CN104436297A - Power material for manufacturing artificial bone and preparation method of power material - Google Patents
Power material for manufacturing artificial bone and preparation method of power material Download PDFInfo
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- CN104436297A CN104436297A CN201410712311.0A CN201410712311A CN104436297A CN 104436297 A CN104436297 A CN 104436297A CN 201410712311 A CN201410712311 A CN 201410712311A CN 104436297 A CN104436297 A CN 104436297A
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Abstract
The invention provides a power material for manufacturing an artificial bone and a preparation method of the power material. The power material is prepared from the following components in percentage by weight: 50-80 percentage of hydroxyapatite (with the specification of 20nm*150nm and a shape of a needle),15-45 percentage of alumina (with the particle size of 0.6 microns) and 4-7 percentage of titanium (with the particle size of 40 microns). The preparation method comprises the following step: carrying out ball milling, drying, grinding, filtering and the like on the components to prepare the power material for manufacturing the artificial bone. The power material is prepared into the artificial bone by adopting an explosive compaction method. According to the power material and the preparation method provided by the invention, as the titanium is added in the power material for manufacturing the artificial bone, the strength of the artificial bone can be improved, and the artificial bone is non-toxic to human tissues; the artificial bone with high strength, high toughness and high biological activity can be prepared by adopting the explosive compaction method.
Description
Technical field
The present invention relates to technical field of biological material, especially relate to a kind of dusty material for the manufacture of artificial bone-head be made up of hydroxyapatite, aluminium oxide and titanium three components and preparation method thereof, and use the method for this dusty material manufacture of intraocular bone.
Background technology
In the fields such as orthopaedics, plastic surgery, oncology, dentistry, hard bone tissue defect is common sufferer.Therefore, need to develop the artificial material of patient autologous tissue can be replaced for the reparation of skeleton and function in an acting capacity of its function.Desirable bone impairment renovation material, should meet the following requirements: 1. good histocompatibility; 2. quantity of originating is unrestricted; 3. easily moulding; 4. can be grown into by biological tissue or substitute; 5. there is certain intensity and anti-pressure ability.Current titanium alloy material and ceramic material are two kinds of artificial bone-head's raw materials that medical circle is generally acknowledged, researcher both domestic and external has carried out large quantity research to this, test and clinically show the reparation that this bi-material all can realize bulk defect skeleton, but all there is certain suitability.
Titanium alloy material hardness is moderate, there is certain elasticity, surface easily produces stable oxide-film, when titanium alloy artificial skeleton implants, repellency can not be produced with human body, can be described as very little than it on the impact of human body with other various alloy phases, be that many hospitals are in order to repair the traditional material of skull from the mid-90 in last century always.The alloy material of Titanium has higher intensity and good toughness, very close to the requirement of biological skeleton, but after implant into body or organism, often be difficult to produce desirable biocompatibility, lack biological activity, just simple mechanical-physical combines, and the application of this material is very restricted.
Hydroxyapatite is the ceramic material the same with animal skeleton composition, because it has the good compatibility with skeleton in vivo, so the artificial bone of hydroxyapatite in implantation animal body is after some months, the muscle of a silk starts " seeking connections with " on it, new and old skeleton then extends gradually, until combine together.This is because after hydroxyapatite and body fluid reacts, osteoid apatite can be formed on its surface, just similar to the host inorganic composition in animal bone tissue.
But a large number of experiments show that, although implant the artificial bone of hydroxyapatite after animal body to have good biocompatibility, intensity and toughness are very low, can not become the desirable succedaneum of skeleton all the time, also significantly limit its application at medical domain.
In order to improve the intensity of the artificial bone of hydroxyapatite, Japanese scholars adds aluminium oxide in hydroxyapatite, then carries out vacuum-sintering under the high temperature conditions, improves its toughness, can be applied to manufacture of intraocular skeleton, but its intensity is still not fully up to expectations.
In recent years, domestic and international researcher has progressively developed multiple manufacturing technology for improving the mechanical performance of bioactive materials artificial bone, as rapid shaping technique, 3D printing technique, freezing extrusion manufacturing technology and selective laser sintering technology etc.Above-mentioned several method all adds the later stage based on the sizing of 3D precision and sinters the making that this conventional Making programme carries out artificial bone, although meet mechanical property and the biological activity of artificial bone, but in view of its making apparatus is accurate, complex manufacturing technology, therefore cannot meet device simple, the cost-effectiveness requirement needed for commercial production in enormous quantities.
Summary of the invention
For the problems referred to above that prior art exists, the invention provides dusty material of a kind of manufacture of intraocular bone and preparation method thereof.Adopt dusty material of the present invention can manufacture the artificial bone-head with high strength, high tenacity and high-biocompatibility by the method for explosive compaction.
