CN104478675B - One class contains derivative and the purposes of alkoxyphenyl radical and fluoroform phenyl propylene glycol structure - Google Patents
One class contains derivative and the purposes of alkoxyphenyl radical and fluoroform phenyl propylene glycol structure Download PDFInfo
- Publication number
- CN104478675B CN104478675B CN201510021675.9A CN201510021675A CN104478675B CN 104478675 B CN104478675 B CN 104478675B CN 201510021675 A CN201510021675 A CN 201510021675A CN 104478675 B CN104478675 B CN 104478675B
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- CN
- China
- Prior art keywords
- compound
- present
- propylene glycol
- glycol structure
- sglt2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *Oc1ccc(Cc2cc(C[C@](CO)O)ccc2*C2)c2c1 Chemical compound *Oc1ccc(Cc2cc(C[C@](CO)O)ccc2*C2)c2c1 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/28—Preparation of ethers by reactions not forming ether-oxygen bonds from acetals, e.g. by dealcoholysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
- C07F1/02—Lithium compounds
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Compound number | IC 50(hSGLT2,nM) |
Reference compound D-1 | 19.5 |
I-1 | 9.3 |
I-2 | 12.6 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510021675.9A CN104478675B (en) | 2015-01-15 | 2015-01-15 | One class contains derivative and the purposes of alkoxyphenyl radical and fluoroform phenyl propylene glycol structure |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510021675.9A CN104478675B (en) | 2015-01-15 | 2015-01-15 | One class contains derivative and the purposes of alkoxyphenyl radical and fluoroform phenyl propylene glycol structure |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104478675A CN104478675A (en) | 2015-04-01 |
CN104478675B true CN104478675B (en) | 2016-01-06 |
Family
ID=52753311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510021675.9A Active CN104478675B (en) | 2015-01-15 | 2015-01-15 | One class contains derivative and the purposes of alkoxyphenyl radical and fluoroform phenyl propylene glycol structure |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104478675B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102387783A (en) * | 2009-02-13 | 2012-03-21 | 贝林格尔.英格海姆国际有限公司 | Pharmaceutical composition comprising glucopyranosyl diphenylmethane derivatives, pharmaceutical dosage form thereof, process for their preparation and uses thereof for improved glycemic control in a patient |
CN103596564A (en) * | 2011-06-01 | 2014-02-19 | 株式会社绿十字 | Novel diphenylmethane derivatives as SGLT2 inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013152476A1 (en) * | 2012-04-10 | 2013-10-17 | Theracos, Inc. | Process for the preparation of benzylbenzene sglt2 inhibitors |
DK2925735T3 (en) * | 2012-11-20 | 2019-06-17 | Lexicon Pharmaceuticals Inc | Inhibitors of sodium glucose co-transporter 1 |
-
2015
- 2015-01-15 CN CN201510021675.9A patent/CN104478675B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102387783A (en) * | 2009-02-13 | 2012-03-21 | 贝林格尔.英格海姆国际有限公司 | Pharmaceutical composition comprising glucopyranosyl diphenylmethane derivatives, pharmaceutical dosage form thereof, process for their preparation and uses thereof for improved glycemic control in a patient |
CN103596564A (en) * | 2011-06-01 | 2014-02-19 | 株式会社绿十字 | Novel diphenylmethane derivatives as SGLT2 inhibitors |
Non-Patent Citations (1)
Title |
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SGLT2 抑制剂Canagliflozin——Ⅱ型糖尿病治疗的新药;曾要富等;《中国现代应用药学》;20140930;第31卷(第9期);第1154-1160页 * |
Also Published As
Publication number | Publication date |
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CN104478675A (en) | 2015-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Class of derivative containing alcoxyl phenyl group and fluoroform phenyl group propylene glycol structure and application of class of derivative containing alcoxyl phenyl group and fluoroform phenyl group propylene glycol structure Effective date of registration: 20170816 Granted publication date: 20160106 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190604 Granted publication date: 20160106 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20191016 Address after: 225321 No. 21 Gangcheng Road, Gaogang District, Taizhou City, Jiangsu Province Patentee after: Sun Jian Chun Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |