forsythia 370-420g, Pu Gong
English 550-650g, stir-baked RHIIZOMA CURCUMAE with vinegar 190-210g, the coptis 170-190g, evodia rutaecarpa 55-65g processed, dried immature fruit of citron orange 230-250g, raw Radix Astragali 190-
210g, bletilla striata 290-310g is made, wherein, stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed add water to submerge, volatilization is extracted in heating distillation
Oil, volatile oil is standby, extracts the another device of the aqueous solution after volatile oil and saves backup；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed extract volatilization
The dregs of a decoction after oil are mixed with vinegar corydalis tuber, the capsule of weeping forsythia, dandelion, the coptis, the raw Radix Astragali, the bletilla striata, are added water to submerge, are decocted three times every time,
1.5h, second and third each pan-fried 1h are decocted for the first time, merges three decocting liquids, and filtration is closed with the aqueous solution after said extracted volatile oil
And, the medicinal extract that 80 DEG C of relative densities are 1.35 is concentrated under reduced pressure into, is pelletized with granulator, is dried, above-mentioned volatile oil is added and mixes, i.e.,
Into the Chinese medicinal granule of the present invention.
Embodiment 2
The present invention is in specific implementation, and the Chinese medicine is by weight meter：Vinegar corydalis tuber 200g, capsule of weeping forsythia 400g, dandelion 600g,
Stir-baked RHIIZOMA CURCUMAE with vinegar 200g, the coptis 180g, evodia rutaecarpa 60g processed, dried immature fruit of citron orange 240g, raw Radix Astragali 200g, bletilla striata 300g are made, wherein, by vinegar cowherb
Art, the dried immature fruit of citron orange and evodia rutaecarpa processed, add water to submerge, and heat distillating extracting oil, and volatile oil is standby, extract the aqueous solution after volatile oil
Another device is saved backup；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed extract the dregs of a decoction and vinegar corydalis tuber, the capsule of weeping forsythia, dandelion, Huang after volatile oil
Even, the raw Radix Astragali, bletilla striata mixing, add water to submerge, decoct three times, 1.5h, second and third each pan-fried 1h are decocted for the first time, merge three every time
Secondary decocting liquid, filtration, merges with the aqueous solution after said extracted volatile oil, is concentrated under reduced pressure into the leaching that 80 DEG C of relative densities are 1.35
Cream, is pelletized with granulator, is dried, and is added above-mentioned volatile oil and is mixed, the present invention Chinese medicinal granule.
Embodiment 3
The present invention also can be by weight meter：Vinegar corydalis tuber 185g, capsule of weeping forsythia 440g, dandelion 510g, stir-baked RHIIZOMA CURCUMAE with vinegar 205g, the coptis
165g, evodia rutaecarpa 68g processed, dried immature fruit of citron orange 205g, raw Radix Astragali 215g, bletilla striata 275g are made, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and Wu Zhu processed
Cornel, is added water to submerge, and heats distillating extracting oil, and volatile oil is standby, is extracted the another device of the aqueous solution after volatile oil and is saved backup；Vinegar
Curcuma zedoary, the dried immature fruit of citron orange and evodia rutaecarpa processed extract the dregs of a decoction and vinegar corydalis tuber after volatile oil, the capsule of weeping forsythia, dandelion, the coptis, the raw Radix Astragali, the bletilla striata
Mixing, is added water to submerge every time, is decocted three times, for the first time pan-fried 1.5h, second and third each pan-fried 1h, three decocting liquids of merging, filtration, with
The aqueous solution after said extracted volatile oil merges, and is concentrated under reduced pressure into the medicinal extract that 80 DEG C of relative densities are 1.35, is pelletized with granulator,
Dry, add above-mentioned volatile oil and mix, the present invention Chinese medicinal granule.
Embodiment 4
The present invention, can also be by weight meter in specific implementation：Vinegar corydalis tuber 215g, capsule of weeping forsythia 360g, dandelion 680g, vinegar
Curcuma zedoary 186g, the coptis 195g, evodia rutaecarpa 53g processed, dried immature fruit of citron orange 255g, raw Radix Astragali 185g, bletilla striata 320g are made, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar,
The dried immature fruit of citron orange and evodia rutaecarpa processed, add water to submerge, and heat distillating extracting oil, and volatile oil is standby, and the aqueous solution extracted after volatile oil is another
Device is saved backup；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed extract the dregs of a decoction and vinegar corydalis tuber, the capsule of weeping forsythia, dandelion, Huang after volatile oil
Even, the raw Radix Astragali, bletilla striata mixing, add water to submerge, decoct three times, 1.5h, second and third each pan-fried 1h are decocted for the first time, merge three every time
Secondary decocting liquid, filtration, merges with the aqueous solution after said extracted volatile oil, is concentrated under reduced pressure into the leaching that 80 DEG C of relative densities are 1.35
Cream, is pelletized with granulator, is dried, and is added above-mentioned volatile oil and is mixed, the present invention Chinese medicinal granule.
