CN104436116A - Rosemary foot bath powder and preparation method thereof - Google Patents
Rosemary foot bath powder and preparation method thereof Download PDFInfo
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Abstract
本发明公开了一种迷迭香足浴粉及其制备方法,该足浴粉包括以下重量份的物质组成:迷迭香10-25份;天竺葵3-10份;广藿香3-8份;杜仲叶4-9份;葡萄籽1-3份;玫瑰花1-5份;生姜粉2-6份;该制备方法包括以下步骤:除杂、风干、发酵、灭菌、酶解、干燥、复配、粉碎。本发明的迷迭香足浴粉见效快,溶出物较多,无需较长时间浸泡即可达到较好保健效果,使用周期短,成本低。The invention discloses a rosemary foot bath powder and a preparation method thereof. The foot bath powder comprises the following components by weight: 10-25 parts of rosemary; 3-10 parts of geranium; 3-8 parts of patchouli; Eucommia ulmoides 4-9 parts of leaves; 1-3 parts of grape seeds; 1-5 parts of roses; With, smash. The rosemary foot bath powder of the present invention has quick effect, more dissolved matter, better health care effect can be achieved without soaking for a long time, short service period and low cost.
Description
技术领域 technical field
本发明属于中药保健品技术领域,具体涉及一种迷迭香足浴粉及其制备方法。 The invention belongs to the technical field of traditional Chinese medicine health care products, and in particular relates to a rosemary foot bath powder and a preparation method thereof.
背景技术 Background technique
在中医中,足浴是治疗疾病的方法之一,属于内病外治的一种,它源于我国远古时代,是我国劳动人民在长期的实践中总结出来的经验。宋代苏东坡曰“热浴足法,其效初不甚觉,但积累百余日,功用不可量,比之服药,其效百倍”。足浴过程中常将一些具有保健作用的中药成分添加到热水中,通过水的温热作用、机械作用、化学作用及借助药物蒸汽和药液薰洗的治疗作用,可疏通奉理,散风降温,透达筋骨,理气和血,从而达到增强心脑血管机能、改善睡眠、消除疲劳的目的。 In traditional Chinese medicine, foot bath is one of the methods of treating diseases, which belongs to a kind of external treatment of internal diseases. It originated from the ancient times of our country and is the experience summed up by the working people in our country in the long-term practice. Su Dongpo of the Song Dynasty said, "The effect of the hot bath foot method is not very noticeable at the beginning, but after more than a hundred days of accumulation, the effect is immeasurable. Compared with taking medicine, its effect is a hundred times." In the process of foot bath, some traditional Chinese medicine ingredients with health care effects are often added to the hot water. Through the warming effect of water, mechanical action, chemical action and the therapeutic effect of medicinal steam and medicinal liquid fumigation, it can dredge the body, disperse wind and cool down. , penetrate the muscles and bones, regulate qi and blood, so as to achieve the purpose of enhancing cardiovascular and cerebrovascular functions, improving sleep and eliminating fatigue.
目前足浴粉包括中药足浴粉及化学合成药物足浴粉。化学合成药物足浴粉主要用于治疗脚气、足癣等皮肤性疾病,中草药足浴粉是目前保健品领域普遍使用和被消费者广泛接受的足浴粉品种,每年使用量大,价格高,长期使用能达到相应中草药的调理保健效果。传统的中草药足浴粉通常将中草药进行干燥、粉碎后直接无菌包装成足浴粉,中草药成分进行简单的粉碎并不能完全破坏植物细胞壁,中药中的有效成分溶出量少,使用过程中需要较高水温较长时间浸泡才能溶出一部分中药有效成分,见效慢,使用周期长,成本高。 At present, foot bath powder includes traditional Chinese medicine foot bath powder and chemically synthesized drug foot bath powder. Chemically synthesized drug foot bath powder is mainly used to treat skin diseases such as beriberi and tinea pedis. Chinese herbal medicine foot bath powder is currently widely used in the field of health care products and widely accepted by consumers. Reach the conditioning health care effect of corresponding Chinese herbal medicine. Traditional Chinese herbal medicine foot bath powder is usually dried and crushed Chinese herbal medicine and directly aseptically packaged into foot bath powder. Simple pulverization of Chinese herbal medicine components cannot completely destroy the plant cell wall. The active ingredients in traditional Chinese medicine are less dissolved, and higher water temperature is required during use. A part of the active ingredients of traditional Chinese medicines can be dissolved only after soaking for a long time, and the effect is slow, the service life is long, and the cost is high.
发明内容 Contents of the invention
为解决上述技术问题,本发明旨在提供一种见效快,溶出物较多,无需较长时间浸泡即可达到较好效果的足浴粉产品;该产品使用周期短且成本低。 In order to solve the above technical problems, the present invention aims to provide a foot bath powder product with quick effect, more leached matter, and better effect without soaking for a long time; the product has a short service life and low cost.
本发明通过以下技术方案实现。 The present invention is realized through the following technical solutions.
一种迷迭香足浴粉,包括以下重量份的物质组成:迷迭香10-25份;天竺葵3-10份;广藿香3-8份;杜仲叶4-9份;葡萄籽1-3份;玫瑰花1-5份;生姜粉2-6份。 A rosemary foot bath powder, comprising the following components by weight: 10-25 parts of rosemary; 3-10 parts of geranium; 3-8 parts of patchouli; 4-9 parts of Eucommia leaves; 1-3 parts of grape seeds 1-5 parts of roses; 2-6 parts of ginger powder.
作为优选方案之一,各物质的重量份组成为:迷迭香15-22份;天竺葵5-8份;广藿香5-7份;杜仲叶5-8份;葡萄籽1-2份;玫瑰花2-4份;生姜粉3-5份。 As one of the preferred schemes, the parts by weight of each substance are composed of: 15-22 parts of rosemary; 5-8 parts of geranium; 5-7 parts of patchouli; 5-8 parts of Eucommia leaves; 1-2 parts of grape seeds; 2-4 parts of roses; 3-5 parts of ginger powder.
作为优选方案之二,各物质的重量份组成为:迷迭香15份;天竺葵5份;广藿香5份;杜仲叶5份;葡萄籽1份;玫瑰花2份;生姜粉3份。 As the second preferred option, the parts by weight of each substance are as follows: 15 parts of rosemary; 5 parts of geranium; 5 parts of patchouli; 5 parts of Eucommia leaves; 1 part of grape seed; 2 parts of rose; 3 parts of ginger powder.
作为优选方案之三,各物质的重量份组成为:迷迭香20份;天竺葵6份;广藿香6份;杜仲叶7份;葡萄籽2份;玫瑰花3份;生姜粉4份。 As the third preferred option, the parts by weight of each material are as follows: 20 parts of rosemary; 6 parts of geranium; 6 parts of patchouli; 7 parts of Eucommia leaves; 2 parts of grape seeds; 3 parts of roses; 4 parts of ginger powder.
迷迭香足浴粉的制备方法,包括除杂、风干、发酵、灭菌、酶解、干燥、复配、粉碎步 骤。 The preparation method of rosemary foot bath powder comprises the steps of impurity removal, air-drying, fermentation, sterilization, enzymolysis, drying, compounding and crushing.
所述具体步骤如下: The specific steps are as follows:
(1)除杂:原料除去树枝、杂草、树叶等杂质,清水清洗干净,备用; (1) Impurity removal: Remove impurities such as branches, weeds and leaves from raw materials, wash them with clean water, and set aside;
(2)风干:将所需原料风干至含水量为10%以下; (2) air-drying: the required raw materials are air-dried until the water content is below 10%;
(3)发酵:除杂后的迷迭香、天竺葵、广藿香、杜仲叶按配方比例混合均匀,粉碎至10-20目,喷洒无菌水,调整水分含量至25%-35%,按质量比0.05%-0.15%接入EM菌剂,恒温恒湿发酵10-20h; (3) Fermentation: the removed rosemary, geranium, patchouli, and Eucommia leaves are mixed evenly according to the formula ratio, crushed to 10-20 mesh, sprayed with sterile water, adjusted to 25%-35% moisture content, press Mass ratio of 0.05%-0.15% is inserted into EM bacterial agent, and fermented at constant temperature and humidity for 10-20h;
(4)灭菌:将步骤(3)中发酵完的物质灭菌10-30min,备用; (4) Sterilization: the material fermented in step (3) is sterilized for 10-30min, for subsequent use;
(5)酶解:将灭菌完的物料冷却后调节pH至中性,加入纤维素酶、中性蛋白酶,30-35℃酶解2-5h,灭酶,备用; (5) Enzymolysis: After cooling the sterilized material, adjust the pH to neutral, add cellulase and neutral protease, enzymolyze at 30-35°C for 2-5 hours, inactivate the enzyme, and set aside;
(6)干燥:将酶解完成后的物质采用微波干燥或热风干燥,干燥至水分含量为10%以下停止干燥; (6) drying: the material after the enzymolysis is completed is dried by microwave or hot air, and the drying is stopped until the moisture content is below 10%;
(7)复配:干燥后的物质与配方比例的葡萄籽、玫瑰花、生姜粉混合均匀,备用; (7) Composite: the grape seed, rose, ginger powder of dried material and formula ratio are mixed evenly, and set aside;
(8)粉碎:复配后的物料置于粉碎机中,粉碎至200-300目后即得迷迭香足浴粉。 (8) Pulverization: the compounded material is placed in a pulverizer, and pulverized to 200-300 mesh to obtain rosemary foot bath powder.
具体的,步骤(3)中所述的灭菌方法为微波灭菌,灭菌温度为50-100℃。 Specifically, the sterilization method described in step (3) is microwave sterilization, and the sterilization temperature is 50-100°C.
具体的,步骤(6)所述的微波干燥条件为微波剂量0.027-0.033kw/kg,干燥温度65-80℃。 Specifically, the microwave drying conditions described in step (6) are a microwave dosage of 0.027-0.033kw/kg, and a drying temperature of 65-80°C.
具体的,步骤(6)所述的微波干燥为间歇脉冲微波干燥,微波剂量为0.027-0.033kw/kg,干燥温度为45-55℃,微波有效时间占总作用时间的50%-70%。 Specifically, the microwave drying described in step (6) is intermittent pulse microwave drying, the microwave dose is 0.027-0.033kw/kg, the drying temperature is 45-55°C, and the effective time of microwaves accounts for 50%-70% of the total action time.
