CN104491291A - Traditional Chinese medicine composition for treating liver-yang hyperactivity type thyroid adenoma - Google Patents
Traditional Chinese medicine composition for treating liver-yang hyperactivity type thyroid adenoma Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating liver-yang hyperactivity type thyroid adenoma, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition disclosed by the invention is prepared from the medicinal raw materials including rhizoma cyperi, selfheal, concha haliotidis, radix paeoniae alba, the root of straight ladybell, turtle shell, white atractylodes rhizome, salvia chinensis, poria cocos, astragalus membranaceus, tuber fleeceflower stem, scutellaria baicalensis, liquorice and the like. The traditional Chinese medicine composition disclosed by the invention takes effect according to different symptoms aiming at the pathogenesis of liver-yang hyperactivity type thyroid adenoma, such as phlegm stasis, phlegm-qi stagnation, deficiency of yin and hyperactivity of fire, and has the effects of discharging liver to relieve depression, soothing liver to purge fire, nourishing yin, suppressing yang, tonifying qi and yin, activating qi, eliminating phlegm and nourishing heart to calm mind; and in addition, aiming at treatment of liver-yang hyperactivity type thyroid adenoma, the clinical effect is obvious.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of liver-Yang sthenia type thyroid adenoma, belong to tcm field.
Background technology
Thyroid adenoma is modal Treatment of Benign Tumor of Thyroid Gland, and general without general malaise symptom, can be sent out in any age, be apt to occur in young and middle-aged women, be the benign goitre originating from thyroid follicle tissue." toxic goiter " category of this Bing Shu motherland medical science.Modern Chinese medicine differentiation of symptoms and signs for classification of syndrome theory think the morbidity of thyroid adenoma patient many unsuitable with residence place, feelings will is smooth, just exogenous pathogen to have crouched close relationship.Under the effect of multiple unfavorable factor, cause the stagnation of QI, blood stasis, expectorant coagulates, and ends in neck, with the passing of time forms lump.
From patient clinical symptom, thyroid adenoma is confined to throat more, outer likeness in form Semen Juglandis, and quality is comparatively hard, can move up and down with the action such as swallowing.Thyroid adenoma patient is general non-evident sympton in the early stage, and generally need could be found by ultrasound diagnosis, patient is treated surgically more, or does not carry out any remedy measures.But compared with tcm therapy, operative treatment costly, and postoperatively very easily to recur.And take the prolongation of patient along with the course of disease not carrying out any treatment, very easily form the thyroid carcinoma healed compared with refractory, therefore, there is very large demand to the Chinese medicine of effectively treating thyroid adenoma in people.
Mainly feelings will is not smooth, caused by the liver failing to maintain the normal flow of QI for the cause of disease of primary disease; Pathogenesis is the stagnation of QI, and expectorant coagulates, blood stasis, derivation becomes goiter, if delay with the passing of time, then expectorant stasis of blood fire-transformation, Tianjin of intimately burning, forms the gesture of cloudy wound; The deficiency of YIN is yang hyperactivity then, and YANG-fire is excessively prosperous, turns to excessive fire, eats gas on the contrary, and therefore cause the positive QI consumed wound of body, cause and effect like this, vicious cycle, finally causes impairment of both QI and YIN, and mental disorder hands over resistance, and phlegm-damp stops gathering, and forms the goiter of obstinate refractory.
Summary of the invention
Inventor thinks, toxic goiter formation time is longer, different symptoms can be there is in disease different phase, also need concrete determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs clinically, a kind of liver-Yang sthenia type thyroid adenoma, clinical condition is shown in neck region lump, with symptoms such as susceptible to lose temper due to restlessness, insomnia and dreamful sleep, dry mouth with bitter taste, bulimia, red tongue yellow fur, wiry and frequent pulse.For above-mentioned symptom, inventor provide a kind of Chinese medicine composition for the treatment of liver-Yang sthenia type thyroid adenoma, it is made primarily of medicinal raw materials such as Rhizoma Cyperi, Spica Prunellae, Concha Haliotidis, the Radix Paeoniae Alba, Radix Adenophorae (Radix Glehniae), Carapax Trionycis, the Rhizoma Atractylodis Macrocephalae, Herba Salviae Chinensis, Poria, the Radix Astragali, Caulis Polygoni Multiflori, Radix Scutellariae, Radix Glycyrrhizaes.
Rhizoma Cyperi promoting QI circulation for relieving depression in side, Spica Prunellae purging liver-fire, Concha Haliotidis suppressing the hyperactive liver and subsiding YANG, Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG, the Radix Paeoniae Alba is nourished blood yin fluid astringing, and all medicines share to be played altogether, promoting QI circulation for relieving depression, soothing the liver pathogenic fire purging, easing the affected liver to relieve pain, suppressing liver-YANG, the merit of nourishing YIN and benefiting blood.Spica Prunellae mass dissipating and swelling eliminating, Carapax Trionycis hard masses softening and resolving, Herba Salviae Chinensis blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis; Mass dissipating and swelling eliminating, it is strong that three medicines share hard masses softening and resolving power.Radix Adenophorae (Radix Glehniae) replenishing YIN and removing heat, moistening the lung and resolving phlegm, reinforcing stomach reg fluid, Radix Astragali invigorating QI to consolidate the body surface resistance, Radix Glycyrrhizae invigorating the spleen and replenishing QI, consumption the moon that three medicines are total to tonification prolonged illness is felt frustrated.Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, Radix Glycyrrhizae invigorating the spleen and replenishing QI, three medicines 5 the spleen strengthening and damp drying and middle QI invigorating, make phlegm-damp not life.It is strong that Spica Prunellae, Herba Salviae Chinensis, Radix Scutellariae share heat-clearing and toxic substances removing power.Caulis Polygoni Multiflori nourishes heart, calm the nerves, dredging collateral and Poria share tranquilizing by nourishing the heart, the susceptible to lose temper due to restlessness for liver-Yang sthenia type patient, insomnia and dreamful sleep, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines combined into dispersing the stagnated live-QI to relieve the stagnation of QI, soothing the liver pathogenic fire purging, nourishing YIN for suppressing the hyperactive YANG, supplementing QI and nourishing YIN, promoting the circulation of QI and reducing phlegm, tranquilizing by nourishing the heart, for the treatment of liver-Yang sthenia type thyroid adenoma, Be very effective.
Preferably, the Chinese medicine composition for the treatment of liver-Yang sthenia type thyroid adenoma described above, it is made up of the medicinal raw material of following weight portion: Rhizoma Cyperi 13-18 part, Spica Prunellae 15-20 part, Concha Haliotidis 11-16 part, Radix Paeoniae Alba 11-14 part, Radix Adenophorae (Radix Glehniae) 14-18 part, Carapax Trionycis 20-25 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Herba Salviae Chinensis 30-35 part, Poria 11-16 part, Radix Astragali 50-55 part, Caulis Polygoni Multiflori 10-15 part, Radix Scutellariae 8-13 part, Radix Glycyrrhizae 5-8 part.
Further preferably, the Chinese medicine composition for the treatment of liver-Yang sthenia type thyroid adenoma described above, it is made up of the medicinal raw material of following weight portion: Rhizoma Cyperi 15 parts, Spica Prunellae 18 parts, Concha Haliotidis 14 parts, the Radix Paeoniae Alba 12 parts, Radix Adenophorae (Radix Glehniae) 16 parts, Carapax Trionycis 24 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Herba Salviae Chinensis 33 parts, 14 parts, Poria, the Radix Astragali 52 parts, Caulis Polygoni Multiflori 14 parts, Radix Scutellariae 10 parts, 6 parts, Radix Glycyrrhizae.
The property of medicine of the present invention's Chinese medicine used is as follows:
Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Spica Prunellae: pungent, bitter, cold.Return liver, gallbladder meridian.Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Concha Haliotidis: salty, cold.Return Liver Channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.
The Radix Paeoniae Alba: bitter, sour, is slightly cold.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Radix Adenophorae (Radix Glehniae): sweet in the mouth; Micro-hardship; Cold nature.Return lung; Stomach warp.Function cures mainly: replenishing YIN and removing heat; Moistening the lung and resolving phlegm; Reinforcing stomach reg fluid.Main deficiency of YIN chronic cough; Consumptive disease is coughed expectorant blood; Cough caused by dryness expectorant is few; Deficiency-heat sore throat; Tianjin wound is thirsty
Carapax Trionycis: salty, is slightly cold.Return liver, kidney channel.Function cures mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Herba Salviae Chinensis: acrid in the mouth; Bitter; Cold nature.Return liver; Spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis; Mass dissipating and swelling eliminating.Main menoxenia; Dysmenorrhea; Amenorrhea; Metrorrhagia, has blood in stool; Jaundice due to damp-heat; Toxic-heat and blood stasis; Drench pain; Leukorrhagia; Rheumatic ostalgia; Scrofula; Skin ulcer swells; Acute mastitis; Herpes zoster; Leprosy; Traumatic injury wound is swollen.
Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Caulis Polygoni Multiflori: sweet micro-hardship is flat.Enter the heart, Liver Channel.Nourish heart, calm the nerves, dredging collateral, dispel the wind.Control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.
Radix Scutellariae: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Present invention also offers a kind of preparation method for the treatment of the Chinese medicine composition of liver-Yang sthenia type thyroid adenoma, it is characterized in that it comprises the following steps: the Carapax Trionycis of the Rhizoma Cyperi of prescription weight portion, Spica Prunellae, Concha Haliotidis, the Radix Paeoniae Alba, Radix Adenophorae (Radix Glehniae), the Rhizoma Atractylodis Macrocephalae, Herba Salviae Chinensis, Poria, the Radix Astragali, Caulis Polygoni Multiflori, Radix Scutellariae, Radix Glycyrrhizae and prescription 0.75 weight portion is decocted with water secondary, first time decocts 1.5-2.0 hour, second time decocts 1.0-1.5 hour, merge decoction liquor, well-done medicinal liquid will be decocted filter, extract clear liquid, leave standstill 6-8 hour; The fine powder that the Carapax Trionycis of prescription 0.25 weight portion grinds to form is joined in the clear liquid after standing 6-8 hour, stir, then it is concentrated, make it become thick shape, add appropriate pharmaceutically acceptable carrier or/and adjuvant, conveniently technique makes peroral dosage form.
Peroral dosage form described above is soft capsule, capsule, tablet, granule or pill.
Most preferably, dosage form described above is capsule.
The present invention is further illustrated below further by clinical observation test.
1. physical data: my institute accepts liver-Yang sthenia type thyroid adenoma patient 60 example for medical treatment in February, 2010 ~ in June, 2012, is women, 22 ~ 65 years old age, average 33.7 years old; The course of disease 3 weeks ~ 13 years, average 4.5 years; Solitary thyroid adenoma 31 example, multiple thyroid adenoma 29 example; Non-row thyroid adenoma excising operation 48 example, postoperative recurrence 19 example; B surpasses check point: in lobus dexter 22 example, lobus sinister 24 example, isthmus 4 example, bilateral 10 example; Cystic adenoma 14 example, solid adenoma 46 example; Tumor size 2cm × 4cm × 3cm ~ 25cm × 32cm × 36cm.Most of patients is without obvious subjective symptoms or with swallowing discomfort, cervical region constriction, the symptom in various degree such as vexed, uncomfortable in chest.Be divided into treatment group and matched group at random, two groups of ages, sex, the course of disease, diseased region, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (P > 0.05).
2. Western medicine diagnose standard: can lay one's hand in thyroid and single or multiple circle or oval tuberosity, smooth surface, matter is soft or tough, can move up and down, cervical lymph node not enlargement with swallowing; B is super turns out to be adenoma; Thyroid function inspection is feminine gender; Radioisotope scanning is warm nodule, and cystic is cold nodule.
3. tcm syndrome differentiation and typing: reference: formulate with reference to " new Chinese medicine guideline of clinical investigations ", disease belongs to excessive rising of liver-YANG, and disease sees neck region lump, with symptoms such as susceptible to lose temper due to restlessness, insomnia and dreamful sleep, dry mouth with bitter taste, bulimia, red tongue yellow fur, wiry and frequent pulse.
4. exclusion standard: do not meet diagnostic criteria person; Be associated with severe primary disease and the psychotics such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system; Age is below 20 years old or more than 50 years old person; Hashimoto's disease patient, or with hyperthyroidism, trachea, esophagus, the obvious person of nerve compression symptom; Gestation or women breast-feeding their children; Not by regulation medication, cannot curative effect be judged, or the not congruent judgement person that affects the treatment of data.