In said medicine, wherein：
Corydalis tuber bitter, pungent, warm-natured, Return liver, spleen, the heart channel of Hang-Shaoyin；Function promoting the circulation of qi, promoting blood circulation, analgesic.Cure mainly all pains of stagnation of QI-blood
Stasis in card, the stagnation of the circulation of vital energy in this product energy promoting circulation of blood, gas.《It is brave that book on Chinese herbal medicine multiplies refined half》Carry it：" drum blood in gas, the blood in promoting the circulation of qi, it is empty then
Mend, put down actually, cause newly pushes away old, push away the new good thing of old cause ".Modern pharmacology confirms that corydalis tuber has expansion blood vessel, changes disease
Blood at change irrigates that there is provided necessary nutriment, it is ensured that, accelerate muscle layer and the speed and matter of mucomembranous epithelial cell renewal
Amount, can promote Ulcer cicatrization quality.
Capsule of weeping forsythia bitter, is slightly cold, return lung, the heart, Liver Channel；Function is clearing heat and detoxicating, carbuncle that disappears dissipating bind, and has the title of " persons particularly liable to develop skin infection's panacea ".
《Bencao Jingshu》Claim it：" refrigerant with except stagnant heat, fragrance lightly floats with Disperse hepatic depression, then seek Wei Tonghe and sore swells disappear ".Modern pharmacology
Research has shown that, the decocting liquid of the capsule of weeping forsythia, to shigella dysenteriae, typhoid bacillus, staphylococcus aureus, has obvious suppression, has
Antibacterial and anti-inflammation functions；Contained rutin, citrin composition, can improve the resistivity of capillary, prevent thin vessels in the capsule of weeping forsythia
Bleeding.
Dandelion is sweet, bitter, cold, Return liver, stomach；Function is clearing heat and detoxicating, and dissipating bind disappears carbuncle.《A supplement to augmented materia medica》Calling it has
The work(of " change heat toxin " " scattered stagnant gas ".《Herbal justice》Claim：" its property is refrigerant, controls all furunculosis, large carbuncle, all diseases of red and swollen heat toxin." medicine
Manage verification experimental verification：Dandelion has height bacteriostasis；Its extract has significant protective effect to gastric mucosa of rat, to repair and
Bleeding, the erosion of adjustment peptic ulcer play an important role, and can reduce inflammation and ooze out, and change the microcirculation of diseased region.
Curcuma zedoary bitter, pungent, nontoxic, Return liver, the spleen channel；Function, promoting qi circulation and relieving pain, disperse accumulations appetizing, anti-nausea sour water.《Book on Chinese herbal medicine is logical
It is profound》Claim it：" broken accumulation extravesated blood is dredged phlegm food and had a pain ",《Japan hanako materia medica》It is claimed " to control all gas, appetite-stimulating indigestion-relieving.”《Book on Chinese herbal medicine is standby
Will》Saying it, " dispersing blood stasis is stimulated the menstrual flow, helping digestion of whetting the appetite, removing toxic substances analgesic." modern pharmacological research shows, its have certain Hang Yan analgesias, antibacterial it
Work(, curcuma zedoary is mainly using curzerenone as main component, and its blood-breaking dissipates the stasis of blood and acts on mainly relevant with increase blood flow volume, can change routed
The blood of ulcer lesion irrigates that there is provided necessary nutriment, it is ensured that, accelerate muscle layer and mucomembranous epithelial cell renewal speed and
Quality, can promote Ulcer cicatrization quality.
The coptis, big hardship Great Cold, the thoughts of returning home, liver, stomach, large intestine channel；Function heat-clearing and damp-drying drug, purging intense heat and detonicating.《Bencao Jingshu》Call it：
" water removal, thick stomach, wash away intestines, stomach, spleen three it is damp and hot." " feeling of fullness stomachache can disappear, and the remorse sore of carbuncle can be cured ".The coptis contains the coptis
Element, with very wide antibacterial action, and can increase the phagocytic activity of leucocyte, a- adrenergics are blocked by competitiveness suppression
Acceptor expands peripheral vascular, improves microcirculation, there is cholagogic, antipyretic, analgesia, calm, elimination anxiety and anti anoxia, antiulcer etc. again
Multi-efficiency.
Evodia rutaecarpa bitter, pungent, heat, slightly poisonous, Return liver, spleen, stomach；Function is soothing the liver lower gas, cold dispelling eliminating dampness.《This warp》Claim
Its：" lower gas, analgesic, dehumidify blood-arthralgia." evodia rutaecarpa and the coptis shared as recipe Zuojin Wan, all have it is pungent open bitter drop, the inverse relieving haperacidity of drop it
Work(.
