CN104491442B - 一种治疗电击损伤药物组合物的制备工艺 - Google Patents

一种治疗电击损伤药物组合物的制备工艺 Download PDF

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CN104491442B
CN104491442B CN201410824538.4A CN201410824538A CN104491442B CN 104491442 B CN104491442 B CN 104491442B CN 201410824538 A CN201410824538 A CN 201410824538A CN 104491442 B CN104491442 B CN 104491442B
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刘玉柱
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Haimen Chuang Hao Industrial Design Co Ltd
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Abstract

本发明属于药物技术领域，公开了一种治疗电击损伤药物组合物的制备工艺，其包括步骤1）称取原料，步骤2）制备物料A，步骤3）制备物料B，步骤4）制备物料C，以及步骤5）搅拌。本发明制备工艺简单可行，原料成本低廉，其制备的药物组合物不仅对电击损伤效果好，而且不容易留下疤痕。

Description

一种治疗电击损伤药物组合物的制备工艺
技术领域
本发明属于药物技术领域，具体的，涉及一种治疗电击损伤药物组合物的制备工艺。
背景技术
电是人们生活工作的必须品，但是由于操作不当或者其他原因，触电事故时有发生。在轻度电击损伤后，在电击部位的局部损伤，电流经过的区域出现红肿、水泡以及夹花状肌肉坏死，骨周围软组织坏死常见。因此，在受到电击后，对外部伤口进行紧急包扎治疗，避免伤情扩大。目前针对烧烫伤药膏较多，存在膏油渗透能力较差，难以被伤口吸收，治疗后会留下难看的疤痕，因此药效有限，特别针对电击伤治疗效果不理想。现有技术需要一种治疗效果好，成本低廉的药物组合物。
发明内容
本发明的目的在于提供一种治疗电击损伤药物组合物的制备工艺，该工艺简单可行，原料成本低廉，其制备的药物组合物不仅对电击损伤效果好，而且不容易留下疤痕。
为实现本发明目的，本发明采用的技术方案如下：
一种治疗电击损伤药物组合物的制备工艺，其包括如下步骤：
1）按照重量份称取各原料，备用；当归25-30份、藏红花20-22份、玉竹15-17份、甘草12-15份、地榆10-12份、白芨8-10份、麦冬6-8份、虎杖5-7份、三七5-7份、丁香4-5份、黄连3-4份、金银花3-4份、合欢皮2-3份、蟾酥2-3份、地龙1-2份、凡士林80-100份；
2）取当归、藏红花、麦冬、虎杖、三七、金银花以及合欢皮，混合均匀，加相对于混合物5倍重量的水武火煮沸，然后文火煎煮1小时，过滤收集滤液，浓缩成密度为1.15g/ml的浸膏；即为物料A；
3）取玉竹、甘草、地榆、白芨、丁香以及黄连，混合，加入相对于混合物3倍重量75%的乙醇，回流提取2小时，收集提取液，浓缩至密度为1.15g/ml的膏状物，80℃烘干，粉碎制得物料B；
4) 取蟾酥和地龙，混合，研磨至100－200目的粉末，即得物料C；
5）取凡士林，将物料A、物料B以及物料C添加到凡士林中，搅拌均匀即得。
患者在使用本发明的药物组合物时，将伤口用消毒水清理后，涂敷本发明的组合物，每12小时换药一次即可；不破皮的采用本发明药物直接涂抹在患处；本发明药物组合物的原料均采用天然的中药原料，其配制简便，药源广泛，成本低廉，其遵循中医的处方用药原则，诸药合用，相得益彰，药性平和，其具备如下效果：治疗效果好见效快，能够有效地促进创面愈合，愈合后疤痕少；本发明药物组合物使用方法简单，每天换药的次数少，给患者带来很多方便；本发明制备方法简单，成本低廉，可以进行规模性生产，应用前景广阔。
具体实施方式
为了使本技术领域的人员更好地理解本申请中的技术方案，下面将结合本申请具体实施例，对本申请的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本申请一部分实施例，而不是全部的实施例。基于本申请中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都应当属于本发明保护的范围。
实施例1
一种治疗电击损伤药物组合物的制备工艺，其包括如下步骤：
1）按照重量份称取各原料，备用；当归25份、藏红花20份、玉竹15份、甘草12份、地榆10份、白芨8份、麦冬6份、虎杖5份、三七5份、丁香4份、黄连3份、金银花3份、合欢皮2份、蟾酥2份、地龙1份、凡士林80份；
2）取当归、藏红花、麦冬、虎杖、三七、金银花以及合欢皮，混合均匀，加相对于混合物5倍重量的水武火煮沸，然后文火煎煮1小时，过滤收集滤液，浓缩成密度为1.15g/ml的浸膏；即为物料A；
3）取玉竹、甘草、地榆、白芨、丁香以及黄连，混合，加入相对于混合物3倍重量75%的乙醇，回流提取2小时，收集提取液，浓缩至密度为1.15g/ml的膏状物，80℃烘干，粉碎制得物料B；
4) 取蟾酥和地龙，混合，研磨至100目的粉末，即得物料C；
5）取凡士林，将物料A、物料B以及物料C添加到凡士林中，搅拌均匀即得。
实施例2
一种治疗电击损伤药物组合物的制备工艺，其包括如下步骤：
1）按照重量份称取各原料，备用；当归30份、藏红花22份、玉竹17份、甘草15份、地榆12份、白芨10份、麦冬8份、虎杖7份、三七7份、丁香5份、黄连4份、金银花4份、合欢皮3份、蟾酥3份、地龙2份、凡士林100份；
2）取当归、藏红花、麦冬、虎杖、三七、金银花以及合欢皮，混合均匀，加相对于混合物5倍重量的水武火煮沸，然后文火煎煮1小时，过滤收集滤液，浓缩成密度为1.15g/ml的浸膏；即为物料A；
3）取玉竹、甘草、地榆、白芨、丁香以及黄连，混合，加入相对于混合物3倍重量75%的乙醇，回流提取2小时，收集提取液，浓缩至密度为1.15g/ml的膏状物，80℃烘干，粉碎制得物料B；
4) 取蟾酥和地龙，混合，研磨至200目的粉末，即得物料C；
5）取凡士林，将物料A、物料B以及物料C添加到凡士林中，搅拌均匀即得。
实施例3
一、本发明实施例1制备的药物组合物毒理实验：
取健康家兔20只将腹部毛剃光，随机分为2组，每组10只。分为对照组和实验组。其中对照组药液用清水代替。
对照组：取清水涂抹至家兔腹部，每天涂抹10次，连续涂抹10天，10只家兔未发现异常。
实验组：取本发明组合物涂抹至家兔腹部，每天涂抹10次，连续涂抹10天，10只家兔未发现异常。
本药物制剂毒理实验证明：本发明药物对家兔无毒副作用。
二、大鼠电烧伤试验：
7－8周的SD大鼠45只，购于市人民医院，雌雄各半，重量在190－200g。按随机数字表法分为空白对照组、本发明组（实施例2制备的药物组合物）和阳性对照组，每组15只。三组大鼠实验前日左前肢、右后肢外涂80g/L硫化钠脱毛并禁食。实验当日经大鼠缘静脉按3ml/kg剂量注射10g／L戊巴比妥钠，待其麻醉后仰卧位固定于实验操作台上。三组模型制作按如下进行，电击时升压器输出电压为1000V，通电时间为0.5s，左前肢为电流人口，右后肢为电流出口。给药方法：伤后2 min内由大鼠耳缘静脉注射生理盐水1ml浓度为 50mg/ml的己酮可可碱注射液，连续三天；本发明组在患处涂抹本发明实施例2制备的药物组合物，每天早晚各一次，连续两周；空白对照组不涂抹任何药物；阳性对照组涂抹京万红软膏，每天早晚各一次，连续两周。实验效果：本发明组：动物无死亡，均具备运动能力，伤口全部愈合，仅三只留下疤痕组织；空白对照组：五只动物神经损伤，运动能力丧失，十三只留下疤痕组织；阳性对照组：一只动物神经损伤，运动能力丧失，六只动物留下疤痕组织。
三、临床试验：
本发明药物组合物（实施例1制备的药物组合物）适合轻度电烧伤患者，共治愈30余例轻度电烧伤患者；对于深度电烧伤患者需要配合手术治疗。本发明药物组合物早晚各涂抹一次，依照患者治疗情况，可酌情改变换药次数。治疗过程中忌酒和辛辣刺激食物。本发明药物组合物还对其他类型烧伤有治疗作用。
典型病例：
宋某某，男，37岁，维修电路过程中，设备漏电，左臂皮肤被电击伤，皮肤上产生红色水疱，涂抹本发明药物组合物两周后，伤口愈合，半年后回访，其伤口无疤痕。
李某，男，42岁，市供电公司线路检修人员，检修电路时触电，手指出现血肿和水疱，强烈疼痛感；涂抹本发明药物组合物，同时配合抗生素消炎治疗，两周后伤口愈合，1年后回访，其伤口没有留下疤痕和结瘤。
黄某某，女，39岁，在烹饪时，被溅出的油液烫伤小臂，皮肤出现红肿并伴随水泡，涂抹本发明药物组合物后，7天后水泡和红肿消退，14天后痊愈，未留下任何疤痕。
虽然，上文中已经用一般性说明及具体实施方式对本案作了详尽的说明，但在本发明基础上，可以对之作一些修改或改进，这对本领域技术人员而言是显而易见的。因此，在不偏离本发明精神的基础上所作的修改或改进，均属于本发明要求保护的范围。

