CN104491515A - Traditional Chinese medicine composite tablet for treating insomnia and preparation method of traditional Chinese medicine composite tablet - Google Patents

Traditional Chinese medicine composite tablet for treating insomnia and preparation method of traditional Chinese medicine composite tablet Download PDF

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CN104491515A
CN104491515A CN201410734350.0A CN201410734350A CN104491515A CN 104491515 A CN104491515 A CN 104491515A CN 201410734350 A CN201410734350 A CN 201410734350A CN 104491515 A CN104491515 A CN 104491515A
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chinese medicine
insomnia
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cure
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张立光
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Suzhou Vocational Health College
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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to traditional Chinese medicine composite tablets for treating insomnia and a preparation method of the traditional Chinese medicine composite tablets. The traditional Chinese medicine composite tablets are prepared from the following traditional Chinese medicines in parts by weight: 26-40 parts of spina date seeds, 13-24 parts of polygala tenuifolia, 12-22 parts of caulis spatholobi, 11-17 parts of uncaria rhynchophylla, 15-19 parts of lygodium japonicum, 14-19 parts of red beans, 6-12 parts of honeysuckle, 4-9 parts of rhizoma acori graminei, 5-11 parts of soapberry, 5-10 parts of Red psychotria leaves, 6-12 parts of aleppo avens, 8-14 parts of rice-grain sprout, 4-9 parts of phoenix tree seeds and 5-11 parts of cuttlebone. The preparation method comprises the following steps: (1) crushing the traditional Chinese medicine materials, uniformly mixing, adding water, heating to 90 DEG C, stirring and extracting twice, and concentrating the extract into an extractum; and (2) uniformly mixing 8 parts of the ointment, 4 parts of cyclodextrin, 2 parts of magnesium stearate and 0.1 part of sucralose, and pressing into tablets, namely the traditional Chinese medicine composite tablets.