Dried immature fruit of citron orange bitter, it is pungent, be slightly cold, returns spleen, stomach, large intestine channel；Function relieving stagnant Qi removes ruffian, and resolving sputum disperse accumulations, pungent row hardship drop " removes stomach
In it is damp and hot " (《Pearl sac》), consumer product dredge stasis, removing heat by catharsis expells the pathogenic heat.《Changsha medicine solution》Claim it：" broken knot opens the stasis of blood, lets out ruffian and disappears completely, washes away strongly fragrant
Old, power is high violent, and non-this of thing that all corruption stop up resistance does not disappear.”《Medicineization justice》Call it：" stomach excess is specially let out, hard knot is convinced by patient analysis, thus it is main
The middle part of gastric cavity is to control blood system." modern study discovery：The dried immature fruit of citron orange contains the materials such as volatile oil and glycosides displayed.Its water decoction can put down dog small intestine
Sliding Muscle tensility and motor function enhancing, and stomach and intestine blood vessel dilatation can be made, improve intestines and stomach blood supply；The dried immature fruit of citron orange can make the courage in blood
Capsule shrinks element or motilin levels increase and promote gallbladder contraction, promotes digestion, and 20% dried immature fruit of citron orange volatile oil has prevention rat pylorus
The effect of ulcer formation is ligatured, and stomach liquid measure, the secretion of hydrochloric acid in gastric juice and the activity of pepsin can be substantially reduced.
The raw Radix Astragali is sweet, warm-natured, return lung, the spleen channel；Function tonifying middle-Jiao and Qi, kind to control weakness of the spleen and the stomach, raw user, there is apocenosis hemostasis
Work(, to being burst in the purulence blood of large carbuncle, yang-energy is empty and unhealed can myogenic meat；It is empty to yang-energy without burst person can joe pus poison,《Soup sheet
Grass》Calling it, " tonifying five zang organs is all empty not enough, and rushes down yin fire, abnormal heat of dispelling.”《Book on Chinese herbal medicine is just》Yan Qi：" survivor, it is micro- cool, ulcer can be controlled ".《This
Grass is standby will》Claim it：" rushing down yin fire, expelling pathogenic factors from muscles and skin heat, bowl spares, strong taste ".Modern pharmacology experimental study proves that the raw Radix Astragali is improved body
Immunologic function, improves stomach and intestine blood circulation, increases stomach and intestine blood supply, corrects local organization hypoxic-ischemic, adjusts gastrointestinal motility,
And the secretory volume of gastric juice and hydrochloric acid in gastric juice can be reduced, and weaken attack factor, gastric mucosa is protected, promotes injury tissue reparation.
Bletilla striata bitter, sweet, cold, return lung, stomach Liver Channel；Function hemostasia and detumescence, myogenic sore controls skin sore, canker sores.
《Bencao Jingshu》Cloud：" bletilla striata, hardship can expel the heat-evil, it is pungent can radiating knot, ulcer is not all by Ying Qi from inverse in being given birth in meat ... ..., enters
Blood system is to expel the heat-evil, and dissipating bind wastes not Liao by corruption, then all diseases.”《Collected statements on the herbal foundation》Calling it, " carbuncle swells can disappear, routed to hold in the palm, and dead flesh can
Go, purulence blood can be clean, there is the new magical effect of de- old life." bletilla striata formed Bletilla glucomannan can mucomembranous surface formation one layer of cover layer, increase
Strong barrier of gastric mucosa, prevents the erosion of hydrochloric acid in gastric juice and pepsin to mucous membrane, so as to weaken the Recurrence of ulcer.
Mutual support between said medicine, with clearing away heat and eliminating dampeness, regulating qi to disperse stagnation, drop against relieving haperacidity, the function of Tuoli myogenic,
Especially for damp and hot middle resistance, the treatment of stagnation of QI-blood type active stage ulcer, with too many levels, stage construction, Mutiple Targets, multipath
Mechanism of action and the few advantage of adverse reaction, be effectively used for treating peptic ulcer, abundant card obtained through clinical test
It is bright, and the advantageous effects for making us very satisfied are achieved, relevant clinical data is as follows：
(1) standard of case is selected
Peptic ulcer refers mainly to betide stomach and duodenal chronic ulcer, is a frequently-occurring disease, common disease.Ulcer
Various factors is formed with, wherein acidic gastric juice is the Fundamentals of ulcer formation to the digestion of mucous membrane, is hence obtained one's name.It is acid
Gastric juice contact any position, as distal esophagus, the postoperative previous anastomotic of gastrointestinal anastomosis, jejunum and with Ectopic Gastric Mucosa
Meckel diverticulums, most of ulcer betides duodenum and stomach, therefore also known as taste-blindness rate.Clinical manifestation is
Pain, turgor receives poor deficiency of food, glutted, general acid regurgitation water after food, and belch frequency is made, the symptom such as bitter taste is sticky, through endoscopy, there is routed
Ulcer face.It is all that there is above-mentioned symptom person, the alternatively standard of case, and give Chinese medicinal granule treatment of the present invention.
