CN104474358A - Prostatitis treatment medicine and preparation method thereof - Google Patents

Prostatitis treatment medicine and preparation method thereof Download PDF

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Publication number
CN104474358A
CN104474358A CN201410644636.XA CN201410644636A CN104474358A CN 104474358 A CN104474358 A CN 104474358A CN 201410644636 A CN201410644636 A CN 201410644636A CN 104474358 A CN104474358 A CN 104474358A
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parts
semen
medicine
radix
herba
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程晟
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Shanxi Zhendong Kaiyuan Pharmaceutical Co Ltd
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Shanxi Zhendong Kaiyuan Pharmaceutical Co Ltd
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Abstract

The invention discloses a prostatitis treatment medicine. The prostatitis treatment medicine is prepared from Fructus Toosendan, Medicinal Cyathula Root, Diverse Wormwood Herb, peach seed, licorice root, Amur Corktree Bark, Fructus Foeniculi, coix seed, white peony root, Herba Patriniae, prepared aconite root, Dianthus superbus, Corydalis tuber, mung bean, Gentiana scabra Bunge, Semen Plantaginis, Cuscuta chinensis Lam., Chinese yam rhizome and Vaccaria segetalis. The medicine adopts a capsule as a preferable dosage form. The medicine has the efficacies of heat clearing, detoxifying, dampness dispelling and blood circulation invigorating, is suitable for treating prostatitis and other diseases, and has the characteristics of fast effectiveness, good curative effect, and no toxic side effects.

Description

One treats prostatitic medicine and preparation method thereof
Technical field
The present invention relates to one and treat prostatitic pharmaceutical composition, particularly relating to a kind of take Chinese herbal medicine as the prostatitic medicine for the treatment of that raw material is made, and the invention still further relates to the preparation method of this medicine.
Background technology
In clinical practice, chronic prostatitis is a kind of common genitourinary diseases, mainly comprises chronic bacterial prostatitis and nonbacterial prostatitis two parts.In China, chronic prostatitis is the very high and disease making people very puzzled of a kind of sickness rate, and the man close to 50% is in its impact that will suffer from prostatitis symptom sometime in life.Because its cause of disease, pathological change, clinical symptoms complexity are various, and there is certain influence to the sexual function of male and reproductive function, seriously have impact on the quality of life of patient, make their spirit and the human body suffer great torment.
The etiology of chronic prostatitis is very complicated, although the pathogenesis numerous to it has had the understanding of certain degree, does not all have breakthrough.Think that chronic prostatitis may be constitutional due to prostate and surrounding tissue organ, muscle and nerve or secondary disease at present, even after these diseases have been cured or thoroughly eradicated, the infringement that it causes and pathological change are still continuing to work independently, the center of its cause of disease may be infect, the combined effect of neuron-muscular activity at the bottom of the basin of inflammation and exception.Circulate some medicines and Therapeutic Method in market now, curative effect, cost and alleviate treat painful aspect mostly can not be satisfactory.
Summary of the invention
The object of this invention is to provide one and treat prostatitic medicine, its curative effect is fast, and good effect, and the medicine of non-evident effect, the invention still further relates to the preparation method of this medicine.
The prostatitic medicine for the treatment of of the present invention is be that raw material prepares by the Chinese herbal medicine of following quality proportioning: Fructus Toosendan 6-15 part, Radix Cyathulae 6-15 part, Herba Artemisiae Anomalae 6-15 part, Semen Persicae 6-15 part, Radix Glycyrrhizae 6-15 part, Cortex Phellodendri 6-15 part, Fructus Foeniculi 6-15 part, Semen Coicis 15-25 part, Radix Paeoniae Alba 15-25 part, Herba Patriniae 20-35 part, Radix Aconiti Lateralis Preparata 2-5 part, Herba Dianthi 10-20 part, Rhizoma Corydalis 10-20 part, Semen phaseoli radiati 6-15 part, Radix Gentianae 3-8 part, Semen Plantaginis 2-5 part, Semen Cuscutae 6-15 part, Rhizoma dioscoreae 6-15 part, Semen Vaccariae 6-15 part.
Further, in medicine of the present invention, the preferred weight portion of each crude drug is: Fructus Toosendan 10 parts, Radix Cyathulae 10 parts, Herba Artemisiae Anomalae 10 parts, 10 parts, Semen Persicae, 10 parts, Radix Glycyrrhizae, Cortex Phellodendri 10 parts, Fructus Foeniculi 10 parts, Semen Coicis 20 parts, the Radix Paeoniae Alba 20 parts, Herba Patriniae 30 parts, Radix Aconiti Lateralis Preparata 3 parts, Herba Dianthi 15 parts, Rhizoma Corydalis 15 parts, 9 parts, Semen phaseoli radiati, Radix Gentianae 4.5 parts, Semen Plantaginis 3 parts, Semen Cuscutae 12 parts, Rhizoma dioscoreae 12 parts, Semen Vaccariae 10 parts.
Said medicine can be made the powder, oral liquid, injection etc. on pharmaceutics, consider the practical situations such as clinical practice Clinical practice effect, easy-to-use, instant effect, preferred dosage form is capsule.
The preparation method of medicine of the present invention is as follows:
By above-mentioned various medicine according to after described ratio of weight and number mix homogeneously, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, be crushed to 100 ~ 120 object medicated powder, in incapsulating, sterilization obtains capsule product.
The traditional Chinese medical science is thought, chronic prostatitis belongs to the traditional Chinese medical science " essence turbid ", " stranguria caused by overstrain ", " excessive in vain " category, as having in what dream precious jade clear " doctor's rock reddish and whitish turbid urine " section " key end often lead silk ribbon greasy, if pus is as gum ", the urine later and decadent stage of a school of thought resembling very much primary disease is white.Its Etiological has following several: the heresy that 1. diseases caused by exogenous pathogenic factor are scorchingly hot, be reluctant to leave and do not go, or sexual behavior is unclean, damp and hotly stays in smart room, and essence is turbid to be obscured, smart in its position; 2. phase hyperactivity of fire is contained, because of be willing to unsuccessful or bear essence and do not let out, and kidney fire stagnation and not faling apart, that offs normal refines as nebulousurine; 3. chamber is excessive, and to exhaust its essence, smart room is hollow, and damp and hot seizing the opportunity is attacked into smart room, essence by force, can not Jing Zang.Do not fall apart because of its kidney fire stagnation, or damp and hot of a specified duration stagnant unclear, smart road stagnation of QI-blood, therefore delay is difficult.
Therefore medicine of the present invention focuses on heat-clearing and toxic substances removing, and eliminating toxic dampness and heat wherein reuses Herba Patriniae, is intended to heat-clearing and toxic substances removing, removing blood stasis and expelling pus.In addition, Fructus Toosendan: except damp and hot, clearing away liver-fire, pain relieving, diuresis water channel.Radix Cyathulae: dispel the wind, dampness removing, stimulates the menstrual flow, and invigorates blood circulation.Herba Artemisiae Anomalae: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Semen Persicae: blood stasis removing and clots absorbing, moisturizes laxation.Cortex Phellodendri: dampness, pathogenic fire purging, removing toxic substances.Fructus Foeniculi: dispersing cold for relieving pain, invigorates blood circulation, promoting the circulation of QI.Semen Coicis: invigorating spleen to remove dampness, clearing away heat and discharging pus, warming spleen and stomach for dispelling cold, benefiting vital QI and blood.The Radix Paeoniae Alba: blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating.Herba Patriniae: heat-clearing and toxic substances removing, removing blood stasis and expelling pus.Radix Aconiti Lateralis Preparata: dispersing cold for relieving pain.Herba Dianthi: clearing away heat and promoting diuresis, removing blood stasis stimulates the menstrual flow.Rhizoma Corydalis: promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.Radix Gentianae: heat clearing away, eliminating pathogen in the liver, arresting convulsion.Semen Plantaginis: diuretic, heat clearing away, improving eyesight, eliminates the phlegm.Semen Cuscutae: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Rhizoma dioscoreae: main damaging the spleen and stomach tonify deficiency, except cold and heat pathogen, invigorating the spleen and replenishing QI power, longue meat, takes normal hearing and eyesight for a long time.Semen Vaccariae promoting blood circulation to restore menstrual flow, stimulating milk secretion is subsided a swelling, inducing diuresis for treating stranguria syndrome.Radix Glycyrrhizae then can coordinating the actions of various ingredients in a prescription.
Each crude drug reasonable compatibility in the present invention, Synergistic treatment, be applicable to multiple prostatitic treatment, large-scale application proves, curative effect is fast, good effect.Medicine of the present invention belongs to pure Chinese medicinal preparation, and no drug residue compared with Western medicine, has no side effect.
For checking medicine of the present invention is to prostatitic therapeutic effect, applying medicine of the present invention, to carry out clinical trial as follows:
Diagnostic method: chronic prostatitis: detailed medical history-taking, complete physical examination (comprising digital rectal examination), urine and the routine examination of massage of prostate liquid.Application NIH chronic prostatitis symptom index carries out symptom score." two agar diffusion methods " or " four agar diffusion methods " is recommended to carry out pathogen location test.
For clarifying a diagnosis and Differential Diagnosis, optional inspection: semen analysis or antibacterial culturing, prostate specific antigen, urinary cytology, through abdomen or Trans-rectal B ultrasound (comprising Residual urine measurement), urinary flow, urodynamics, CT, MRI, urethrocystoscope inspection and aspiration biopsy of prostatic gland etc.
Acquired for materials: to collect Changzhi, Shanxi Province routine patient in peace hospital's year August 200 in January, 2009 to 2014, be all diagnosed as classic chronic prostatitis.
Experimental agents: medicine of the present invention, is prepared by Shanxi Zhendong Kaiyuan Pharmaceutical Co., Ltd..
Control drug: the prostatitic conventional medicine fleroxacin for the treatment of at present.
The prostatitis patient that this medicine taken to 100 examples carried out clinical observation and prostatitis patient 100 example selecting to have comparability as a control group, treatment group patient takes medicine of the present invention twice every day, sooner or later respectively once, once take 6.5 grams of medicines, matched group patient took the Drug therapy of conventional therapy pneumonia after 30 days, and therapeutic outcome sees the following form:
Patient numbers Cure Effectively Cure rate Effective percentage
Experimental group 100 69 examples 93 examples 69% 93%
Matched group 100 42 examples 73 examples 42% 73%
Note: compare between matched group with experimental group, P < 0.01
The statistical analysis of efficacy result shows: experimental group compare matched group have higher cure rate, effective percentage ( p <0.01), illustrate that the therapeutic process of medicine of the present invention is successful from clinical symptoms and pathological change.Think thus, Drug therapy prostatitis of the present invention, chronic prostatitis etc. have good effect, and through the tracking Ureteral Calculus of 150 days, taking medicine of the present invention did not occur any toxic and side effects, safe and reliable.
Detailed description of the invention
embodiment 1
Take the raw material of following quality proportioning: Fructus Toosendan 6kg, Radix Cyathulae 6 kg, Herba Artemisiae Anomalae 6 kg, Semen Persicae 6 kg, Radix Glycyrrhizae 6 kg, Cortex Phellodendri 6 kg, Fructus Foeniculi 15 kg, Semen Coicis 25 kg, the Radix Paeoniae Alba 25 kg, Herba Patriniae 35kg, Radix Aconiti Lateralis Preparata 5 kg, Herba Dianthi 20 kg, Rhizoma Corydalis 20 kg, Semen phaseoli radiati 15 kg, Radix Gentianae 8 kg, Semen Plantaginis 5 kg, Semen Cuscutae 15 kg, Rhizoma dioscoreae 15 kg, Semen Vaccariae 15 kg.
By above-mentioned various medicine according to after described ratio of weight and number mix homogeneously, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, be crushed to 100 ~ 120 object medicated powder, in incapsulating, sterilization obtains capsule product.
embodiment 2
Take the raw material of following quality proportioning: Fructus Toosendan 15kg, Radix Cyathulae 15 kg, Herba Artemisiae Anomalae 15 kg, Semen Persicae 15 kg, Radix Glycyrrhizae 15 kg, Cortex Phellodendri 15 kg, Fructus Foeniculi 6 kg, Semen Coicis 15 kg, the Radix Paeoniae Alba 15 kg, Herba Patriniae 20 kg, Radix Aconiti Lateralis Preparata 2 kg, Herba Dianthi 10 kg, Rhizoma Corydalis 10 kg, Semen phaseoli radiati 6 kg, Radix Gentianae 3kg, Semen Plantaginis 2 kg, Semen Cuscutae 6 kg, Rhizoma dioscoreae 6 kg, Semen Vaccariae 6 kg.
By above-mentioned various medicine according to after described ratio of weight and number mix homogeneously, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, be crushed to 100 ~ 120 object medicated powder, in incapsulating, sterilization obtains capsule product.
embodiment 3
Take the raw material of following quality proportioning: Fructus Toosendan 10kg, Radix Cyathulae 10 kg, Herba Artemisiae Anomalae 10 kg, Semen Persicae 10 kg, Radix Glycyrrhizae 10kg, Cortex Phellodendri 10kg, Fructus Foeniculi 10 kg, Semen Coicis 20 kg, the Radix Paeoniae Alba 20 kg, Herba Patriniae 30 kg, Radix Aconiti Lateralis Preparata 3 kg, Herba Dianthi 15kg, Rhizoma Corydalis 15 kg, Semen phaseoli radiati 9 kg, Radix Gentianae 5 kg, Semen Plantaginis 3 kg, Semen Cuscutae 12 kg, Rhizoma dioscoreae 12 kg, Semen Vaccariae 12kg.
By above-mentioned various medicine according to after described ratio of weight and number mix homogeneously, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, be crushed to 100 ~ 120 object medicated powder, in incapsulating, sterilization obtains capsule product.