Description

Chinese medicine compound tablet of Cure for insomnia and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicinal tablet and preparation method thereof, Chinese medicine compound tablet particularly relating to Cure for insomnia and preparation method thereof.
Background technology
Insomnia refers to that the length of one's sleep not enough, or sleeps not dark, not yet done, can be divided into following three kinds: (1) initial insomnia: be difficulty falling asleep, arrive and could fall asleep after midnight, how to be caused by psychentonia, anxiety, fear etc.(2) insomnia is interrupted: be sleep unquiet, easily wake up with a start, often have nightmare, middle age is dyspeptic, and often easily this thing happens.(3) terminal insomnia: be fall asleep not difficult, but the persistent period is not long, and namely can not fall asleep after waking up after midnight, senile hypertension, arteriosclerosis, dysthymia patient, often have this kind of insomnia again.Cause the reason of insomnia a lot, the Nervous and Mental Factors such as psychentonia, excitement, depression, fear, anxiety, unhappiness often can cause insomnia; Working and learning pressure is overweight, the social environmental factor such as environment change, noise, light and air pollution is another major reason; Dinner satiety, sleep before to drink tea and these bad life habits of coffee also can cause insomnia.
In the Chinese medicine of Cure for insomnia, Bulbus Lilii, Semen Ziziphi Spinosae, Herba Apii graveolentis, Caulis Spatholobi etc. all have certain effect, but the Chinese medicine can treating the insomnia of chronic insomnia patient is completely less.
Summary of the invention
The technical problem solved: the Chinese patent medicine of Cure for insomnia is more, but its therapeutic effect of the Chinese patent medicine of the Cure for insomnia of routine is poor, therefore the Chinese medicine developing new Cure for insomnia is needed, Chinese medicine compound tablet that therefore the invention discloses Cure for insomnia and preparation method thereof.
Technical scheme: the Chinese medicine compound tablet that the invention discloses Cure for insomnia, the Chinese medicine compound tablet of described Cure for insomnia comprises Chinese medicine extract and adjuvant, and described Chinese medicine extract is prepared by the raw material of Chinese medicine of following weight parts:
Semen Ziziphi Spinosae 26-40 part, Radix Polygalae 13-24 part,
Caulis Spatholobi 12-22 part, Ramulus Uncariae Cum Uncis 11-17 part,
Spora Lygodii 15-19 part, Semen Phaseoli 14-19 part,
Flos Lonicerae 6-12 part, Rhizoma Acori Graminei 4-9 part,
Fructus Sapindi Mukouossi 5-11 part, Red Psychotria Leaf 5-10 part,
Radix seu Herba Gei aleppici 6-12 part, Fructus Oryzae Germinatus 8-14 part,
Semen Firmianae 4-9 part, extra large Piao sheath 5-11 part.
Preferably, the Chinese medicine compound tablet of described Cure for insomnia, described Chinese medicine extract is prepared by the raw material of Chinese medicine of following weight parts:
Semen Ziziphi Spinosae 32-36 part, Radix Polygalae 17-20 part,
Caulis Spatholobi 15-19 part, Ramulus Uncariae Cum Uncis 13-15 part,
Spora Lygodii 16-18 part, Semen Phaseoli 15-17 part,
Flos Lonicerae 8-10 part, Rhizoma Acori Graminei 6-8 part,
Fructus Sapindi Mukouossi 6-10 part, Red Psychotria Leaf 7-9 part,
Radix seu Herba Gei aleppici 8-10 part, Fructus Oryzae Germinatus 9-13 part,
Semen Firmianae 5-8 part, extra large Piao sheath 7-10 part.
The Chinese medicine compound tablet of described Cure for insomnia, described adjuvant comprises cyclodextrin, sucralose, magnesium stearate.
The preparation method of the Chinese medicine compound tablet of described Cure for insomnia, step is as follows:
(1) Semen Ziziphi Spinosae 26-40 part is got by weight, Radix Polygalae 13-24 part, Caulis Spatholobi 12-22 part, Ramulus Uncariae Cum Uncis 11-17 part, Spora Lygodii 15-19 part, Semen Phaseoli 14-19 part, Flos Lonicerae 6-12 part, Rhizoma Acori Graminei 4-9 part, Fructus Sapindi Mukouossi 5-11 part, Red Psychotria Leaf 5-10 part, Radix seu Herba Gei aleppici 6-12 part, Fructus Oryzae Germinatus 8-14 part, Semen Firmianae 4-9 part, sea Piao sheath 5-11 part, by mix homogeneously after above-mentioned Chinese medicine material disintegrating, add the water of Chinese medicine gross weight 8 times, be heated to 90 DEG C, stir 50min at such a temperature, Chinese medicine slag is separated with extracting solution, the water adding weight 5 times in Chinese crude drug again stirs 50min and carries out second extraction at 90 DEG C, the extracting solution vacuum concentration merging twice is extractum,
(2) get the concentrated extractum 8 parts obtained of step (1) by weight, then add that cyclodextrin is 4 parts, magnesium stearate is 2 parts, sucralose is 0.1 part, being suppressed into tablet after being stirred by above-mentioned composition, is the Chinese medicine compound tablet of the Cure for insomnia of preparation.