(2), diagnostic criteria
1 Western medicine diagnostic criteria：Reference《New Chinese medicine treats the guideline of clinical investigations of peptic ulcer》(try within 2002
OK) and national higher institutions of Chinese medicine programming textbook the 7th edition《Chinese Internal Medicine》
1.1. clinical criteria
(1) periodicity of prolonged and repeated breaking-out, the chronic upper abdomen pain of rhythmicity, using antisecretory and alkaline drug
It can alleviate.
(2) upper abdomen has limitation deep in tenderness.
(3) the visible active stage ulcer of endoscopy.
Showed by stages under 1.2 canker gastroscopes
(1) active stage (A phases) is the initial stage of morbidity, and ulcer edge inflammation, oedema is obvious, and tissue repair is not yet sent out
It is raw.
A1Phase：Thick white tongue is draped over one's shoulders at bottom, can be filthy, tongue can exceed at some positions can have on ulcer margin, tongue blutpunkte or
Sludged blood adheres to, and periphery mucous membrane bulges into dike shape, and hyperemia, oedema, erosion are showed in obvious inflammation.
A2Phase：The inflammation oedema of this phase ulcer margin substantially mitigates, and white tongue cleaning, border is distinct, and marginal portion starts
The re-epithelialize now taken on a red color, starts the performance for pleat concentration occur.
(2) healing stage (H phases) this phase ulcer reduces, inflammatory resolution, and re-epithelialize and pleat concentrate obvious.
H1Phase：Ulcer reduces, and shoals, white tongue the smooth of the edge, and peripheral oedema disappears, and edge re-epithelialize substantially, takes on a red color
Palisade, pleat is concentrated, and reaches ulcer edge.
H2Phase：Ulcer is obviously reduced, and white tongue is thinning, and re-epithelialize scope is widened.
(3) scar phase (S phases) this phase ulcer is repaired completely, is re-epithelialize covering.
S1Phase：Mucosa Defect has been entirely re-epithelialize covering, and rubescent re-epithelialize is in palisade, the radial row of centrality
Row, there is the red cicatricial phase of title.
S2Phase：Re-epithelialize is thickened, and red disappears, roughly the same with mucous membrane around, and pleat concentrates unobvious, but visible glutinous
Film concentrates picture, also known as white cicatricial phase.
2 Syndrome in TCM marquis diagnostic criteria (retention of damp-heat in the interior, stagnation of QI-blood type)：Reference《New Chinese medicine treatment peptic ulcer
Guideline of clinical investigations》(trying for 2002) and national higher institutions of Chinese medicine programming textbook the 7th edition《Chinese Internal Medicine》
2.1 primary symptom：(1) gastral cavilty portion distending pain, shouting pain, scorching hot pain.(2) gastral cavilty turgor
2.2 diseases：(1) food of receiving reduces glutted after (2) food.
(3) the general acid regurgitation water of belch (4).
(5) bitter taste is sticky
2.3 tongue picture：Red tongue body, or dimly red tongue, or tongue with ecchymosis；Thin lingual fur is yellow, or yellow greasy.
2.4 pulse condition：Uneven pulse, or chord number.
2.5 tcm symptom weights are classified and scored：Reference《The clinical research of new Chinese medicine treatment peptic ulcer is instructed
Principle》.
3 experiment case standards：
3.1 include case standard：
(1) age is between 18-65 Sui, no matter men and women
(2) meet Western medicine diagnostic criteria and tcm diagnosis standard (primary symptom possess more than one or two, secondary disease binomial and
Tongue, pulse condition possess).
Ulcer active stage is turned out to be through gastroscope in (3) 1 weeks, ulcer diameter is in 3mm to person between 10mm.
(4) HP positives are included after being sterilized by the course for the treatment of.
3.2 Excluded cases standards：
(1) endoscope turns out to be giving a farfetched interpretation property ulcer, gastric ulcer merging severe dysplasia person.
(2) occur complication in 30 days before the test and carry out operator.
(3) there is the gastric ulcer of cause specific, the person as caused by gastrinoma, hepatic sclerosis etc..
(4) women of the gestational period or preparation gestation, women breast-feeding their children.
(5) allergic constitution or to multi-medicament allergy sufferers.
(6) having other complication to affect the treatment observation or has the disease of taboo to trial drug.
(7) severe primary such as angiocarpy, liver, kidney and hemopoietic system disease, mental patient are associated with.
(8) indulge in excessive drinking or there are other to be unfit to do drug test observer.
