CN104482720B - A kind of low-temp low-pressure freeze-drying method of Radix Notoginseng chewable tablet - Google Patents
A kind of low-temp low-pressure freeze-drying method of Radix Notoginseng chewable tablet Download PDFInfo
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- CN104482720B CN104482720B CN201410697677.5A CN201410697677A CN104482720B CN 104482720 B CN104482720 B CN 104482720B CN 201410697677 A CN201410697677 A CN 201410697677A CN 104482720 B CN104482720 B CN 104482720B
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Abstract
The invention discloses the low-temp low-pressure freeze-drying method of a kind of Radix Notoginseng chewable tablet, comprise the following steps: (1) pretreatment: by fresh Radix Notoginseng main root, clean, drain well；Section, sprays tea polyphenols aqueous solution and sugar aqueous solution on Radix Notoginseng Tabellae；(2) precooling: the Radix Notoginseng Tabellae that step (1) obtains is placed in vacuum desiccator, is cooled to-30 DEG C～-40 DEG C, make Radix Notoginseng Tabellae freeze；(3) vacuum lyophilization: to vacuum desiccator evacuation, making pressure was 10-20Pa, keeps 1～2 hour, heating, made temperature rise to 0 DEG C from-30 DEG C～-40 DEG C at 20～30 hours, reheats, made temperature rise to 20 DEG C from 0 DEG C at 2～4 hours；Take out from vacuum desiccator, obtain Radix Notoginseng chewable tablet.The method cost of the present invention is low, the Radix Notoginseng chewable tablet of preparation, it is possible to be effectively retained active constituent content, it is ensured that good dried frozen aquatic products outward appearance shape, mouthfeel is good.
Description
Technical field
The present invention relates to the manufacture method of a kind of Radix Notoginseng Tabellae, particularly relate to the low-temp low-pressure freeze-drying method of a kind of Radix Notoginseng chewable tablet.
Background technology
The Radix Notoginseng plantation history of existing more than 400 year, it is a jewel in Chinese Medicine treasure-house, is the treasure generally acknowledged both at home and abroad.Radix Notoginseng contains the several physiological active substances such as VB, VE of tens kinds of Saponins, ten several amino acids, ten various trace elements, tens kinds of volatile oil and Radix Notoginseng polysaccharide, Radix Notoginseng flavone and needed by human.Principle active component at high temperature easily decomposes, and causes the loss of bioactive substance in Radix Notoginseng, makes the drug effect of Radix Notoginseng decline.Modern medicine and pharmaceutical research find: Radix Notoginseng has significantly to be expanded blood vessel, increase coronary flow, attenuating coronary resistance and reduces the function of myocardial oxygen consumption；Nervus centralis is had certain inhibitory action；Radix Notoginseng has immunoregulation effect, and tumor cell is had obvious inhibitory action by Radix Notoginseng.
Adopting the Radix Notoginseng that commonsense method dries, baking temperature is too high, and long-time exposure in atmosphere, can cause the destruction of active component, effective ingredient.Too hard plus the Radix Notoginseng dried or dry, difficult pulverizing, in-convenience in use, and mouthfeel is too bitter, and a lot of consumers are all difficult to accept.And fresh Radix Notoginseng due to transport, store difficulty, add the restriction in buying season, and mouthfeel be too bitter, the use scope of restriction Radix Notoginseng.
The domestic Radix Notoginseng also having some patents to adopt Freeze Drying Technique processing fresh at present, resolution temperature, up to 120 DEG C, is difficult to keep the effective ingredient of Radix Notoginseng.
Inventor adopts existing freeze drying technology that Radix Notoginseng Tabellae carries out discovery during lyophilizing, although adopting existing lyophilizing technique can reduce the loss of the compositions such as R1, Rg1, Rb1, but the Radix Notoginseng Tabellae after lyophilizing can deform or drum or white patches on surface are played in sliver or surface, can not more fully keep health product original state, affect lyophilizing Radix Notoginseng Tabellae outward appearance and the later stage sells.It addition, in some method, also boil Radix Notoginseng to scald before lyophilizing and kill enzyme, due to the existence of hot conditions, too increase the loss amount of R1, Rg1, Rb1.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that one can keep compound components of panax notoginseng, nutritional labeling, appearance luster not to destroy and maintain health product original state, the low-temp low-pressure freeze-drying method of the Radix Notoginseng chewable tablet that mouthfeel is suitable.