5. Therapeutic Method: treatment group: give Chinese medicinal composition capsules agent every day 2 times prepared by the embodiment of the present invention 1, each 3-4 grain.2 months was 1 course for the treatment of, took 6 months continuously; Matched group: oral thyroid element sheet first week 20 ~ 40 μ g/d, start for the 2nd week to be increased to 50 μ g/d, 2 months was 1 course for the treatment of, took 6 months continuously.
6. observation index: 1. observe front and back clinical symptoms change of taking medicine, judge clinical total effects.2. the clinical efficacy of more solitary and multiple thyroid adenoma, and do not performed the operation and the clinical efficacy of postoperative recurrence patient.3. all adverse reactions of patients situations are observed.
7. curative effect judging standard: recovery from illness: original transference cure, palpation lump dissipates, and B super (or isotope) checks and shows that lump disappears, and thyroid size form is normal, follows up a case by regular visits to more than 6 months without recurrence; Effective: original transference cure, palpation and B super (or isotope) check and show that mass reduction reaches more than 1/2, follow up a case by regular visits to more than 6 months former lumps reduced without increase; Effective: original transference cure, palpation and B super (or isotope) check and show mass reduction 1/3 ~ 1/2, follow up a case by regular visits to more than 6 months former lumps reduced without increase; Invalid: conscious original symptom is unchanged, though or original transference cure/improvement, palpation and B super (or isotope) check show mass reduction < 1/3 or without reducing (as long as adenoma multiple wherein 1 adenoma lump comparatively before increase be namely decided to be invalid).
8. date processing: adopt SPSS16.0 statistical software, measurement data employing means standard deviation (
± s) represent, compare between group with one factor analysis of variance and t inspection, enumeration data adopts χ
2inspection, with P < 0.05 for there being statistical significance.
9. result
9.1. after three courses for the treatment of, two groups through statistical procedures, treatment group total effective rate is 93.3%, and matched group is that 73.3%, two groups of total effective rates compare, and difference has statistical significance (P < 0.05), in table 1.
Two groups of Clinical efficacy comparisons after three courses for the treatment of of table 1, ［ routine (%) ］
After 9.2 3 courses for the treatment of, two groups solitary compares with multiple, and visible the present invention is obviously better than solitary thyroid adenoma to multiple thyroid adenoma curative effect, and difference has statistical significance (P < 0.05), in table 2.
Solitary and the multiple thyroid adenoma comparitive study of table 2 ［ routine (%) ］
Two groups are showed no serious adverse reaction, and two groups of untoward reaction degree are similar, but treatment group is slighter.
Brief summary: as can be seen from Table 1, adopts treatment by Chinese herbs liver-Yang sthenia type thyroid adenoma of the present invention, relative to Western medicine on therapeutic effect, has significant progress; As can be seen from Table 2, the present invention is obviously better than solitary thyroid adenoma to multiple thyroid adenoma curative effect, and between group, comparing difference has statistical significance (P < 0.05).Present invention also offers a kind of pharmaceutical applications as seen, that is, the application of Chinese medicine composition of the present invention in the medicine of preparation treatment liver-Yang sthenia type thyroid adenoma.
The present invention compared with prior art, there is following beneficial effect: the present invention selects all reasons of medical material all standby, the property of medicine is suitable mutually auxiliary mutually, the causes of disease such as the expectorant for liver-Yang sthenia type thyroid adenoma is solidifying, mental disorder pent-up, the deficiency of YIN, hyperactivity of fire are suited the remedy to the case, there is effect of dispersing the stagnated live-QI to relieve the stagnation of QI, soothing the liver pathogenic fire purging, nourishing YIN for suppressing the hyperactive YANG, supplementing QI and nourishing YIN, promoting the circulation of QI and reducing phlegm, tranquilizing by nourishing the heart, for the treatment of liver-Yang sthenia type thyroid adenoma, clinical effectiveness is remarkable.
