CN104491728A - Traditional Chinese medicine particles for treating peptic ulcer with syndrome of interior dampness-heat and stagnation of qi and blood stasis - Google Patents

Traditional Chinese medicine particles for treating peptic ulcer with syndrome of interior dampness-heat and stagnation of qi and blood stasis Download PDF

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CN104491728A
CN104491728A CN201410815663.9A CN201410815663A CN104491728A CN 104491728 A CN104491728 A CN 104491728A CN 201410815663 A CN201410815663 A CN 201410815663A CN 104491728 A CN104491728 A CN 104491728A
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volatile oil
vinegar
fructus
stir
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CN104491728B (en
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郭淑云
李墨航
陈天朝
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Henan University of Traditional Chinese Medicine HUTCM
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Abstract

The invention relates to traditional Chinese medicine particles for treating peptic ulcer with syndrome of interior dampness-heat and stagnation of qi and blood stasis and aims at effectively solving the medication problems of treating peptic ulcer and eliminating symptoms including pains, turgor, poor appetite, deficiency of foods, bloating after eating, acid reflux, frequent belching and bitter and sticky taste. The traditional Chinese medicine particles are prepared from the following medicinal raw materials in parts by weight: 180-220g of vinegar pickled rhizoma corydalis, 350-450g of fructus forsythia, 500-700g of dandelion, 180-220g of vinegar pickled rhizoma zedoariae, 160-200g of rhizoma coptidis, 50-70g of prepared fructus evodiae, 220-260g of fruit of immature citron, 180-220g of raw astragaloside and 270-330g of common bletilla pseudobulb and are prepared by the following steps: extracting volatile oil of the vinegar pickled rhizoma zedoariae, the fruits of immature citron and the prepared fructus evodiae by distillation with water, and preserving an aqueous solution after extracting the volatile oil by another vessel; and mixing dregs obtained after extracting the volatile oil, the vinegar pickled rhizoma corydalis, the fructus forsythia, the dandelions, the rhizoma coptidis, the raw astragaloside and the common bletilla pseudobulb, decocting with water, combining a decoction solution and the aqueous solution after extracting the volatile oil, carrying out vacuum concentration to obtain an extractum with temperature to be 80 DEG C and relative density to be 1.35, carrying out granulation, drying, and adding the volatile oil to obtain the traditional Chinese medicine particles. The traditional Chinese medicine particles are scientific in composition, have the functions of clearing heat, eliminating dampness, promoting qi circulation, dispersing blood stasis, calming adverse-rising energy, relieving hyperacidity, strengthening the middle warmer and genuine qi and promoting granulation and are good in curative effect.

Description

A kind of Chinese medicinal granule for the treatment of retention of damp-heat in the interior, stagnation of QI-blood type peptic ulcer
Technical field
The present invention relates to medicine, is a kind of Chinese medicinal granule (connecting granule also known as compound recipe is profound) for the treatment of retention of damp-heat in the interior, stagnation of QI-blood type peptic ulcer.
Background technology
Peptic ulcer (peptic ulcer, PU) is clinical common, multiple digestive system disease, and the people of most data display about 10% ~ 12% can suffer from this disease in life.At present, due to the continuous aggravation of social competition, under the stimulation of a series of undesirable element such as change, habits of smoking and alcohol drinking of, eating and drinking without temperance, diet structure irregular in thought of people pressure increase, psychentonia, life, the sickness rate of this disease is caused constantly to rise, although along with Western medicine H 2the extensive use of the antisecretory such as receptor antagonist and proton pump inhibitor, its recent cure rate reaches about 90%, but generally observation shows, its Ulcer cicatrization quality (QOUH) is poor, and relapse rate height is a clinical still unsolved difficult problem.According to relevant statistics, after ulcer healing the natural relapse rate of 1 year be relapse rate in 50 ~ 60%, 2 years then up to more than 60 ~ 90%, therefore improve Ulcer cicatrization quality, prevent the recurrence after healing from being the emphasis should studied from now on.So far, increasing expert thinks: " healing of ulcer does not refer to merely filling and the repairing of mucomembranous defect more need the reconstruction of mucosal tissue structure." simple acid suppression, antacid is only the pH value that improve Stomach duodenum chamber; but do not change the natural history of ulcer; and point out Acidinhibitor stronger on evidence; after its drug withdrawal, the time of ulcer recurrence is more early; so improve the healing quality of ulcer; improve the structure of callus, strengthens it and resists the ability damaged again, thus prevention is recurred and is then seemed and be even more important effectively.