(9) inclusive criteria is not met, not by regulation drug user.
(3), therapeutic scheme
It is all to make a definite diagnosis the patient with retention of damp-heat in the interior, stagnation of QI-blood type peptic ulcer and be entered using Chinese medicinal granule of the present invention
Row treatment, sets during treatment and simultaneously control group, and treatment group's Chinese medicinal granule of the present invention is twice daily taken with warm water, every time
10g, even served two months；Control group uses Couoidal bismuth pectin capsules, every time 3 (150mg), and 3 times a day, while even served two
Month, count curative effect.
(4), efficacy assessment standard
(reference《New drug (Chinese medicine) guideline of clinical investigations》)
1st, gastroscopy effect evaluation criterion
(1) fully recover：Ulcer tongue, which disappears, under gastroscope (is in S2Phase), gastric mucosa is congested, and the sign such as oedema disappears, and gastric mucosa is in
Chinese red, symptom is wholly absent.
(2) it is effective：Ulcer tongue disappears substantially under gastroscope (is in S1Phase), the sign such as gastric mucosa hyperemia, oedema is clearly better,
Remission, has clear improvement.
(3) effectively：Ulcer tongue is substantially thinning under gastroscope, and ulcer (is in H close to healing2Phase), gastric mucosa is congested, oedema has
Improved, other symptoms also make moderate progress.
(4) it is invalid：Ulcer surface is reduced below 50%, and the sign such as gastric mucosa hyperemia, oedema is unchanged.
2nd, tcm syndrome efficacy assessment standard
Therapeutic effect of syndrome is judged according to integration method：
Therapeutic index (n) ﹦ (treat after preceding integration ﹣ is treated and integrate)/treat preceding integration × 100%
(1) clinical recovery：Clinical symptoms, sign disappear or basic disappearance, therapeutic index >=90%.
(2) it is effective：Clinical symptoms, sign are obviously improved, therapeutic index >=70%, ＜ 90%.
(3) effectively：Clinical symptoms, sign take a favorable turn, therapeutic index >=30%, ＜ 70%.
(4) it is invalid：Clinical symptoms, sign are not improved, even aggravate, therapeutic index ＜ 30%.
(5), statistical procedures
Handled using SPSS13.0 statistical analysis softwares, measurement data is examined with t, enumeration data χ2Examine, grade money
Material is analyzed with Ridit.
Two groups are divided at random to 120 patients made a definite diagnosis according to above-mentioned therapeutic scheme, two groups in sex, age, the course of disease
On without significant difference, Chinese medicine syndrome integral is without significant difference (table 1).
The ordinary circumstance of the treatment group of table 1 and control group compares
Using χ2Examine, there was no significant difference in treatment group and control group gender's composition, p>0.05, examined using t
There was no significant difference in age, the course of disease for two groups of cases, P>0.05.
1st, two groups of case gastroscopy effects compare
Two groups of gastroscopy effects compare
Note：Two groups of gastroscopy effects compare, χ2=5.10, P<0.05, treatment group is better than control group
2nd, two groups of case tcm syndrome comparitive studies
Two groups of tcm syndrome comparitive studies
Note：Two groups of tcm syndrome comparitive studies, χ2=4.01, P<0.05, treatment group is better than control group.
During treating, do not occur obvious adverse reaction and obvious toxic-side effects before and after two groups of case treatments.
(6) model case
Gong, man, 52 years old, office worker.The first visit date：On October 18th, 2013.
Main suit：Gastral cavilty portion pain more than 3 years.
Medical history and therapeutic process：Patient before 3 years unknown cause there is gastral cavilty portion turgor pain, before meals, after meal more so, appetite
Can.From medicine unsatisfactory curative effects such as clothes " hedgehog hydnum stomach invigorating spirit ", i.e., to the diagnosis and treatment of Baoji institute of traditional Chinese medicine.On July 17th, 2012 looks into stomach mirror：1.
Chronic superficial gastritis, 2. plyability multiple ulcer active stages.Taking anti-ulcer medicament (specific medicine is unknown), symptom has afterwards
Alleviated, but above-mentioned symptom is aggravated in the recent period.It is existing symptoms include：The scorching hot distending pain in gastral cavilty portion, when tingle, gastral cavilty turgor, receive food reduce,
Glutted after food, general acid regurgitation water, bitter taste is sticky.Red tongue body, tongue slightly yellow greasy, arteries and veins slightly chord number.Tcm diagnosis：Stomachache (retention of damp-heat in the interior, gas
Blood stasis type).Doctor trained in Western medicine is diagnosed：1. chronic superficial gastritis；2. plyability multiple ulcer active stage.Give compound profound company
Grain, daily 1 dose (bag) divides 2 times orally.After clothes medicine-feeding 15 days, the scorching hot distending pain in patient's gastral cavilty portion substantially mitigates, tingling sensation disappears,
Gastral cavilty turgor, general acid regurgitation water, bitter taste is sticky also mitigates, and receives food increase, glutted after food to disappear.Keep prescription following the service first quarter moon, patient
The diseases such as the scorching hot distending pain in gastral cavilty portion disappear substantially, and slightly gastral cavilty turgor, general acid regurgitation water, bitter taste are sticky, and food of receiving increases.Still with above-mentioned side
Medicine following the service one month, all diseases of patient disappear, and check stomach mirror：Chronic superficial gastritis；Ulcer healing.