Detailed description of the invention
The following stated is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of following announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done following examples according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Embodiment 1
Prescription: Rhizoma Cyperi 15 parts, Spica Prunellae 18 parts, Concha Haliotidis 14 parts, the Radix Paeoniae Alba 12 parts, Radix Adenophorae (Radix Glehniae) 16 parts, Carapax Trionycis 24 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Herba Salviae Chinensis 33 parts, 14 parts, Poria, the Radix Astragali 52 parts, Caulis Polygoni Multiflori 14 parts, Radix Scutellariae 10 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: the Carapax Trionycis of the Rhizoma Cyperi of prescription weight portion, Spica Prunellae, Concha Haliotidis, the Radix Paeoniae Alba, Radix Adenophorae (Radix Glehniae), the Rhizoma Atractylodis Macrocephalae, Herba Salviae Chinensis, Poria, the Radix Astragali, Caulis Polygoni Multiflori, Radix Scutellariae, Radix Glycyrrhizae and prescription 0.75 weight portion is decocted with water secondary, first time decocts 1.5-2.0 hour, second time decocts 1.0-1.5 hour, merge decoction liquor, well-done medicinal liquid will be decocted filter, extract clear liquid, leave standstill 6-8 hour; Joined in the clear liquid after standing 6-8 hour by the fine powder that the Carapax Trionycis of prescription 0.25 weight portion grinds to form, stir, then concentrate it, make it become thick shape, add appropriate pharmaceutically acceptable carrier or/and adjuvant, conveniently technique makes capsule.
Embodiment 2
Prescription: Rhizoma Cyperi 13 parts, Spica Prunellae 15 parts, Concha Haliotidis 11 parts, the Radix Paeoniae Alba 11 parts, Radix Adenophorae (Radix Glehniae) 14 parts, Carapax Trionycis 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Salviae Chinensis 30 parts, 11 parts, Poria, the Radix Astragali 50 parts, Caulis Polygoni Multiflori 10 parts, Radix Scutellariae 8 parts, 5 parts, Radix Glycyrrhizae.
Preparation method: the operation with reference to embodiment 1 is carried out.
Embodiment 3
Prescription: Rhizoma Cyperi 18 parts, Spica Prunellae 20 parts, Concha Haliotidis 16 parts, the Radix Paeoniae Alba 14 parts, Radix Adenophorae (Radix Glehniae) 18 parts, Carapax Trionycis 25 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Herba Salviae Chinensis 35 parts, 16 parts, Poria, the Radix Astragali 55 parts, Caulis Polygoni Multiflori 15 parts, Radix Scutellariae 13 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: the operation with reference to embodiment 1 is carried out.
Embodiment 4
Prescription: Rhizoma Cyperi 15 parts, Spica Prunellae 17 parts, Concha Haliotidis 15 parts, the Radix Paeoniae Alba 12 parts, Radix Adenophorae (Radix Glehniae) 16 parts, Carapax Trionycis 23 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Herba Salviae Chinensis 32 parts, 12 parts, Poria, the Radix Astragali 50 parts, Caulis Polygoni Multiflori 12 parts, Radix Scutellariae 11 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: the operation with reference to embodiment 1 is carried out.
Embodiment 5
Prescription: Rhizoma Cyperi 14 parts, Spica Prunellae 18 parts, Concha Haliotidis 14 parts, the Radix Paeoniae Alba 13 parts, Radix Adenophorae (Radix Glehniae) 17 parts, Carapax Trionycis 24 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Herba Salviae Chinensis 33 parts, 13 parts, Poria, the Radix Astragali 53 parts, Caulis Polygoni Multiflori 13 parts, Radix Scutellariae 10 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: the operation with reference to embodiment 1 is carried out.
Embodiment 6
Prescription: Rhizoma Cyperi 13 parts, Spica Prunellae 15 parts, Concha Haliotidis 16 parts, the Radix Paeoniae Alba 14 parts, Radix Adenophorae (Radix Glehniae) 16 parts, Carapax Trionycis 23 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Salviae Chinensis 33 parts, 13 parts, Poria, the Radix Astragali 53 parts, Caulis Polygoni Multiflori 12 parts, Radix Scutellariae 11 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: the operation with reference to embodiment 1 is carried out.
