CN104474449A - 一种治疗消化性溃疡的中药组合物及其制备方法 - Google Patents
一种治疗消化性溃疡的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗消化性溃疡的中药组合物及其制备方法,由以下重量配比的药材制备而成:党参10-15份,白芨3-6份,白术5-8份,砂仁1-6份,玄参1-3份,肿节风2-8份,芡实3-6份,人参1-3份,枳实6-10份,海螵蛸5-13份,山楂5-16份,陈皮2-8份,蒲公英3-7份,厚朴1-3份,青皮1-4份,蒲黄3-8份,地榆5-9份,血余炭3-7份,地骨皮3-6份,茜草1-3份,延胡索3-8份,三七1-6份,甘草3-6份。本发明为纯中药方剂,毒副作用小,疗效好,疗程短,用于治疗消化性溃疡治愈率高,且其药源广、成本低、适于临床推广应用。
Description
技术领域
本发明涉及一种治疗消化性溃疡的中药组合物及其制备方法。
背景技术
消化性溃疡主要指发生在胃和十二指肠的溃疡,具有发病率高、病程长、易转化等特点。其病因及发病机理较为复杂,中医认为主要是由肝气郁结、横逆犯胃,饮食内伤、脾胃受损,遗传因素或某些药物所致。其临床表现除了脘腹疼痛外,尚伴有泛酸、呕吐、恶心等胃肠道症状。少数病人可无先兆,以出血或穿孔为首见症状。消化性溃疡是常见病,多发病。目前国内外的有关医学资料表明,无论西医治疗或中医治疗,效果虽明显,但治愈后二年内的复发率达95%以上,给人们的身体造成极大的伤害。所以消化性溃疡治愈后复发的问题一直是医学界难以解决的问题,中医临床上多采取辩证施治的治疗方法,常用药物有香砂平胃丸、左金丸、香砂六君丸等,但这些药物存在疗程长,见效慢,效果不明显等缺点。
发明内容
本发明所要解决的技术问题是提供一种消化性溃疡治愈后不复发的中药组合物,同时还提供一种制备中药组合物的方法。
为解决上述技术问题,本发明采用的技术方案是:
本发明提供的治疗消化性溃疡的中药组合物,由以下重量配比的药材制备而成:党参10-15份,白芨3-6份,白术5-8份,砂仁1-6份,玄参1-3份,肿节风2-8份,芡实3-6份,人参1-3份,枳实6-10份,海螵蛸5-13份,山楂5-16份,陈皮2-8份,蒲公英3-7份,厚朴1-3份,青皮1-4份,蒲黄3-8份,地榆5-9份,血余炭3-7份,地骨皮3-6份,茜草1-3份,延胡索3-8份,三七1-6份,甘草3-6份。
优选的,本发明提供的治疗消化性溃疡的中药组合物,由以下重量配比的药材制备而成:党参12-13份,白芨4-5份,白术6-7份,砂仁3-5份,玄参1-3份,肿节风3-6份,芡实4-5份,人参1-3份,枳实8-9份,海螵蛸6-10份,山楂8-12份,陈皮3-5份,蒲公英4-6份,厚朴1-3份,青皮2-3份,蒲黄4-6份,地榆6-8份,血余炭4-6份,地骨皮4-5份,茜草1-3份,延胡索5-6份,三七2-4份,甘草4-5份。
优选的,本发明提供的治疗消化性溃疡的中药组合物,由以下重量配比的药材制备而成:党参13份,白芨5份,白术7份,砂仁5份,玄参3份,肿节风6份,芡实5份,人参3份,枳实9份,海螵蛸10份,山楂12份,陈皮5份,蒲公英6份,厚朴3份,青皮3份,蒲黄6份,地榆8份,血余炭6份,地骨皮5份,茜草3份,延胡索6份,三七4份,甘草5份。
优选的,本发明提供的治疗消化性溃疡的中药组合物,由以下重量配比的药材制备而成:党参12-份,白芨4份,白术6份,砂仁3份,玄参1份,肿节风3份,芡实4份,人参1份,枳实8份,海螵蛸6份,山楂8份,陈皮3份,蒲公英4份,厚朴1份,青皮2份,蒲黄4份,地榆6份,血余炭4份,地骨皮4份,茜草1份,延胡索5份,三七2份,甘草4份。
优选的,本发明提供的治疗消化性溃疡的中药组合物,由以下重量配比的药材制备而成:党参12份,白芨5份,白术7份,砂仁4份,玄参2份,肿节风5份,芡实4份,人参2份,枳实9份,海螵蛸8份,山楂10份,陈皮4份,蒲公英5份,厚朴2份,青皮3份,蒲黄5份,地榆7份,血余炭5份,地骨皮5份,茜草2份,延胡索6份,三七3份,甘草5份。
本发明提供的制备上述中药组合物的方法,包括下列步骤:
(1)按照重量配比取党参、白芨、白术、砂仁、玄参、肿节风、芡实、人参和枳实,加入重量为药材总重量3-5倍的水,50-60摄氏度浸泡10-15个小时。
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态20-30分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)1-3次,合并所得的药液,将药液在50摄氏度的温度下进行烘干2-3小时,得到药物浸膏。
(4)将海螵蛸、山楂、陈皮、蒲公英、厚朴、青皮和蒲黄研磨成500-800目的细粉末。
(5)将地榆、血余炭、地骨皮、茜草、延胡索、三七和甘草用水蒸气蒸馏法提取挥发油。
(6)将步骤(3)的药物浸膏、步骤(4)的药物细粉末和步骤(5)的药物挥发油混合,搅拌混着均匀,制成颗粒剂或装胶囊,或者做成片剂。
优选的,将步骤(1)中的药材研磨成粉末,粉末的大小在300-500目之间。粉末状药材可以大大提高有效成分的浸出率。
优选的,步骤(2)中的水温梯度升高到沸腾的方式是:水温每3-5分钟升高10摄氏度,并且每升高10摄氏度保持10分钟。通过梯度升温煎煮中药的方法,比传统的煎煮效果好,也可以提高有效成分的提取率。
优选的,步骤(5)中的药物研磨成300-500目的粉末。
本发明各中药成份的药理分析如下:
党参:补中益气、健脾益肺的功效;白芨:补肺,止血,消肿,生肌,敛疮的功效;白术:补脾,益胃,燥湿,利水;砂仁:化湿理气,和中暖胃,用于湿浊中阻,脘痞不饥,脾胃虚寒,呕吐泄泻,气滞腹胀,玄参:苦咸,凉,入肺、肾经,滋阴,降火,除烦,解毒,治热病伤阴,舌绎烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬,温毒发斑、目赤、白喉、疮毒;肿节风、;性味归经,性微温,味苦、辛,抗菌消炎,祛风通络,活血散结;芡实:健脾除湿,止泻止带;人参,味甘、微苦,性微温;归脾、肺、心、肾经,气雄体润,升多于降;枳实:苦、辛,微寒,归脾、胃、大肠经,破气除痞,化痰消积;海螵蛸:制酸止痛,止血止带,敛疮,治胃酸过多,溃疡病吐血与便血,崩漏带下及湿疹;山楂:消食化积,行气散瘀;促进脂肪分解;陈皮:醒脾理气,宽胸利膈,存进消化液分泌,排除肠内积气;蒲公英,味甘、微苦,性平;归肝、胃经,具有清热解毒,消肿散结,行水利尿之功效;厚朴:具有抗病毒、抗菌、防抗溃疡、镇痛抗炎、抗肿瘤、肌肉松弛、降胆固醇和抗衰老;青皮:性味苦辛、微温,具有疏肝破气、散结消痰的功效,用于胸胁胃脘疼痛、疝气、食积、乳肿、乳核、久疟癖块;蒲黄:止血,化瘀,通淋。用于吐血、衄血、咯血、崩漏、外伤出血、经闭、痛经、脘腹刺痛、跌打肿痛、血淋湿痛;地榆:凉血上血,清热解毒,治吐血,衄血,血痢,崩漏,肠风,痔漏,痈肿,湿疹,金疮,烧伤;血余炭:味苦、性微温,具有消瘀,止血,利小便的功效;地骨皮:味甘寒,归肺、肝、肾经,治凉血除蒸,清肺降火,阴虚潮热,骨蒸盗汗,肺热咳嗽,咯血,衄血,内热消渴;茜草:性寒,味苦,具有凉血止血、祛瘀通经的作用,用于血热妄行之出血症、兼淤血者尤宜;延胡索:辛苦,温,入肝、胃经,活血,散瘀,理气,止痛;三七:味微苦,性温,入肝、胃、大肠经,具有活血、化瘀、理气、止痛、温中、散寒等功效;甘草,味甘,性平;归心、脾、肺、胃经。具有补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药之功效。
