CN104491253A - Traditional Chinese medicine composition used for treating acute gouty arthritis - Google Patents
Traditional Chinese medicine composition used for treating acute gouty arthritis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition used for treating acute gouty arthritis. The traditional Chinese medicine composition is composed of, by weight, 50 parts to 100 parts of bulbiferous stonecrop, 50 parts to 100 parts of microsorium punctatum, 50 parts to 200 parts of Japanese pachysandra herbs, 50 parts to 100 parts of abrus cantoniensis hance, 50 parts to 100 parts of rhaphidophora decursiva, 10 parts to 50 parts of perilla leaves, 50 parts to 100 parts of thlaspi arvense, 10 parts to 100 parts of fructus quisqualis, 50 parts to 100 parts of agaric, 10 parts to 100 parts of emblic leafflower fruit, 50 parts to 100 parts of ivy glorybind herb roots, 10 parts to 100 parts of all-grass of broadleaf ainslaea, 10 parts to 100 parts of ampelopsis japonica, 50 parts to 100 parts of sea-buckthorn, 10 parts to 100 parts of fructus aurantii, 10 parts to 50 parts of cowherb seeds, 50 parts to 100 parts of cortex albiziae, 10 parts to 30 parts of herba epimedii, 10 parts to 50 parts of inula flowers, 50 parts to 100 parts of calamondin oranges, 50 parts to 100 parts of immature bitter oranges, 50 parts to 100 parts of cottonrose hibiscus leaves, 50 parts to 100 parts of red beans and 50 parts to 100 parts of liquorice. The traditional Chinese medicine composition is reasonable in component and has the advantages that the curative effect is confirmed, and the traditional Chinese medicine composition is safe and convenient to use, free of toxic and side effects and low in price.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of pharmaceutical composition for the treatment of acute gouty arthritis.
Background technology
A kind of disease of goat to be urate deposition cause in joint capsule, synovial bursa, cartilage, sclerotin, kidney, subcutaneous and hetero-organization corresponding disease damage and inflammatory reaction, be a kind of metabolic disease caused by purine metabolic disturbance, increase as its feature with urate in blood.The clinical characters of acute gouty arthritis is: onset is hurried, how in burst at night, common with hallux joint, and redness and swelling of joints burning pain, sharp ache, outbreak all peaks in 1d.It is one of clinical difficult treatment.Mainly use western medicine at present: the non-steroidal anti-inflammatory and analgesic medicine such as colchicine or indometacin thing, but toxic and side effects is comparatively large, especially huge to GI irritation, patient is often difficult to tolerance, has a strong impact on life and the work of patient.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of acute gouty arthritis.
In order to realize object of the present invention, the invention provides a kind of pharmaceutical composition for the treatment of acute gouty arthritis, it is made up by weight of following bulk drugs: bulbil half 50-100 part, Microsorium Link 50-100 part, Herba Pachysandrae Terminalis 50-200 part, Herba Abri 50-100 part, Radix Seu Caulis Rhaphidophorae Decursivae 50-100 part, Folium Perillae 10-50 part, Herba Thlaspis 50-100 part, Fructus Quisqualis 10-100 part, Auricularia 50-100 part, Fructus Phyllanthi 10-100 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 50-100 part, Herba Ainsliaeae Latifoliae 10-100 part, Radix Ampelopsis 10-100 part, Fructus Hippophae 50-100 part, Fructus Aurantii 10-100 part, Semen Vaccariae 10-50 part, Cortex Albiziae 50-100 part, Herba Epimedii 10-30 part, Flos Inulae 10-50 part, Fructus Fortunellae Margaritae 50-100 part, Fructus Aurantii Immaturus 50-100 part, Folium Hibisci Mutabilis 50-100 part, Semen Phaseoli 50-100 part and Radix Glycyrrhizae 50-100 part.
Preferably, the pharmaceutical composition for the treatment of acute gouty arthritis of the present invention is made up by weight of following bulk drugs: bulbil half 80 parts, Microsorium Link 70 parts, Herba Pachysandrae Terminalis 90 parts, Herba Abri 75 parts, Radix Seu Caulis Rhaphidophorae Decursivae 60 parts, Folium Perillae 40 parts, Herba Thlaspis 80 parts, Fructus Quisqualis 50 parts, 80 parts, Auricularia, Fructus Phyllanthi 50 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 80 parts, Herba Ainsliaeae Latifoliae 50 parts, Radix Ampelopsis 50 parts, Fructus Hippophae 60 parts, Fructus Aurantii 50 parts, Semen Vaccariae 30 parts, Cortex Albiziae 60 parts, Herba Epimedii 20 parts, Flos Inulae 40 parts, Fructus Fortunellae Margaritae 65 parts, Fructus Aurantii Immaturus 60 parts, Folium Hibisci Mutabilis 60 parts, 70 parts, Semen Phaseoli and 60 parts, Radix Glycyrrhizae.