Embodiment 7
Prescription: Rhizoma Cyperi 18 parts, Spica Prunellae 20 parts, Concha Haliotidis 16 parts, the Radix Paeoniae Alba 14 parts, Radix Adenophorae (Radix Glehniae) 16 parts, Carapax Trionycis 23 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Salviae Chinensis 33 parts, 13 parts, Poria, the Radix Astragali 55 parts, Caulis Polygoni Multiflori 15 parts, Radix Scutellariae 13 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: the Carapax Trionycis of the Rhizoma Cyperi of prescription weight portion, Spica Prunellae, Concha Haliotidis, the Radix Paeoniae Alba, Radix Adenophorae (Radix Glehniae), the Rhizoma Atractylodis Macrocephalae, Herba Salviae Chinensis, Poria, the Radix Astragali, Caulis Polygoni Multiflori, Radix Scutellariae, Radix Glycyrrhizae and prescription 0.75 weight portion is decocted with water secondary, first time decocts 1.5-2.0 hour, second time decocts 1.0-1.5 hour, merge decoction liquor, well-done medicinal liquid will be decocted filter, extract clear liquid, leave standstill 6-8 hour; Joined in the clear liquid after standing 6-8 hour by the fine powder that the Carapax Trionycis of prescription 0.25 weight portion grinds to form, stir, then concentrate it, make it become thick shape, add appropriate pharmaceutically acceptable carrier or/and adjuvant, conveniently technique makes tablet.
Embodiment 8
Prescription: Rhizoma Cyperi 15 parts, Spica Prunellae 17 parts, Concha Haliotidis 13 parts, the Radix Paeoniae Alba 14 parts, Radix Adenophorae (Radix Glehniae) 16 parts, Carapax Trionycis 22 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Herba Salviae Chinensis 35 parts, 16 parts, Poria, the Radix Astragali 55 parts, Caulis Polygoni Multiflori 10 parts, Radix Scutellariae 8 parts, 5 parts, Radix Glycyrrhizae.
Preparation method: the Carapax Trionycis of the Rhizoma Cyperi of prescription weight portion, Spica Prunellae, Concha Haliotidis, the Radix Paeoniae Alba, Radix Adenophorae (Radix Glehniae), the Rhizoma Atractylodis Macrocephalae, Herba Salviae Chinensis, Poria, the Radix Astragali, Caulis Polygoni Multiflori, Radix Scutellariae, Radix Glycyrrhizae and prescription 0.75 weight portion is decocted with water secondary, first time decocts 1.5-2.0 hour, second time decocts 1.0-1.5 hour, merge decoction liquor, well-done medicinal liquid will be decocted filter, extract clear liquid, leave standstill 6-8 hour; Joined in the clear liquid after standing 6-8 hour by the fine powder that the Carapax Trionycis of prescription 0.25 weight portion grinds to form, stir, then concentrate it, make it become thick shape, add appropriate pharmaceutically acceptable carrier or/and adjuvant, conveniently technique makes pill.
Claims (7)
1. treat a Chinese medicine composition for liver-Yang sthenia type thyroid adenoma, it is characterized in that being made up of following medicinal raw material: Rhizoma Cyperi, Spica Prunellae, Concha Haliotidis, the Radix Paeoniae Alba, Radix Adenophorae (Radix Glehniae), Carapax Trionycis, the Rhizoma Atractylodis Macrocephalae, Herba Salviae Chinensis, Poria, the Radix Astragali, Caulis Polygoni Multiflori, Radix Scutellariae, Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of liver-Yang sthenia type thyroid adenoma as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following weight portion: Rhizoma Cyperi 13-18 part, Spica Prunellae 15-20 part, Concha Haliotidis 11-16 part, Radix Paeoniae Alba 11-14 part, Radix Adenophorae (Radix Glehniae) 14-18 part, Carapax Trionycis 20-25 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Herba Salviae Chinensis 30-35 part, Poria 11-16 part, Radix Astragali 50-55 part, Caulis Polygoni Multiflori 10-15 part, Radix Scutellariae 8-13 part, Radix Glycyrrhizae 5-8 part.
3. the Chinese medicine composition for the treatment of liver-Yang sthenia type thyroid adenoma as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following weight portion: Rhizoma Cyperi 15 parts, Spica Prunellae 18 parts, Concha Haliotidis 14 parts, the Radix Paeoniae Alba 12 parts, Radix Adenophorae (Radix Glehniae) 16 parts, Carapax Trionycis 24 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Herba Salviae Chinensis 33 parts, 14 parts, Poria, the Radix Astragali 52 parts, Caulis Polygoni Multiflori 14 parts, Radix Scutellariae 10 parts, 6 parts, Radix Glycyrrhizae.