本发明以迷迭香为基料,配以天竺葵、广藿香、杜仲叶,经除杂、风干、发酵、灭菌、酶解、干燥、复配、粉碎后与葡萄籽、玫瑰花、生姜粉复配。迷迭香是目前公认的一种高抗氧化性的植物,富含鼠尾草酸、鼠尾草酚、迷迭香酚、熊果酸、迷迭香酸等成分,能有效清除体内自由基,具有抗肿消炎、抗肿瘤等功效。迷迭香中所含有的迷迭香碱类物质能加强大脑皮层的一直过程有抗惊厥的作用,迷迭香中的挥发性精油对金黄色葡萄球菌、大肠杆菌、霍乱杆菌等有显著的抗菌作用。因此,采用迷迭香做基料可有效抑制足部细菌繁殖,对细菌、真菌等引起的脚气、足癣等有较好的效果。广藿香又名海藿香,是唇形科植物藿香的干燥地上部分,既是名贵的植物香料,又是常见的中药材,具有芳香化浊、开胃止呕、发表解暑之功效,常用于治疗湿浊中阻、暑湿倦怠、胸闷不舒、腹痛吐泄等疾病。天竺葵又名洋绣球,具有浓烈的香气,是一种精油含量比较高的植物,其中所提取的精油是一种较好的情绪平衡剂,能较好的消除疲劳,具有抗氧化延缓衰老等功能。杜仲叶为杜仲科植物杜仲的叶,是我 国特有的经济树种,杜仲叶是一种传统的中药,研究发现杜仲叶提取物可作用人体骨骼和肌肉中蛋白质胶原的合成和分解,具有促进代谢,预防骨质疏松的功能。杜仲叶中含有较高的绿原酸,具有利胆、降压、抗菌等作用,同时具有较高的抗氧化活性,被应用于食品的抗氧化中。本发明将迷迭香、广藿香、天竺葵、杜仲叶进行混合,能增加浸出物的抗氧化活性,更好的达到了杀菌、消炎、抗氧化的功效,同时本发明中富含多种植物精油成分可促进皮肤细胞再生,使得皮肤更加光滑、细腻,防止皮肤干燥皲裂。 The invention uses rosemary as the base material, is equipped with geranium, patchouli and Eucommia leaves, and is mixed with grape seeds, roses and ginger powder compound. Rosemary is currently recognized as a high antioxidant plant, rich in carnosic acid, carnosol, rosmanol, ursolic acid, rosmarinic acid and other ingredients, which can effectively remove free radicals in the body, It has anti-inflammatory, anti-tumor and other effects. The rosmarinic substances contained in rosemary can strengthen the process of the cerebral cortex and have anticonvulsant effects. The volatile essential oils in rosemary have significant antibacterial effects on Staphylococcus aureus, Escherichia coli, and Bacillus cholerae. effect. Therefore, using rosemary as a base material can effectively inhibit the reproduction of foot bacteria, and has a good effect on athlete's foot and tinea pedis caused by bacteria and fungi. Patchouli, also known as Patchouli, is the dry aboveground part of the Lamiaceae plant Patchouli. It is not only a precious plant spice, but also a common Chinese herbal medicine. It is used to treat diseases such as dampness and turbidity, fatigue due to summer heat, chest tightness and discomfort, abdominal pain and vomiting. Geranium, also known as hydrangea, has a strong aroma and is a plant with a relatively high content of essential oil. The extracted essential oil is a good emotional balance agent, which can better relieve fatigue and has anti-oxidation and anti-aging functions. . Eucommia ulmoides leaf is the leaf of Eucommia ulmoides, a unique economic tree species in China. Eucommia ulmoides leaf is a traditional Chinese medicine. Studies have found that eucommia ulmoides leaf extract can act on the synthesis and decomposition of protein collagen in human bones and muscles, and has the effect of promoting metabolism. , The function of preventing osteoporosis. Eucommia ulmoides leaves contain high chlorogenic acid, which has choleretic, antihypertensive, antibacterial and other effects. It also has high antioxidant activity and is used in the antioxidant of food. The present invention mixes rosemary, patchouli, geranium, and Eucommia leaves, which can increase the antioxidant activity of the extract, and better achieve the effects of sterilization, anti-inflammatory, and anti-oxidation. At the same time, the present invention is rich in various plants Essential oil ingredients can promote skin cell regeneration, make the skin smoother and more delicate, and prevent dry and chapped skin.