Claims (1)

1.一种治疗电击损伤药物组合物的制备工艺，其特征在于，所述工艺包括如下步骤：
步骤1）称取原料：按照重量份称取各原料，备用；其中，当归25-30份、藏红花20-22份、玉竹15-17份、甘草12-15份、地榆10-12份、白芨8-10份、麦冬6-8份、虎杖5-7份、三七5-7份、丁香4-5份、黄连3-4份、金银花3-4份、合欢皮2-3份、蟾酥2-3份、地龙1-2份、凡士林80-100份；
步骤2）制备物料A：取当归、藏红花、麦冬、虎杖、三七、金银花以及合欢皮，混合均匀，加相对于混合物5倍重量的水武火煮沸，然后文火煎煮1小时，过滤收集滤液，浓缩成密度为1.15g/ml的浸膏；即为物料A；
步骤3）制备物料B：取玉竹、甘草、地榆、白芨、丁香以及黄连，混合，加入相对于混合物3倍重量75%的乙醇，回流提取2小时，收集提取液，浓缩至密度为1.15g/ml的膏状物，80℃烘干，粉碎制得物料B；
步骤4）制备物料C： 取蟾酥和地龙，混合，研磨至100－200目的粉末，即得物料C；
步骤5）搅拌：取凡士林，将物料A、物料B以及物料C添加到凡士林中，搅拌均匀即得。
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