Liu, man, 38 years old.First visit：On March 6th, 2012.
Main suit：Discontinuity gastral cavity pain more than 6 years.
Medical history and therapeutic process：Readme discontinuity gastral cavity pain more than 6 years, it is long-term alternately to take compound stomach friend, readily take the opportunity to stomach, thunder
Buddhist nun replaces fourth, stomach celestial being-u, bisuc stomach tablet, the Western medicine such as famotidine, weight when light during the state of an illness.Prompted for through multiple gastroscope, barium meal examination
Gastric ulcer.The scorching hot pain of existing gastral cavilty, sore spot tenderness, belch, dry mouth with bitter taste, food of receiving is reduced, vexed irritability, noisy pantothenic acid, bitter taste
Sticky, just dry color is black.Red tongue body, tongue slightly yellow greasy, arteries and veins slightly chord number.Tcm diagnosis：Have a stomachache (retention of damp-heat in the interior, stagnation of QI-blood type).West
Doctor's diagnosis：Gastric ulcer.Give compound profound even particle, daily 1 dose (bag) divides 2 times orally.After clothes medicine-feeding 15 days, patient's gastral cavilty burns
Bitterly, dry mouth with bitter taste, belch, dysphoria subtracts greatly, noisy pantothenic acid, and just dry color is black disappears, and sense poor appetite, tongue nature is slightly red, and tongue is micro-
Yellow greasy, arteries and veins slightly chord number.Still with the profound even particle of compound, daily 1 dose (bag) divides 2 times orally.Patient's slightly gastral cavilty take medicine 15 days again after
The diseases such as cusalgia, dry mouth with bitter taste, noisy pantothenic acid, receive food increase, and after with above-mentioned Regimen Chemotherapy one month, all diseases disappear, and check gastroscope
Show：Gastric ulcer healing.
(7), conclusion
By above-mentioned it should be apparent that Chinese medicinal granule abundant raw material of the present invention, method is simple, easily preparation carries kimonos
With convenient, with clearing away heat and eliminating dampeness, regulating qi to disperse stagnation, drop against relieving haperacidity, the function of Tuoli myogenic, effective for treatment peptic ulcer
(retention of damp-heat in the interior, stagnation of QI-blood type) patient, good effect, effective percentage up to more than 93% and has no toxic side effect, and faces with very big
Bed meaning and practical value, are to treat the innovation on digestive ulcer medicament, economic and social benefit is huge.
It is noted that the above-mentioned embodiment that provides is for illustrating the embodiment of the present invention, rather than it is used for
Limit the scope of the invention, Chinese medicine of the present invention in practice can also be as needed, be made according to a conventional method tablet, pill,
Capsule, powder, oral liquid and decoction etc. are various to be suitable to oral preparation, therefore, every to use Chinese medicine composition of the present invention, no matter
It is that, into line translation or modification, its essence is identical, belongs to protection scope of the present invention.
Claims (5)
1. a kind of treat retention of damp-heat in the interior, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer, it is characterised in that by weight meter：
Vinegar corydalis tuber 180-220g, capsule of weeping forsythia 350-450g, dandelion 500-700g, stir-baked RHIIZOMA CURCUMAE with vinegar 180-220g, coptis 160-200g, Wu processed
Fruit of medicinal cornel 50-70g, dried immature fruit of citron orange 220-260g, raw Radix Astragali 180-220g, bletilla striata 270-330g are made, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and
Evodia rutaecarpa processed, adds water to submerge, and heats distillating extracting oil, and volatile oil is standby, extracts the another device of the aqueous solution after volatile oil and preserves
It is standby；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed extract the dregs of a decoction and vinegar corydalis tuber after volatile oil, the capsule of weeping forsythia, dandelion, the coptis, raw Huang
Stilbene, bletilla striata mixing, add water to submerge, decoct three times, 1.5h, second and third each pan-fried 1h are decocted for the first time, merge three decocting liquids every time,
Filtration, merges with the aqueous solution after said extracted volatile oil, is concentrated under reduced pressure into the medicinal extract that 80 DEG C of relative densities are 1.35, pelletizes,
Dry, add above-mentioned volatile oil and mix,.