Find according to a large amount of clinical observations, with the Peptic Ulcers of Chinese medicine, relapse rate obviously reduces, and even has for many years not recidivist, and some patients are in autumn and winter or at the end of winter and the beginning of spring of easily recurrence, take Chinese herb on the prevention in advance, then entirely prevented the recurrence of ulcer, therefore think, further investigation Chinese medicine is at promotion Ulcer cicatrization quality, prevent the aspects such as ulcer recurrence, have good prospect.At present with Chinese medicine peptic ulcer, dialectical mainly with tradition clinically, according to different pathogenesis and pattern of syndrome, impose different square medicines respectively, existing prescription medicine for various reasons, its use is also unsatisfactory, particularly patient consumes is inconvenient, some Chinese patent drugs for treatment peptic ulcer adaptive surface is narrower, can not meet the actual needs to treatment digestive ulcer medicament, therefore, strengthen the rule for the treatment of prescription research that Chinese medicine promotes Ulcer cicatrization quality and antiulcer recurrence, in specification case standard, under the prerequisite of the course for the treatment of and efficacy evaluation, find adaptation wide, late result is consolidated, taking convenience, effective, medicine without any side effects, it is problem demanding prompt solution.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the object of the present invention is just to provide a kind of Chinese medicinal granule for the treatment of retention of damp-heat in the interior, stagnation of QI-blood type peptic ulcer, can effectively solve treatment peptic ulcer, and eliminate pain, distension, poor appetite lack of appetite, glutted after food, general acid regurgitation water, belch is done frequently, the medication problem of the symptoms such as bitter taste is sticky.
The technical scheme that the present invention solves is, this Chinese medicine is by weighing scale: vinegar corydalis tuber 180-220g, Fructus Forsythiae 350-450g, Herba Taraxaci 500-700g, stir-baked RHIIZOMA CURCUMAE with vinegar 180-220g, Rhizoma Coptidis 160-200g, Fructus Evodiae (processed) 50-70g, Fructus Aurantii Immaturus 220-260g, Radix Astragali 180-220g, Pseudobulbus Bletillae (Rhizoma Bletillae) 270-330g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times, first time decocts 1.5h, second and third time respectively decocts 1h, merges three decocting liquids, filters, merge with the aqueous solution after said extracted volatile oil, being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates, dry, add above-mentioned volatile oil mixing, Chinese medicinal granule of the present invention.
Scientific formula of the present invention, abundant raw material, easy manufacture, medicine, by monarch, minister, the principles of formulating prescriptions of helping, making, supports to have the function of clearing away heat and eliminating dampness, regulating qi to disperse stagnation, sending down the abnormal ascending QI antacid, Tuoli granulation promoting mutually.Clinical being mainly used in treats the common retention of damp-heat in the interior of peptic ulcer, stagnation of QI-blood type patient.Good effect, cheap, taking easy to carry, is the innovation on treatment digestive ulcer medicament.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is elaborated.
The present invention, in concrete enforcement, can be provided by following examples.
Embodiment 1
The present invention, also can by weighing scale: vinegar corydalis tuber 190-210g, Fructus Forsythiae 370-420g in concrete enforcement, Herba Taraxaci 550-650g, stir-baked RHIIZOMA CURCUMAE with vinegar 190-210g, Rhizoma Coptidis 170-190g, Fructus Evodiae (processed) 55-65g, Fructus Aurantii Immaturus 230-250g, Radix Astragali 190-210g, Pseudobulbus Bletillae (Rhizoma Bletillae) 290-310g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times; first time decocts 1.5h; second and third time respectively decocts 1h, merges three decocting liquids, filters; merge with the aqueous solution after said extracted volatile oil; being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates with granulator, dry; add above-mentioned volatile oil mixing, Chinese medicinal granule of the present invention.
Embodiment 2
The present invention is in concrete enforcement, and this Chinese medicine is by weighing scale: vinegar corydalis tuber 200g, Fructus Forsythiae 400g, Herba Taraxaci 600g, stir-baked RHIIZOMA CURCUMAE with vinegar 200g, Rhizoma Coptidis 180g, Fructus Evodiae (processed) 60g, Fructus Aurantii Immaturus 240g, Radix Astragali 200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 300g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times; first time decocts 1.5h; second and third time respectively decocts 1h, merges three decocting liquids, filters; merge with the aqueous solution after said extracted volatile oil; being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates with granulator, dry; add above-mentioned volatile oil mixing, Chinese medicinal granule of the present invention.
Embodiment 3
The present invention also can by weighing scale: vinegar corydalis tuber 185g, Fructus Forsythiae 440g, Herba Taraxaci 510g, stir-baked RHIIZOMA CURCUMAE with vinegar 205g, Rhizoma Coptidis 165g, Fructus Evodiae (processed) 68g, Fructus Aurantii Immaturus 205g, Radix Astragali 215g, Pseudobulbus Bletillae (Rhizoma Bletillae) 275g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times; first time decocts 1.5h; second and third time respectively decocts 1h, merges three decocting liquids, filters; merge with the aqueous solution after said extracted volatile oil; being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates with granulator, dry; add above-mentioned volatile oil mixing, Chinese medicinal granule of the present invention.
Embodiment 4
The present invention, also can by weighing scale: vinegar corydalis tuber 215g, Fructus Forsythiae 360g in concrete enforcement, Herba Taraxaci 680g, stir-baked RHIIZOMA CURCUMAE with vinegar 186g, Rhizoma Coptidis 195g, Fructus Evodiae (processed) 53g, Fructus Aurantii Immaturus 255g, Radix Astragali 185g, Pseudobulbus Bletillae (Rhizoma Bletillae) 320g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times; first time decocts 1.5h; second and third time respectively decocts 1h, merges three decocting liquids, filters; merge with the aqueous solution after said extracted volatile oil; being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates with granulator, dry; add above-mentioned volatile oil mixing, Chinese medicinal granule of the present invention.
In said medicine, wherein:
Corydalis tuber bitter in the mouth, pungent, warm in nature, return liver, spleen, heart channel; Function circulation of qi promoting, invigorate blood circulation, pain relieving.Cure mainly all pain cards of stagnation of QI-blood, the stagnation of QI in the promoting the circulation of blood of this product energy, stasis in gas." book on Chinese herbal medicine take advantage of refined half brave " carries it: " void is then mended, actually flat for the gas in drum blood, the blood in circulation of qi promoting, causes newly to push away old, pushes away oldly causing new good thing also ".Modern pharmacology confirmation corydalis tuber has and has blood vessel dilating, and the blood changing lesion is irrigated, and provides necessary nutrient substance, and the speed that guarantee, acceleration muscle layer and mucomembranous epithelial cell upgrade and quality, can promote Ulcer cicatrization quality.
Fructus Forsythiae bitter in the mouth, is slightly cold, and returns lung, the heart, Liver Channel; Function heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, and have the title of " persons particularly liable to develop skin infection's panacea "." Bencao Jingshu " claims it: " refrigerant with except stagnant heat, fragrance lightly floats with Disperse hepatic depression, then seek Wei Tonghe and skin ulcer is swollen disappears ".Modern pharmacological research proves, the decocting liquid of Fructus Forsythiae, to dysentery bacterium, Bacillus typhi, staphylococcus aureus, all has obvious suppression, has antibacterial and anti-inflammation functions; Rutin contained in Fructus Forsythiae, Citrin composition, can improve the resistivity of blood capillary, prevent thin vessels hemorrhage.
Herba Taraxaci sweet in the mouth, hardship, cold, return liver, stomach warp; Function heat-clearing and toxic substances removing, eliminating stagnation eliminating carbuncle.The merit that " Amplification on Materia Medica addendum " calls it to be had " heat-transformation poison " " loose stagnant gas "." book on Chinese herbal medicine justice " claims: " its property is refrigerant, controls all furuncle, carbuncle and ulcer, all diseases of red and swollen pyretic toxicity." pharmacological testing checking: Herba Taraxaci has height bacteriostasis; Its extract has significant protective effect to gastric mucosa of rat, to repair and hemorrhage, the erosion of adjustment peptic ulcer play an important role, and can reduce inflammation and oozes out, change the microcirculation of diseased region.
Rhizoma Curcumae bitter in the mouth, pungent, nontoxic, return liver, spleen channel; Function, promoting the circulation of QI to relieve pain, removing food stagnancy whets the appetite, anti-nausea sour water." explaining abstruseness of the canon of materia medica " claims it: " removing mass gathers stagnant blood, dredges expectorant food and has a pain ", " Japan hanako materia medica " claims it " to control all gas, appetite-stimulating indigestion-relieving." essentials of Matea Medica say its " repercussive stimulates the menstrual flow, appetizing relieving dyspepsia, removing toxic substances pain relieving." modern pharmacological research shows; it has certain Hang Yan to ease pain, antibacterial merit; Rhizoma Curcumae is mainly main component with curzerenone; its removing blood stasis dissipating blood stasis effect is main relevant with increasing blood flow volume; the blood that can change ulcer lesion is irrigated; provide necessary nutrient substance, ensures, speed that acceleration muscle layer and mucomembranous epithelial cell upgrade and quality, can promote Ulcer cicatrization quality.
