CN104491495A - 治疗脱发性疾病的中药组合物及中药制剂 - Google Patents
治疗脱发性疾病的中药组合物及中药制剂 Download PDFInfo
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Abstract
本发明公开了一种治疗脱发性疾病的中药组合物及中药制剂,而提供一种能够治疗各种脱发性疾病的组合物及中药制剂。按重量份数包括下述原料药:当归8-10份,女贞子28-30份,羌活4-6份,何首乌28-30份,天麻8-10份,红花8-10份,山萸肉8-10份,五味子8-10份,黄连8-10份,白术8-10份,茯苓8-10份,党参28-30份,甘草4-6份。将上述原料加水煎煮后,与淀粉混合,烘干制成颗粒剂;其中,原料药与淀粉的比例为7:3。本发明采用传统的中国中医中药配伍,力求从根本上治愈脱发,且制造工艺简单,生产成本低,服用方便,并且治愈的患者复发率低。
Description
技术领域
本发明涉及中药技术领域,特别是涉及一种治疗脱发性疾病的中药组合物及中药制剂。
背景技术
以往的防脱生发的药物很多,但大多数的药品均含有不同的化学成分与激素,对人体伤害较大,且服药只对病理性脱发有一定的疗效,对提高人体的自身免疫力作用不大。
发明内容
本发明的目的是针对现有技术中存在的技术缺陷,而提供一种能够治疗各种脱发性疾病的组合物。
本发明的另一个目的是提供一种能够治疗各种脱发性疾病的中药制剂。
为实现本发明的目的所采用的技术方案是:
一种治疗脱发性疾病的中药组合物,按重量份数包括下述原料药:当归8-10份,女贞子28-30份,羌活4-6份,何首乌28-30份,天麻8-10份,红花8-10份,山萸肉8-10份,五味子8-10份,黄连8-10份,白术8-10份,茯苓8-10份,党参28-30份,甘草4-6份。
一种治疗脱发性疾病的中药制剂,将上述原料加水煎煮后,与淀粉混合,烘干制成颗粒剂;其中,原料药与淀粉的比例为7:3。
与现有技术相比,本发明的有益效果是:
本发明经多年研究与实验,采用传统的中国中医中药配伍,力求从根本上治愈脱发,且制造工艺简单,生产成本低,服用方便。
本发明中药组成物中何首乌、当归、党参、山萸肉能够起到补虚益损,逐瘀生新,乌黑缤发的作用。羌活、天麻、木瓜等起到祛风除湿、平肝熄风、强筋骨祛湿的作用,黄柏、白术、茯苓起到滋阴降火、补脾胃。渗湿利窍的作用,黄连起到祛湿清热、泻心火的作用,总之通过诸药作用改善患者的头部血液循环、消炎抗菌、破积通络、活血化瘀的功效。
具体实施方式
以下结合具体实施例对本发明作进一步详细说明。
实施例1
称取中药原料当归10克、女贞子30克、羌活6克、何首乌30克、天麻10克、红花10克、山萸肉10克、五味子10克、黄连10克、白术10克、茯苓10克、党参30克、甘草6克,加水煎煮后过滤,去掉药渣,药液用淀粉混合,烘干制成颗粒剂,包装成每袋6克。每日两次,每次一袋。病重者可每次两袋。
应用试验:
1、病例选择:
入选病例随机分成两组:对照组和试验组。
临床观察治疗组223例,对照组74例,性别分布如表1所示,年龄分布如表2所示,分型情况如表3所示,病程情况(月)如表4所示,
表1
组别 | 男 | 女 | 合计 |
治疗组 | 100 | 123 | 223 |
对照组 | 35 | 39 | 74 |
男女两组治疗于对照组相比较,两组经X2检验法得到P>0.05无显著意义。
表2
组别 | 1-10 | 11-20 | 21-30 | 31-40 | 41-50 | 51-60 | 60以上 | 合计 |
治疗组 | 8 | 36 | 67 | 68 | 32 | 8 | 4 | 223 |
对照组 | 3 | 8 | 24 | 22 | 10 | 6 | 1 | 74 |
男女两组治疗组于对照组相比较,两组经X2检验法得到P>0.05无显著意义
表3
组别 | 血热 | 血虚 | 肝郁血瘀 | 合计 |
治疗组 | 4 | 201 | 18 | 223 |
对照组 | 3 | 64 | 7 | 74 |
治疗组与对照组个型比较,经X2检验法得到P>0.05无显著意义。
表4
治疗组与对照组个型比较,经X2检验法得到P>0.05无显著意义。
经上述性别、年龄、病情、病程等方面分析、治疗组与对照组差异无显著性,说明两组具有可比性。
2、疗效分析
实验组口服本发明实施例1的中药制剂颗粒剂每袋6克,每日二次,病情重的每次2袋,每次12克,每日二次。
对照组为口服胱氨酸50毫克,每日三次。维生素B610毫克,每日三次。
疗效判断标准来源:中国中西药结合学会皮肤性病专业委员会,1991.10。
痊愈:头发全部长出,其分布密度及色泽均正常,拉发实验阴性。
显效:发新生70%,包括密度,粗细及色泽均接近正常。
有效:发新生30%以上,包括有毳毛及白发长出,且治疗后毛发停止脱落。