本发明的中药制剂益气健脾增强脾胃机能,可以止血、活血双向调节、使溃疡最下层的陈旧瘢痕组织减少或消失,服用后其药物中所含的胶质在溃疡面迅速形成保护膜,避免胃酸和蛋白酶的侵蚀。
本发明用于临床,不仅快速消除临床症状治其标,而且在短期内使溃疡愈合治其本,所治病例无一例复发,特别是对经过和中西药物治疗后病情反复发作的溃疡患者,口服本发明的中药制剂同样有彻底治愈不再复发的较好疗效,临床应用中未见不良反应发生,而且还能增强人体免疫力。
本发明为纯中药方剂,毒副作用小,疗效好,疗程短,用于治疗消化性溃疡治愈率高,且其药源广、成本低、适于临床推广应用。
下面结合临床实验数据说明本发明的有益效果:
经临床收治消化性溃疡患者135例,服用按照实施例1制成的胶囊,每次一粒,每天三次,连续使用20天为一个疗程,可连服3至6个疗程。
疗效评价:治愈:症状消失不复发;显效:症状减轻,但未完全消失;无效:症状未消失,无明显改变。
治疗结果:治愈和显效共128例,有效率高达95%,3-5月后再随访,均无复发。
具体实施方式
实施例1
本实施例提供的治疗消化性溃疡的中药组合物,由以下重量配比的药材制备而成:党参13份,白芨5份,白术7份,砂仁5份,玄参3份,肿节风6份,芡实5份,人参3份,枳实9份,海螵蛸10份,山楂12份,陈皮5份,蒲公英6份,厚朴3份,青皮3份,蒲黄6份,地榆8份,血余炭6份,地骨皮5份,茜草3份,延胡索6份,三七4份,甘草5份。
制备上述中药组合物的方法,包括下列步骤:
(1)按照重量配比取党参、白芨、白术、砂仁、玄参、肿节风、芡实、人参和枳实,将药材研磨成粉末,粉末的大小是500目,加入重量为药材总重量5倍的水,60摄氏度浸泡15个小时。
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态30分钟,过滤得药液和药渣;水温梯度升高到沸腾的方式是:水温每5分钟升高10摄氏度,并且每升高10摄氏度保持10分钟。
(3)将药渣重复步骤(1)和步骤(2)3次,合并所得的药液,将药液在50摄氏度的温度下进行烘干3小时,得到药物浸膏。
(4)将海螵蛸、山楂、陈皮、蒲公英、厚朴、青皮和蒲黄研磨成800目的细粉末。
(5)将地榆、血余炭、地骨皮、茜草、延胡索、三七和甘草研磨成500目的粉末,用水蒸气蒸馏法提取挥发油。
(6)将步骤(3)的药物浸膏、步骤(4)的药物细粉末和步骤(5)的药物挥发油混合,搅拌混着均匀,制成胶囊。
实施例2
本实施例提供的治疗消化性溃疡的中药组合物,由以下重量配比的药材制备而成:党参12份,白芨5份,白术7份,砂仁4份,玄参2份,肿节风5份,芡实4份,人参2份,枳实9份,海螵蛸8份,山楂10份,陈皮4份,蒲公英5份,厚朴2份,青皮3份,蒲黄5份,地榆7份,血余炭5份,地骨皮5份,茜草2份,延胡索6份,三七3份,甘草5份。
制备上述中药组合物的方法,包括下列步骤:
(1)按照重量配比取党参、白芨、白术、砂仁、玄参、肿节风、芡实、人参和枳实,药材研磨成粉末,粉末的大小是300目,加入重量为药材总重量3倍的水,50摄氏度浸泡10个小时。