Technical scheme is summarized as follows:
The low-temp low-pressure freeze-drying method of a kind of Radix Notoginseng chewable tablet, comprises the following steps:
(1) pretreatment: by fresh Radix Notoginseng, obtains main root after removing fibrous root, floss root and clip, with sterile water wash, drain well；Cut into slices sheet thickness is the Radix Notoginseng Tabellae of 2-5mm, on Radix Notoginseng Tabellae spray mass concentration be 5%～20% tea polyphenols aqueous solution and mass concentration be the sugar aqueous solution of 1%～60%, the mass ratio of described Radix Notoginseng Tabellae and tea polyphenols aqueous solution, sugar aqueous solution is (1～4) 11；
(2) precooling: the Radix Notoginseng Tabellae that step (1) obtains is placed in vacuum desiccator, is cooled to-30 DEG C～-40 DEG C, make Radix Notoginseng Tabellae freeze；
(3) vacuum lyophilization: to vacuum desiccator evacuation, making pressure was 10-20Pa, keeps 1～2 hour, heating, made temperature rise to 0 DEG C from-30 DEG C～-40 DEG C at 20～30 hours, reheats, made temperature rise to 20 DEG C from 0 DEG C at 2～4 hours；Take out from vacuum desiccator, obtain Radix Notoginseng chewable tablet.
Step (1) pretreatment is preferably: by fresh Radix Notoginseng, obtains main root, with sterile water wash, drain well after removing fibrous root, floss root and clip；Cutting into slices to obtain Radix Notoginseng Tabellae, spray tea polyphenols aqueous solution that mass concentration is 10% and mass concentration is the sugar aqueous solution of 20% on Radix Notoginseng Tabellae, the mass ratio of described Radix Notoginseng Tabellae and tea polyphenols aqueous solution, sugar aqueous solution is 211.
Step (3) vacuum lyophilization was preferably: to vacuum desiccator evacuation, making pressure is 15Pa, keeps 1.5 hours, heating, made temperature rise to-1 DEG C from-30 DEG C at 25 hours, reheats, made at 3 hours temperature rise to 20 DEG C from-1 DEG C；Take out from vacuum desiccator, obtain Radix Notoginseng chewable tablet.
Sugar is preferably sucrose, fructose, glucose, sucralose, stevia glucoside, maltose alcohol or xylitol.
Advantages of the present invention:
Radix Notoginseng chewable tablet prepared by the method for the present invention, it is possible to be effectively retained active constituent content, it is ensured that good dried frozen aquatic products outward appearance shape, mouthfeel is good.
The method of the present invention is under meeting the premise of outward appearance and product quality, and freeze drying rate is high, effectively saves freeze-drying time, and production cost is low.
Accompanying drawing explanation
Radix Notoginseng chewable tablet photo prepared by the method for Fig. 1 present invention.
The photo of the Radix Notoginseng Tabellae prepared during Fig. 2 vacuum 30Pa.
Detailed description of the invention
The tea polyphenols that each embodiment adopts is that commercially available prod polyphenol content is more than 95%.
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
The low-temp low-pressure freeze-drying method of a kind of Radix Notoginseng chewable tablet, comprises the following steps:
(1) pretreatment: by fresh Radix Notoginseng, obtains main root after removing fibrous root, floss root and clip, with sterile water wash, drain well；Cut into slices sheet thickness is the Radix Notoginseng Tabellae of 3mm, on Radix Notoginseng Tabellae spray mass concentration be 10% tea polyphenols aqueous solution and mass concentration be the aqueous sucrose solution of 20%, the mass ratio of described Radix Notoginseng Tabellae and tea polyphenols aqueous solution, aqueous sucrose solution is 211；
(2) precooling: by step 1) Radix Notoginseng Tabellae that obtains is placed in vacuum desiccator, and it is cooled to-35 DEG C, makes Radix Notoginseng Tabellae freeze；
(3) vacuum lyophilization: to vacuum desiccator evacuation, making pressure was 15Pa, keeps 1.5 hours, heating, made temperature rise to 0 DEG C from-35 DEG C at 25 hours, reheats, made at 3 hours temperature rise to 20 DEG C from 0 DEG C；Take out from vacuum desiccator, obtain Radix Notoginseng chewable tablet.Moisture is 3%, sees Fig. 1.
When evacuation in step (3), making pressure is 30Pa, and other Radix Notoginseng chewable tablet prepared with the present embodiment is shown in Fig. 2.