4. one kind as arbitrary in claim 1-3 as described in the preparation method of Chinese medicine composition for the treatment of liver-Yang sthenia type thyroid adenoma, it is characterized in that comprising the following steps: the Carapax Trionycis of the Rhizoma Cyperi of prescription weight portion, Spica Prunellae, Concha Haliotidis, the Radix Paeoniae Alba, Radix Adenophorae (Radix Glehniae), the Rhizoma Atractylodis Macrocephalae, Herba Salviae Chinensis, Poria, the Radix Astragali, Caulis Polygoni Multiflori, Radix Scutellariae, Radix Glycyrrhizae and prescription 0.75 weight portion is decocted with water secondary, first time decocts 1.5-2.0 hour, second time decocts 1.0-1.5 hour, merge decoction liquor, well-done medicinal liquid will be decocted filter, extract clear liquid, leave standstill 6-8 hour; The fine powder that the Carapax Trionycis of prescription 0.25 weight portion grinds to form is joined in the clear liquid after standing 6-8 hour, stir, then it is concentrated, make it become thick shape, add appropriate pharmaceutically acceptable carrier or/and adjuvant, conveniently technique makes peroral dosage form.
5. the Chinese medicine composition of the treatment liver-Yang sthenia type thyroid adenoma as described in as arbitrary in claim 1-3, is characterized in that: described Chinese medicine composition is soft capsule, capsule, tablet, granule or pill.
6. the Chinese medicine composition for the treatment of liver-Yang sthenia type thyroid adenoma as claimed in claim 5, is characterized in that: described Chinese medicine composition is soft capsule.
7. the application of the Chinese medicine composition of the arbitrary described treatment liver-Yang sthenia type thyroid adenoma of claim 1-3 in the medicine of preparation treatment liver-Yang sthenia type thyroid adenoma.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796848A (en) * | 2016-05-13 | 2016-07-27 | 青岛辰达生物科技有限公司 | Medical composition for treating yin-deficiency yang-excess type thyroid adenoma |
| RU2601917C1 (en) * | 2015-04-13 | 2016-11-10 | Федеральное государственное бюджетное учреждение науки Институт общей и экспериментальной биологии Сибирского отделения Российской академии наук | Method of producing medicinal agent for correction of thyroid functions |
| CN108686133A (en) * | 2018-08-29 | 2018-10-23 | 河南中医药大学 | A kind of Chinese medicine improving thyroid cancer patients Postoperative Anxiety state |
| CN114177244A (en) * | 2021-12-16 | 2022-03-15 | 浙江省人民医院 | Traditional Chinese medicine composition for treating thyroid cancer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272150A (en) * | 2013-06-22 | 2013-09-04 | 张春治 | Traditional Chinese medicine preparation for curing thyroid adenoma |
-
2014
- 2014-12-17 CN CN201410777065.7A patent/CN104491291A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272150A (en) * | 2013-06-22 | 2013-09-04 | 张春治 | Traditional Chinese medicine preparation for curing thyroid adenoma |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2601917C1 (en) * | 2015-04-13 | 2016-11-10 | Федеральное государственное бюджетное учреждение науки Институт общей и экспериментальной биологии Сибирского отделения Российской академии наук | Method of producing medicinal agent for correction of thyroid functions |
| CN105796848A (en) * | 2016-05-13 | 2016-07-27 | 青岛辰达生物科技有限公司 | Medical composition for treating yin-deficiency yang-excess type thyroid adenoma |
| CN108686133A (en) * | 2018-08-29 | 2018-10-23 | 河南中医药大学 | A kind of Chinese medicine improving thyroid cancer patients Postoperative Anxiety state |
| CN114177244A (en) * | 2021-12-16 | 2022-03-15 | 浙江省人民医院 | Traditional Chinese medicine composition for treating thyroid cancer and preparation method thereof |
| CN114177244B (en) * | 2021-12-16 | 2022-09-23 | 浙江省人民医院 | Traditional Chinese medicine composition for treating thyroid cancer and preparation method thereof |
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