无效:治疗1个月以上,新发生长不足30%或继续脱落者。
统计学处理采用X2检验法及Ridit分析,治疗组疗效分析结果如表5所示,对照组疗效分析表如表6所示,治疗组与对照组疗效比较如表7所示。
表5
疗效 | 脂溢性脱发 | 普秃 | 全秃 | 斑秃 | 合计 |
痊愈 | 0 | 4 | 3 | 48 | 55 |
显效 | 26 | 4 | 8 | 43 | 81 |
有效 | 42 | 3 | 1 | 25 | 71 |
无效 | 12 | 1 | 1 | 2 | 16 |
合计 | 80 | 12 | 13 | 118 | 223 |
表6
疗效 | 脂溢性脱发 | 普秃 | 全秃 | 斑秃 | 合计 |
痊愈 | 0 | 0 | 0 | 1 | 55 |
显效 | 0 | 0 | 0 | 2 | 2 |
有效 | 5 | 0 | 0 | 10 | 15 |
无效 | 23 | 5 | 6 | 22 | 56 |
合计 | 28 | 5 | 6 | 35 | 74 |
表7
两组疗效比较经Ridit分析P<0.01有显著性差异
3、临床资料
(1)病例:30例患者均脱发专科病人,男性22例,女性8例,年龄最大为53岁,最小为4.5岁,发病期限不一,最短为两周,最长为7年。均为斑秃病人,脱发可发生在头部任何部位。
(2)检查方法:
采用激光多普勒血流仪(Perilox-1)型瑞典产品,测量脱发处微血流量,患者于检查前休息20分钟,卧位,将血流仪探头用粘圈固定于缺血脱发出处,探头局里皮肤约0.88mm频率为4KH2,时间常数0.2Sec增益3倍,用记录仪描记血流曲线,同时测量器脱发相对应部位有发处的皮肤血流,测量前将有发处头发尽量剪去,做为对照,以波高及振幅二项指标表示。
(3)结果分析
有发处平均血流量为1.96±0.96,而脱发处明显降低为1.28±0.393/4,经统计学处理,P<0.01。其振幅又发处为0.260±12,脱发处为0.15±0.08,两者之间亦有明显性差异(P<0.01)。
激光多普勒微血流仪是一种无创伤性测定微压、微血流的方法。以上检测结果表明,在斑秃区局部微循环中血流量明显低于有发区血流量,表明脱发局部微循环缺血,微循环障碍。
综上所述,治疗组的治疗效果明显高于对照组,治疗组223例,痊愈1例,显效81例,有效71例,显效率60.9%,对照组74例,痊愈1例,显效2例,有效15例,显效率4%,其中对一般特效疗法或其他药物治疗上比较困难的脂溢性脱发、全秃、普秃有较好的疗效。
从辩论分型上分析,各种脱发病人,不论是治疗组、对照组均以血虚型最多,约占总病例数的90%以上,与祖国医学对脱发病的论述相吻合,发为血之余,肾主骨生髓,其华在发。本发明的中药制剂(颗粒剂)以熟地、首乌、女贞子、山萸肉养血补肾,以党参、白术、茯苓、五味子健脾益气,红花等活血化瘀。此方共奏养血补肾、健脾益气、活血化瘀之效。
在实验研究中,用瑞典激光多普勒微血流仪检测结果表明,在斑秃局部微循环中血流量明显低于有发区血流量,表明脱发局部微循环缺血,微循环障碍,经用本发明的颗粒剂治疗后,使脱发区的微循环缺血,微循环障碍得到彻底改善,治疗前后的检测经统计学处理,有极显著疗效,也是此发剂治疗脱发的根本环节。
由上述实验结果可以说明,本发明的颗粒剂治疗各种脱发性疾病是建立在改善脱发区的微循环缺血和微循环障碍,治疗各种脱发性疾病疗效显著,无副作用。
以上所述仅是本发明的优选实施方式,应当指出的是,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (2)
1.一种治疗脱发性疾病的中药组合物,其特征在于,按重量份数包括下述原料药:当归8-10份,女贞子28-30份,羌活4-6份,何首乌28-30份,天麻8-10份,红花8-10份,山萸肉8-10份,五味子8-10份,黄连8-10份,白术8-10份,茯苓8-10份,党参28-30份,甘草4-6份。
2.一种含有权利要求1所述的治疗脱发性疾病的中药组合物的中药制剂,其特征在于,将权利要求1所述的原料加水煎煮后,与淀粉混合,烘干制成颗粒剂;其中,原料药与淀粉的比例为7:3。
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CN102846972A (zh) * | 2012-09-06 | 2013-01-02 | 丁海望 | 一种治疗脱发的药物 |
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CN102846972A (zh) * | 2012-09-06 | 2013-01-02 | 丁海望 | 一种治疗脱发的药物 |
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