Preferably, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or ointment.
The present invention also provides the purposes of compositions in the medicine of preparation treatment acute gouty arthritis, described compositions is made up by weight of following bulk drugs: bulbil half 50-100 part, Microsorium Link 50-100 part, Herba Pachysandrae Terminalis 50-200 part, Herba Abri 50-100 part, Radix Seu Caulis Rhaphidophorae Decursivae 50-100 part, Folium Perillae 10-50 part, Herba Thlaspis 50-100 part, Fructus Quisqualis 10-100 part, Auricularia 50-100 part, Fructus Phyllanthi 10-100 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 50-100 part, Herba Ainsliaeae Latifoliae 10-100 part, Radix Ampelopsis 10-100 part, Fructus Hippophae 50-100 part, Fructus Aurantii 10-100 part, Semen Vaccariae 10-50 part, Cortex Albiziae 50-100 part, Herba Epimedii 10-30 part, Flos Inulae 10-50 part, Fructus Fortunellae Margaritae 50-100 part, Fructus Aurantii Immaturus 50-100 part, Folium Hibisci Mutabilis 50-100 part, Semen Phaseoli 50-100 part and Radix Glycyrrhizae 50-100 part.
Preferably, described compositions is made up by weight of following bulk drugs: bulbil half 80 parts, Microsorium Link 70 parts, Herba Pachysandrae Terminalis 90 parts, Herba Abri 75 parts, Radix Seu Caulis Rhaphidophorae Decursivae 60 parts, Folium Perillae 40 parts of, Herba Thlaspiss 80 parts, Fructus Quisqualis 50 parts, 80 parts, Auricularia, Fructus Phyllanthi 50 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 80 parts, Herba Ainsliaeae Latifoliae 50 parts, Radix Ampelopsis 50 parts, Fructus Hippophae 60 parts, Fructus Aurantii 50 parts, Semen Vaccariae 30 parts, Cortex Albiziae 60 parts, Herba Epimedii 20 parts, Flos Inulae 40 parts, Fructus Fortunellae Margaritae 65 parts, Fructus Aurantii Immaturus 60 parts, Folium Hibisci Mutabilis 60 parts, 70 parts, Semen Phaseoli and 60 parts, Radix Glycyrrhizae.
Preferably, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or ointment.
In the present invention, bulbil half, Microsorium Link, Herba Pachysandrae Terminalis are monarch drug; Herba Abri, Radix Seu Caulis Rhaphidophorae Decursivae, Folium Perillae, Herba Thlaspis, Fructus Quisqualis, Auricularia, Fructus Phyllanthi are ministerial drug; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Ainsliaeae Latifoliae, Radix Ampelopsis, Fructus Hippophae, Fructus Aurantii, Semen Vaccariae, Cortex Albiziae, Herba Epimedii, Flos Inulae, Fructus Fortunellae Margaritae, Fructus Aurantii Immaturus, Folium Hibisci Mutabilis, Semen Phaseoli are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, plays the effect making medicine in the compositions of the present invention.All medicines are harmonious in the present invention, reasonable recipe, have determined curative effect, safe ready, have no side effect, cheap feature.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment ointment of the present invention
Take bulbil half 80 grams, Microsorium Link 70 grams, Herba Pachysandrae Terminalis 90 grams, Herba Abri 75 grams, Radix Seu Caulis Rhaphidophorae Decursivae 60 grams, Folium Perillae 40 grams, Herba Thlaspis 80 grams, Fructus Quisqualis 50 grams, 80 grams, Auricularia, Fructus Phyllanthi 50 grams, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 80 grams, Herba Ainsliaeae Latifoliae 50 grams, Radix Ampelopsis 50 grams, Fructus Hippophae 60 grams, Fructus Aurantii 50 grams, Semen Vaccariae 30 grams, Cortex Albiziae 60 grams, Herba Epimedii 20 grams, Flos Inulae 40 grams, Fructus Fortunellae Margaritae 65 grams, Fructus Aurantii Immaturus 60 grams, Folium Hibisci Mutabilis 60 grams, 70 grams, Semen Phaseoli and 60 grams, Radix Glycyrrhizae, add 20 liters, water, heating 5 hours under the condition of backflow, filter, by filtrate evaporate to dryness, pulverize, add 200 grams, mannitol, 80 mesh sieves were pulverized in stirring, add lanoline 350 grams, stir, be dispensed in 100 flexible pipes, obtain.
Experimental example
Diagnostic criteria
With reference to the acute gouty arthritis diagnostic criteria of American Rheumatism Association's formulation in 1977.1. acute arthritis is shown effect more than 1 time, namely reaches outbreak peak in 1d; 2. acute arthritis is confined to indivedual joint; 3. whole joint is kermesinus; 4. hallux arthralgia; 5. the scorching acute attack of one-sided tarsal joint; 6. tophus is had; 7. hyperuricemia; 8. asymmetry arthralgia; 9. outbreak can self termination.All possess more than 3, can make a definite diagnosis.
Inclusive criteria
Meet diagnostic criteria, in blood test, numeration of leukocyte increases, and Uric Acid Content obviously raises, and erythrocyte sedimentation rate is accelerated, and hepatic and renal function is without exception.
Exclusion standard
1. cardiovascular and cerebrovascular vessel, Liver and kidney and hemopoietic system and severe primary disease patient is merged.2. lopsided, stiff, the disability person of advanced joint severe.
Selector close standard of stating patient 50 example, man 25 example, female 25 example, the mean age is 38 years old.The ointment using embodiment to prepare is treated, and every day 2 times, at every turn for the ointment of sore place uniform application 1 pipe.
Curative effect determinate standard
1. effective: arthralgia swelling disappears, movable normal; Effective: arthralgia, swelling alleviate, movable function takes a turn for the better; Invalid: arthralgia, swelling without improvement, movable function obstacle.2. the arthralgia relief time.Medication starts the time painless to joint.
Therapeutic outcome
Through treatment, find in 50 routine patients, effective 33 examples, effective 16 examples, invalid 1 example, total effective rate is 98%.The arthralgia relief time is 6.5 ± 1.5 hours, and swelling regression time is 5.5 ± 1.5 days.
Untoward reaction and toxic and side effects supervision
By detect patient blood pressure, pulse, whether there is Nausea and vomiting, dizzy clinical symptoms judges untoward reaction.Find that the systolic pressure of patient is between 90-140mmHg, diastolic pressure is between 60-90mmHg, and pulse is 60-100 beat/min, and blood pressure and pulse all within normal range, and does not occur Nausea and vomiting, dizzy clinical symptoms.This illustrates that pharmaceutical composition of the present invention does not have obvious untoward reaction, and then proves that medicine does not have obvious toxic and side effects for human body.
Model case
Yang, man, 43 years old, brings out me because of festive occasion surfeit seafood and institute treats.Look into: two ankle joint red and swollen heat pain, there is redness, touch a tender spot, cross mountains and go in right instep, suddenly have a blood test uric acid 695mmoL/L, erythrocyte sedimentation rate 59mm/h, and routine blood test shows numeration of leukocyte 12 × 10
9/ L.Diagnosis: acute gouty arthritis.The ointment using embodiment to prepare is treated, and every day 2 times, at every turn for the ointment of sore place uniform application 1 pipe.Treat pain after 5 hours to stop, disappearing at treatment 5 days posterior joint pain and swellings, movable normal.
Claims (6)
1. treat the pharmaceutical composition of acute gouty arthritis for one kind, it is characterized in that, it is made up by weight of following bulk drugs: bulbil half 50-100 part, Microsorium Link 50-100 part, Herba Pachysandrae Terminalis 50-200 part, Herba Abri 50-100 part, Radix Seu Caulis Rhaphidophorae Decursivae 50-100 part, Folium Perillae 10-50 part, Herba Thlaspis 50-100 part, Fructus Quisqualis 10-100 part, Auricularia 50-100 part, Fructus Phyllanthi 10-100 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 50-100 part, Herba Ainsliaeae Latifoliae 10-100 part, Radix Ampelopsis 10-100 part, Fructus Hippophae 50-100 part, Fructus Aurantii 10-100 part, Semen Vaccariae 10-50 part, Cortex Albiziae 50-100 part, Herba Epimedii 10-30 part, Flos Inulae 10-50 part, Fructus Fortunellae Margaritae 50-100 part, Fructus Aurantii Immaturus 50-100 part, Folium Hibisci Mutabilis 50-100 part, Semen Phaseoli 50-100 part and Radix Glycyrrhizae 50-100 part.
2. the pharmaceutical composition for the treatment of acute gouty arthritis according to claim 1, it is characterized in that, it is made up by weight of following bulk drugs: bulbil half 80 parts, Microsorium Link 70 parts, Herba Pachysandrae Terminalis 90 parts, Herba Abri 75 parts, Radix Seu Caulis Rhaphidophorae Decursivae 60 parts, Folium Perillae 40 parts, Herba Thlaspis 80 parts, Fructus Quisqualis 50 parts, 80 parts, Auricularia, Fructus Phyllanthi 50 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 80 parts, Herba Ainsliaeae Latifoliae 50 parts, Radix Ampelopsis 50 parts, Fructus Hippophae 60 parts, Fructus Aurantii 50 parts, Semen Vaccariae 30 parts, Cortex Albiziae 60 parts, Herba Epimedii 20 parts, Flos Inulae 40 parts, Fructus Fortunellae Margaritae 65 parts, Fructus Aurantii Immaturus 60 parts, Folium Hibisci Mutabilis 60 parts, 70 parts, Semen Phaseoli and 60 parts, Radix Glycyrrhizae.
3. the pharmaceutical composition for the treatment of acute gouty arthritis according to claim 2, is characterized in that, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or ointment.
4. the purposes of compositions in the medicine of preparation treatment acute gouty arthritis, it is characterized in that, described compositions is made up by weight of following bulk drugs: bulbil half 50-100 part, Microsorium Link 50-100 part, Herba Pachysandrae Terminalis 50-200 part, Herba Abri 50-100 part, Radix Seu Caulis Rhaphidophorae Decursivae 50-100 part, Folium Perillae 10-50 part, Herba Thlaspis 50-100 part, Fructus Quisqualis 10-100 part, Auricularia 50-100 part, Fructus Phyllanthi 10-100 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 50-100 part, Herba Ainsliaeae Latifoliae 10-100 part, Radix Ampelopsis 10-100 part, Fructus Hippophae 50-100 part, Fructus Aurantii 10-100 part, Semen Vaccariae 10-50 part, Cortex Albiziae 50-100 part, Herba Epimedii 10-30 part, Flos Inulae 10-50 part, Fructus Fortunellae Margaritae 50-100 part, Fructus Aurantii Immaturus 50-100 part, Folium Hibisci Mutabilis 50-100 part, Semen Phaseoli 50-100 part and Radix Glycyrrhizae 50-100 part.
5. purposes according to claim 4, it is characterized in that, described compositions is made up by weight of following bulk drugs: bulbil half 80 parts, Microsorium Link 70 parts, Herba Pachysandrae Terminalis 90 parts, Herba Abri 75 parts, Radix Seu Caulis Rhaphidophorae Decursivae 60 parts, Folium Perillae 40 parts, Herba Thlaspis 80 parts, Fructus Quisqualis 50 parts, 80 parts, Auricularia, Fructus Phyllanthi 50 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 80 parts, Herba Ainsliaeae Latifoliae 50 parts, Radix Ampelopsis 50 parts, Fructus Hippophae 60 parts, Fructus Aurantii 50 parts, Semen Vaccariae 30 parts, Cortex Albiziae 60 parts, Herba Epimedii 20 parts, Flos Inulae 40 parts, Fructus Fortunellae Margaritae 65 parts, Fructus Aurantii Immaturus 60 parts, Folium Hibisci Mutabilis 60 parts, 70 parts, Semen Phaseoli and 60 parts, Radix Glycyrrhizae.
6. purposes according to claim 5, is characterized in that, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or ointment.
Priority Applications (1)
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814215A (en) * | 2005-12-06 | 2006-08-09 | 四川亚泰药业有限责任公司 | Medicine for treating gout and gout arthritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814215A (en) * | 2005-12-06 | 2006-08-09 | 四川亚泰药业有限责任公司 | Medicine for treating gout and gout arthritis |
Non-Patent Citations (2)
| Title |
|---|
| 倪毓生: "四妙丸加味治疗急性痛风性关节炎34例", 《江苏中医》 * |
| 罗明: "黄宏兴教授治疗急性痛风性关节炎", 《吉林中医药》 * |
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Application publication date: 20150408 |