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态20分钟,过滤得药液和药渣;水温梯度升高到沸腾的方式是:水温每3-5分钟升高10摄氏度,并且每升高10摄氏度保持10分钟。通过梯度升温煎煮中药的方法,比传统的煎煮效果好,也可以提高有效成分的提取率。
(3)将药渣重复步骤(1)和步骤(2)3次,合并所得的药液,将药液在50摄氏度的温度下进行烘干2小时,得到药物浸膏。
(4)将海螵蛸、山楂、陈皮、蒲公英、厚朴、青皮和蒲黄研磨成500-800目的细粉末。
(5)将地榆、血余炭、地骨皮、茜草、延胡索、三七和甘草药物研磨成300-500目的粉末,用水蒸气蒸馏法提取挥发油。
(6)将步骤(3)的药物浸膏、步骤(4)的药物细粉末和步骤(5)的药物挥发油混合,搅拌混着均匀,制成颗粒剂,每袋装25-35克。
实施例3
本实施例提供的治疗消化性溃疡的中药组合物,由以下重量配比的药材制备而成:党参12-份,白芨4份,白术6份,砂仁3份,玄参1份,肿节风3份,芡实4份,人参1份,枳实8份,海螵蛸6份,山楂8份,陈皮3份,蒲公英4份,厚朴1份,青皮2份,蒲黄4份,地榆6份,血余炭4份,地骨皮4份,茜草1份,延胡索5份,三七2份,甘草4份。
本发明提供的制备上述中药组合物的方法,包括下列步骤:
(1)按照重量配比取党参、白芨、白术、砂仁、玄参、肿节风、芡实、人参和枳实,药材研磨成粉末,粉末的大小是400目,加入重量为药材总重量3-5倍的水,55摄氏度浸泡13个小时。
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态25分钟,过滤得药液和药渣;水温梯度升高到沸腾的方式是:水温每4分钟升高10摄氏度,并且每升高10摄氏度保持10分钟。通过梯度升温煎煮中药的方法,比传统的煎煮效果好,也可以提高有效成分的提取率。
(3)将药渣重复步骤(1)和步骤(2)2次,合并所得的药液,将药液在50摄氏度的温度下进行烘干3小时,得到药物浸膏。
(4)将海螵蛸、山楂、陈皮、蒲公英、厚朴、青皮和蒲黄研磨成600目的细粉末。
(5)将地榆、血余炭、地骨皮、茜草、延胡索、三七和甘草药物研磨成300-500目的粉末,用水蒸气蒸馏法提取挥发油。
(6)将步骤(3)的药物浸膏、步骤(4)的药物细粉末和步骤(5)的药物挥发油混合,搅拌混着均匀,制成片剂。
典型病例:
1、王某,男,55岁,医院钡餐检查,诊断为十二指肠球部溃疡,中医断为脾胃虚弱胃出血,西医诊断为十二指肠溃疡,用本发明的药物组合物三个疗程即治愈至今未复发。
2、李某,女,47岁,医院钡餐检查,诊断为胃溃疡,中医诊断为胃脘痛,多次服用西药治疗,但多次复发,用本发明的药物组合物四个疗程治愈,至今未复发。
3、许某,男,65岁,医院胃镜检查,诊断为十二指肠溃疡和糜烂性炎,用本发明的药物组合物三个疗程治愈至今未复发。
4、刘某:男,57岁,患消化性溃疡5年,长期服用药物治疗,但效果均不明显且副作用大,后服用本发明药物治疗,两个疗程见效,六个疗程痊愈。
5、李某:女,54岁,患消化性溃疡3年,经常半夜腹部疼痛,夜不能寐,用本发明的药物组合物四个疗程治愈,至今未复发。
Claims (9)
1. 一种治疗消化性溃疡的中药组合物,其特征在于,由以下重量配比的药材制备而成:党参10-15份,白芨3-6份,白术5-8份,砂仁1-6份,玄参1-3份,肿节风2-8份,芡实3-6份,人参1-3份,枳实6-10份,海螵蛸5-13份,山楂5-16份,陈皮2-8份,蒲公英3-7份,厚朴1-3份,青皮1-4份,蒲黄3-8份,地榆5-9份,血余炭3-7份,地骨皮3-6份,茜草1-3份,延胡索3-8份,三七1-6份,甘草3-6份。
