CN104491708A - External patch for treating mammitis and breast hyperplasia and relieving breast tumor pain and preparation method of patch for external use - Google Patents

External patch for treating mammitis and breast hyperplasia and relieving breast tumor pain and preparation method of patch for external use Download PDF

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CN104491708A
CN104491708A CN201410749297.1A CN201410749297A CN104491708A CN 104491708 A CN104491708 A CN 104491708A CN 201410749297 A CN201410749297 A CN 201410749297A CN 104491708 A CN104491708 A CN 104491708A
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radix
patch
camphora
fine powders
external
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CN104491708B (en
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李去病
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Shaanxi Qubing Pharmaceutical Co Ltd
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Shaanxi Qubing Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

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Abstract

The invention provides an external patch for treating mammitis and breast hyperplasia and relieving breast tumor pain and a preparation method of the external patch for external use. Pure natural Chinese medicinal herbs such as nutgrass galingale rhizome, clematis root, turmeric root-tuber, dahurian angelica root, Szechuan lovage rhizome and Chinese angelica are selected as raw materials. The external patch has the effects of promoting blood circulation and removing blood stasis, reducing swelling and resolving mass, and regulating the flow of Qi to alleviate pain; the obtained patch is convenient to use, and effectively and quickly takes effect on the focus without toxic and side effects. Toxicity test results indicate that acute dermal toxicity of white rats is at the actually nontoxic class and acute skin irritation intensity of white rabbits is nonirritant, and therefore, the external patch completely conforms to the national related health standards and is very safe to use.

Description

Treatment mastitis, cyclomastopathy and the external use plaster alleviating breast tumor pain and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind ofly treat mastitis, cyclomastopathy and the external use plaster alleviating breast tumor pain and preparation method thereof.
Background technology
Mastitis, cyclomastopathy, be the common a kind of frequently-occurring disease of young women, commonly encountered diseases, belongs to the category of motherland's medical science " nodules of the breast ", causes great sufferings to numerous women.Its etiology and pathogenesis is mainly depression of liver-QI, loses and rushes down in dredging, the retardance of newborn network, and caused by hematogenous blockage, the rule for the treatment of is with depressed liver-energy dispersing and QI regulating, and blood circulation promoting and blood stasis dispelling is main, gas along blood and, caking is from disappearing.Because the height morbidity age level of cyclomastopathy has many decades, all can not ensure after western medicines in treatment not recur, the side effect of Western medicine is large, traditional decoction decocting is inconvenient, the course for the treatment of is long, patient is difficult to adhere to long-term prescription, cause Relapse rate variable, incur loss through delay best occasion for the treatment, therefore propose to improve.
Summary of the invention
The technical problem that the present invention solves: provide a kind of and treat mastitis, cyclomastopathy and the external use plaster alleviating breast tumor pain and preparation method thereof, the pure natural Chinese herbal medicine such as Rhizoma Cyperi, Radix Clematidis, Radix Curcumae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis are meticulously selected to be raw material, there is blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, effect of regulating QI to relieve pain, and easy to use after making patch, drug effect can arrive focus rapidly, has no side effect.
The technical solution used in the present invention: the external use plaster for the treatment of mastitis, cyclomastopathy and alleviation breast tumor pain, is made up of the crude drug of following weight parts: Radix Clematidis 250 ~ 350, the Radix Angelicae Dahuricae 100 ~ 200, Rhizoma Cyperi 100 ~ 200, Radix Curcumae 50 ~ 150, Rhizoma Atractylodis 50 ~ 150, Radix Angelicae Sinensis 50 ~ 150, Rhizoma Chuanxiong 25 ~ 75, Alumen 10 ~ 30, Natrii Sulfas 10 ~ 30, Camphora 1 ~ 10, Radix Aconiti Preparata 1 ~ 10, the cold drying of above-mentioned raw materials medicine also to load nonwoven bag after pulverizing.
Also comprise a kind of preparation method for the treatment of the external use plaster of mastitis, cyclomastopathy and alleviation breast tumor pain, comprise the steps:
1) after medical material is made only, for subsequent use;
2) by Camphora porphyrize, cross 100 orders and make into Camphora fine powder;
3) pulverize after Radix Clematidis, the Radix Angelicae Dahuricae, Rhizoma Cyperi, Radix Curcumae, Rhizoma Atractylodis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Alumen, Natrii Sulfas and Radix Aconiti Preparata cold drying, cross 80 orders and make into mixing fine powders;
4) Camphora fine powder and mixing fine powders are stirred by geometric ratio incremental method, obtain hybrid medicine after mixing for subsequent use;
5) select non-woven fabrics through cutting, be sewn into medicated core bag, load hybrid medicine by labelled amount, seal;
6) subpackage, sterilizing, warehouse-in.
Above-mentioned steps 4) in, described geometric ratio incremental method refers to, get Camphora fine powder and the mixing fine powders of equivalent, be placed in mortar mix homogeneously simultaneously and obtain mixture, and then add and dilute evenly with the mixing fine powders of mixture equivalent, times amount like this increases till the component adding full mixing fine powders, then mixes, sieves.
The present invention's advantage compared with prior art:
1, we select pure natural Chinese herbal medicine to be raw material, have blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, effect of regulating QI to relieve pain, and easy to use after making patch, and drug effect can arrive focus rapidly, has no side effect;
2, select Rhizoma Cyperi promoting QI circulation for relieving depression in we, the monarch drug in the menstruction regulating and pain relieving side of being, be aided with Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving; Rhizoma Chuanxiong, Radix Clematidis blood-activating and qi-promoting, wind-expelling pain-stopping; Chinese angelica blood supplementing is invigorated blood circulation, removing obstruction in the collateral to relieve pain; Radix Aconiti Preparata Eradicates wind dehumidifies, and antalgic is ministerial drug altogether; Angelica dahurica powder wind dehumidifies, reducing swelling and alleviating pain; Natrii Sulfas moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat; Alumen dampness removing to stop itchin is adjuvant drug; Camphora understand things pain-stopping, and fragrance is walked to alter, in the current Zhu Jinger side of drawing, all medicines go directly the exterior and the interior up and down for making medicine; Above-mentioned all medicines tie in, and gather the effects such as dispersing swelling and dissipating binds, removing obstruction in the collateral to relieve pain altogether;
2, we have antiinflammatory, analgesia and improving micro_circulation effect, through antibacterial, mycete and pathogenic microbes detect result, total number of bacterial colonies (cfu/ml) is 50, mold colony sum (cfu/ml) ﹤ 10, and escherichia coli, bacillus pyocyaneus, staphylococcus aureus all do not detect;
3, through toxicological test result, the nontoxic level in the true border of rat acute dermal toxicity, White Rabbit single-use skin stimulus intensity belongs to nonirritant, meets the relevant sanitary standard of country completely, uses very safe.
Detailed description of the invention
Three embodiments of the present invention are described below.
Embodiment one: the external use plaster for the treatment of mastitis, cyclomastopathy and alleviation breast tumor pain, gets Radix Clematidis 250g, Radix Angelicae Dahuricae 100g, Rhizoma Cyperi 100g, Radix Curcumae 50g, Rhizoma Atractylodis 50g, Radix Angelicae Sinensis 50g, Rhizoma Chuanxiong 25g, Alumen 10g, Natrii Sulfas 10g, Camphora 1g, Radix Aconiti Preparata 1g, preparation method is as follows:
1) after medical material being made only, for subsequent use;
2) by Camphora 1g porphyrize, cross 100 orders and make into Camphora fine powder;
3) by Radix Clematidis 250g, Radix Angelicae Dahuricae 100g, Rhizoma Cyperi 100g, Radix Curcumae 50g, Rhizoma Atractylodis 50g, Radix Angelicae Sinensis 50g, Rhizoma Chuanxiong 25g, Alumen 10g, Natrii Sulfas 10g, Radix Aconiti Preparata 1g, pulverize after 60 DEG C of cold drying, crosses 80 orders and make into mixing fine powders;
4) Camphora fine powder and mixing fine powders are stirred by geometric ratio incremental method, obtain hybrid medicine after mixing for subsequent use; Described geometric ratio incremental method refers to, gets Camphora fine powder and the mixing fine powders of equivalent, is placed in mortar mix homogeneously simultaneously and obtains mixture, and then add and dilute evenly with the mixing fine powders of mixture equivalent, times amount like this increases till the component adding full mixing fine powders, then mixes, sieves;
5) select non-woven fabrics through cutting, be sewn into medicated core bag, load hybrid medicine by labelled amount, seal;
6) subpackage, sterilization, warehouse-in.
Embodiment two: the external use plaster for the treatment of mastitis, cyclomastopathy and alleviation breast tumor pain, gets Radix Clematidis 350g, Radix Angelicae Dahuricae 200g, Rhizoma Cyperi 200g, Radix Curcumae 150g, Rhizoma Atractylodis 150g, Radix Angelicae Sinensis 150g, Rhizoma Chuanxiong 75g, Alumen 30g, Natrii Sulfas 30g, Camphora 10g, Radix Aconiti Preparata 10g, preparation method is as follows:
1) after medical material being made only, for subsequent use;
2) by Camphora 10g porphyrize, cross 100 orders and make into Camphora fine powder;
3) by Radix Clematidis 350g, Radix Angelicae Dahuricae 200g, Rhizoma Cyperi 200g, Radix Curcumae 150g, Rhizoma Atractylodis 150g, Radix Angelicae Sinensis 150g, Rhizoma Chuanxiong 75g, Alumen 30g, Natrii Sulfas 30g, Camphora 10g, Radix Aconiti Preparata 10g, pulverize after 60 DEG C of cold drying, crosses 80 orders and make into mixing fine powders;
4) Camphora fine powder and mixing fine powders are stirred by geometric ratio incremental method, obtain hybrid medicine after mixing for subsequent use; Described geometric ratio incremental method refers to, gets Camphora fine powder and the mixing fine powders of equivalent, is placed in mortar mix homogeneously simultaneously and obtains mixture, and then add and dilute evenly with the mixing fine powders of mixture equivalent, times amount like this increases till the component adding full mixing fine powders, then mixes, sieves;
5) select non-woven fabrics through cutting, be sewn into medicated core bag, load hybrid medicine by labelled amount, seal;
6) subpackage, sterilization, warehouse-in.
Embodiment three: the external use plaster for the treatment of mastitis, cyclomastopathy and alleviation breast tumor pain, gets Radix Clematidis 300g, Radix Angelicae Dahuricae 150g, Rhizoma Cyperi 150g, Radix Curcumae 100g, Rhizoma Atractylodis 100g, Radix Angelicae Sinensis 100g, Rhizoma Chuanxiong 50g, Alumen 20g, Natrii Sulfas 20g, Camphora 5g, Radix Aconiti Preparata 5g, preparation method is as follows:
1) after medical material being made only, for subsequent use;
2) by Camphora 5g porphyrize, cross 100 orders and make into Camphora fine powder;
3) by Radix Clematidis 300g, Radix Angelicae Dahuricae 150g, Rhizoma Cyperi 150g, Radix Curcumae 100g, Rhizoma Atractylodis 100g, Radix Angelicae Sinensis 100g, Rhizoma Chuanxiong 50g, Alumen 20g, Natrii Sulfas 20g, Camphora 5g, Radix Aconiti Preparata 5g, pulverize after 60 DEG C of cold drying, crosses 80 orders and make into mixing fine powders;
4) Camphora fine powder and mixing fine powders are stirred by geometric ratio incremental method, obtain hybrid medicine after mixing for subsequent use; Described geometric ratio incremental method refers to, gets Camphora fine powder and the mixing fine powders of equivalent, is placed in mortar mix homogeneously simultaneously and obtains mixture, and then add and dilute evenly with the mixing fine powders of mixture equivalent, times amount like this increases till the component adding full mixing fine powders, then mixes, sieves;
5) select non-woven fabrics through cutting, be sewn into medicated core bag, load hybrid medicine by labelled amount, seal;
6) subpackage, sterilization, warehouse-in.
This product is the patch made by medicated powder and non-woven fabrics, often pastes net weight 8g.
For further introducing we in detail, introduce the inspection method of the source of above-mentioned Chinese crude drug, character, discriminating and check criteria and product below in detail.