Preferably, the preparation method of the Chinese medicine compound tablet of described Cure for insomnia, Semen Ziziphi Spinosae is 32-36 part, Radix Polygalae is 17-20 part, Caulis Spatholobi is 15-19 part, Ramulus Uncariae Cum Uncis is 13-15 part, Spora Lygodii is 16-18 part, Semen Phaseoli is 15-17 part, Flos Lonicerae is 8-10 part, Rhizoma Acori Graminei is 6-8 part, Fructus Sapindi Mukouossi is 6-10 part, Red Psychotria Leaf is 7-9 part, Radix seu Herba Gei aleppici is 8-10 part, Fructus Oryzae Germinatus is 9-13 part, Semen Firmianae is 5-8 part, extra large Piao sheath is 7-10 part.
Beneficial effect: Chinese medicine compound tablet of the present invention has extraordinary curative effect in Cure for insomnia, insomniac took tablet of the present invention after 15 days, and complete cure rate reaches more than 90%, can be effective to Cure for insomnia and related symptoms thereof.Wherein, when Semen Ziziphi Spinosae is 32-36 part, Radix Polygalae is 17-20 part, Caulis Spatholobi is 15-19 part, Ramulus Uncariae Cum Uncis is 13-15 part, Spora Lygodii is 16-18 part, Semen Phaseoli is 15-17 part, Flos Lonicerae is 8-10 part, Rhizoma Acori Graminei is 6-8 part, Fructus Sapindi Mukouossi is 6-10 part, Red Psychotria Leaf is 7-9 part, Radix seu Herba Gei aleppici is 8-10 part, Fructus Oryzae Germinatus is 9-13 part, Semen Firmianae is 5-8 part, extra large Piao sheath is 7-10 part, therapeutic effect is best.
Detailed description of the invention
Embodiment 1
(1) Semen Ziziphi Spinosae 26 parts is got by weight, Radix Polygalae 24 parts, Caulis Spatholobi 12 parts, Ramulus Uncariae Cum Uncis 11 parts, Spora Lygodii 19 parts, Semen Phaseoli 19 parts, Flos Lonicerae 12 parts, Rhizoma Acori Graminei 4 parts, Fructus Sapindi Mukouossi 5 parts, Red Psychotria Leaf 5 parts, Radix seu Herba Gei aleppici 12 parts, Fructus Oryzae Germinatus 8 parts, Semen Firmianae 9 parts, 11 parts, sea Piao sheath, by mix homogeneously after above-mentioned Chinese medicine material disintegrating, add the water of Chinese medicine gross weight 8 times, be heated to 90 DEG C, stir 50min at such a temperature, Chinese medicine slag is separated with extracting solution, the water adding weight 5 times in Chinese crude drug again stirs 50min and carries out second extraction at 90 DEG C, the extracting solution vacuum concentration merging twice is extractum,
(2) get the concentrated extractum 8 parts obtained of step (1) by weight, then add that cyclodextrin is 4 parts, magnesium stearate is 2 parts, sucralose is 0.1 part, being suppressed into tablet after being stirred by above-mentioned composition, is the Chinese medicine compound tablet of the Cure for insomnia of preparation.
Embodiment 2
(1) Semen Ziziphi Spinosae 40 parts is got by weight, Radix Polygalae 13 parts, Caulis Spatholobi 22 parts, Ramulus Uncariae Cum Uncis 17 parts, Spora Lygodii 15 parts, Semen Phaseoli 14 parts, Flos Lonicerae 6 parts, Rhizoma Acori Graminei 9 parts, Fructus Sapindi Mukouossi 11 parts, Red Psychotria Leaf 10 parts, Radix seu Herba Gei aleppici 6 parts, Fructus Oryzae Germinatus 14 parts, Semen Firmianae 4 parts, 5 parts, sea Piao sheath, by mix homogeneously after above-mentioned Chinese medicine material disintegrating, add the water of Chinese medicine gross weight 8 times, be heated to 90 DEG C, stir 50min at such a temperature, Chinese medicine slag is separated with extracting solution, the water adding weight 5 times in Chinese crude drug again stirs 50min and carries out second extraction at 90 DEG C, the extracting solution vacuum concentration merging twice is extractum,
(2) get the concentrated extractum 8 parts obtained of step (1) by weight, then add that cyclodextrin is 4 parts, magnesium stearate is 2 parts, sucralose is 0.1 part, being suppressed into tablet after being stirred by above-mentioned composition, is the Chinese medicine compound tablet of the Cure for insomnia of preparation.
Embodiment 3
(1) getting Semen Ziziphi Spinosae is by weight 36 parts, Radix Polygalae is 20 parts, Caulis Spatholobi is 15 parts, Ramulus Uncariae Cum Uncis is 13 parts, Spora Lygodii is 18 parts, Semen Phaseoli is 17 parts, Flos Lonicerae is 10 parts, Rhizoma Acori Graminei is 8 parts, Fructus Sapindi Mukouossi is 10 parts, Red Psychotria Leaf is 9 parts, Radix seu Herba Gei aleppici is 10 parts, Fructus Oryzae Germinatus is 13 parts, Semen Firmianae is 8 parts, sea Piao sheath is 10 parts, by mix homogeneously after above-mentioned Chinese medicine material disintegrating, add the water of Chinese medicine gross weight 8 times, be heated to 90 DEG C, stir 50min at such a temperature, Chinese medicine slag is separated with extracting solution, the water adding weight 5 times in Chinese crude drug again stirs 50min and carries out second extraction at 90 DEG C, the extracting solution vacuum concentration merging twice is extractum,
(2) get the concentrated extractum 8 parts obtained of step (1) by weight, then add that cyclodextrin is 4 parts, magnesium stearate is 2 parts, sucralose is 0.1 part, being suppressed into tablet after being stirred by above-mentioned composition, is the Chinese medicine compound tablet of the Cure for insomnia of preparation.
Embodiment 4
(1) getting Semen Ziziphi Spinosae is by weight 32 parts, Radix Polygalae is 17 parts, Caulis Spatholobi is 19 parts, Ramulus Uncariae Cum Uncis is 15 parts, Spora Lygodii is 16 parts, Semen Phaseoli is 15 parts, Flos Lonicerae is 8 parts, Rhizoma Acori Graminei is 6 parts, Fructus Sapindi Mukouossi is 6 parts, Red Psychotria Leaf is 7 parts, Radix seu Herba Gei aleppici is 8 parts, Fructus Oryzae Germinatus is 9 parts, Semen Firmianae is 5 parts, sea Piao sheath is 7 parts, by mix homogeneously after above-mentioned Chinese medicine material disintegrating, add the water of Chinese medicine gross weight 8 times, be heated to 90 DEG C, stir 50min at such a temperature, Chinese medicine slag is separated with extracting solution, the water adding weight 5 times in Chinese crude drug again stirs 50min and carries out second extraction at 90 DEG C, the extracting solution vacuum concentration merging twice is extractum,
(2) get the concentrated extractum 8 parts obtained of step (1) by weight, then add that cyclodextrin is 4 parts, magnesium stearate is 2 parts, sucralose is 0.1 part, being suppressed into tablet after being stirred by above-mentioned composition, is the Chinese medicine compound tablet of the Cure for insomnia of preparation.
Embodiment 5
(1) getting Semen Ziziphi Spinosae is by weight 34 parts, Radix Polygalae is 19 parts, Caulis Spatholobi is 17 parts, Ramulus Uncariae Cum Uncis is 14 parts, Spora Lygodii is 17 parts, Semen Phaseoli is 16 parts, Flos Lonicerae is 9 parts, Rhizoma Acori Graminei is 7 parts, Fructus Sapindi Mukouossi is 8 parts, Red Psychotria Leaf is 8 parts, Radix seu Herba Gei aleppici is 9 parts, Fructus Oryzae Germinatus is 11 parts, Semen Firmianae is 7 parts, sea Piao sheath is 9 parts, by mix homogeneously after above-mentioned Chinese medicine material disintegrating, add the water of Chinese medicine gross weight 8 times, be heated to 90 DEG C, stir 50min at such a temperature, Chinese medicine slag is separated with extracting solution, the water adding weight 5 times in Chinese crude drug again stirs 50min and carries out second extraction at 90 DEG C, the extracting solution vacuum concentration merging twice is extractum,
(2) get the concentrated extractum 8 parts obtained of step (1) by weight, then add that cyclodextrin is 4 parts, magnesium stearate is 2 parts, sucralose is 0.1 part, being suppressed into tablet after being stirred by above-mentioned composition, is the Chinese medicine compound tablet of the Cure for insomnia of preparation.
Comparative example
(1) Semen Ziziphi Spinosae 26 parts, Radix Polygalae 24 parts, Caulis Spatholobi 12 parts, Ramulus Uncariae Cum Uncis 11 parts, Spora Lygodii 19 parts, Semen Phaseoli 19 parts, Flos Lonicerae 12 parts, Rhizoma Acori Graminei 4 parts, Fructus Sapindi Mukouossi 5 parts, Red Psychotria Leaf 5 parts is got by weight, by mix homogeneously after above-mentioned Chinese medicine material disintegrating, add the water of Chinese medicine gross weight 8 times, be heated to 90 DEG C, stir 50min at such a temperature, Chinese medicine slag is separated with extracting solution, the water adding weight 5 times in Chinese crude drug again stirs 50min and carries out second extraction at 90 DEG C, and the extracting solution vacuum concentration merging twice is extractum;
(2) get the concentrated extractum 8 parts obtained of step (1) by weight, then add that cyclodextrin is 4 parts, magnesium stearate is 2 parts, sucralose is 0.1 part, being suppressed into tablet after being stirred by above-mentioned composition, is the Chinese medicine compound tablet of the Cure for insomnia of preparation.
The patient suffering from insomnia is for a long time taken the Chinese medicine compound tablet of embodiment 1 to 5 and comparative example.The patient populations that each embodiment and comparative example are taken is 50.Take 1 every day, each 0.5g, within 15 days, observe the insomnia Cure of insomniac afterwards, be divided into basic alleviation, significantly alleviate, cure three situations completely, result is as follows:
Basic alleviation example Remarkable alleviation example Cure example completely
Embodiment 1 3 25 22
Embodiment 2 2 24 24
Embodiment 3 4 17 29
Embodiment 4 2 16 32
Embodiment 5 0 9 41
Comparative example 1 19 26 5
The tablet of Cure for insomnia of the present invention has the curative effect of highly significant in Cure for insomnia, be better than the therapeutic effect of comparative example significantly, after adding Radix seu Herba Gei aleppici, Fructus Oryzae Germinatus, Semen Firmianae, extra large Piao sheath, achieve a therapeutic effect beyond expectation, the insomnia of chronic insomnia patient can be used for the treatment of clinically.

