CN104471406A - 用于诊断骨关节炎的方法 - Google Patents

用于诊断骨关节炎的方法 Download PDF

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Publication number
CN104471406A
CN104471406A CN201380037434.2A CN201380037434A CN104471406A CN 104471406 A CN104471406 A CN 104471406A CN 201380037434 A CN201380037434 A CN 201380037434A CN 104471406 A CN104471406 A CN 104471406A
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CN
China
Prior art keywords
concentration
osteoarthritis
cell factor
pdgf
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380037434.2A
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English (en)
Chinese (zh)
Inventor
克丽斯塔·欧肖内西
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Biomet Biologics LLC
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Biomet Biologics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomet Biologics LLC filed Critical Biomet Biologics LLC
Publication of CN104471406A publication Critical patent/CN104471406A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/49—Platelet-derived growth factor [PDGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201380037434.2A 2012-06-04 2013-06-04 用于诊断骨关节炎的方法 Pending CN104471406A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261655322P 2012-06-04 2012-06-04
US61/655,322 2012-06-04
PCT/US2013/044075 WO2013184660A1 (en) 2012-06-04 2013-06-04 Methods for diagnosing osteoarthritis

Publications (1)

Publication Number Publication Date
CN104471406A true CN104471406A (zh) 2015-03-25

Family

ID=48626668

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380037434.2A Pending CN104471406A (zh) 2012-06-04 2013-06-04 用于诊断骨关节炎的方法

Country Status (5)

Country Link
US (1) US20150141332A1 (https=)
EP (1) EP2856171A1 (https=)
JP (1) JP2015520383A (https=)
CN (1) CN104471406A (https=)
WO (1) WO2013184660A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111855999A (zh) * 2020-06-02 2020-10-30 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所） 一种化妆品中rhEGF快速检测试纸卡、试剂盒及其检测方法

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EP2620139B1 (en) 2008-02-27 2016-07-20 Biomet Biologics, LLC Interleukin-1 receptor antagonist rich solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9878011B2 (en) 2013-03-15 2018-01-30 Biomet Biologics, Llc Treatment of inflammatory respiratory disease using biological solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9758806B2 (en) 2013-03-15 2017-09-12 Biomet Biologics, Llc Acellular compositions for treating inflammatory disorders
EP3074507B1 (en) 2013-11-26 2022-01-05 Biomet Biologics, LLC Methods of mediating macrophage phenotypes
US10441635B2 (en) 2014-11-10 2019-10-15 Biomet Biologics, Llc Methods of treating pain using protein solutions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006023412A2 (en) * 2004-08-18 2006-03-02 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Biomarkers for osteoarthritis
CN1977049A (zh) * 2004-04-26 2007-06-06 儿童医疗中心有限公司 用于检测疾病的血小板生物标志物

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US20120030593A1 (en) 1995-11-13 2012-02-02 Lakshmi Arunachalam Method and apparatus for enabling real-time bi-directional transactions on a network
JP4344436B2 (ja) * 1999-08-24 2009-10-14 生化学工業株式会社 変形性関節症の検出方法
EP2287616A1 (en) * 2003-09-15 2011-02-23 Oklahoma Medical Research Foundation Method of using cytokine assays to diagnose, treat, and evaluate systemic lupus erythematosus
US8753690B2 (en) 2008-02-27 2014-06-17 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
EP2620139B1 (en) 2008-02-27 2016-07-20 Biomet Biologics, LLC Interleukin-1 receptor antagonist rich solutions
CA2728537A1 (en) * 2008-06-25 2009-12-30 Source Precision Medicine, Inc. D/B/A Source Mdx Gene expression profiling for identification, monitoring, and treatment of osteoarthritis
CA2772084C (en) 2009-08-27 2016-10-18 Biomet Biologics, Llc Implantable device for production of interleukin-1 receptor antagonist
US20110052561A1 (en) 2009-08-27 2011-03-03 Biomet Biologics,LLC Osteolysis treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1977049A (zh) * 2004-04-26 2007-06-06 儿童医疗中心有限公司 用于检测疾病的血小板生物标志物
WO2006023412A2 (en) * 2004-08-18 2006-03-02 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Biomarkers for osteoarthritis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAVID A.WALSH等: "Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis", 《RHEUMATOLOGY》, vol. 49, 26 June 2010 (2010-06-26) *
EDUARDO ANITUA等: "Relationship between investigative biomarkers and radiographic grading in patients with knee osteoarthritis", 《INTERNATIONAL JOURNAL OF RHEUMATOLOGY》, 31 December 2009 (2009-12-31) *
JENNIFER WOODELL-MAY等: "Autologous protein solution inhibits MMP-13 production by IL-1b and TNFa-stimulated human articular chondrocytes", 《JOURNAL OF ORTHOPAEDIC RESEARCH》, 15 March 2011 (2011-03-15) *
VERENA MOOS等: "Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage.", 《THE JOURNAL OF RHEUMATOLOGY》, vol. 26, 31 December 1999 (1999-12-31) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111855999A (zh) * 2020-06-02 2020-10-30 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所） 一种化妆品中rhEGF快速检测试纸卡、试剂盒及其检测方法

Also Published As

Publication number Publication date
WO2013184660A1 (en) 2013-12-12
EP2856171A1 (en) 2015-04-08
JP2015520383A (ja) 2015-07-16
US20150141332A1 (en) 2015-05-21

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Application publication date: 20150325