Technical scheme of the present invention is as follows:
A dusty material for manufacture of intraocular bone, the mass fraction that described dusty material comprises component and each component is:
Hydroxyapatite 50% ~ 80%
Aluminium oxide 15% ~ 45%
Titanium 4% ~ 7%
Described dusty material manufactures artificial bone-head by explosive compaction method.
The specification of described hydroxyapatite is: 20nm × 150nm, needle-like; The particle diameter of described aluminium oxide is 0.6 μm; The particle diameter of described titanium is 40 μm.
The method of described explosive compaction is explosive blasting, propagates the shock wave of blast generation to layer of powder material, make dusty material be compacted into artificial bone-head by aqueous medium.
A preparation method for the dusty material of manufacture of intraocular bone, concrete preparation process is as follows:
(1) hydroxyapatite 50% ~ 80%, aluminium oxide 15% ~ 45% and titanium 4% ~ 7% are added in ball grinder form mixed-powder;
(2) then in ball grinder, add dehydrated alcohol and zirconium ball, make the solution of mixed-powder;
(3) ball grinder is closed, be placed on planetary ball mill and be milled to mixed-powder mix homogeneously;
(4) the mixed-powder solution of mix homogeneously is poured in Stainless steel basin, put it in baking oven dry, the dehydrated alcohol in mixed-powder solution is volatilized completely, obtain dry block mixed-powder;
(5) finally by the block mixed-powder mortar grinder of drying, then filter with sub-sieve, obtain can be used for manufacturing the dusty material of artificial bone-head of high strength, high tenacity, high bioactivity.
The mass ratio of described mixed-powder, dehydrated alcohol and zirconium ball is 1:1:1.
The technique effect that the present invention is useful is:
1, the titanium added in dusty material of the present invention, improves intensity and the toughness of artificial bone-head;
2, dusty material of the present invention is nontoxic to tissue;
3, dusty material of the present invention has higher biocompatibility;
4, explosive compaction method of the present invention can provide the compaction pressure of GPa level, improves compacted density and the intensity of artificial bone-head.
Accompanying drawing explanation
Fig. 1 is the present invention's explosive compaction apparatus structure used schematic diagram;
Description of reference numerals:
1, powder charge pipe; 2, water pipe is filled; 3, tube cell is filled; 4, TNT; 5, water; 6, powder.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is specifically described.
The preparation method of the dusty material of manufacture of intraocular bone of the present invention, implement according to following step:
(1) hydroxyapatite 50% ~ 80%, aluminium oxide 15% ~ 45% and titanium 4% ~ 7% are added in ball grinder form mixed-powder;
(2) then in ball grinder, add dehydrated alcohol and zirconium ball, make the solution of mixed-powder; The mass ratio of mixed-powder, dehydrated alcohol and zirconium ball is 1:1:1
(3) ball grinder is closed, be placed on planetary ball mill and be milled to mixed-powder mix homogeneously;
(4) the mixed-powder solution of mix homogeneously is poured in Stainless steel basin, put it in baking oven dry, the dehydrated alcohol in mixed-powder solution is volatilized completely, obtain dry block mixed-powder;
(5) last, by the block mixed-powder mortar grinder of drying, then filter with sub-sieve, obtain can be used for manufacturing the dusty material of artificial bone-head of high strength, high tenacity, high bioactivity.
Component contained by product embodiments 1 to embodiment 3 of the present invention and the mass fraction of each component are in table 1.Obtained product of the present invention according to the method described above.
Table 1
As shown in Figure 1,1 is powder charge pipe; 2 is dress water pipe; 3 is dress tube cell; 4 is TNT; 5 is water; 6 is powder.First the embodiment of the present invention 1 to embodiment 3 gained dusty material is loaded dress to be in charge of in 3, then water is loaded in dress water pipe 2, finally explosive TNT is loaded powder charge pipe, after filling, light the explosive in powder charge pipe, blast; The shock wave that blast produces, to be transmitted to the layer of powder material in powder charge pipe, thus to make dusty material of the present invention be compacted into artificial bone-head's material by aqueous medium along pipeline.
The mechanics properties testing result of table 1 illustrated embodiment 1 to embodiment 3 gained artificial bone-head is as shown in table 2.
Table 2
| Sequence number | Density (g/cm 3) | Webster hardness (Hv) | Fracture toughness (MPa.m 1/2) | Comprcssive strength (MPa) |
| Embodiment 1 | 3.19 | 215 | 2.2 | 98 |
| Embodiment 2 | 3.26 | 213 | 2.4 | 100 |
| Embodiment 3 | 3.36 | 215 | 2.7 | 103 |
| Skeleton | 0.57～1.48 | 160 | 1.2 | 34.3～108.8 |
As can be seen from table 2 data, the mechanical property of the dusty material manufacture of intraocular bone that embodiment 1 ~ 3 is obtained is all good than skeleton, the reparation of human body affected bone can be applied to completely and substitute, can be applicable to the manufacture of artificial bone-head of high strength, high tenacity, high bioactivity.