Claims (5)

1. the Chinese medicine compound tablet of Cure for insomnia, the Chinese medicine compound tablet of described Cure for insomnia comprises Chinese medicine extract and adjuvant, it is characterized in that described Chinese medicine extract is prepared by the raw material of Chinese medicine of following weight parts:
Semen Ziziphi Spinosae 26-40 part, Radix Polygalae 13-24 part,
Caulis Spatholobi 12-22 part, Ramulus Uncariae Cum Uncis 11-17 part,
Spora Lygodii 15-19 part, Semen Phaseoli 14-19 part,
Flos Lonicerae 6-12 part, Rhizoma Acori Graminei 4-9 part,
Fructus Sapindi Mukouossi 5-11 part, Red Psychotria Leaf 5-10 part,
Radix seu Herba Gei aleppici 6-12 part, Fructus Oryzae Germinatus 8-14 part,
Semen Firmianae 4-9 part, extra large Piao sheath 5-11 part.
2. the Chinese medicine compound tablet of Cure for insomnia according to claim 1, is characterized in that, described Chinese medicine extract is prepared by the raw material of Chinese medicine of following weight parts:
Semen Ziziphi Spinosae 32-36 part, Radix Polygalae 17-20 part,
Caulis Spatholobi 15-19 part, Ramulus Uncariae Cum Uncis 13-15 part,
Spora Lygodii 16-18 part, Semen Phaseoli 15-17 part,
Flos Lonicerae 8-10 part, Rhizoma Acori Graminei 6-8 part,
Fructus Sapindi Mukouossi 6-10 part, Red Psychotria Leaf 7-9 part,
Radix seu Herba Gei aleppici 8-10 part, Fructus Oryzae Germinatus 9-13 part,
Semen Firmianae 5-8 part, extra large Piao sheath 7-10 part.
3. the Chinese medicine compound tablet of Cure for insomnia according to claim 1, is characterized in that, described adjuvant comprises cyclodextrin, sucralose, magnesium stearate.
4. the preparation method of the Chinese medicine compound tablet of Cure for insomnia according to claim 1, is characterized in that, described preparation method step is as follows:
(1) Semen Ziziphi Spinosae 26-40 part is got by weight, Radix Polygalae 13-24 part, Caulis Spatholobi 12-22 part, Ramulus Uncariae Cum Uncis 11-17 part, Spora Lygodii 15-19 part, Semen Phaseoli 14-19 part, Flos Lonicerae 6-12 part, Rhizoma Acori Graminei 4-9 part, Fructus Sapindi Mukouossi 5-11 part, Red Psychotria Leaf 5-10 part, Radix seu Herba Gei aleppici 6-12 part, Fructus Oryzae Germinatus 8-14 part, Semen Firmianae 4-9 part, sea Piao sheath 5-11 part, by mix homogeneously after above-mentioned Chinese medicine material disintegrating, add the water of Chinese medicine gross weight 8 times, be heated to 90 DEG C, stir 50min at such a temperature, Chinese medicine slag is separated with extracting solution, the water adding weight 5 times in Chinese crude drug again stirs 50min and carries out second extraction at 90 DEG C, the extracting solution vacuum concentration merging twice is extractum,
(2) get the concentrated extractum 8 parts obtained of step (1) by weight, then add that cyclodextrin is 4 parts, magnesium stearate is 2 parts, sucralose is 0.1 part, being suppressed into tablet after being stirred by above-mentioned composition, is the Chinese medicine compound tablet of the Cure for insomnia of preparation.
5. the preparation method of the Chinese medicine compound tablet of Cure for insomnia according to claim 4, it is characterized in that, in described preparation method, Semen Ziziphi Spinosae is 32-36 part, Radix Polygalae is 17-20 part, Caulis Spatholobi is 15-19 part, Ramulus Uncariae Cum Uncis is 13-15 part, Spora Lygodii is 16-18 part, Semen Phaseoli is 15-17 part, Flos Lonicerae is 8-10 part, Rhizoma Acori Graminei is 6-8 part, Fructus Sapindi Mukouossi is 6-10 part, Red Psychotria Leaf is 7-9 part, Radix seu Herba Gei aleppici is 8-10 part, Fructus Oryzae Germinatus is 9-13 part, Semen Firmianae is 5-8 part, extra large Piao sheath is 7-10 part.
CN201410734350.0A 2014-12-08 2014-12-08 Traditional Chinese medicine composite tablet for treating insomnia and preparation method of traditional Chinese medicine composite tablet Pending CN104491515A (en)

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CN108159305A (en) * 2018-03-12 2018-06-15 潘秀华 Treat the Chinese medicine composition of chronic insomnia
CN108186869A (en) * 2018-03-12 2018-06-22 潘秀华 For treating the Chinese medicine composition of short-term insomnia

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CN108159305A (en) * 2018-03-12 2018-06-15 潘秀华 Treat the Chinese medicine composition of chronic insomnia
CN108186869A (en) * 2018-03-12 2018-06-22 潘秀华 For treating the Chinese medicine composition of short-term insomnia

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