Claims (3)

1. treat a prostatitic medicine, it is characterized in that described medicine is is that raw material prepares by the Chinese herbal medicine of following quality proportioning: Fructus Toosendan 6-15 part, Radix Cyathulae 6-15 part, Herba Artemisiae Anomalae 6-15 part, Semen Persicae 6-15 part, Radix Glycyrrhizae 6-15 part, Cortex Phellodendri 6-15 part, Fructus Foeniculi 6-15 part, Semen Coicis 15-25 part, Radix Paeoniae Alba 15-25 part, Herba Patriniae 20-35 part, Radix Aconiti Lateralis Preparata 2-5 part, Herba Dianthi 10-20 part, Rhizoma Corydalis 10-20 part, Semen phaseoli radiati 6-15 part, Radix Gentianae 3-8 part, Semen Plantaginis 2-5 part, Semen Cuscutae 6-15 part, Rhizoma dioscoreae 6-15 part, Semen Vaccariae 6-15 part.
2. the prostatitic medicine for the treatment of according to claim 1, is characterized in that the quality proportioning of each crude drug is: Fructus Toosendan 10 parts, Radix Cyathulae 10 parts, Herba Artemisiae Anomalae 10 parts, 10 parts, Semen Persicae, 10 parts, Radix Glycyrrhizae, Cortex Phellodendri 10 parts, Fructus Foeniculi 10 parts, Semen Coicis 20 parts, the Radix Paeoniae Alba 20 parts, Herba Patriniae 30 parts, Radix Aconiti Lateralis Preparata 3 parts, Herba Dianthi 15 parts, Rhizoma Corydalis 15 parts, 9 parts, Semen phaseoli radiati, Radix Gentianae 4.5 parts, Semen Plantaginis 3 parts, Semen Cuscutae 12 parts, Rhizoma dioscoreae 12 parts, Semen Vaccariae 10 parts.
3. the preparation method of the prostatitic medicine for the treatment of according to claim 1 and 2, according to after described ratio of weight and number mix homogeneously by above-mentioned various crude drug, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, is crushed to 100 ~ 120 object medicated powder, in incapsulating, sterilization obtains capsule product.
CN201410644636.XA 2014-11-14 2014-11-14 Prostatitis treatment medicine and preparation method thereof Pending CN104474358A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593477A (en) * 2003-09-11 2005-03-16 谢昌贞 Chinese herbal medicine for treating chronic prostatitis and its preparation
CN103656334A (en) * 2012-09-17 2014-03-26 青岛信立德中药技术研究开发有限公司 Traditional Chinese medicine for treating prostatitis
CN103656377A (en) * 2013-11-27 2014-03-26 夏毓 Traditional Chinese medicine medicament for internally and externally treating chronic prostatitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593477A (en) * 2003-09-11 2005-03-16 谢昌贞 Chinese herbal medicine for treating chronic prostatitis and its preparation
CN103656334A (en) * 2012-09-17 2014-03-26 青岛信立德中药技术研究开发有限公司 Traditional Chinese medicine for treating prostatitis
CN103656377A (en) * 2013-11-27 2014-03-26 夏毓 Traditional Chinese medicine medicament for internally and externally treating chronic prostatitis

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