One, the Identification of The Origin of crude drug
A.1 Radix Clematidis
[source] this product is the dry root welding technology of cohosh Radix Clematidis Clematis chinensis Osbeck..Autumn excavates, and removing silt, dries.
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 clematis chinensis medicinal materials item.
A2. the Radix Angelicae Dahuricae
[source] this product is the dry root of samphire Radix Angelicae Dahuricae Angelica dahurica (Fisch.exHoffm.) Benth.et Hook.f..Excavate when between summer, autumn, leaf is yellow, removing fibrous root and silt, dry or cold drying.
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 angelica root item.
A3. Rhizoma Cyperi
[source] this product is the dry rhizome of sedge dried tuber Cyperus rotundus L..Autumn excavates, sing the hair must, put in boiling water after slightly boiling or steaming and dry, or burn and directly to dry afterwards.
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Rhizoma Cyperi medical material item.
A4. Radix Curcumae
[source] this product is zingiberaceous plant RADIX CURCUMAE Curcuma rcenyujin Y, the dried root of H.Chenet C.Ling.
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Radix Curcumae medical material item.
A5. Rhizoma Atractylodis
[source] this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atract μ lodes lancea (Thunb.) DC. or Atractylis chinensis Atract μ lodes chinensis (DC.) Koidz..Spring, Qiu Erji excavate, and removing silt, dries, hit fibrous root.
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Rhizoma Atractylodis medical material item.
A6. Radix Angelicae Sinensis
[source] this product is the dry root of umbelliferae angelica Angelica sin:ensis (Oliv.) Diels.
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Radix Angelicae Sinensis medical material item.
A7. Rhizoma Chuanxiong
[source] this product is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuam.iong Hort..
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Ligusticum chuanxiong Hort item.
A8. Alumen
[source] this product is that Sulfates mineral alunite is made through processing refinement.Main containing aqueous sulfuric acid aluminum potassium [KAI (SO 4) 2l2H 20].
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Alumen medical material item.
A9. Natrii Sulfas
[source] this product is Sulfates mineral Natrii Sulfas race Natrii Sulfas, through the crystalline solid of processing and refining.Main containing aqueous sulfuric acid sodium (Na 2sO 410H 2o).
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Natrii Sulfas medical material item.
A10. Camphora
[source] this product is the fresh branch of canella Camphor tree Cinnamomum camphora (L.) Presl, leaf is processed into through extracting.
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Camphora medical material item.
A11. Radix Aconiti Preparata
[source] this product is the Preparation process product of Radix Aconiti.
[qualification] should meet the regulation under " Chinese Pharmacopoeia " version in 2010 Radix Aconiti Preparata medical material item.
Two, Product checking index
1, organoleptic indicator: organoleptic indicator should meet table 1 and specify.
Table 1 organoleptic indicator
Project Index
Color and luster Sepia
State Powdery pastes
Abnormal smells from the patient Tool Chinese herbal medicine aromatic odor
2, net content allowed minus deviation: net content allowed minus deviation should meet table 2 requirement.
Net content (g) Allowed minus deviation (%)
8g × 1 subsides=8g ≤9.0
Table 2 net content allowed minus deviation
3, physical and chemical index: physical and chemical index should meet table 3 and specify.
Table 3 physical and chemical index
Project Index
Moisture (%) ≤9.0
Volatile oil is differentiated In positive reaction
Alkaloid is differentiated In positive reaction
4, microbiological indicator: microbiological indicator should meet table 4 and specify.
Table 4 microbiological indicator
Project Index
Total number of bacterial colonies (cfu/g) ≤1000
Mold colony sum (cfu/g) ≤100
Coliform, bacillus pyocyaneus, staphylococcus aureus Must not detect
Select Rhizoma Cyperi promoting QI circulation for relieving depression in we, the monarch drug in the menstruction regulating and pain relieving side of being, be aided with Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving; Rhizoma Chuanxiong, Radix Clematidis blood-activating and qi-promoting, wind-expelling pain-stopping; Chinese angelica blood supplementing is invigorated blood circulation, removing obstruction in the collateral to relieve pain; Radix Aconiti Preparata Eradicates wind dehumidifies, and antalgic is ministerial drug altogether; Angelica dahurica powder wind dehumidifies, reducing swelling and alleviating pain; Natrii Sulfas moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat; Alumen dampness removing to stop itchin is adjuvant drug; Camphora understand things pain-stopping, and fragrance is walked to alter, in the current Zhu Jinger side of drawing, all medicines go directly the exterior and the interior up and down for making medicine; Above-mentioned all medicines tie in, and gather the effects such as dispersing swelling and dissipating binds, removing obstruction in the collateral to relieve pain altogether.
Above-described embodiment, just preferred embodiment of the present invention, is not used for limiting the scope of the present invention, therefore all equivalence changes done with content described in the claims in the present invention, all should be included within the claims in the present invention scope.