2. 根据权利要求1所述的治疗消化性溃疡的中药组合物,其特征在于,由以下重量配比的药材制备而成:党参12-13份,白芨4-5份,白术6-7份,砂仁3-5份,玄参1-3份,肿节风3-6份,芡实4-5份,人参1-3份,枳实8-9份,海螵蛸6-10份,山楂8-12份,陈皮3-5份,蒲公英4-6份,厚朴1-3份,青皮2-3份,蒲黄4-6份,地榆6-8份,血余炭4-6份,地骨皮4-5份,茜草1-3份,延胡索5-6份,三七2-4份,甘草4-5份。
3. 根据权利要求1所述的治疗消化性溃疡的中药组合物,其特征在于,由以下重量配比的药材制备而成:党参13份,白芨5份,白术7份,砂仁5份,玄参3份,肿节风6份,芡实5份,人参3份,枳实9份,海螵蛸10份,山楂12份,陈皮5份,蒲公英6份,厚朴3份,青皮3份,蒲黄6份,地榆8份,血余炭6份,地骨皮5份,茜草3份,延胡索6份,三七4份,甘草5份。
4. 根据权利要求1所述的治疗消化性溃疡的中药组合物,其特征在于,由以下重量配比的药材制备而成:党参12-份,白芨4份,白术6份,砂仁3份,玄参1份,肿节风3份,芡实4份,人参1份,枳实8份,海螵蛸6份,山楂8份,陈皮3份,蒲公英4份,厚朴1份,青皮2份,蒲黄4份,地榆6份,血余炭4份,地骨皮4份,茜草1份,延胡索5份,三七2份,甘草4份。
5. 根据权利要求1所述的治疗消化性溃疡的中药组合物,其特征在于,由以下重量配比的药材制备而成:党参12份,白芨5份,白术7份,砂仁4份,玄参2份,肿节风5份,芡实4份,人参2份,枳实9份,海螵蛸8份,山楂10份,陈皮4份,蒲公英5份,厚朴2份,青皮3份,蒲黄5份,地榆7份,血余炭5份,地骨皮5份,茜草2份,延胡索6份,三七3份,甘草5份。
6. 制备上述任一项权利要求所述的治疗消化性溃疡的中药组合物的方法,其特征在于,包括下列步骤:
(1)按照重量配比取党参、白芨、白术、砂仁、玄参、肿节风、芡实、人参和枳实,加入重量为药材总重量3-5倍的水,50-60摄氏度浸泡10-15个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态20-30分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)1-3次,合并所得的药液,将药液在50摄氏度的温度下进行烘干2-3小时,得到药物浸膏;
(4)将海螵蛸、山楂、陈皮、蒲公英、厚朴、青皮和蒲黄研磨成500-800目的细粉末;
(5)将地榆、血余炭、地骨皮、茜草、延胡索、三七和甘草用水蒸气蒸馏法提取挥发油;
(6)将步骤(3)的药物浸膏、步骤(4)的药物细粉末和步骤(5)的药物挥发油混合,搅拌混着均匀,制成颗粒剂或装胶囊,或者做成片剂。
7. 根据权利要求6所述的治疗消化性溃疡的中药组合物的制备方法,其特征在于,将步骤(1)中的药材研磨成粉末,粉末的大小在300-500目之间。
8. 根据权利要求6所述的治疗消化性溃疡的中药组合物的制备方法,其特征在于,步骤(2)中的水温梯度升高到沸腾的方式是:水温每3-5分钟升高10摄氏度,并且每升高10摄氏度保持10分钟。
9. 根据权利要求6所述的治疗消化性溃疡的中药组合物的制备方法,其特征在于,步骤(5)中的药物研磨成300-500目的粉末。
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