2. treatment retention of damp-heat in the interior according to claim 1, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer, its feature exist
In by weight meter：Vinegar corydalis tuber 190-210g, capsule of weeping forsythia 370-420g, dandelion 550-650g, stir-baked RHIIZOMA CURCUMAE with vinegar 190-210g, it is yellow
Connect 170-190g, evodia rutaecarpa 55-65g processed, dried immature fruit of citron orange 230-250g, raw Radix Astragali 190-210g, bletilla striata 290-310g is made, wherein,
By stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed, add water to submerge, heat distillating extracting oil, volatile oil is standby, extract after volatile oil
The another device of the aqueous solution is saved backup；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed extract the dregs of a decoction and vinegar corydalis tuber, the capsule of weeping forsythia, Pu after volatile oil
Public English, the coptis, the raw Radix Astragali, bletilla striata mixing, add water to submerge, decoct three times, 1.5h, second and third each pan-fried 1h are decocted for the first time every time,
Merge three decocting liquids, filtration merges with the aqueous solution after said extracted volatile oil, and it is 1.35 to be concentrated under reduced pressure into 80 DEG C of relative densities
Medicinal extract, pelletize, dry, add above-mentioned volatile oil and mix,.
3. treatment retention of damp-heat in the interior according to claim 1, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer, its feature exist
In by weight meter：Vinegar corydalis tuber 200g, capsule of weeping forsythia 400g, dandelion 600g, stir-baked RHIIZOMA CURCUMAE with vinegar 200g, coptis 180g, evodia rutaecarpa processed
60g, dried immature fruit of citron orange 240g, raw Radix Astragali 200g, bletilla striata 300g are made, wherein, stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed add water to submerge, plus
Volatile oil is extracted in thermal distillation, and volatile oil is standby, is extracted the another device of the aqueous solution after volatile oil and is saved backup；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and system
Evodia rutaecarpa extracts the dregs of a decoction after volatile oil and mixed with vinegar corydalis tuber, the capsule of weeping forsythia, dandelion, the coptis, the raw Radix Astragali, the bletilla striata, adds water every time
Submergence, is decocted three times, and 1.5h, second and third each pan-fried 1h are decocted for the first time, merges three decocting liquids, filtration, with said extracted volatile oil
The aqueous solution afterwards merges, and is concentrated under reduced pressure into the medicinal extract that 80 DEG C of relative densities are 1.35, pelletizes, dries, and adds above-mentioned volatile oil and mixes
It is even,.
4. treatment retention of damp-heat in the interior according to claim 1, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer, its feature exist
In by weight meter：Vinegar corydalis tuber 185g, capsule of weeping forsythia 440g, dandelion 510g, stir-baked RHIIZOMA CURCUMAE with vinegar 205g, coptis 165g, evodia rutaecarpa processed
68g, dried immature fruit of citron orange 205g, raw Radix Astragali 215g, bletilla striata 275g are made, wherein, stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed add water to submerge, plus
Volatile oil is extracted in thermal distillation, and volatile oil is standby, is extracted the another device of the aqueous solution after volatile oil and is saved backup；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and system
Evodia rutaecarpa extracts the dregs of a decoction after volatile oil and mixed with vinegar corydalis tuber, the capsule of weeping forsythia, dandelion, the coptis, the raw Radix Astragali, the bletilla striata, adds water every time
Submergence, is decocted three times, and 1.5h, second and third each pan-fried 1h are decocted for the first time, merges three decocting liquids, filtration, with said extracted volatile oil
The aqueous solution afterwards merges, and is concentrated under reduced pressure into the medicinal extract that 80 DEG C of relative densities are 1.35, pelletizes, dries, and adds above-mentioned volatile oil and mixes
It is even,.