本发明将迷迭香、天竺葵、广藿香、杜仲叶混合干燥后进行发酵,发酵过程调整水分含量为25%-35%,避免过多的汁液带走产品中的有效成分,发酵过程中产生一些腐殖酸类物质,有效增加产品杀菌消炎的作用。发酵完成后的物质灭菌后采用纤维素酶、蛋白酶复合酶系进行酶解,将原料中的大分子纤维素、蛋白质等进行酶解,产生多种小分子多肽、氨基酸、植物多糖等成分,可有效增加产品有效成分的溶解,保证药效的同时增加本发明产品的护肤作用。 In the present invention, rosemary, geranium, patchouli, and Eucommia leaves are mixed and dried, and then fermented. During the fermentation process, the water content is adjusted to 25%-35%, so as to avoid excessive juice from taking away the active ingredients in the product, and produce Some humic acid substances can effectively increase the bactericidal and anti-inflammatory effect of the product. After the fermentation is completed, the material is sterilized and enzymatically hydrolyzed by cellulase and protease compound enzyme system to enzymatically hydrolyze the macromolecular cellulose and protein in the raw materials to produce a variety of small molecular polypeptides, amino acids, plant polysaccharides and other components. It can effectively increase the dissolution of the active ingredients of the product, and increase the skin care effect of the product of the invention while ensuring the efficacy of the drug.
葡萄籽、玫瑰花、生姜粉在其他原料发酵后加入,保证了此类原料原有的性状,达到活血、驱寒的目的。 Grape seed, rose flower, and ginger powder are added after other raw materials are fermented to ensure the original properties of these raw materials and achieve the purpose of promoting blood circulation and dispelling cold.
为验证本发明的效果,申请人对本发明的水浸出物含量、抑菌圈大小、抗炎效果、自由基清除率进行测定,测量方法及测量结果如下: In order to verify the effect of the present invention, the applicant measures the water extract content, the size of the antibacterial zone, the anti-inflammatory effect, and the free radical scavenging rate of the present invention, and the measurement method and measurement results are as follows:
一、本发明足浴粉水浸出物含量测定 One, the content determination of foot bath powder water extract of the present invention
以本发明制备的足浴粉作为试验组,不酶解作为对照组1,不发酵作为对照组2,不酶解、不发酵为对照组3,所有对照组均采用本发明配方,其它工艺与本发明工艺相同;采用称重法测定水浸出物含量,分别取3g试验品,加入沸水200mL,浸泡45min,过滤,称量滤渣重量,计算浸出物含量,测量结果如下表1所示。 Take the foot bath powder prepared by the present invention as the test group, without enzymolysis as the control group 1, without fermentation as the control group 2, without enzymolysis and non-fermentation as the control group 3, all control groups adopt the formula of the present invention, and other processes are the same as those of the present invention. The invention process is the same; adopt the weighing method to measure the water extract content, take 3g of the test product respectively, add 200mL of boiling water, soak for 45min, filter, weigh the weight of the filter residue, calculate the extract content, and the measurement results are shown in Table 1 below.
表1 本发明与对照试验水浸出物含量 Table 1 The present invention and comparative test water extract content
由表1可知,本发明制备的足浴粉浸泡过程中水浸出物含量明显高于另外3组对照组样品,单纯进行粉碎,不酶解、不发酵的对照组3样品水浸出物含量最低,由此可知将足浴粉进行发酵、酶解可有效增加水浸出物含量,且明显高于仅进行物理粉碎的足浴粉产品。 As can be seen from Table 1, the content of water extracts in the soaking process of foot bath powder prepared by the present invention is significantly higher than that of the other 3 groups of control samples, and the content of water extracts in 3 samples of the control group without enzymolysis and fermentation is the lowest when it is simply pulverized. It can be seen that fermenting and enzymatic hydrolysis of foot bath powder can effectively increase the content of water extract, which is significantly higher than that of foot bath powder products that are only physically crushed.
二、本发明足浴粉抗菌试验 Two, foot bath powder antibacterial test of the present invention
以本发明制备的足浴粉作为试验组,不酶解作为对照组1,不发酵作为对照组2,不酶解、不发酵为对照组3,所有对照组均采用本发明配方,其它工艺与本发明工艺相同;检测各组 足浴粉对不同菌类的抑菌圈大小,测定抑菌圈直径大小作为结果,测量结果如表2所示。 Take the foot bath powder prepared by the present invention as the test group, without enzymolysis as the control group 1, without fermentation as the control group 2, without enzymolysis and non-fermentation as the control group 3, all control groups adopt the formula of the present invention, and other processes are the same as those of the present invention. The invention process is the same; each group of foot bath powder is detected to the size of the inhibition zone of different fungi, and the diameter of the measurement inhibition zone is taken as the result, and the measurement results are shown in Table 2.
表2 不同组足浴粉抑菌圈大小 Table 2 The size of the antibacterial zone of different groups of foot bath powder
由表2可知,试验组足浴粉对所测各种菌类均有明显抑制生长作用,且试验组产品抑菌圈直径最大,而对照组3的足浴粉仅进行粉碎,抑菌圈较小,虽有抑菌效果,但效果较差,经过酶解、发酵工序的本发明足浴粉即试验组,具有较好的抑菌效果,抑菌圈最大。由此可知,本发明具有好的杀菌效果。结果表明:本发明足浴粉对金黄色葡萄球菌、大肠杆菌、红色毛癣菌、念珠菌、絮状毛癣菌均有良好抑菌作用,可应用于足癣、脚气、灰指甲、皮肤瘙痒等的辅助治疗。 It can be seen from Table 2 that the foot bath powder in the test group has obvious growth inhibitory effect on the tested various fungi, and the diameter of the antibacterial zone of the product in the test group is the largest, while the foot bath powder in the control group 3 is only pulverized, and the antibacterial zone is smaller. Although it has antibacterial effect, the effect is relatively poor. The foot bath powder of the present invention, which is the test group, has a better antibacterial effect after enzymolysis and fermentation processes, and the antibacterial circle is the largest. It can be seen that the present invention has a good bactericidal effect. The results show that the foot bath powder of the present invention has a good antibacterial effect on Staphylococcus aureus, Escherichia coli, Trichophyton rubrum, Candida, and Trichophyton flocculus, and can be applied to athlete's foot, athlete's foot, onychomycosis, skin itching, etc. adjuvant therapy.
三、本发明足浴粉抗炎效果 Three, foot bath powder anti-inflammatory effect of the present invention
抗炎试验以本发明制备的足浴粉作为试验组,不酶解作为对照组1,不发酵作为对照组2,不酶解、不发酵为对照组3,所有对照组均采用本发明配方,其它工艺与本发明工艺相同;测定不同产品对小鼠耳肿胀试验中小鼠肿胀抑制率的影响,试验表明四组样品均能明显抑制小鼠耳肿胀试验中小鼠的耳肿胀程度,而试验组抑制率明显高于其他三个对照组产品,且以对照组3抑制率最低。试验结果如表3所示。 In the anti-inflammatory test, the foot bath powder prepared by the present invention was used as the test group, without enzymolysis as the control group 1, without fermentation as the control group 2, without enzymolysis and non-fermentation as the control group 3, all the control groups used the formula of the present invention, and other Process is the same as the process of the present invention; measure the impact of different products on the mouse swelling inhibition rate in the mouse ear swelling test, the test shows that four groups of samples can obviously inhibit the ear swelling degree of mice in the mouse ear swelling test, and the test group inhibition rate Significantly higher than the other three control groups, and the inhibition rate of control group 3 was the lowest. The test results are shown in Table 3.
表3 不同组足浴粉对小鼠耳肿胀试验的影响 Table 3 Effect of different groups of foot bath powder on mouse ear swelling test
注:“**”示与模型对照组比较,P<0.01。 Note: "**" indicates the comparison with the model control group, P<0.01.
四、本发明足浴粉对自由基清除率效果试验 Four, foot bath powder of the present invention is to free radical scavenging effect test
自由基清除率试验以本发明制备的足浴粉作为试验组,不酶解作为对照组1,不发酵作为对照组2,不酶解、不发酵为对照组3,所有对照组均采用本发明配方,其它工艺与本发明工艺相同;验证足浴粉对羟基自由基、DPPH、超氧自由基清除率的影响,检测结果如表4所示。 In the free radical scavenging rate test, the foot bath powder prepared by the present invention is used as the test group, without enzymolysis as the control group 1, without fermentation as the control group 2, without enzymolysis and non-fermentation as the control group 3, and all the control groups use the formula of the present invention , other processes are identical with the process of the present invention; verify the impact of foot bath powder on hydroxyl radicals, DPPH, superoxide radical scavenging rate, test result is as shown in table 4.
表4 不同组足浴粉对自由基清除效率的比较 Table 4 Comparison of free radical scavenging efficiency of different groups of foot bath powder
由表4可知四组足浴粉产品能较好的清除羟基自由基、DPPH自由基、超氧阴离子自由基,试验组自由基清除效果最好,以单纯粉碎无酶解、物发酵的对照3自由基清除率最小,效果最差。由此可知,本发明具有较好的清除自由基能力,可有效延缓皮肤老化,具有较好的抗氧化效果。 It can be seen from Table 4 that the four groups of foot bath powder products can better scavenge hydroxyl radicals, DPPH free radicals, and superoxide anion free radicals, and the free radical scavenging effect of the test group is the best. The base clearance rate is the smallest and the effect is the worst. It can be seen that the present invention has a better ability to scavenge free radicals, can effectively delay skin aging, and has a better anti-oxidation effect.
五、临床使用效果验证 V. Validation of Clinical Use Effects
以本发明制备的足浴粉作为试验组,不酶解作为对照组1,不发酵作为对照组2,不酶解、不发酵为对照组3,所有对照组均采用本发明配方,其它工艺与本发明工艺相同;使用四种产品泡脚,以清水泡脚为空白,检测本发明足浴粉的使用效果。 Take the foot bath powder prepared by the present invention as the test group, without enzymolysis as the control group 1, without fermentation as the control group 2, without enzymolysis and non-fermentation as the control group 3, all control groups adopt the formula of the present invention, and other processes are the same as those of the present invention. The invention process is the same; four kinds of products are used to soak the feet, and the clear water is used as a blank to test the use effect of the foot bath powder of the present invention.
选用足部有水泡、皮肤瘙痒,真菌检测呈阳性的脚气病患者为试验对象,试验组男女各5人,空白组男女各5人,采用各组样品20g,选用相同规格足浴盆,加2L水至没过脚踝,连续泡脚2周,每天泡脚时间为20-30min,试验结束检测足部皮肤性状,检测真菌含量,检测结果如下表5所示。 Choose beriberi patients with blisters on their feet, itchy skin, and positive fungal tests as the test subjects. The test group has 5 men and women each, and the blank group has 5 men and women each. Use 20g of samples from each group, use the same specification foot tub, and add 2L of water Soak the feet continuously for 2 weeks until the ankles are covered, and soak the feet for 20-30 minutes every day. At the end of the test, the skin properties of the feet and the fungal content are detected. The test results are shown in Table 5 below.
表5 临床试验检测结果 Table 5 Clinical test results
由表5可知,本发明能较好的治疗由于真菌引起的脚气病,且能有效改善皮肤症状,长期使用不仅有治疗脚气的作用,同时具有改善肤质,美容护肤效果。 As can be seen from Table 5, the present invention can better treat beriberi caused by fungi, and can effectively improve skin symptoms. Long-term use not only has the effect of treating beriberi, but also has the effect of improving skin quality and beautifying skin care.
具体实施方式 Detailed ways
下面结合具体实施方式对本发明做进一步说明,但本发明的保护范围并不仅限于此,所有本领域技术人员以本发明的精神对本发明所做的等效的变化均落入本发明的保护范围。 The present invention will be further described below in conjunction with specific embodiments, but the protection scope of the present invention is not limited thereto, and all equivalent changes made by those skilled in the art to the present invention with the spirit of the present invention all fall within the protection scope of the present invention.
实施例1 Example 1
迷迭香足浴粉,包括迷迭香10份;天竺葵3份;广藿香3份;杜仲叶4份;葡萄籽1份;玫瑰花1份;生姜粉2份。 Rosemary foot bath powder, including 10 parts rosemary; 3 parts geranium; 3 parts patchouli; 4 parts Eucommia leaves; 1 part grape seed; 1 part rose; 2 parts ginger powder.
其制备方法包括除杂、风干、发酵、灭菌、酶解、干燥、复配、粉碎步骤。具体操作方法为: The preparation method includes the steps of impurity removal, air drying, fermentation, sterilization, enzymolysis, drying, compounding and crushing. The specific operation method is:
(1)除杂:原料除去树枝、杂草、树叶等杂质,清水清洗干净,备用; (1) Impurity removal: Remove impurities such as branches, weeds and leaves from raw materials, wash them with clean water, and set aside;
(2)风干:将所需原料风干至含水量为10%以下; (2) air-drying: the required raw materials are air-dried until the water content is below 10%;
(3)发酵:除杂后的迷迭香10份、天竺葵3份、广藿香3份、杜仲叶4份混合均匀,粉碎至10目,喷洒无菌水,调整水分含量至25%,按质量比0.05%接入EM菌剂,恒温恒湿发酵10h; (3) Fermentation: 10 parts of rosemary, 3 parts of geranium, 3 parts of patchouli, and 4 parts of Eucommia leaves after removal of impurities are mixed evenly, pulverized to 10 mesh, sprayed with sterile water, adjusted to 25% moisture content, press Mass ratio 0.05% was inserted into EM bacterial agent, and fermented at constant temperature and humidity for 10 hours;
(4)灭菌:将步骤(3)中发酵完的物质微波灭菌10min,灭菌温度为100℃,备用; (4) Sterilization: Microwave sterilize the material fermented in step (3) for 10 minutes, the sterilization temperature is 100°C, and set aside;
(5)酶解:将灭菌完的物料冷却后调节pH至中性,加入纤维素酶、中性蛋白酶,30℃酶解5h后灭酶,备用; (5) Enzymolysis: After cooling the sterilized material, adjust the pH to neutral, add cellulase and neutral protease, enzymatically hydrolyze at 30°C for 5 hours, then inactivate the enzyme, and set aside;
(6)干燥:将酶解完成后的物质采用微波干燥,微波剂量0.027kw/kg,干燥温度80℃,干燥至水分含量为10%以下停止干燥; (6) Drying: The material after the enzymolysis is completed is dried by microwave, the microwave dose is 0.027kw/kg, the drying temperature is 80°C, and the drying is stopped until the moisture content is below 10%;
(7)复配:干燥后的物质与配方比例的葡萄籽、玫瑰花、生姜粉混合均匀,备用; (7) Composite: the grape seed, rose, ginger powder of dried material and formula ratio are mixed evenly, and set aside;
(8)粉碎:复配后的物料置于粉碎机中,粉碎至200目后即得迷迭香足浴粉。 (8) Pulverization: the compounded material is placed in a pulverizer, and pulverized to 200 mesh to obtain rosemary foot bath powder.
本实施例足浴粉水溶物溶出量高,具有杀菌去脚气、净心安神、改善睡眠、保健护肤等功能,产品各项指标符合;其各项指标符合QB/T 1859-2004的标准。 The foot bath powder of this example has a high dissolution rate of water-soluble matter, and has the functions of sterilizing and removing beriberi, calming the mind, improving sleep, health care and skin care, etc., and all indicators of the product meet the standards of QB/T 1859-2004.
实施例2 Example 2
迷迭香足浴粉,包括迷迭香25份;天竺葵10份;广藿香8份;杜仲叶9份;葡萄籽3份;玫瑰花5份;生姜粉6份。 Rosemary foot bath powder, including 25 parts of rosemary; 10 parts of geranium; 8 parts of patchouli; 9 parts of Eucommia leaves; 3 parts of grape seed; 5 parts of rose; 6 parts of ginger powder.
其制备方法包括除杂、风干、发酵、灭菌、酶解、干燥、复配、粉碎步骤。具体操作方法为: The preparation method includes the steps of impurity removal, air drying, fermentation, sterilization, enzymolysis, drying, compounding and crushing. The specific operation method is:
(1)除杂:原料除去树枝、杂草、树叶等杂质,清水清洗干净,备用; (1) Impurity removal: Remove impurities such as branches, weeds and leaves from raw materials, wash them with clean water, and set aside;
(2)风干:将所需原料风干至含水量为10%以下; (2) air-drying: the required raw materials are air-dried until the water content is below 10%;
(3)发酵:除杂后的迷迭香25份、天竺葵10份、广藿香8份、杜仲叶9份混合均匀,粉碎至20目,喷洒无菌水,调整水分含量至35%,按质量比0.15%接入EM菌剂,恒温恒湿发酵20h; (3) Fermentation: 25 parts of rosemary after impurity removal, 10 parts of geranium, 8 parts of patchouli, and 9 parts of Eucommia leaves are mixed evenly, pulverized to 20 mesh, sprayed with sterile water, adjusted to 35% moisture content, press Mass ratio 0.15% was inserted into EM bacterial agent, and fermented at constant temperature and humidity for 20 hours;
(4)灭菌:将步骤(3)中发酵完的物质微波灭菌30min,灭菌温度为50℃,备用; (4) Sterilization: Microwave sterilize the fermented material in step (3) for 30 minutes, the sterilization temperature is 50°C, and set aside;
(5)酶解:将灭菌完的物料冷却后调节pH至中性,加入纤维素酶、中性蛋白酶,30℃酶解2h后灭酶,备用; (5) Enzymolysis: After cooling the sterilized material, adjust the pH to neutral, add cellulase and neutral protease, enzymatically hydrolyze at 30°C for 2 hours, then inactivate the enzyme, and set aside;
(6)干燥:将酶解完成后的物质采用微波干燥,微波剂量0.033kw/kg,干燥温度65℃,干燥至水分含量为10%以下停止干燥; (6) Drying: The material after the enzymolysis is completed is dried by microwave, the microwave dose is 0.033kw/kg, the drying temperature is 65°C, and the drying is stopped until the moisture content is below 10%;
(7)复配:干燥后的物质与葡萄籽3份、玫瑰花5份、生姜粉6份混合均匀,备用; (7) Compounding: the dried material is mixed evenly with 3 parts of grape seeds, 5 parts of roses, and 6 parts of ginger powder, and set aside;
(8)粉碎:复配后的物料置于粉碎机中,粉碎至300目后即得迷迭香足浴粉。 (8) Pulverization: the compounded material is placed in a pulverizer, and pulverized to 300 mesh to obtain rosemary foot bath powder.
本实施例足浴粉水溶物溶出量高,具有杀菌去脚气、净心安神、改善睡眠、保健护肤等功能,产品各项指标符合;其各项指标符合QB/T 1859-2004的标准。 The foot bath powder of this example has a high dissolution rate of water-soluble matter, and has the functions of sterilizing and removing beriberi, calming the mind, improving sleep, health care and skin care, etc., and all indicators of the product meet the standards of QB/T 1859-2004.
实施例3 Example 3
迷迭香足浴粉,包括迷迷迭香15份;天竺葵5份;广藿香5份;杜仲叶5份;葡萄籽1份;玫瑰花2份;生姜粉3份。 Rosemary foot bath powder, including 15 parts of rosemary; 5 parts of geranium; 5 parts of patchouli; 5 parts of Eucommia leaves; 1 part of grape seed; 2 parts of rose; 3 parts of ginger powder.
其制备方法包括除杂、风干、发酵、灭菌、酶解、干燥、复配、粉碎步骤。具体操作方法为: The preparation method includes the steps of impurity removal, air drying, fermentation, sterilization, enzymolysis, drying, compounding and crushing. The specific operation method is:
(1)除杂:原料除去树枝、杂草、树叶等杂质,清水清洗干净,备用; (1) Impurity removal: Remove impurities such as branches, weeds and leaves from raw materials, wash them with clean water, and set aside;
(2)风干:将所需原料风干至含水量为10%以下; (2) air-drying: the required raw materials are air-dried until the water content is below 10%;
(3)发酵:除杂后的迷迭香20份;天竺葵6份;广藿香6份;杜仲叶7份混合均匀,粉碎至20目,喷洒无菌水,调整水分含量至30%,按质量比0.10%接入EM菌剂,恒温恒湿发酵15h; (3) Fermentation: 20 parts of rosemary after impurity removal; 6 parts of geranium; 6 parts of patchouli; 0.10% mass ratio was added to EM bacterial agent, and fermented at constant temperature and humidity for 15 hours;
(4)灭菌:将步骤(3)中发酵完的物质微波灭菌15min,灭菌温度为60℃,备用; (4) Sterilization: Microwave sterilize the fermented material in step (3) for 15 minutes, the sterilization temperature is 60°C, and set aside;
(5)酶解:将灭菌完的物料冷却后调节pH至中性,加入纤维素酶、中性蛋白酶,32℃酶解3h,灭酶,备用; (5) Enzymolysis: After cooling the sterilized material, adjust the pH to neutral, add cellulase and neutral protease, enzymatically hydrolyze at 32°C for 3 hours, inactivate the enzyme, and set aside;
(6)干燥:将酶解完成后的物质采用微波干燥,微波剂量为0.033kw/kg,干燥温度为45℃,微波有效时间占总作用时间的70%,干燥至水分含量为10%以下停止干燥; (6) Drying: The material after the enzymolysis is completed is dried by microwave, the microwave dose is 0.033kw/kg, the drying temperature is 45°C, the effective time of microwave is 70% of the total action time, and the drying is stopped until the moisture content is below 10%. dry;
(7)复配:干燥后的物质与葡萄籽2份;玫瑰花3份;生姜粉4份混合均匀,备用; (7) compounding: the dried substance and 2 parts of grape seeds; 3 parts of roses; 4 parts of ginger powder are mixed evenly and set aside;
(8)粉碎:复配后的物料置于粉碎机中,粉碎至300目后即得迷迭香足浴粉。 (8) Pulverization: the compounded material is placed in a pulverizer, and pulverized to 300 mesh to obtain rosemary foot bath powder.