Claims (3)

1. treat the externally applied ointment patch of mastitis, cyclomastopathy and alleviation breast tumor pain, it is characterized in that being made up of the crude drug of following weight parts: Radix Clematidis 250 ~ 350, the Radix Angelicae Dahuricae 100 ~ 200, Rhizoma Cyperi 100 ~ 200, Radix Curcumae 50 ~ 150, Rhizoma Atractylodis 50 ~ 150, Radix Angelicae Sinensis 50 ~ 150, Rhizoma Chuanxiong 25 ~ 75, Alumen 10 ~ 30, Natrii Sulfas 10 ~ 30, Camphora 1 ~ 10, Radix Aconiti Preparata 1 ~ 10, the cold drying of above-mentioned raw materials medicine also to load nonwoven bag after pulverizing.
2. treat the preparation method of the externally applied ointment patch of mastitis, cyclomastopathy and alleviation breast tumor pain as claimed in claim 1, it is characterized in that comprising the steps:
1) after medical material is made only, for subsequent use;
2) by Camphora porphyrize, cross 100 orders and make into Camphora fine powder;
3) pulverize after Radix Clematidis, the Radix Angelicae Dahuricae, Rhizoma Cyperi, Radix Curcumae, Rhizoma Atractylodis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Alumen, Natrii Sulfas and Radix Aconiti Preparata cold drying, cross 80 orders and make into mixing fine powders;
4) Camphora fine powder and mixing fine powders are stirred by geometric ratio incremental method, obtain hybrid medicine after mixing for subsequent use;
5) select non-woven fabrics through cutting, be sewn into medicated core bag, load hybrid medicine by labelled amount, seal;
6) subpackage, sterilizing, warehouse-in.
3. the preparation method of the externally applied ointment patch for the treatment of mastitis according to claim 2, cyclomastopathy and alleviation breast tumor pain, it is characterized in that: above-mentioned steps 4) in, described geometric ratio incremental method refers to, get Camphora fine powder and the mixing fine powders of equivalent, be placed in mortar mix homogeneously simultaneously and obtain mixture, and then add and dilute evenly with the mixing fine powders of mixture equivalent, times amount like this increases till the component adding full mixing fine powders, then mix, sieve.
CN201410749297.1A 2014-12-05 2014-12-05 Treat mastitis, the proliferation of mammary gland and alleviate external use plaster of tumor of breast pain and preparation method thereof Active CN104491708B (en)

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CN201410749297.1A CN104491708B (en) 2014-12-05 2014-12-05 Treat mastitis, the proliferation of mammary gland and alleviate external use plaster of tumor of breast pain and preparation method thereof

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Application Number Priority Date Filing Date Title
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105456895A (en) * 2015-12-25 2016-04-06 青岛市第三人民医院 Plaster for treating hyperplasia of mammary glands and preparation method thereof
CN105963504A (en) * 2016-07-17 2016-09-28 佛山市朗达信息科技有限公司 Traditional Chinese medicine hot medicated compress bag for treating hyperplasia of mammary glands and preparation method thereof
CN109395019A (en) * 2018-11-29 2019-03-01 河南省中医院（河南中医药大学第二附属医院） Swelling-reducing pain-relieving plaster for treating mastitis and relieving mammary swelling and pain and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陕西去病药业有限公司: ""乳增康"", 《HTTP://WWW.QUBING.COM.CN/INFODISP.ASP?ID=78》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105456895A (en) * 2015-12-25 2016-04-06 青岛市第三人民医院 Plaster for treating hyperplasia of mammary glands and preparation method thereof
CN105963504A (en) * 2016-07-17 2016-09-28 佛山市朗达信息科技有限公司 Traditional Chinese medicine hot medicated compress bag for treating hyperplasia of mammary glands and preparation method thereof
CN109395019A (en) * 2018-11-29 2019-03-01 河南省中医院（河南中医药大学第二附属医院） Swelling-reducing pain-relieving plaster for treating mastitis and relieving mammary swelling and pain and preparation method thereof

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