Claims (5)
1. a dusty material for manufacture of intraocular bone, is characterized in that the mass fraction that described dusty material comprises component and each component is:
Hydroxyapatite 50% ~ 80%
Aluminium oxide 15% ~ 45%
Titanium 4% ~ 7%
Described dusty material manufactures artificial bone-head by explosive compaction method.
2. the dusty material of manufacture of intraocular bone according to claim 1, is characterized in that the specification of described hydroxyapatite is: 20nm × 150nm, needle-like; The particle diameter of described aluminium oxide is 0.6 μm; The particle diameter of described titanium is 40 μm.
3. the dusty material of manufacture of intraocular bone according to claim 1, is characterized in that the method for described explosive compaction is explosive blasting, propagates the shock wave of blast generation to layer of powder material, make dusty material be compacted into artificial bone-head by aqueous medium.
4. a preparation method for the dusty material of manufacture of intraocular bone according to claim 1, is characterized in that concrete preparation process is as follows:
(1) hydroxyapatite 50% ~ 80%, aluminium oxide 15% ~ 45% and titanium 4% ~ 7% are added in ball grinder form mixed-powder;
(2) then in ball grinder, add dehydrated alcohol and zirconium ball, make the solution of mixed-powder;
(3) ball grinder is closed, be placed on planetary ball mill and be milled to mixed-powder mix homogeneously;
(4) the mixed-powder solution of mix homogeneously is poured in Stainless steel basin, put it in baking oven dry, the dehydrated alcohol in mixed-powder solution is volatilized completely, obtain dry block mixed-powder;
(5) finally by the block mixed-powder mortar grinder of drying, then filter with sub-sieve, obtain can be used for manufacturing the dusty material of artificial bone-head of high strength, high tenacity, high bioactivity.
5. preparation method according to claim 4, is characterized in that the mass ratio of described mixed-powder, dehydrated alcohol and zirconium ball is 1:1:1.
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| CN201410712311.0A CN104436297B (en) | 2014-11-28 | 2014-11-28 | Dusty material of a kind of manufacture of intraocular bone and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106045526A (en) * | 2016-08-22 | 2016-10-26 | 中国科学院力学研究所 | Method for preparing ceramic powder through liquid-state CO2 |
| CN106581745A (en) * | 2016-11-08 | 2017-04-26 | 深圳大学 | Method of utilizing direct ink writing to prepare alumina toughened hydroxyapatite biological scaffold |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004007399A2 (en) * | 2002-07-12 | 2004-01-22 | Pilliar Robert M | Method of manufacture of porous inorganic structures and infiltration with organic polymers |
| WO2005105166A1 (en) * | 2004-05-04 | 2005-11-10 | Tibone Limited | A composite |
| CN101125224A (en) * | 2007-08-02 | 2008-02-20 | 哈尔滨工业大学 | Titanium/hydroxyl apatite biological composite material and preparation method thereof |
| CN101229587A (en) * | 2008-02-20 | 2008-07-30 | 暨南大学 | Biological ceramics titanium base compound material and manufacturing method thereof |
| CN101250058A (en) * | 2008-03-06 | 2008-08-27 | 张木蕃 | Alumina-based biologic active ceramic composite material |
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2014
- 2014-11-28 CN CN201410712311.0A patent/CN104436297B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004007399A2 (en) * | 2002-07-12 | 2004-01-22 | Pilliar Robert M | Method of manufacture of porous inorganic structures and infiltration with organic polymers |
| WO2005105166A1 (en) * | 2004-05-04 | 2005-11-10 | Tibone Limited | A composite |
| CN101125224A (en) * | 2007-08-02 | 2008-02-20 | 哈尔滨工业大学 | Titanium/hydroxyl apatite biological composite material and preparation method thereof |
| CN101229587A (en) * | 2008-02-20 | 2008-07-30 | 暨南大学 | Biological ceramics titanium base compound material and manufacturing method thereof |
| CN101250058A (en) * | 2008-03-06 | 2008-08-27 | 张木蕃 | Alumina-based biologic active ceramic composite material |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106045526A (en) * | 2016-08-22 | 2016-10-26 | 中国科学院力学研究所 | Method for preparing ceramic powder through liquid-state CO2 |
| CN106581745A (en) * | 2016-11-08 | 2017-04-26 | 深圳大学 | Method of utilizing direct ink writing to prepare alumina toughened hydroxyapatite biological scaffold |
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| CN104436297B (en) | 2016-02-03 |
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