Embodiment 2
The low-temp low-pressure freeze-drying method of a kind of Radix Notoginseng chewable tablet, comprises the following steps:
(1) pretreatment: by fresh Radix Notoginseng, obtains main root after removing fibrous root, floss root and clip, with sterile water wash, drain well；Cut into slices sheet thickness is the Radix Notoginseng Tabellae of 2mm, on Radix Notoginseng Tabellae, spray tea polyphenols aqueous solution and fructose water solution that mass concentration is 60% that mass concentration is 5%, the mass ratio of described Radix Notoginseng Tabellae and tea polyphenols aqueous solution, fructose water solution is 111；
(2) precooling: by step 1) Radix Notoginseng Tabellae that obtains is placed in vacuum desiccator, and it is cooled to-30 DEG C, makes Radix Notoginseng Tabellae freeze；
(3) vacuum lyophilization: to vacuum desiccator evacuation, making pressure was 10Pa, keeps 1 hour, heating, made temperature rise to 0 DEG C from-30 DEG C at 20 hours, reheats, made at 2 hours temperature rise to 20 DEG C from 0 DEG C；Taking out from vacuum desiccator, obtain Radix Notoginseng chewable tablet, moisture is 6%.
The low-temp low-pressure freeze-drying method of 3 one kinds of Radix Notoginseng chewable tablet of embodiment, comprises the following steps:
(1) pretreatment: by fresh Radix Notoginseng, obtains main root after removing fibrous root, floss root and clip, with sterile water wash, drain well；Cut into slices sheet thickness is the Radix Notoginseng Tabellae of 5mm, on Radix Notoginseng Tabellae spray mass concentration be 20% tea polyphenols aqueous solution and mass concentration be the aqueous solution of sucrose trichloride of 1%, the mass ratio of described Radix Notoginseng Tabellae and tea polyphenols aqueous solution, aqueous solution of sucrose trichloride is 411；
(2) precooling: by step 1) Radix Notoginseng Tabellae that obtains is placed in vacuum desiccator, and it is cooled to-40 DEG C, makes Radix Notoginseng Tabellae freeze；
(3) vacuum lyophilization: to vacuum desiccator evacuation, making pressure was 20Pa, keeps 2 hours, heating, made temperature rise to 0 DEG C from-40 DEG C at 30 hours, reheats, made at 4 hours temperature rise to 20 DEG C from 0 DEG C；Taking out from vacuum desiccator, obtain Radix Notoginseng chewable tablet, moisture is 2%.
The Radix Notoginseng chewable tablet that the present invention prepares loads in clean packaging, and nitrogen packaging is packed or rushed to airtight vacuum, makes Radix Notoginseng chewable tablet more stable in storage process, and the shelf-life is longer,
After testing, in the Radix Notoginseng chewable tablet that embodiment 1 prepares, Panax Notoginseng saponin R l, ginsenoside Rg l, ginsenoside Re, ginsenoside Rb1, ginsenoside Rd mass content respectively 1.18%, 3.65%, 0.43%, 3.32%, 0.74%.In fresh Radix Notoginseng, Panax Notoginseng saponin R l, ginsenoside Rg l, ginsenoside Re, ginsenoside Rb1, ginsenoside Rd content respectively 1.16%, 3.67%, 0.44%, 3.31%, 0.72%.Adopt in the dry Radix Notoginseng that conventional drying process (drying) prepares, Panax Notoginseng saponin R l, ginsenoside Rg l, ginsenoside Re, ginsenoside Rb1, ginsenoside Rd content respectively 0.8%, 2.4%, 0.32%, 2.45%, 0.51%.
Show that Radix Notoginseng chewable tablet effective ingredient prepared by the method for the present invention does not change substantially by comparing, and adopt pass conventional drying process prepare Radix Notoginseng in effective ingredient suppression ratio more apparent.
The present invention sprays antioxidant tea polyphenols aqueous solution at pretreatment stage, it is to avoid at pretreatment stage, deliver from godown the chemical changes such as oxidation that stage, packing stage and air contact cause after drying.Spray sugar aqueous solution and significantly improve Radix Notoginseng bitterness, make consumer more receptive.
In the method for the present invention, control at 0 DEG C and following in sublimation drying phase temperature, temperature rise period controls at 20 DEG C and following, vacuum degree control is at 20Pa and following, thus the quality deterioration reaction such as effective ingredient oxidation, volatile oil and other heat-sensitive substances that Radix Notoginseng occurs in dry run can be avoided destroyed.Further, since the passivation of the reduction of chemical reaction velocity and enzyme under low temperature, almost without the browning phenomenon caused by enzyme and aminoacid in freezing dry process, it is ensured that outward appearance, color and luster after notoginseng drying are consistent with fresh Radix Notoginseng, and drug effect, quality do not change.
The method that the present invention adopts, sublimation drying phase temperature controls at 0 DEG C and following, vacuum degree control is at 20Pa and following, sublimation drying phases-time controls at more than 20-30h, ensure that whole freeze-drying process is all carried out below at eutectic point, thus avoid because too fast, the vacuum of heating up plays drum (see Fig. 2) more than the 20Pa deformation caused or sliver or surface, it is to avoid cause Surface hardened layer and nutrition to be gathered in surface because internal batch moisture, to surface migration, inorganic salt and nutrient is carried to material surface white macula occurs.