Rhizoma Coptidis, large bitter Great Cold, GUIXIN, liver, stomach, large intestine channel; Function heat clearing and damp drying, eliminating fire and detoxication." Bencao Jingshu " calls it: " dewater, thick the intestines and stomach, wash away intestinal, stomach, spleen three damp and hot." " feeling of fullness stomachache can disappear, and the remorse skin infection of carbuncle can be healed ".Rhizoma Coptidis is containing berberine, there is very wide antibacterial action, and can leukocytic phagocytic activity be increased, pressed down blocking a-adrenoreceptor expansion peripheral blood vessel by competitiveness, improve microcirculation, have again function of gallbladder promoting, antipyretic, analgesia, calm, eliminate anxiety and the multi-efficiency such as anti-hypoxia, antiulcer.
Fructus Evodiae bitter in the mouth, pungent, hot, slightly poisonous, return liver, spleen, stomach warp; The therapeutic method to keep the adverse QI flowing downwards that function is soothing the liver, cold expelling dampness." herbal classic " claims it: " therapeutic method to keep the adverse QI flowing downwards, pain relieving, dehumidifying arthralgia due to stagnation of blood." Fructus Evodiae and Rhizoma Coptidis share as recipe Zuojin Wan, all has pungent drugs can disperse and bitter drugs can descend, the merit of sending down the abnormal ascending QI antacid.
Fructus Aurantii Immaturus bitter in the mouth, pungent, be slightly cold, return spleen, stomach, large intestine channel; Function dispelling the stagnated QI is except painful abdominal mass, and transforming phlegm and dispersing accumulations, pungent row hardship is fallen, " going in stomach damp and hot " (" pearl sac "), consumer product dredge stasis, removing heat by catharsis expells the pathogenic heat." Changsha medicine solution " claims it: " broken knot opens the stasis of blood, and let out painful abdominal mass and disappear full, wash away strongly fragrant old, power is suddenly high, and all corrupt non-these of thing stopping up resistance do not disappear." " medicineization justice " call it: " specially let out excess of the stomach, convince hard knot by patient analysis, therefore the main middle part of gastric cavity is to control blood system." modern study discovery: Fructus Aurantii Immaturus contains the material such as volatile oil and flavonoid glycoside.Its water decoction can make dog intestinal smooth muscle tension force and motor function strengthen, and can make gastrointestinal vasodilation, improves gastrointestinal tract blood supply; Fructus Aurantii Immaturus can make the cholecystokinin in blood or motilin levels increase and impel gallbladder contraction, facilitating digestion, and 20% Fructus Aurantii Immaturus volatile oil has the effect of prevention rat pylorus ligation ulcer, and can significantly reduce gastric juice amount, the secretion of gastric acid and pepsic activity.
Radix Astragali sweet in the mouth, warm in nature, return lung, spleen channel; Function invigorating the spleen and replenishing QI, kind controls weakness of the spleen and stomach, and raw user, has the merit of evacuation of pus hemostasis, and to the pus and blood internal ulceration of carbuncle and ulcer, deficiency of YANG QI and unhealed can granulation promoting meat; Deficiency of YANG QI not being burst to person can pus expelling by strengthening vital QI poison, and Materia Medica of Decoction calls it, and " tonifying five ZANG-organs is all empty not enough, and rushes down YIN-fire, deficiency-heat of dispelling." " book on Chinese herbal medicine is just " say it: " and survivor, micro-cool, can carbuncle be controlled ".Essentials of Matea Medica claims it: " rushing down YIN-fire, expelling pathogenic factors from muscles heat, invigorating middle warmer, strong taste ".Modern pharmacology experimentation proves; Radix Astragali is improved body's immunity; improve gastrointestinal blood circulation; increase gastrointestinal blood supply, correct local organization hypoxic-ischemic, adjustment gastrointestinal motility; and the secretory volume of gastric juice and gastric acid can be reduced; and attack factor is weakened, protection gastric mucosa, promotes damaged tissue reparation.
Pseudobulbus Bletillae (Rhizoma Bletillae) bitter in the mouth, sweet, cold, return lung, stomach Liver Channel; Function hemostasia and detumescence, promoting tissue regeneration and ulcer healing, controls skin sore, canker sores." Bencao Jingshu " cloud: " Pseudobulbus Bletillae (Rhizoma Bletillae), hardship can expel the heat-evil, pungent can heat radiation knot, carbuncle all by Ying Qi not from, inverse in meat give birth to ..., enter blood system to expel the heat-evil, eliminating stagnation is by corruption, then all diseases waste not Liao." " book on Chinese herbal medicine converge with speech " call it " carbuncle can disappear, and routedly holds in the palm, and dead flesh can go, and pus and blood can be clean, has the magical effect of de-old tissue regeneration promoting also." Bletilla glucomannan that formed of the Pseudobulbus Bletillae (Rhizoma Bletillae) can form one deck coverlay at mucomembranous surface, strengthen gastric mucosal barrier, prevent gastric acid and pepsin to the erosion of mucosa, thus weaken the Recurrence of ulcer.
Mutual support between said medicine, there is the function of clearing away heat and eliminating dampness, regulating qi to disperse stagnation, sending down the abnormal ascending QI antacid, Tuoli granulation promoting, particularly for the treatment of damp and hot middle resistance, stagnation of QI-blood type active stage ulcer, there is the advantage that too many levels, stage construction, Mutiple Targets, multipath mechanism of action and untoward reaction are few, effectively be used for the treatment of peptic ulcer, obtain sufficient proof through clinical trial, and achieve the Advantageous Effects making us being satisfied with very much, pertinent clinical data is as follows:
(1) standard of case is selected
Peptic ulcer mainly refers to betide the duodenal chronic ulcer of harmonization of the stomach, is a frequently-occurring disease, commonly encountered diseases.Ulcer be formed with various factors, wherein the Digestion of acidic gastric juice to mucosa is the Fundamentals of ulcer, hence obtains one's name.Any position of acidic gastric juice contact, as distal esophagus, the postoperative anastomotic stoma of gastrointestinal anastomosis, jejunum and the Meckel diverticulum with Ectopic Gastric Mucosa, most ulcer betides duodenum stomach function regulating, therefore also known as taste-blindness rate.Clinical manifestation is pain, distension, poor appetite lack of appetite, glutted after food, general acid regurgitation water, and belch is done frequently, and the symptoms such as bitter taste is sticky, through endoscopy, have ulcer surface.All persons that has above-mentioned symptom, all as the standard selecting case, and give Chinese medicinal granule of the present invention treatment.
(2), diagnostic criteria
1 Western medicine diagnose standard: with reference to " guideline of clinical investigations of new Chinese medicine treatment peptic ulcer " (trying for 2002) and national higher institutions of Chinese medicine programming textbook the 7th edition " Chinese Internal Medicine "
1.1. clinical criteria
(1) periodicity of prolonged and repeated outbreak, the chronic epigastrium pain of rhythmicity, application antisecretory and alkalescent medicine can be alleviated.
(2) epigastrium has limitation deeply in tenderness.
(3) splanchnoscopy can see active stage ulcer.
Show by stages under 1.2 Peptic Ulcers gastroscopes
(1) active stage (A phase) is the initial stage of morbidity, and ulcer edge inflammation, edema is obvious, and tissue repair not yet occurs.
A 1phase: thick white fur is draped over one's shoulders at the end, can be filthy, tongue can exceed ulcer margin at some position, and tongue can have petechia or sludged blood attachment, periphery mucosa bulges into dike shape, hyperemia, edema, erosion, shows in obvious inflammation.
A 2phase: the inflammation edema of this phase ulcer margin obviously alleviates, white fur cleans, and border is distinct, and marginal portion starts the re-epithelialize occurring taking on a red color, and starts the performance occurring that pleat is concentrated.
(2) healing stage (H phase) this phase ulcer reduces, inflammatory resolution, and re-epithelialize and pleat are concentrated obviously.
H 1phase: ulcer reduces, shoal, white fur the smooth of the edge, peripheral oedema disappears, and edge re-epithelialize is obvious, and take on a red color palisade, and pleat is concentrated, and arrives ulcer edge.
H 2phase: ulcer obviously reduces, white fur is thinning, re-epithelialize range widens.
(3) cicatrix phase (S phase) this phase ulcer is repaired completely, for re-epithelialize covers.
S 1phase: Mucosa Defect has been entirely re-epithelialize and has covered, re-epithelialize is rubescent, and in palisade, centration radially arranges, and has and claims red cicatricial phase.
S 2phase: re-epithelialize thickens, red disappearance, with around mucosa is roughly the same, pleat is concentrated not obvious, but visible mucosa concentrates picture, also known as white cicatricial phase.
2 Syndrome in TCM marquis diagnostic criterias (retention of damp-heat in the interior, stagnation of QI-blood type): with reference to " guideline of clinical investigations of new Chinese medicine treatment peptic ulcer " (trying for 2002) and national higher institutions of Chinese medicine programming textbook the 7th edition " Chinese Internal Medicine "
2.1 primary symptoms: (1) gastral cavilty portion distending pain, twinge, scorching hot pain.(2) gastral cavilty distension
2.2 diseases: (1) receive decreased food intake few (2) food after glutted.
(3) the general acid regurgitation water of belch (4).
(5) bitter taste is sticky
2.3 picture of the tongues: red tongue, or dimly red tongue, or tongue with ecchymosis; Tongue fur BOHUANG, or yellow greasy.
2.4 pulse conditions: hesitant pulse, or stringy and rapid pulse.
2.5 tcm symptom weight classifications and scoring: with reference to " guideline of clinical investigations of new Chinese medicine treatment peptic ulcer ".
3 test case standards:
3.1 include case standard in:
(1) age is between 18-65 year, no matter men and women
(2) meet Western medicine diagnose standard and tcm diagnosis standard (primary symptom possesses one or two, more than secondary disease binomial and tongue, pulse condition possess).
Ulcer active stage is turned out to be through gastroscope, ulcer diameter person between 3mm to 10mm in (3) 1 weeks.
(4) HP positive was included in after sterilization by the course for the treatment of.
3.2 Excluded cases standards:
(1) endoscope turns out to be giving a farfetched interpretation property ulcer, gastric ulcer merges severe dysplasia person.
(2) there is complication in 30 days before the test and carry out operator.
(3) gastric ulcer of cause specific is had, person as caused in gastrinoma, liver cirrhosis etc.
(4) women of trimester of pregnancy or preparation gestation, women breast-feeding their children.
(5) allergic constitution or to multi-medicament allergy sufferers.
(6) there are other complication to affect the treatment and observe or have trial drug the disease of taboo.
(7) severe primary disease, the psychotics such as cardiovascular, liver, kidney and hemopoietic system is associated with.
(8) indulge in excessive drinking or have other to be unfit to do drug test observer.
(9) inclusive criteria is not met, not by regulation medication person.
(3), therapeutic scheme
All make a definite diagnosis suffer from retention of damp-heat in the interior, the patient of stagnation of QI-blood type peptic ulcer all can adopt Chinese medicinal granule of the present invention to treat, also establish matched group, treatment group Chinese medicinal granule of the present invention during treatment, every day uses warm boiled water twice simultaneously, each 10g, serve on two months; Matched group adopts Couoidal bismuth pectin capsules, and each 3 (150mg), every day 3 times, serve on two months simultaneously, statistics curative effect.
(4), efficacy assessment standard
(with reference to " new drug (Chinese medicine) guideline of clinical investigations ")
1, gastroscopy effect evaluation criterion
(1) fully recover: under gastroscope, ulcer tongue disappears and (is in S 2phase), the signs such as gastric mucosa is congested, edema disappear, and gastric mucosa is Chinese red, and symptom disappears completely.
(2) effective: under gastroscope, ulcer tongue substantially disappears and (is in S 1phase), the signs such as gastric mucosa hyperemia, edema are clearly better, and remission, has clear improvement.
(3) effective: under gastroscope, ulcer tongue is obviously thinning, ulcer (is in H close to healing 2phase), gastric mucosa is congested, edema makes moderate progress, and other symptom also makes moderate progress.
(4) invalid: ulcer surface reduces below 50%, the signs such as gastric mucosa hyperemia, edema are unchanged.
2, tcm syndrome efficacy assessment standard
Therapeutic effect of syndrome is judged according to integration method:
Integration × 100% before therapeutic index (n) ﹦ (before treating, integration ﹣ treats rear integration)/treatment
(1) clinical recovery: clinical symptoms, sign disappear or substantially disappear, therapeutic index >=90%.
(2) effective: clinical symptoms, sign are obviously improved, therapeutic index >=70%, < 90%.
(3) effective: clinical symptoms, sign all take a favorable turn, therapeutic index >=30%, < 70%.
(4) invalid: clinical symptoms, sign are not improved, even increase the weight of, therapeutic index < 30%.
(5), statistical procedures
Adopt the process of SPSS13.0 statistical analysis software, measurement data t checks, enumeration data χ 2inspection, ranked data Ridit analyzes.
According to above-mentioned therapeutic scheme, two groups are divided at random to make a definite diagnosis 120 routine patients, two groups in sex, age, the course of disease without significant difference, Chinese medicine syndrome integral is without significant difference (table 1).
The ordinary circumstance of table 1 treatment group and matched group compares
Adopt χ 2inspection, treatment group and matched group gender form upper there was no significant difference, p>0.05, adopt t to check two groups of cases there was no significant difference in age, the course of disease, P>0.05.
1, two groups of case gastroscopy effects compare
Two groups of gastroscopy effects compare
Note: two groups of gastroscopy effects compare, χ 2=5.10, P<0.05, treatment group is better than matched group
2, two groups of case tcm syndrome comparitive study
Two groups of tcm syndrome comparitive study
Note: two groups of tcm syndrome comparitive study, χ 2=4.01, P<0.05, treatment group is better than matched group.
At treatments period, before and after two groups of case treatments, all there is not obvious untoward reaction and obvious toxic-side effects.
(6) model case
Gong, man, 52 years old, office worker.The first visit date: on October 18th, 2013.
Main suit: gastral cavilty portion pain more than 3 years.
