CN104472515A - Azadirachtin effervescent tablets for household gardening and production process - Google Patents
Azadirachtin effervescent tablets for household gardening and production process Download PDFInfo
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- CN104472515A CN104472515A CN201410797720.5A CN201410797720A CN104472515A CN 104472515 A CN104472515 A CN 104472515A CN 201410797720 A CN201410797720 A CN 201410797720A CN 104472515 A CN104472515 A CN 104472515A
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- nimbin
- acid
- azadirachtin
- effervescent tablet
- home gardening
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Abstract
The invention discloses azadirachtin effervescent tablets for household gardening. The azadirachtin effervescent tablets comprises the following raw materials by weight percent: 0.1-3% of azadirachtin, 1-20% of neem oil, 6-45% of a disintegrating agent, 1-20% of a wetting agent, 1-20% of a dispersing agent and the balance being supplemented filler, and the total weight percent is 100%. The invention also discloses a production process of the azadirachtin effervescent tablets for household gardening. The production process comprises the following steps of mixing all the raw materials; milling the mixed raw materials by using a jet mill, sieving powder by using 75-micron testing sieve so as to obtain fine-particle powder with the particle diameter being less than 75 microns; wetting and kneading the powder by using a little amount of bonding agent; carrying out tabletting by using a tabletting machine; carrying out drying treatment, controlling the temperature to be 18-21 DEG C, controlling the humidity to be 20%-25%, carrying out package after the bonding agent is completely evaporated so as to obtain the azadirachtin effervescent tablets. According to the azadirachtin effervescent tablets disclosed by the invention, the problem that azadirachtin products are blank in the household gardening market is well solved; when the azadirachtin effervescent tablets are used, the effective components are fully contacted with a target, the medicinal effect can be exerted well and the low-toxicity and environmental-friendly effects are achieved.
Description
Technical field
The present invention relates to a kind of effervescent tablet and production technology, particularly relate to a kind of home gardening nimbin effervescent tablet and production technology.
Background technology
Due to home gardening agricultural chemicals, to there is packing cost high, packing instructions are harsh, Product Safety requires comparatively high, a lot of agricultural chemicals company is made to segment market hang back to this, so be not substantially specifically designed to the Pesticidal products in home gardening market at present, the inner wrapping of the general agricultural chemicals of home gardening market pesticide recovery uses, and causes current home gardening pesticide market to belong to blank market.
More single for the kind of the commercial preparation in home gardening market at present, mostly be missible oil, separately have water dispersible granules.Missible oil due to containing organic solvent (as toluene, dimethylbenzene etc.), therefore inflammable, easily reveal, have pollution to environment, and consumption is large, production and transport uses inconvenience.Water dispersible granules is little due to granularity, and the volume accounted for is large, and in storage, granula is easily broken, brings inconvenience to use.So, develop active ingredient that applicable home gardening market uses, formulation, packaging be current home gardening market facing challenges.
Effervescent table as agricultural chemical is a kind of without the aqueous dispersion tablets that uses in the direct input paddy field of agricultural chemicals dust or droplet drift, and overflow from water because producing rapidly a large amount of bubble when water met by this tablet, water just as boiling, therefore is referred to as effervescent tablet.
Effervescent tablet is pharmaceutically using comparatively early, and the effervescent tablet agriculturally used, just start recent years, received people and pay attention to.Reason is that effervescent table as agricultural chemical has the following advantages:
(1) formulation environmental protection more, safety: without dust from flying, environmental pollution is little, use safety;
(2) be convenient to storage and transport: solid pharmaceutical preparation, store transportation safety, easy to use, used packing container adheres to without powder, is easy to process;
(3) effervescent tablet disintegration is quick, easy to use, onset is rapid: effervescent tablet produces a large amount of bubble after meeting water, rely on the motive force of tablet generates gas inside, make disintegration of tablet rapid, it is faster that active ingredient spreads, distribute evenly, this is that general aqueous dispersion tablets can not be compared, and can give full play to drug effect; And easy to use, can stand on ridge by tablet drop into or be thrown into Tanaka, also tablet can be put into the sprayer be filled with water;
(4) bioavilability is high, can improve product result of use;
(5) a large amount of foams produced due to disintegration add the plate-out ability of property of medicine composition on crop, allow product be adsorbed on plant surface better, play its curative effect effect better;
(6) consumption level is improved, client easily accepts, and is conducive to marketing.
Print chinaberry is the title of a kind of fast-growing deciduous tree, and seed and bark all can be used as medicine.Print chinaberry is the desirable pesticide plant of generally acknowledging in the world for 2013.Print chinaberry system Meliaceae Melia arbor, extensively plants in tropical and subtropical region.Originally analysis is investigated to a plague of locusts, in the print seed of chinaberry, leaf and bark, containing a kind of material---nimbin, just because of its existence, the magical function making print chinaberry have worm to cure the disease.Show through modern study, the compositions such as the nimbin extracted from print chinaberry fruit are wide spectrums recognized in the world, efficient, low toxicity, easily degraded, noresidue insecticide and there is no pesticide resistance, to nearly all plant insect, indoor bedbug, flea, fly, mosquito etc. all have repelling and killing efficacy, and to people and animals and surrounding environment without any pollution, nimbin also has medical function to numerous disease simultaneously, will have and apply widely in medicine.
Current nimbin series of products are blank in the home gardening market of China.Azadirachtin preparation product is unstable under natural environmental condition due to it, easy photodissociation, hydrolysis, and the stability problem that solve azadirachtin preparation product governs the formulation research and development of product all the time.The formulation of the nimbin series of products of current exploitation is missible oil, water dispersible granules, microcapsule formulations, and wherein, missible oil formulation containing benzene class aromatic hydrocarbon solvent, endangers greatly to people and animals usually; Pesticidal products formulation due to the home gardening market demand needs inner wrapping, dosage little, so water dispersible granules and microcapsule formulations exist in home gardening market use problem that is inconvenient, that not easily increase dosage.
Summary of the invention
The home gardening nimbin effervescent tablet that object of the present invention is just to provide a kind of to solve the problem is convenient to packaging, store, transport and use and production technology.
The present invention is achieved through the following technical solutions above-mentioned purpose:
A kind of home gardening nimbin effervescent tablet, comprise each raw material of following mass percent: nimbin 0.1-3%, neem oil 1-20%, disintegrant 6-45%, wetting agent 1-20%, dispersant 1-20%, filler supplies 100%.
Wherein, nimbin can be one or more in nimbin A, B, D, E, F, G, H, I, K, L, can be former medicine, containing the plant extracts of nimbin or azadirachtin preparation; Neem oil adopts neem seed to carry out cold-press acquisition.
As preferably, described home gardening nimbin effervescent tablet is made up of each raw material of following mass percent: nimbin 0.1-3%, neem oil 1-20%, disintegrant 6-45%, wetting agent 1-20%, dispersant 1-20%, filler supplies 100%.
Described disintegrant comprises acid source that mass percent is 5-35% and mass percent is the carbon dioxide source of 1-10%, and wherein, acid source is organic acid or inorganic acid, and carbon dioxide source is alkali and alkaline earth metal ions carbonate.
Described acid source is in one in succinic acid, tartaric acid, adipic acid, malic acid and fumaric acid or several.
Described carbon dioxide source is one or more in sodium carbonate, potassium sodium carbonate, sodium bicarbonate, saleratus, calcium carbonate, ammonium carbonate, glycine, sodium carbonate and concentrated crystal soda, is more preferably sodium carbonate, sodium bicarbonate.
Described wetting agent is that tea is withered, Chinese honey locust, silkworm excrement, alkylsurfuric acid salt or Morwet EFW.Alkylsurfuric acid salt preferably sodium dodecyl sulfate; Morwet EFW is the wetting agent of a excellent performance of Akzo Nobel, is the mixture of alkylnaphthalene sulfonate and anion wetting agent.
Described dispersant is lignosulfite and dry substance thereof, with the serial sulfonate that lignin and derivative thereof are raw material, a series of sulfonate based on the formaldehyde condensation products of naphthalene and Fluhyzon, the sulphate that molecular weight is larger, or the copolymer of oxirane and expoxy propane, as Morwet D and TERWET series of products.
Described filler is one or more in bentonite, kaolin, attapulgite, diatomite, precipitated calcium carbonate and white carbon.These fillers are inert filler.
A production technology for home gardening nimbin effervescent tablet, comprises the following steps:
(1) mixed by each raw material of following mass percent: nimbin 0.1-3%, neem oil 1-20%, disintegrant 6-45%, wetting agent 1-20%, dispersant 1-20%, filler supplies 100%;
(2) with airslide disintegrating mill mixed material carried out pulverizing and use 75um testing sieve to be sieved by powder, obtaining the particulate powders that particle diameter is less than 75um;
(3) with a small amount of binding agent, powder is soaked kneading;
(4) compressing tablet is carried out with tablet press machine;
(5) dry process, temperature controls at 18-21 DEG C, and humid control, at 20%-25%, is packed after binding agent evaporates completely, obtains nimbin effervescent tablet.
In above-mentioned steps, the thickness of the pulverized powder particle of mixed material of step (2) is extremely important, prove through test, its powder is thinner, the property of medicine of nimbin is better, and particle diameter 75um is an important separation, can achieve this end with airslide disintegrating mill in the market, in other words, adopting micropowder technology to reduce particle diameter is improve the effective method of the solvability of insoluble drug as nimbin; Baking temperature in step (5) and humidity are also through the optimization control parameter that test proves, because nimbin is comparatively responsive to temperature and humidity, and the too high or too low property of medicine that all can reduce nimbin of temperature and humidity.
As preferably, in described step (1), described disintegrant comprises acid source that mass percent is 5-35% and mass percent is the carbon dioxide source of 1-10%, wherein, acid source is in one in succinic acid, tartaric acid, adipic acid, malic acid and fumaric acid or several, and carbon dioxide source is one or more in sodium carbonate, potassium sodium carbonate, sodium bicarbonate, saleratus, calcium carbonate, ammonium carbonate, glycine, sodium carbonate and concentrated crystal soda; Described wetting agent is that tea is withered, Chinese honey locust, silkworm excrement, alkylsurfuric acid salt or Morwet EFW; Described dispersant is lignosulfite and dry substance thereof, with the serial sulfonate that lignin and derivative thereof are raw material, a series of sulfonate based on the formaldehyde condensation products of naphthalene and Fluhyzon, the sulphate that molecular weight is larger, or the copolymer of oxirane and expoxy propane; Described filler is one or more in bentonite, kaolin, attapulgite, diatomite, precipitated calcium carbonate and white carbon; Binding agent in described step (3) is water.
Beneficial effect of the present invention is:
Home gardening nimbin effervescent tablet of the present invention solves the nimbin series of products problem still blank in home gardening market well, the outward appearance of effervescent tablet is sheet, directly tablet is dropped in water during use, in tablet, carbonate and organic acid react rapidly and produce carbon dioxide in water, make its effervesce disintegration, by diffusant effect, evenly spread towards periphery, active ingredient is made fully to contact target, drug effect plays effective, compares traditional non-nimbin agricultural chemicals low toxic and environment-friendly more simultaneously; Production technology of the present invention makes nimbin can keep its efficacy stability in process of production, and it is more thorough by the control of fineness, temperature, humidity, the property of medicine of nimbin to be played, and reaches better insecticidal effect.
Embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
The nimbin effervescent tablet of production home gardening according to the following steps:
(1) get each raw material of following mass percent and mix: nimbin 0.3%, neem oil 5%, fumaric acid 5 %, sodium bicarbonate 2%, Morwet EFW12%, Morwet D-110 12%, lauryl sodium sulfate 5%, white carbon 5%, kaolin 53.7%;
(2) with airslide disintegrating mill mixed material carried out pulverizing and use 75um testing sieve to be sieved by powder, obtaining the particulate powders that particle diameter is less than 75um;
(3) with a small amount of binding agent, powder is soaked kneading;
(4) compressing tablet is carried out with tablet press machine;
(5) dry process, temperature controls at 18-21 DEG C, and humid control, at 20%-25%, is packed after binding agent evaporates completely, obtains 0.3% nimbin effervescent tablet.
Embodiment 2:
The nimbin effervescent tablet of production home gardening according to the following steps:
(1) get each raw material of following mass percent and mix: nimbin 1%, neem oil 8%, adipic acid 6 %, sodium carbonate 3%, Chinese honey locust 15%, Morwet D-110 12%, lauryl sodium sulfate 8%, white carbon 8%, bentonite 39%;
(2) with airslide disintegrating mill mixed material carried out pulverizing and use 75um testing sieve to be sieved by powder, obtaining the particulate powders that particle diameter is less than 75um;
(3) with a small amount of binding agent, powder is soaked kneading;
(4) compressing tablet is carried out with tablet press machine;
(5) dry process, temperature controls at 18-21 DEG C, and humid control, at 20%-25%, is packed after binding agent evaporates completely, obtains 1% nimbin effervescent tablet.
Be enumerated above two embodiments, also have other embodiment a lot, such as: the mass percent of nimbin adopts 0.1%, 0.5%, 1.5%, 2%, 2.5% or 3%; The mass percent of neem oil adopts 1%, 3%, 10%, 12%, 15% or 20%; The mass percent of fumaric acid adopts 8%, 10%, 15%, 20%, 25%, 30% or 35%, and fumaric acid also can be replaced by succinic acid, tartaric acid, adipic acid or malic acid; The mass percent of sodium bicarbonate adopts 1%, 4%, 5%, 6%, 8%, 9% or 10%, and sodium bicarbonate also can be replaced by sodium carbonate, potassium sodium carbonate, saleratus, calcium carbonate, ammonium carbonate, glycine, sodium carbonate or concentrated crystal soda; The mass percent of Morwet EFW adopt 1%, 5%, 8%, 10%, 15%, 18% or 20%, Morwet EFW also can, Chinese honey locust, silkworm excrement withered by tea or alkylsurfuric acid salt replace; The mass percent of Morwet D-110 adopts 1%, 5%, 8%, 10%, 15%, 18% or 20%, Morwet D-110 also can by lignosulfite and dry substance thereof, by lignin and derivative thereof the serial sulfonate that is raw material, a series of sulfonate based on the formaldehyde condensation products of naphthalene and Fluhyzon, sulphate that molecular weight is larger, or other copolymer of oxirane and expoxy propane replaces; White carbon and kaolin also can be replaced by one or more in bentonite, high attapulgite, diatomite and precipitated calcium carbonate, and its content is for supplying 100%.
In home gardening plant, property of medicine experiment is carried out to the various embodiments described above gained nimbin effervescent tablet, all can realize good insecticidal effect, dissimilar according to insect, adopt the nimbin effervescent tablet of different Azadirachtin Cotent, after dilute with water, spray desinsection.
On above embodiment basis, soluble starch and lubricant can also be added in the feed, the performance of this nimbin effervescent tablet is not affected.
Above-described embodiment is preferred embodiment of the present invention; it is not the restriction to technical solution of the present invention; as long as without the technical scheme that creative work can realize on the basis of above-described embodiment, all should be considered as falling within the scope of the rights protection of patent of the present invention.
Claims (10)
1. a home gardening nimbin effervescent tablet, is characterized in that: each raw material comprising following mass percent: nimbin 0.1-3%, and neem oil 1-20%, disintegrant 6-45%, wetting agent 1-20%, dispersant 1-20%, filler supplies 100%.
2. home gardening nimbin effervescent tablet according to claim 1, is characterized in that: be made up of each raw material of following mass percent: nimbin 0.1-3%, neem oil 1-20%, disintegrant 6-45%, wetting agent 1-20%, dispersant 1-20%, filler supplies 100%.
3. home gardening nimbin effervescent tablet according to claim 1 and 2, it is characterized in that: described disintegrant comprises acid source that mass percent is 5-35% and mass percent is the carbon dioxide source of 1-10%, wherein, acid source is organic acid or inorganic acid, and carbon dioxide source is alkali and alkaline earth metal ions carbonate.
4. home gardening nimbin effervescent tablet according to claim 3, is characterized in that: described acid source is in one in succinic acid, tartaric acid, adipic acid, malic acid and fumaric acid or several.
5. home gardening nimbin effervescent tablet according to claim 3, is characterized in that: described carbon dioxide source is one or more in sodium carbonate, potassium sodium carbonate, sodium bicarbonate, saleratus, calcium carbonate, ammonium carbonate, glycine, sodium carbonate and concentrated crystal soda.
6. home gardening nimbin effervescent tablet according to claim 1 and 2, is characterized in that: described wetting agent is that tea is withered, Chinese honey locust, silkworm excrement, alkylsurfuric acid salt or Morwet EFW.
7. home gardening nimbin effervescent tablet according to claim 1 and 2, it is characterized in that: described dispersant is lignosulfite and dry substance thereof, with the serial sulfonate that lignin and derivative thereof are raw material, a series of sulfonate based on the formaldehyde condensation products of naphthalene and Fluhyzon, the sulphate that molecular weight is larger, or the copolymer of oxirane and expoxy propane.
8. home gardening nimbin effervescent tablet according to claim 1 and 2, is characterized in that: described filler is one or more in bentonite, kaolin, attapulgite, diatomite, precipitated calcium carbonate and white carbon.
9. a home gardening production technology for nimbin effervescent tablet, is characterized in that: comprise the following steps:
Mixed by each raw material of following mass percent: nimbin 0.1-3%, neem oil 1-20%, disintegrant 6-45%, wetting agent 1-20%, dispersant 1-20%, filler supplies 100%;
With airslide disintegrating mill mixed material carried out pulverizing and use 75um testing sieve to be sieved by powder, obtaining the particulate powders that particle diameter is less than 75um;
With a small amount of binding agent, powder is soaked kneading;
Compressing tablet is carried out with tablet press machine;
Dry process, temperature controls at 18-21 DEG C, and humid control, at 20%-25%, is packed after binding agent evaporates completely, obtains nimbin effervescent tablet.
10. the production technology of home gardening nimbin effervescent tablet according to claim 9, it is characterized in that: in described step (1), described disintegrant comprises acid source that mass percent is 5-35% and mass percent is the carbon dioxide source of 1-10%, wherein, acid source is in one in succinic acid, tartaric acid, adipic acid, malic acid and fumaric acid or several, and carbon dioxide source is one or more in sodium carbonate, potassium sodium carbonate, sodium bicarbonate, saleratus, calcium carbonate, ammonium carbonate, glycine, sodium carbonate and concentrated crystal soda; Described wetting agent is that tea is withered, Chinese honey locust, silkworm excrement, alkylsurfuric acid salt or Morwet EFW; Described dispersant is lignosulfite and dry substance thereof, with the serial sulfonate that lignin and derivative thereof are raw material, a series of sulfonate based on the formaldehyde condensation products of naphthalene and Fluhyzon, the sulphate that molecular weight is larger, or the copolymer of oxirane and expoxy propane; Described filler is one or more in bentonite, kaolin, attapulgite, diatomite, precipitated calcium carbonate and white carbon; Binding agent in described step (3) is water.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410797720.5A CN104472515A (en) | 2014-12-22 | 2014-12-22 | Azadirachtin effervescent tablets for household gardening and production process |
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| CN201410797720.5A CN104472515A (en) | 2014-12-22 | 2014-12-22 | Azadirachtin effervescent tablets for household gardening and production process |
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| CN104472515A true CN104472515A (en) | 2015-04-01 |
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| CN201410797720.5A Pending CN104472515A (en) | 2014-12-22 | 2014-12-22 | Azadirachtin effervescent tablets for household gardening and production process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11944091B2 (en) | 2016-12-07 | 2024-04-02 | Adama Makhteshim Ltd. | Stable, self-dispersible, low foaming solid pesticide formulation |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1276161A (en) * | 2000-04-27 | 2000-12-13 | 华南农业大学 | Plant-type nimbin insecticide |
| WO2006082596A2 (en) * | 2005-01-19 | 2006-08-10 | Kamalinder Kaur Singh | Neem oil contraceptive formulations |
| CN101703076A (en) * | 2009-09-22 | 2010-05-12 | 成都绿金高新技术股份有限公司 | Nimbin general oil solution |
| CN102823589A (en) * | 2012-09-24 | 2012-12-19 | 发事达(南通)化工有限公司 | Pesticide water effervescent dispersible tablet and preparation method thereof |
-
2014
- 2014-12-22 CN CN201410797720.5A patent/CN104472515A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1276161A (en) * | 2000-04-27 | 2000-12-13 | 华南农业大学 | Plant-type nimbin insecticide |
| WO2006082596A2 (en) * | 2005-01-19 | 2006-08-10 | Kamalinder Kaur Singh | Neem oil contraceptive formulations |
| CN101703076A (en) * | 2009-09-22 | 2010-05-12 | 成都绿金高新技术股份有限公司 | Nimbin general oil solution |
| CN102823589A (en) * | 2012-09-24 | 2012-12-19 | 发事达(南通)化工有限公司 | Pesticide water effervescent dispersible tablet and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘广文: "《现代农药剂型加工技术》", 31 January 2013 * |
| 环境保护部科技标准司: "《"十一五"环境保护科学技术奖汇编》", 29 February 2012 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11944091B2 (en) | 2016-12-07 | 2024-04-02 | Adama Makhteshim Ltd. | Stable, self-dispersible, low foaming solid pesticide formulation |
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