5. treatment retention of damp-heat in the interior according to claim 1, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer, its feature exist
In by weight meter：Vinegar corydalis tuber 215g, capsule of weeping forsythia 360g, dandelion 680g, stir-baked RHIIZOMA CURCUMAE with vinegar 186g, coptis 195g, evodia rutaecarpa processed
53g, dried immature fruit of citron orange 255g, raw Radix Astragali 185g, bletilla striata 320g are made, wherein, stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and evodia rutaecarpa processed add water to submerge, plus
Volatile oil is extracted in thermal distillation, and volatile oil is standby, is extracted the another device of the aqueous solution after volatile oil and is saved backup；Stir-baked RHIIZOMA CURCUMAE with vinegar, the dried immature fruit of citron orange and system
Evodia rutaecarpa extracts the dregs of a decoction after volatile oil and mixed with vinegar corydalis tuber, the capsule of weeping forsythia, dandelion, the coptis, the raw Radix Astragali, the bletilla striata, adds water every time
Submergence, is decocted three times, and 1.5h, second and third each pan-fried 1h are decocted for the first time, merges three decocting liquids, filtration, with said extracted volatile oil
The aqueous solution afterwards merges, and is concentrated under reduced pressure into the medicinal extract that 80 DEG C of relative densities are 1.35, pelletizes, dries, and adds above-mentioned volatile oil and mixes
It is even,.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410815663.9A CN104491728B (en) | 2014-12-22 | 2014-12-22 | It is a kind of to treat retention of damp-heat in the interior, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410815663.9A CN104491728B (en) | 2014-12-22 | 2014-12-22 | It is a kind of to treat retention of damp-heat in the interior, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104491728A CN104491728A (en) | 2015-04-08 |
| CN104491728B true CN104491728B (en) | 2017-09-22 |
Family
ID=52933242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410815663.9A Expired - Fee Related CN104491728B (en) | 2014-12-22 | 2014-12-22 | It is a kind of to treat retention of damp-heat in the interior, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104491728B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876155A (en) * | 2006-04-28 | 2006-12-13 | 四川宝光药业股份有限公司 | A medicine for treating gastric disease and preparation method thereof |
-
2014
- 2014-12-22 CN CN201410815663.9A patent/CN104491728B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876155A (en) * | 2006-04-28 | 2006-12-13 | 四川宝光药业股份有限公司 | A medicine for treating gastric disease and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| "活血愈疡汤治疗消化性溃疡49例";马宏明;《中医药学报》;20060831;第34卷(第2期);第38页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104491728A (en) | 2015-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091282B (en) | Medicament for treating chronic gastritis and gastric ulcer | |
| CN103751739A (en) | Traditional Chinese medicine composition for treating chronic gastritis, application of composition in preparation of medicine for treating chronic gastritis, and preparation method of composition | |
| CN103463584B (en) | Peptic ulcer treatment traditional Chinese medicine composition and preparation method thereof | |
| CN101450149B (en) | Medicine for treating abdominal postoperative stomach palsy syndrome and preparation method | |
| CN103989955A (en) | Pharmaceutical composition for treating stomach and duodenum ulcer, superficial multiple gastric ulcer and erosive gastric ulcer | |
| CN104491728B (en) | It is a kind of to treat retention of damp-heat in the interior, the Chinese medicinal granule of stagnation of QI-blood type peptic ulcer | |
| CN104147524A (en) | Traditional Chinese medicine preparation for treating peptic ulcer | |
| CN103877203B (en) | One treats myocarditic medicine and preparation method | |
| CN100509041C (en) | Stomach-clearing pill | |
| CN103212012A (en) | Traditional Chinese medicine composition used for treating gastric ulcer | |
| CN103520620B (en) | A kind of Chinese medicine preparation and preparation method for the treatment of due to weakness of spleen and stomach chronic gastritis | |
| CN103463452A (en) | Medicine for treating chronic atrophic gastritis | |
| CN110038111B (en) | Traditional Chinese medicine ointment preparation for treating chronic atrophic gastritis and preparation method thereof | |
| CN106266827B (en) | Alpine yallow herb compound oral administration preparation and purposes | |
| CN105125688B (en) | A kind of relieving haperacidity analgesic composition containing milk basic protein and preparation method thereof | |
| CN105726695A (en) | Medicine composition for treating chronic superficial gastritis | |
| CN101632826B (en) | Traditional Chinese medicine composition for treating peptic ulcer and preparation method thereof | |
| CN103417845B (en) | Traditional Chinese medicine preparation used for preventing and treating postoperative complications of gastric cancer and preparation method thereof | |
| CN107837356A (en) | A kind of medicine for treating stomach trouble and preparation method thereof | |
| CN110339235A (en) | A kind of Chinese medicine composition for treating hemorrhoid | |
| CN107913400A (en) | A kind of Chinese and western medicinal composition and preparation method for treating acute peritonitis | |
| CN102784206B (en) | Niweikang and preparation method thereof | |
| CN110141642A (en) | One group for cleaning the Chinese medicine of nettle rash | |
| CN109925443A (en) | A kind of Chinese medicine composition for treating ulcerative colitis | |
| CN112826912A (en) | Medicine for quickly treating spleen-stomach deficiency-cold type chronic atrophic gastritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 450008 Jinshui Road, Zhengzhou, Henan, No. 1 Applicant after: Henan University of traditional Chinese Medicine Address before: 450008 Jinshui Road, Zhengzhou, Henan, No. 1 Applicant before: Henan University of Traditional Chinese Medicine |
|
| CB02 | Change of applicant information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Mohang Inventor after: Dang Hui Inventor after: Chen Tianchao Inventor after: Guo Shuyun Inventor before: Guo Shuyun Inventor before: Li Mohang Inventor before: Chen Tianchao |
|
| CB03 | Change of inventor or designer information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170922 Termination date: 20201222 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |