CN104474505A - Nepeta cataria-containing zingiber officinale roscoe crystal particles and preparation method thereof - Google Patents

Nepeta cataria-containing zingiber officinale roscoe crystal particles and preparation method thereof Download PDF

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CN104474505A
CN104474505A CN201410702834.7A CN201410702834A CN104474505A CN 104474505 A CN104474505 A CN 104474505A CN 201410702834 A CN201410702834 A CN 201410702834A CN 104474505 A CN104474505 A CN 104474505A
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rhizoma zingiberis
zingiberis recens
herb
herba schizonepetae
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徐国华
林国友
韦玲菊
陈程
谢美萱
黄南概
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    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses nepeta cataria-containing zingiber officinale roscoe crystal particles. The nepeta cataria-containing zingiber officinale roscoe crystal particles are mainly prepared from the following ingredients in parts by weight: 15-40 parts of zingiber officinale roscoe extract, 2-5 parts of nepeta cataria powder, 1-3 parts of elsholtzia ciliata powder, 5-10 parts of honey and 50-75 parts of cane sugar, wherein the zingiber officinale roscoe extract is a product obtained through cleaning zingiber officinale roscoe, drying, crushing, adding water, carrying out ultrasonic extraction, clarifying, filtrating and concentrating. The zingiber officinale roscoe crystal particles are simple in production processing technology and low in cost, can be used for effectively preventing and treating wind-cold type cold, and have remarkable pathogenic wind and cold expelling effects.

Description

A kind of Jiang Jing granule containing Herba Schizonepetae and preparation method thereof
Technical field
The present invention relates to a kind of can the daily health caring beverage granule of preventing common cold flu, be specifically related to a kind of Jiang Jing granule containing Herba Schizonepetae and preparation method.
Background technology
Along with the Working Life rhythm of people is constantly accelerated, the pressure that people bear constantly increases, and work and rest diet aspect does not more and more have rule, causes the resistance of a lot of people, immunity constantly declines, and becomes typical subhealth state colony.And subhealth state colony major part is all working clan, when being warm, like blowing facing to air-conditioning or fan; When being cold, do not note again warming; Therefore, these people extremely have an aptitude to anemofrigid cold.In addition, present weather is always changeable, for a moment fine rain for a moment, and the people of some uncomfortable band umbrellas of going out easily is caught in the rain, if can not change medicated clothing in time, also has an aptitude to anemofrigid cold.But, society there is a kind of saying do not advocated somewhat little flu and just take medicine, have an injection a few days ago, and accepted by many people (especially youngster), but if do not taken medicine, likely can cause heavy cold; Thus, market has occurred that some are not that medicine but can the beverage of preventing cold or electuary granule.
Rhizoma Zingiberis Recens (Classification system Zingiber officinale Roscoe) is the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens, and another name has race, hundred peppery clouds, hook dress refers to, because of pungent, the hot and cold boy in ground, fresh ginger, processed with honey Rhizoma Zingiberis Recens.The rhizome (Rhizoma Zingiberis) of Rhizoma Zingiberis Recens, cork (Cortex Zingiberis), leaf (Folium Zingiberis) all can be used as medicine.Rhizoma Zingiberis Recens have in Chinese medicine and pharmacy disperse, preventing or arresting vomiting, the effect such as cough-relieving.CORTEX ZINGIBERIS RHIZOMAE is pungent cool, controls skin edema, the row severe edema due to hypofunction of the spleen; The pungent temperature of Rhizoma Zingiberis Recens juice, pungent loose cold syndrome of the stomach strength is strong, is used for vomiting; The pungent temperature of Rhizoma Zingiberis, warming middle-JIAO is instigated cold, and recuperating depleted YANG is promoted blood circulation, and warming the spleen trembles with fear strength greatly, and Rhizoma Zingiberis Preparatum acrid in the mouth hardship does not walk table in walking, and the warm part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is cold; Carbonized Rhizoma Zingiberis (processed) is warm in nature, and relatively homoiothermy divides cold; The bitter temperature of Roast Rhizoma Zingiberis Recens, relatively warming intestines and stomach is cold.Pungent and the loose temperature of Rhizoma Zingiberis Recens, strengthening the spleen stomach, kind warming middle-JIAO to send down the adverse QI preventing or arresting vomiting, dehumidify the painful abdominal mass that disappears, and eliminating phlegm and stopping cough take stopping nausea and vomiting by lowering the adverse flow of QI as length.
Effect that Rhizoma Zingiberis Recens possesses wind dispelling cold relieving is well known, and when catching cold, people are also accustomed to boiling ginger syrup and drink.But it is cumbersome to boil ginger syrup, catch cold during operation, ginger syrup cannot be obtained in time and drink.For this reason, namely people's production and processing one rushes formula Rhizoma Zingiberis Recens Icing Sugar.If Chinese Patent Application No. is 201110307474.7 disclose a kind of Jiang Jing and production technology thereof, form primarily of ginger powder, brown sugar and Mel, brown sugar pulverizing is added Mel mixing, dries 2 hours through 90 DEG C, drying room, then mix with ginger powder, dry, pulverizing, packaging.This product can allow people rush anywhere or anytime and drink ginger syrup, convenient and swift; But still come with some shortcomings, as directly adopted ginger powder, in it, effective ingredient " (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone " comparision contents of wind dispelling cold relieving is few, and for single effective ingredient the more weak people of body constitution dispel cold effect not soon, obvious not.Therefore, market being badly in need of one has plurality of active ingredients mating reaction, makes wind dispelling cold relieving better effects if namely rush formula Jiang Jing faster.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, provide a kind of Jiang Jing granule and the preparation method that effectively can prevent and treat anemofrigid cold, wind dispelling cold relieving better effects and if contain Herba Schizonepetae faster.This Jiang Jing granule, except having (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone, also has the composition such as Herba Schizonepetae, Herba Moslae, and complement each other for control anemofrigid cold, wind dispelling cold relieving Be very effective is obvious.
To achieve these goals, present invention employs following technical scheme:
Containing a Jiang Jing granule for Herba Schizonepetae, each component primarily of following parts by weight ratio is formulated: Rhizoma Zingiberis Recens extract 15 ~ 40 parts, Fineleaf Schizonepeta Herb 2 ~ 5 parts, Chinese Mosla Herb 1 ~ 3 part, Mel 5 ~ 10 parts and sucrose 50 ~ 75 parts; Described Rhizoma Zingiberis Recens extract be by Rhizoma Zingiberis Recens through cleaning, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, concentrated after the product that obtains.
In the present invention, preparation raw material Rhizoma Zingiberis Recens is through pretreatment (pulverizing, ultrasonic extraction, concentrated etc.), and making contained by final granule finished product basic is effective ingredient, does not have too much impurity; And it can the effective ingredient out (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone of wind dispelling cold relieving, and also have Herba Schizonepetae, Herba Moslae etc., each effective ingredient complements each other, together synergism, makes the effect of Jiang Jing granule wind dispelling cold relieving of the present invention more remarkable obvious.
The present invention utilizes the effective ingredient of ultrasonic extraction technology to raw material to extract, dissolve, mix etc., ensure that the activity of effective ingredient.The strong cavitation that ultrasonic extraction utilizes Ultrasonic Radiation pressure to produce is answered effect, mechanical vibration, disturbance effect, high acceleration, emulsifying, spreads, is smashed and the multistage effects such as stirring action, increase molecular motion of material frequency and speed, increase solvent penetration power, thus acceleration target component enters solvent, promotes the carrying out of extracting.
As technical scheme in the present invention further preferably, the above-mentioned Jiang Jing granule containing Herba Schizonepetae is formulated primarily of each component of following parts by weight ratio: Rhizoma Zingiberis Recens extract 20 ~ 30 parts, Fineleaf Schizonepeta Herb 2 ~ 5 parts, Chinese Mosla Herb 1 ~ 3 part, Mel 5 ~ 10 parts and sucrose 60 ~ 70 parts.
As technical scheme in the present invention further preferably, the above-mentioned Jiang Jing granule containing Herba Schizonepetae is formulated primarily of each component of following parts by weight ratio: Rhizoma Zingiberis Recens extract 25 parts, Fineleaf Schizonepeta Herb 3 parts, Chinese Mosla Herb 2 parts, Mel 5 parts and sucrose 65 parts.
