CN104490932A - Externally-used medicine for recovering burned cortical tissue and preparation method thereof - Google Patents
Externally-used medicine for recovering burned cortical tissue and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 17
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses an externally-used medicine for recovering a burned cortical tissue and a preparation method thereof. The externally-used medicine is prepared from the following raw materials in parts by weight: 3-8 parts of elephant skin, 10-15 parts of sulfur, 15-20 parts of sodium borate, 1-3 parts of borneol, 1-3 parts of musk, 20-30 parts of calamine, 20-30 parts of gypsum and 100-120 parts of sesame oil. The preparation method comprises the following steps: (1) putting the sulfur, the elephant skin, the sodium borate, the borneol, the calamine and the gypsum into a marmite, sealing the marmite by a porcelain bowl and totally sealing the joint of the porcelain bowl and the marmite with mud; (2) heating for half an hour by strong fire, subsequently heating for two hours by soft fire and cooling to room temperature; (3) opening the marmite, removing the medicine attached to the porcelain bowl, adding musk, uniformly mixing, grinding into powder and sieving by a sieve of which the size is 100 meshes to obtain medicine powder; (4) mixing the obtained medicine powder with the sesame oil according to a ratio of 1:20 to obtain an oily externally-used medicine for recovering the burned cortical tissue. The externally-used medicine disclosed by the invention has the advantages of being rapid in healing, good in treatment effect, capable of being used for recovering the burned cortical tissue and the like.
Description
Technical field
The invention belongs to external used medicine technical field, particularly relate to and a kind ofly bring back to life the external used medicine and preparation method thereof scalding burn cortical tissue.
Background technology
China scalds the every annual morbidity of burn and is about 1.5 ~ 2%, and namely about have 2,000 ten thousand people to suffer to scald burn in various degree every year, as can be seen here, boiling hot burn is common a kind of skin wound disease.Medical research shows, large area scalds burn can cause serious complication (as infected and shock) even threat to life.If treat not in time, then some can be caused to be difficult to the sequela (as scar hyperplasia, pigmentation etc.) of curing, and especially scar hyperplasia can bring huge misery to patient, and the lighter itches pain unbearably, function limitation; Severe one afunction, can't take care of oneself, cloudy day and night pruritus unbearably, had a strong impact on the orthobiosis of patient.Research finds, the extremely individual fire victim that is not scalded can secondary cicatrix place skin carcinoma after the several years, threat to life, therefore rationally treating in time the early stage of boiling hot burn, significant, never can adopt a casual attitude.
At present, the relevant report of the external used medicine for the treatment of burn is more, is all the Therapeutic Method of the combination of Chinese and Western medicine mostly, for the quick dispenser of focus, solve the misery of patient on the one hand as early as possible, isolate wound surface on the other hand, wound surface and air insulated are opened, avoids dry stimulation and cause infection to wait initiation symptom.As patent 2006100422278 discloses the ointment that wound is burnt in a kind for the treatment of containing rare earth, although achieve treatment and the combination of protecting from infection, employing rare earth element is sterilization factors, and it is expensive, and application is restricted; Patent CN 101537124 A discloses a kind of ointment for the treatment of burn and also achieves treatment and the combination of protecting from infection, but adopt vaseline to realize isolated air and wound surface, although can breed by anti-bacteria, this composition is chemical material, concerning patient, there is potential danger; MAYINGLONG MUSK HEMORRHOID UNGUENTUM adopts artificial Moschus, Calculus Bovis, Borneolum Syntheticum, Borax, Calamina, Margarita, succinum, vaseline, lanoline, diformazan evil vitriol to be material composition; realize the object of dispersing swelling and dissipating binds; but adopt vaseline as the effective ingredient of isolated air too, the object of safety, sterilization, isolation can not be reached.In a word, though external use burn treating medicine thing is scalded at present treatment antibacterial action in various degree, all there is the wound healing slowly problem such as slow, thus cause medication effect not obvious.