Medical history and therapeutic process: patient before 3 years unknown cause there is gastral cavilty portion distension pain, ante cibum, after meal more so, appetite can.From medicine unsatisfactory curative effects such as clothes " HOUTOU JIANWEI LING ", namely arrive the diagnosis and treatment of Baoji institute of traditional Chinese medicine.On July 17th, 2012 looks into gastroscope and shows: 1. chronic superficial gastritis, 2. plyability multiple ulcer active stage.Take anti-ulcer medicament (concrete medicine is not quite clear) afterwards symptom alleviate to some extent, but in the recent period above-mentioned symptom increases the weight of.Existing disease is seen: the scorching hot distending pain in gastral cavilty portion, time tingle, gastral cavilty distension, decreased food intake of receiving is few, and glutted after food, general acid regurgitation water, bitter taste is sticky.Red tongue, tongue is slightly yellow greasy, and arteries and veins is stringy and rapid pulse slightly.Tcm diagnosis: stomachache (retention of damp-heat in the interior, stagnation of QI-blood type).Western medicine diagnose: 1. chronic superficial gastritis; 2. plyability multiple ulcer active stage.Give that compound recipe is profound connects granule, every day 1 dose (bag), points 2 times oral.Take medicine-feeding after 15 days, the scorching hot distending pain in patient's gastral cavilty portion obviously alleviates, sensation of pricking disappears, gastral cavilty distension, general acid regurgitation water, bitter taste is sticky also alleviates, and food of receiving increases, glutted disappearance after food.Keep top medicine following the service first quarter moon, the diseases such as the scorching hot distending pain in patient's gastral cavilty portion disappear substantially, and slightly gastral cavilty distension, general acid regurgitation water, bitter taste are sticky, and food of receiving increases.Still with above-mentioned side's medicine following the service one month, all diseases of patient disappear, and check gastroscope shows: chronic superficial gastritis; Ulcer healing.
Liu, man, 38 years old.First visit: on March 6th, 2012.
Main suit: discontinuity gastralgia more than 6 years.
Medical history and therapeutic process: readme discontinuity gastralgia more than 6 years, alternately take compound recipe Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), roter tablets, ranitidine, weisen-u, bismuth aluminate compound, the Western medicine such as famotidine for a long time, heavy time light during the state of an illness.Through repeatedly gastroscope, barium meal examination all prompt for gastric ulcer.The existing scorching hot pain of gastral cavilty, sore spot tenderness, belch, dry mouth with bitter taste, decreased food intake of receiving is few, vexed irritability, noisy pantothenic acid, and bitter taste is sticky, dry stool darkish complexion.Red tongue, tongue is slightly yellow greasy, and arteries and veins is stringy and rapid pulse slightly.Tcm diagnosis: stomachache (retention of damp-heat in the interior, stagnation of QI-blood type).Western medicine diagnose: gastric ulcer.Give that compound recipe is profound connects granule, every day 1 dose (bag), points 2 times oral.Take medicine-feeding after 15 days, patient's burning pain in the epigastrium, dry mouth with bitter taste, belch, susceptible to lose temper due to restlessness subtracts greatly, noisy pantothenic acid, and dry stool darkish complexion disappears, and sense inappetence, body of the tongue is slightly red, and the micro-Huang of tongue is greasy, and arteries and veins is stringy and rapid pulse slightly.Still connect granule, every day 1 dose (bag) so that compound recipe is profound, points 2 times oral.Patient's slightly disease such as burning pain in the epigastrium, dry mouth with bitter taste, noisy pantothenic acid after taking medicine again 15 days, food of receiving increases, and continue with above-mentioned Regimen Chemotherapy one month, all diseases disappear, and check gastroscope shows: gastric ulcer healing.
(7), conclusion
Can clearly be found out by above-mentioned, Chinese medicinal granule abundant raw material of the present invention, method is simple, easy preparation, easy to carry and use, there is the function of clearing away heat and eliminating dampness, regulating qi to disperse stagnation, sending down the abnormal ascending QI antacid, Tuoli granulation promoting, be effective to treatment peptic ulcer (retention of damp-heat in the interior, stagnation of QI-blood type) patient, good effect, effective percentage is up to more than 93%, and have no side effect, have very large clinical meaning and practical value, be the innovation on treatment digestive ulcer medicament, economic and social benefit is huge.
It is to be noted; the above-mentioned embodiment provided is for illustration of the specific embodiment of the present invention; instead of for limiting the scope of the invention; Chinese medicine of the present invention in practice also can as required, makes that tablet, pill, capsule, powder, oral liquid and decoction etc. are various is suitable for oral preparation according to a conventional method, therefore; every employing Chinese medicine composition of the present invention; no matter be carry out converting or modifying, its essence is identical, all belongs to protection scope of the present invention.

Claims (5)

1. treat the Chinese medicinal granule of retention of damp-heat in the interior, stagnation of QI-blood type peptic ulcer for one kind, it is characterized in that, by weighing scale: vinegar corydalis tuber 180-220g, Fructus Forsythiae 350-450g, Herba Taraxaci 500-700g, stir-baked RHIIZOMA CURCUMAE with vinegar 180-220g, Rhizoma Coptidis 160-200g, Fructus Evodiae (processed) 50-70g, Fructus Aurantii Immaturus 220-260g, Radix Astragali 180-220g, Pseudobulbus Bletillae (Rhizoma Bletillae) 270-330g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times, first time decocts 1.5h, second and third time respectively decocts 1h, merges three decocting liquids, filters, merge with the aqueous solution after said extracted volatile oil, being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates, dry, add the mixing of above-mentioned volatile oil.
2. the Chinese medicinal granule for the treatment of retention of damp-heat in the interior according to claim 1, stagnation of QI-blood type peptic ulcer, it is characterized in that, by weighing scale: vinegar corydalis tuber 190-210g, Fructus Forsythiae 370-420g, Herba Taraxaci 550-650g, stir-baked RHIIZOMA CURCUMAE with vinegar 190-210g, Rhizoma Coptidis 170-190g, Fructus Evodiae (processed) 55-65g, Fructus Aurantii Immaturus 230-250g, Radix Astragali 190-210g, Pseudobulbus Bletillae (Rhizoma Bletillae) 290-310g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times, first time decocts 1.5h, second and third time respectively decocts 1h, merges three decocting liquids, filters, merge with the aqueous solution after said extracted volatile oil, being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates, dry, add the mixing of above-mentioned volatile oil.
3. the Chinese medicinal granule for the treatment of retention of damp-heat in the interior according to claim 1, stagnation of QI-blood type peptic ulcer, is characterized in that, by weighing scale: vinegar corydalis tuber 200g, Fructus Forsythiae 400g, Herba Taraxaci 600g, stir-baked RHIIZOMA CURCUMAE with vinegar 200g, Rhizoma Coptidis 180g, Fructus Evodiae (processed) 60g, Fructus Aurantii Immaturus 240g, Radix Astragali 200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 300g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times, first time decocts 1.5h, second and third time respectively decocts 1h, merges three decocting liquids, filters, merge with the aqueous solution after said extracted volatile oil, being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates, dry, add the mixing of above-mentioned volatile oil.
4. the Chinese medicinal granule for the treatment of retention of damp-heat in the interior according to claim 1, stagnation of QI-blood type peptic ulcer, is characterized in that, by weighing scale: vinegar corydalis tuber 185g, Fructus Forsythiae 440g, Herba Taraxaci 510g, stir-baked RHIIZOMA CURCUMAE with vinegar 205g, Rhizoma Coptidis 165g, Fructus Evodiae (processed) 68g, Fructus Aurantii Immaturus 205g, Radix Astragali 215g, Pseudobulbus Bletillae (Rhizoma Bletillae) 275g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times, first time decocts 1.5h, second and third time respectively decocts 1h, merges three decocting liquids, filters, merge with the aqueous solution after said extracted volatile oil, being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates, dry, add the mixing of above-mentioned volatile oil.
5. the Chinese medicinal granule for the treatment of retention of damp-heat in the interior according to claim 1, stagnation of QI-blood type peptic ulcer, is characterized in that, by weighing scale: vinegar corydalis tuber 215g, Fructus Forsythiae 360g, Herba Taraxaci 680g, stir-baked RHIIZOMA CURCUMAE with vinegar 186g, Rhizoma Coptidis 195g, Fructus Evodiae (processed) 53g, Fructus Aurantii Immaturus 255g, Radix Astragali 185g, Pseudobulbus Bletillae (Rhizoma Bletillae) 320g makes, wherein, by stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed), add water to submerge, heating distillating extracting oil, volatile oil is for subsequent use, and the another device of aqueous solution extracted after volatile oil saves backup; Medicinal residues after stir-baked RHIIZOMA CURCUMAE with vinegar, Fructus Aurantii Immaturus and Fructus Evodiae (processed) extract volatile oil mix with vinegar corydalis tuber, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), add water to submerge at every turn, decoct three times, first time decocts 1.5h, second and third time respectively decocts 1h, merges three decocting liquids, filters, merge with the aqueous solution after said extracted volatile oil, being evaporated to 80 DEG C of relative densities is the extractum of 1.35, granulates, dry, add the mixing of above-mentioned volatile oil.
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Publication number Priority date Publication date Assignee Title
CN1876155A (en) * 2006-04-28 2006-12-13 四川宝光药业股份有限公司 A medicine for treating gastric disease and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1876155A (en) * 2006-04-28 2006-12-13 四川宝光药业股份有限公司 A medicine for treating gastric disease and preparation method thereof

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