Herba Schizonepetae (Classification system: Nepeta cataria L.), another name: fragrant Schizonepeta tenuifolia Briq, line shepherd's purse, Herba Schizonepetae, false Soviet Union are Labiatae, Nepeta perennial plant.Stem is strong, base portion lignifying, multi-branched, high 40-150 centimetre, nearly four prismatics of base portion, and blunt four prismatics in top, tool shallow slot, by white pubescence.Enter medicinal its dry stem and leaf and spica.Fresh and tender bud children's is calm best, balm leaf yellow green, stem side shaped microstrip purple, cross section yellow-white, the slightly black purple yellow green of tassel.Taste is put down, and warm in nature, nontoxic, faint scent is dense.Herba Schizonepetae is diaphoresis, antipyretic, is one of conventional medical herbs of China, can town expectorant, dispel the wind, removing heat from blood.Control influenza, the diaphoresis of headache cold and heat, vomiting.Chemical composition: containing volatile oil 1.8%, in oil, main constituent is D-menthone, racemization book lotus ketone, a small amount of d-limonen etc.
Herba Moslae (Latin literary fame; Elsholtzia ciliata(Thunb.) Hyland.), another name: water Herba Schizonepetae, smelly Herba Schizonepetae, Herba rabdosiae coetsae, to hold high to Shandong wood-its its lattice, half ray flower, Bian Zhihua, smelly Herba Pogostemonis, smelly perfume fiber crops, Dechang Herba Moslae, otopyorrhagia grass, cockscomb Herba Moslae, Herba Coriandri, Rhizoma et radix valerianae, Herba Glossogynes tenuifoliae, Herba Moslae, little Herba Schizonepetae, purple Herba Moslae etc.Labiatae, Elsholtzia species, [1] upright draft, intensive fibrous root.Stem usually above the central branch, blunt four prism shape, groove, glabrous or puberulous, often a straw yellow, old time-varying maroon.Avette or the ellipticity lanceolar of leaf, spike, bennet is very thin, and near without hair, calyx is bell, corolla lavender, filigree without hair, flower pesticide atropurpureus.7 ~ October of florescence.Be born in roadside, hillside, wasteland, in woods, riverbank, height above sea level reaches 3400 meters.Herba Moslae energy relieving the exterior syndrome by diaphoresis, removing dampness for regulating stomach, inducing diuresis to remove edema.Cure mainly: Xia Yue sense cold fluid-retention is cold, and have a headache and fever, aversion to cold is lossless, and the feeling of stuffiness in chest is suffered from abdominal pain, vomiting and diarrhoea, edema, beriberi.
Prepare a method for the Jiang Jing granule containing Herba Schizonepetae described above, comprise the following steps:
(1) preparation of Rhizoma Zingiberis Recens extract
After being cleaned up by fresh Rhizoma Zingiberis Recens, carry out drying, pulverizing, then cross 40 ~ 60 orders, be dissolved in water, ultrasonic extraction more than 30 minutes, clarification, filter, concentrated after obtain Rhizoma Zingiberis Recens extract;
(2) preparation of Fineleaf Schizonepeta Herb
Herba Schizonepetae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Fineleaf Schizonepeta Herb;
(3) preparation of Chinese Mosla Herb
Herba Moslae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Chinese Mosla Herb;
(4) preparation of Jiang Jing granule
First Rhizoma Zingiberis Recens extract, Fineleaf Schizonepeta Herb and Chinese Mosla Herb that step (1)-(3) obtain respectively are mixed according to corresponding parts by weight ratio, then add water and stir, add the Mel of corresponding parts by weight, sucrose again, stir, ultrasonic extraction is carried out more than 30 minutes to mixed serum, concentrated, pelletize, weighed, encapsulate and obtain Jiang Jing finished granule containing Herba Schizonepetae.
Jiang Jing finished granule of the present invention adopts pouch encapsulation, the heavy 15g of each pouch, daily each Instant Drinks 1 ~ 2 pouch when drinking, when catching cold, can optionally suitable dosage, but once no more than 5 pouches.
Advantage of the present invention:
1. the wide and low price of raw material sources, cost is low, and production and processing technology is simple.
2. can catch a cold by preventing common cold, wind dispelling cold relieving Be very effective is obvious.Main material is through pretreatment such as ultrasonic extractions, and the active constituent content of finished granule is high, and is easily absorbed by the body; Containing plurality of active ingredients, except (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone, also add the effective ingredient such as Herba Schizonepetae, Herba Moslae, each composition complements each other, together synergism, makes the effect of wind dispelling cold relieving more remarkable obviously.
3. have no side effect, safe and reliable.Rhizoma Zingiberis Recens, Herba Schizonepetae, Herba Moslae are conventional Chinese herbal medicine, and its property of medicine complements each other, and use the effect that can reach Synergistic together.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, but protection scope of the present invention is not only confined to following specific embodiment.
Embodiment 1:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 15kg, Fineleaf Schizonepeta Herb 2kg, Chinese Mosla Herb 1kg, Mel 5kg and sucrose 50kg.
Embodiment 2:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 40kg, Fineleaf Schizonepeta Herb 5kg, Chinese Mosla Herb 3kg, Mel 10kg and sucrose 75kg.
Embodiment 3:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 20kg, Fineleaf Schizonepeta Herb 2kg, Chinese Mosla Herb 1kg, Mel 5kg and sucrose 60kg.
Embodiment 4:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 30kg, Fineleaf Schizonepeta Herb 5kg, Chinese Mosla Herb 3kg, Mel 10kg and sucrose 70kg.
Embodiment 5:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 25kg, Fineleaf Schizonepeta Herb 3kg, Chinese Mosla Herb 2kg, Mel 5kg and sucrose 65kg.
The preparation method of the Jiang Jing granule containing Herba Schizonepetae of above-described embodiment 1-embodiment 5, comprises the following steps:
(1) preparation of Rhizoma Zingiberis Recens extract
After being cleaned up by fresh Rhizoma Zingiberis Recens, carry out drying, pulverizing, then cross 40 orders, be dissolved in water, ultrasonic extraction 30 minutes, clarification, filter, concentrated after obtain Rhizoma Zingiberis Recens extract;
(2) preparation of Fineleaf Schizonepeta Herb
Herba Schizonepetae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Fineleaf Schizonepeta Herb;
(3) preparation of Chinese Mosla Herb
Herba Moslae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Chinese Mosla Herb;
(4) preparation of Jiang Jing granule
First Rhizoma Zingiberis Recens extract, Fineleaf Schizonepeta Herb and Chinese Mosla Herb that step (1)-(3) obtain respectively are mixed according to corresponding parts by weight ratio, then add water and stir, add the Mel of corresponding parts by weight, sucrose again, stir, ultrasonic extraction is carried out 30 minutes to mixed serum, concentrated, pelletize, weighed, encapsulate and obtain Jiang Jing finished granule containing Herba Schizonepetae.
Embodiment 6:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 15kg, Fineleaf Schizonepeta Herb 2kg, Chinese Mosla Herb 2kg, Mel 5kg and sucrose 75kg.
Embodiment 7:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 40kg, Fineleaf Schizonepeta Herb 2kg, Chinese Mosla Herb 1kg, Mel 10kg and sucrose 50kg.
Embodiment 8:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 18kg, Fineleaf Schizonepeta Herb 2kg, Chinese Mosla Herb 2kg, Mel 8kg and sucrose 60kg.
The preparation method of the Jiang Jing granule containing Herba Schizonepetae of above-described embodiment 6-embodiment 8, comprises the following steps:
(1) preparation of Rhizoma Zingiberis Recens extract
After being cleaned up by fresh Rhizoma Zingiberis Recens, carry out drying, pulverizing, then cross 60 orders, be dissolved in water, ultrasonic extraction 45 minutes, clarification, filter, concentrated after obtain Rhizoma Zingiberis Recens extract;
(2) preparation of Fineleaf Schizonepeta Herb
Herba Schizonepetae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Fineleaf Schizonepeta Herb;
(3) preparation of Chinese Mosla Herb
Herba Moslae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Chinese Mosla Herb;
(4) preparation of Jiang Jing granule
First Rhizoma Zingiberis Recens extract, Fineleaf Schizonepeta Herb and Chinese Mosla Herb that step (1)-(3) obtain respectively are mixed according to corresponding parts by weight ratio, then add water and stir, add the Mel of corresponding parts by weight, sucrose again, stir, ultrasonic extraction is carried out 60 minutes to mixed serum, concentrated, pelletize, weighed, encapsulate and obtain Jiang Jing finished granule containing Herba Schizonepetae.
Embodiment 9:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 35kg, Fineleaf Schizonepeta Herb 2kg, Chinese Mosla Herb 3kg, Mel 5kg and sucrose 65kg.
Embodiment 10:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 26kg, Fineleaf Schizonepeta Herb 4kg, Chinese Mosla Herb 2kg, Mel 8kg and sucrose 70kg.
Embodiment 11:
A kind of Jiang Jing granule containing Herba Schizonepetae forms primarily of following component mixed preparing: Rhizoma Zingiberis Recens extract 28kg, Fineleaf Schizonepeta Herb 2kg, Chinese Mosla Herb 1kg, Mel 6kg and sucrose 60kg.
The preparation method of the Jiang Jing granule containing Herba Schizonepetae of above-described embodiment 9-embodiment 11, comprises the following steps:
(1) preparation of Rhizoma Zingiberis Recens extract
After being cleaned up by fresh Rhizoma Zingiberis Recens, carry out drying, pulverizing, then cross 50 orders, be dissolved in water, ultrasonic extraction 30 minutes, clarification, filter, concentrated after obtain Rhizoma Zingiberis Recens extract;
(2) preparation of Fineleaf Schizonepeta Herb
Herba Schizonepetae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Fineleaf Schizonepeta Herb;
(3) preparation of Chinese Mosla Herb
Herba Moslae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Chinese Mosla Herb;
(4) preparation of Jiang Jing granule
First Rhizoma Zingiberis Recens extract, Fineleaf Schizonepeta Herb and Chinese Mosla Herb that step (1)-(3) obtain respectively are mixed according to corresponding parts by weight ratio, then add water and stir, add the Mel of corresponding parts by weight, sucrose again, stir, ultrasonic extraction is carried out 45 minutes to mixed serum, concentrated, pelletize, weighed, encapsulate and obtain Jiang Jing finished granule containing Herba Schizonepetae.

Claims (4)

1., containing a Jiang Jing granule for Herba Schizonepetae, it is characterized in that, each component primarily of following parts by weight ratio is formulated: Rhizoma Zingiberis Recens extract 15 ~ 40 parts, Fineleaf Schizonepeta Herb 2 ~ 5 parts, Chinese Mosla Herb 1 ~ 3 part, Mel 5 ~ 10 parts and sucrose 50 ~ 75 parts; Described Rhizoma Zingiberis Recens extract be by Rhizoma Zingiberis Recens through cleaning, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, concentrated after the product that obtains.
2. the Jiang Jing granule containing Herba Schizonepetae according to claim 1, it is characterized in that, each component primarily of following parts by weight ratio is formulated: Rhizoma Zingiberis Recens extract 20 ~ 30 parts, Fineleaf Schizonepeta Herb 2 ~ 5 parts, Chinese Mosla Herb 1 ~ 3 part, Mel 5 ~ 10 parts and sucrose 60 ~ 70 parts.
3. the Jiang Jing granule containing Herba Schizonepetae according to claim 2, it is characterized in that, each component primarily of following parts by weight ratio is formulated: Rhizoma Zingiberis Recens extract 25 parts, Fineleaf Schizonepeta Herb 3 parts, Chinese Mosla Herb 2 parts, Mel 5 parts and sucrose 65 parts.
4. prepare as arbitrary in claim 1-3 as described in the method for Jiang Jing granule containing Herba Schizonepetae, it is characterized in that, comprise the following steps:
(1) preparation of Rhizoma Zingiberis Recens extract
After being cleaned up by fresh Rhizoma Zingiberis Recens, carry out drying, pulverizing, then cross 40 ~ 60 orders, be dissolved in water, ultrasonic extraction more than 30 minutes, clarification, filter, concentrated after obtain Rhizoma Zingiberis Recens extract;
(2) preparation of Fineleaf Schizonepeta Herb
Herba Schizonepetae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Fineleaf Schizonepeta Herb;
(3) preparation of Chinese Mosla Herb
Herba Moslae cleaned up and after drying, pulverizes, after crossing 100 orders, obtaining Chinese Mosla Herb;
(4) preparation of Jiang Jing granule
First Rhizoma Zingiberis Recens extract, Fineleaf Schizonepeta Herb and Chinese Mosla Herb that step (1)-(3) obtain respectively are mixed according to corresponding parts by weight ratio, then add water and stir, add the Mel of corresponding parts by weight, sucrose again, stir, ultrasonic extraction is carried out more than 30 minutes to mixed serum, concentrated, pelletize, weighed, encapsulate and obtain Jiang Jing finished granule containing Herba Schizonepetae.
CN201410702834.7A 2014-11-29 2014-11-29 Nepeta cataria-containing zingiber officinale roscoe crystal particles and preparation method thereof Pending CN104474505A (en)

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