Summary of the invention
The object of the invention is to: provide a kind of and bring back to life external used medicine scalding burn cortical tissue and preparation method thereof, merge the technological means that air-isolation and sterilizing are integrated, and be added with the elephant leather promoting cortical tissue's restoration ecosystem, realize fast, efficiently curing scalding burn wound, and can reach and bring back to life burn cortical tissue, for the follow-up skin grafting of severe burn patients creates conditions.
To achieve these goals, the present invention adopts following technical scheme:
Bring back to life the external used medicine scalding burn cortical tissue, it is characterized in that: be made up of the raw material of following parts by weight: elephant leather 3 ~ 8 parts, 10 ~ 15 parts, sulfur, Borax 15 ~ 20 parts, Borneolum Syntheticum 1 ~ 3 part, 1 ~ 3 part, Moschus, Calamina 20 ~ 30 parts, 20 ~ 30 parts, Gypsum Fibrosum, Oleum sesami 100 ~ 120 parts.
As preferably, described a kind of external used medicine bringing back to life boiling hot burn cortical tissue, is characterized in that: be made up of the raw material of following parts by weight: elephant leather 5 parts, 12.5 parts, sulfur, Borax 18 parts, Borneolum Syntheticum 2 parts, 2 parts, Moschus, Calamina 25 parts, 25 parts, Gypsum Fibrosum, Oleum sesami 110 parts.
Further, the external used medicine that burn cortical tissue is scalded in described resurrection is prepared into oil preparation.
Another object of the present invention is to: provide a kind of preparation method of bringing back to life the external used medicine scalding burn cortical tissue, concrete steps are as follows:
1) sulfur of parts by weight described in above-mentioned formula, elephant leather, Borax, Borneolum Syntheticum, Calamina, Gypsum Fibrosum are put into marmite, then use china bowl capping, then with earth by china bowl and marmite junction completely closed;
2) to heat pharmacy, first heat half an hour with high heat, then heat recession in two hours from burning things which may cause a fire disaster with slow fire, naturally cool to room temperature;
3) open marmite and scrape the medicine overlayed in china bowl, then add appropriate Moschus, and evenly grind into powder and cross 100 mesh sieves, obtained medicated powder;
4) above-mentioned gained medicated powder and Oleum sesami are mixed up by 1:20, load in bottle, the external used medicine oil preparation of burn cortical tissue is scalded in obtained resurrection of the present invention.
Pharmic function and effect thereof:
Sulfur: external removing toxic substances parasite killing, treatment skin ulcer are antipruritic, after contact skin, form hydrogen sulfide and pentathionic acid, hydrogen sulfide has dissolving cutin, softening epidermis and depilation to skin; Pentathionic acid has parasite killing, antifungal effect;
Elephant leather: the property of medicine enter through: sweet, salty, temperature, promotion skin growth in have original effect.
Borax: external heat-clearing and toxic substances removing, detumescence, anticorrosion, has inhibitory action to multiple bacillus, also has protective effect to skin mucosa;
Borneolum Syntheticum: be commonly called as " Borneolum Syntheticum ", external has the effect of heat-clearing and toxic substances removing, pain relieving, granulation promoting, and its main component Borneolum Syntheticum and isoborneol also have antibacterial action;
Moschus: the effect having blood circulation promoting and dispersing pathogen accumulation, reducing swelling and alleviating pain, has antithrombase effect, and has weak platelet aggregation inhibitory action, and musk tincture diluent has inhibitory action to escherichia coli, staphylococcus aureus in vitro, and has stronger antiinflammatory action;
Calamina: main containing zinc carbonate and a small amount of magnesium, ferrum, calcium etc., have removing dampness, antipruritic, sore and in and the effect of skin acid secretions, and can suppress locally staphylococcic growth.
Medication mechanism: the pathologic lesion main manifestations scalding burn is concentrically ringed three bands, i.e. downright bad band, blood stasis and stagnant zone, congested band, the wherein stagnant pathological process often presenting necrosis progrediens of the stasis of blood, proper application of the present invention makes congested band and blood stasis and stagnant zone recover as soon as possible and reach physiological reparation state, prevent it from developing to darker or worse pathological change, and the cell that coagulation band part is at death's door can be activated, do not allow it that irreversible damage occurs, thus reach the object of bringing back to life burn cortical tissue.
Administrated method: after wound surface does necessary clean, dip medicine of the present invention with brush pen and be applied to wound surface, bleb skin avulsion wound-surface plaster one deck sterile gauze, repastes burn medicine of the present invention, can adopt ultraviolet partly sterilised half an hour when wound surface oozes out too much.
Compared with the external used medicine scalding burn with existing treatment, the present invention take Oleum sesami as medium, and by wound surface and air exclusion, can avoid dry stimulation or the infection of the pathogenic bacteria degree of depth, be again natural safe composition, patient can relievedly use simultaneously; Also merge the ingredient of pain relieving granulation promoting, impel the fast quick-recovery of wound surface and reach physiological reparation state, and then wound surface becomes fresh granulation tissue, the lighter can cure completely, then provide necessary skin-grafting to prepare for large-area deep burn, its beneficial effect is as follows:
1) adopt combination therapy of Chinese and western method, determined curative effect, patient pain are gently, misery is little, the course of disease is short, has higher learning value and practical value.
2) for the dermal tissue insult that boiling hot burnt degree causes, add granulation promoting active ingredient, impel the fast quick-recovery of wound surface and reach physiological reparation state, make after healing fresh attractive in appearance without cicatrix, skin histology.
Detailed description of the invention
Be described further below in conjunction with instantiation, be intended to make object of the present invention, technical scheme and advantage clearly, understand, do not limit interest field of the present invention.
Embodiment 1
Bring back to life the external used medicine scalding burn cortical tissue, be prepared into oil preparation, be made up of the raw material of following parts by weight: elephant leather 3 parts, 10 parts, sulfur, Borax 15 parts, Borneolum Syntheticum 1 part, 1 part, Moschus, Calamina 20 parts, 20 parts, Gypsum Fibrosum, Oleum sesami 100 parts;
Get the raw materials ready according to above-mentioned formula constituent, then adopt following steps to produce and form:
1) sulfur of parts by weight described in above-mentioned formula, elephant leather, Borax, Borneolum Syntheticum, Calamina, Gypsum Fibrosum are put into marmite, then use china bowl capping, then with earth by china bowl and marmite junction completely closed;
2) to heat pharmacy, first heat half an hour with high heat, then heat recession in two hours from burning things which may cause a fire disaster with slow fire, naturally cool to room temperature;
3) open marmite and scrape the medicine overlayed in china bowl, then add appropriate Moschus, and evenly grind into powder and cross 100 mesh sieves, medicated powder;
4) above-mentioned gained medicated powder and Oleum sesami are mixed up by 1: 20, load in bottle and can obtain oil preparation.
Embodiment 2
Bring back to life the external used medicine scalding burn cortical tissue, be made up of the raw material of following parts by weight: elephant leather 5 parts, 12.5 parts, sulfur, Borax 18 parts, Borneolum Syntheticum 2 parts, 2 parts, Moschus, Calamina 25 parts, 25 parts, Gypsum Fibrosum, Oleum sesami 110 parts.
Get the raw materials ready according to above-mentioned formula constituent, then adopt following steps to produce and form:
1) sulfur of parts by weight described in above-mentioned formula, elephant leather, Borax, Borneolum Syntheticum, Calamina, Gypsum Fibrosum are put into marmite, then use china bowl capping, then with earth by china bowl and marmite junction completely closed;
2) to heat pharmacy, first heat half an hour with high heat, then heat recession in two hours from burning things which may cause a fire disaster with slow fire, naturally cool to room temperature;
3) open marmite and scrape the medicine overlayed in china bowl, then add appropriate Moschus, and evenly grind into powder and cross 100 mesh sieves, medicated powder;
4) above-mentioned gained medicated powder and Oleum sesami are mixed up by 1: 20, load in bottle and can obtain oil preparation.
Embodiment 3
Bring back to life the external used medicine scalding burn cortical tissue, be made up of the raw material of following parts by weight: elephant leather 8 parts, 15 parts, sulfur, Borax 20 parts, Borneolum Syntheticum 3 parts, 3 parts, Moschus, Calamina 30 parts, 30 parts, Gypsum Fibrosum, Oleum sesami 120 parts.
Get the raw materials ready according to above-mentioned formula constituent, then adopt following steps to produce and form:
1) sulfur of parts by weight described in above-mentioned formula, elephant leather, Borax, Borneolum Syntheticum, Calamina, Gypsum Fibrosum are put into marmite, then use china bowl capping, then with earth by china bowl and marmite junction completely closed;
2) to heat pharmacy, first heat half an hour with high heat, then heat recession in two hours from burning things which may cause a fire disaster with slow fire, naturally cool to room temperature;
3) open marmite and scrape the medicine overlayed in china bowl, then add appropriate Moschus, and evenly grind into powder and cross 100 mesh sieves, medicated powder;
4) above-mentioned gained medicated powder and Oleum sesami are mixed up by 1: 20, load in bottle and can obtain oil preparation.
The using method of external used medicine of the present invention: after wound surface does necessary clean, dip medicine of the present invention with brush pen and be applied to wound surface, bleb skin avulsion wound-surface plaster one deck sterile gauze, repastes burn medicine of the present invention, can adopt ultraviolet partly sterilised half an hour when wound surface oozes out too much.Changed dressings every 10 ~ 12 hours, when changing dressings, wipe left drug and liquefied substance, expose topical agent, until recover from injury.
In order to verify the actual effect of medicine of the present invention, be illustrated below in conjunction with clinical trial.
Research institution and clinical trials unit: Anding District, Dingxi City China bus station, road Community Health Station scalds Department of B urn.
The judgment criteria adopted in clinical course is respectively in table 1 and table 2.
Table 1-scalds the criterion of the burn number of degrees
Table 2-scalds burn deciding degree standard
Object of study: the Dingxi City of matching medication and the light degree Ⅱ of surrounding area, dark II degree, III degree 306 example scald fire victim, according to burn age graduate as following table 3.
Table 3-treats the case age and scalds burn degree statistics
Therapeutic outcome and analysis: in table 4.
Table 4-therapeutic outcome and analysis
In order to further illustrate the actual availability of medicine of the present invention, following is a list part treat case.
Case 1: week certain, man, 32 years old, Dingxi, Gansu Qing Lan people from town, because both hands be wound by gunpowder, after outer court treats 15 days, hospital's suggestion cuts and refers to, patient and family members can not accept the fact of cutting and referring to, on July 8th, 2005 accepts external medication of the present invention, give external used medicine of the present invention after being admitted to hospital, and give the Comprehensive Treatment to the ill such as blood circulation promoting and nutritional support, fully recover after 30 days.
Case 2: poplar, man, 23 years old, burning diesel oil scalded face, accepts external medication of the present invention on July 9th, 2009, and gave antiinflammatory and to suit the medicine to the illness Supporting Therapy, fully recovered after 25 days.
Case 3: Tang, man, 50 years old, drunk rear scald buttocks, left heel, after outer court's treatment first quarter moon, accepted Drug therapy of the present invention on March 2nd, 2010, infection and necrosis wound surface when being admitted to hospital, recovery from illness after treatment in 30 days.
Case 4: Lee, female, 20 years old, capital jumped Hua Da Hotel Staff, Caustic soda scald after half an hour, within 10th, accept Drug therapy of the present invention in JIUYUE in 2010, wound surface downright bad, depression when being admitted to hospital, recovery from illness after treatment in 20 days.
Case 5: Lee, female, 78 years old, boiled water was scalded outside left knee joint, and after January is treated in locality, downright bad wound surface, blush around wound surface, limb pain can not land, and accepts Drug therapy of the present invention on April 15th, 2009, recovery from illness after treatment in 18 days.
Above clinical fact explanation, adopt Drug therapy of the present invention to burn and there is good effect, mainly because medicine of the present invention adopts Oleum sesami to be closed dielectric, can by wound surface and air insulated, avoid dry stimulation and cause infection, patient can relievedly use, and has merged again the wound healing medicines such as elephant leather, also can play the effect of sterilizing, prevent wound deterioration from infecting.
Claims (4)
1. bring back to life the external used medicine scalding burn cortical tissue, it is characterized in that: be made up of the raw material of following parts by weight: elephant leather 3 ~ 8 parts, 10 ~ 15 parts, sulfur, Borax 15 ~ 20 parts, Borneolum Syntheticum 1 ~ 3 part, 1 ~ 3 part, Moschus, Calamina 20 ~ 30 parts, 20 ~ 30 parts, Gypsum Fibrosum, Oleum sesami 100 ~ 120 parts.
2. a kind of external used medicine bringing back to life boiling hot burn cortical tissue as claimed in claim 1, is characterized in that: be made up of the raw material of following parts by weight: elephant leather 5 parts, 12.5 parts, sulfur, Borax 18 parts, Borneolum Syntheticum 2 parts, 2 parts, Moschus, Calamina 25 parts, 25 parts, Gypsum Fibrosum, Oleum sesami 110 parts.
3. a kind of external used medicine bringing back to life boiling hot burn cortical tissue as claimed in claim 1, is characterized in that: the external used medicine that burn cortical tissue is scalded in described bringing back to life is prepared into oil preparation.
4. the preparation method of the external used medicine of burn cortical tissue is scalded in a resurrection according to claim 1, it is characterized in that: concrete preparation process for: 1) sulfur of parts by weight described in above-mentioned formula, elephant leather, Borax, Borneolum Syntheticum, Calamina, Gypsum Fibrosum are put into marmite, then use china bowl capping, then with earth by china bowl and marmite junction completely closed; 2) to heat pharmacy, first heat half an hour with high heat, then heat recession in two hours from burning things which may cause a fire disaster with slow fire, naturally cool to room temperature; 3) open marmite and scrape the medicine overlayed in china bowl, then add appropriate Moschus, and evenly grind into powder and cross 100 mesh sieves, obtained medicated powder; 4) above-mentioned gained medicated powder and Oleum sesami are mixed up by 1: 20, the external used medicine of burn cortical tissue is scalded in the resurrection loading obtained oil preparation in bottle.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107046A (en) * | 1994-01-19 | 1995-08-23 | 俞初忠 | Chinese proprietary medicine for curing scalding |
| CN1528413A (en) * | 2003-10-14 | 2004-09-15 | 华 阎 | Medicine for treating bum, empyrosis and bedsore |
| CN1695661A (en) * | 2004-08-31 | 2005-11-16 | 黄庙春 | Powder for treating burn |
| CN1935159A (en) * | 2006-09-18 | 2007-03-28 | 吴方忠 | Chinese medicine composition for treating burn, empyrosis and bodysurface ulcer and its preparing method |
-
2014
- 2014-12-29 CN CN201410838042.2A patent/CN104490932B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107046A (en) * | 1994-01-19 | 1995-08-23 | 俞初忠 | Chinese proprietary medicine for curing scalding |
| CN1528413A (en) * | 2003-10-14 | 2004-09-15 | 华 阎 | Medicine for treating bum, empyrosis and bedsore |
| CN1695661A (en) * | 2004-08-31 | 2005-11-16 | 黄庙春 | Powder for treating burn |
| CN1935159A (en) * | 2006-09-18 | 2007-03-28 | 吴方忠 | Chinese medicine composition for treating burn, empyrosis and bodysurface ulcer and its preparing method |
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| CN104490932B (en) | 2018-03-06 |
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