As seen from Figure 2, when vacuum is more than 20Pa, although freeze-drying time can be shortened, but Radix Notoginseng chewable tablet shape produces substantially to change, and has the phenomenons such as crackle, fold and flexural deformation；And Radix Notoginseng chewable tablet surfacing prepared by the inventive method, corrugationless deformation and sliver phenomenon, its shape size and appearance luster and health product Radix Notoginseng are almost without difference (see Fig. 1).
It is demonstrated experimentally that embodiment 2, embodiment 3 preparation a kind of Radix Notoginseng chewable tablet in Panax Notoginseng saponin R l, ginsenoside Rg l, ginsenoside Re, ginsenoside Rb1, ginsenoside Rd's content respectively to embodiment 1 preparation Radix Notoginseng chewable tablet similar.
Claims (4)
1. a low-temp low-pressure freeze-drying method for Radix Notoginseng chewable tablet, is characterized in that comprising the following steps:
(1) pretreatment: by fresh Radix Notoginseng, obtains main root after removing fibrous root, floss root and clip, with sterile water wash, drain well；Cutting into slices to obtain Radix Notoginseng Tabellae, spray tea polyphenols aqueous solution that mass concentration is 5%～20% and mass concentration is the sugar aqueous solution of 1%～60% on Radix Notoginseng Tabellae, the mass ratio of described Radix Notoginseng Tabellae and tea polyphenols aqueous solution, sugar aqueous solution is (1～4) 11；
(2) precooling: the Radix Notoginseng Tabellae that step (1) obtains is placed in vacuum desiccator, is cooled to-30 DEG C～-40 DEG C, make Radix Notoginseng Tabellae freeze；
(3) vacuum lyophilization: to vacuum desiccator evacuation, making pressure was 10-20Pa, keeps 1～2 hour, heating, made temperature rise to 0 DEG C from-30 DEG C～-40 DEG C at 20～30 hours, reheats, made temperature rise to 20 DEG C from 0 DEG C at 2～4 hours；Take out from vacuum desiccator, obtain Radix Notoginseng chewable tablet.
2. the low-temp low-pressure freeze-drying method of a kind of Radix Notoginseng chewable tablet according to claim 1, it is characterized in that described step (1) pretreatment is: by fresh Radix Notoginseng, main root is obtained, with sterile water wash, drain well after removing fibrous root, floss root and clip；Cutting into slices to obtain Radix Notoginseng Tabellae, spray tea polyphenols aqueous solution that mass concentration is 10% and mass concentration is the sugar aqueous solution of 20% on Radix Notoginseng Tabellae, the mass ratio of described Radix Notoginseng Tabellae and tea polyphenols aqueous solution, sugar aqueous solution is 211.
3. the low-temp low-pressure freeze-drying method of a kind of Radix Notoginseng chewable tablet according to claim 1, it is characterized in that described step (3) vacuum lyophilization is: to vacuum desiccator evacuation, making pressure is 15Pa, keep 1.5 hours, heating, made at 25 hours temperature rise to 0 DEG C from-30 DEG C, reheat, made at 3 hours temperature rise to 20 DEG C from 0 DEG C；Take out from vacuum desiccator, obtain Radix Notoginseng chewable tablet.
4. the low-temp low-pressure freeze-drying method of a kind of Radix Notoginseng chewable tablet according to claim 1 and 2, is characterized in that described sugar is sucrose, fructose, glucose, sucralose, stevia glucoside, maltose alcohol or xylitol.
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| CN106643005A (en) * | 2015-07-29 | 2017-05-10 | 广西梧州制药（集团）股份有限公司 | Application of tert-butyl alcohol in freeze drying process of panax notoginseng saponins or composition thereof |
| CN107455531A (en) * | 2017-09-12 | 2017-12-12 | 昆明电掣广告有限公司 | A kind of lyophilized Baggeed pseudo-ginseng powder tea and preparation method thereof |
| CN107736545A (en) * | 2017-10-27 | 2018-02-27 | 云南师宗凤凰谷食品有限责任公司 | A kind of vacuum freeze-drying method of food and medicine rhizome |
| CN108613940B (en) * | 2018-05-04 | 2020-01-07 | 黑龙江神守药业有限公司 | Panax notoginseng freeze-drying processing system and control method thereof |
| CN111595108A (en) * | 2020-06-01 | 2020-08-28 | 云南昊辰食品有限公司 | Vacuum freeze-drying method for preserving effective components in angelica sinensis medicinal material |
| CN112229148A (en) * | 2020-10-21 | 2021-01-15 | 湖北金贵中药饮片有限公司 | Vacuum freeze-drying method for pseudo-ginseng and application thereof |
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