本实施例足浴粉水溶物溶出量高,具有杀菌去脚气、净心安神、改善睡眠、保健护肤等功能,产品各项指标符合;其各项指标符合QB/T 1859-2004的标准。 The foot bath powder of this example has a high dissolution rate of water-soluble matter, and has the functions of sterilizing and removing beriberi, calming the mind, improving sleep, health care and skin care, etc., and all indicators of the product meet the standards of QB/T 1859-2004.
实施例4 Example 4
迷迭香足浴粉,包括迷迭香20份;天竺葵6份;广藿香6份;杜仲叶7份;葡萄籽2份;玫瑰花3份;生姜粉4份。 Rosemary foot bath powder, including 20 parts of rosemary; 6 parts of geranium; 6 parts of patchouli; 7 parts of Eucommia leaves; 2 parts of grape seeds; 3 parts of roses; 4 parts of ginger powder.
其制备方法包括除杂、风干、发酵、灭菌、酶解、干燥、复配、粉碎步骤。具体操作方法为: The preparation method includes the steps of impurity removal, air drying, fermentation, sterilization, enzymolysis, drying, compounding and crushing. The specific operation method is:
(1)除杂:原料除去树枝、杂草、树叶等杂质,清水清洗干净,备用; (1) Impurity removal: Remove impurities such as branches, weeds and leaves from raw materials, wash them with clean water, and set aside;
(2)风干:将所需原料风干至含水量为10%以下; (2) air-drying: the required raw materials are air-dried until the water content is below 10%;
(3)发酵:除杂后的迷迭香20份、天竺葵6份、广藿香6份、杜仲叶7份混合均匀,粉碎至20目,喷洒无菌水,调整水分含量至25%,按质量比0.15%接入EM菌剂,恒温恒湿发酵10h; (3) Fermentation: 20 parts of rosemary, 6 parts of geranium, 6 parts of patchouli, and 7 parts of Eucommia leaves after removal of impurities are mixed evenly, pulverized to 20 mesh, sprayed with sterile water, adjusted to 25% moisture content, press 0.15% mass ratio was added to EM bacterial agent, and fermented at constant temperature and humidity for 10 hours;
(4)灭菌:将步骤(3)中发酵完的物质微波灭菌20min,灭菌温度为70℃,备用; (4) Sterilization: Microwave sterilize the fermented material in step (3) for 20 minutes, the sterilization temperature is 70°C, and set aside;
(5)酶解:将灭菌完的物料冷却后调节pH至中性,加入纤维素酶、中性蛋白酶,30℃酶解5h后灭酶,备用; (5) Enzymolysis: After cooling the sterilized material, adjust the pH to neutral, add cellulase and neutral protease, enzymatically hydrolyze at 30°C for 5 hours, then inactivate the enzyme, and set aside;
(6)干燥:将酶解完成后的物质采用热风干燥至水分含量为10%以下停止干燥; (6) Drying: the material after the enzymolysis is completed is dried with hot air until the moisture content is below 10%, and the drying is stopped;
(7)复配:干燥后的物质与葡萄籽2份;玫瑰花3份;生姜粉4份混合均匀,备用; (7) compounding: the dried substance and 2 parts of grape seeds; 3 parts of roses; 4 parts of ginger powder are mixed evenly and set aside;
(8)粉碎:复配后的物料置于粉碎机中,粉碎至200目后即得迷迭香足浴粉。 (8) Pulverization: the compounded material is placed in a pulverizer, and pulverized to 200 mesh to obtain rosemary foot bath powder.
本实施例足浴粉水溶物溶出量高,具有杀菌去脚气、净心安神、改善睡眠、保健护肤等功能,产品各项指标符合;其各项指标符合QB/T 1859-2004的标准。 The foot bath powder of this example has a high dissolution rate of water-soluble matter, and has the functions of sterilizing and removing beriberi, calming the mind, improving sleep, health care and skin care, etc., and all indicators of the product meet the standards of QB/T 1859-2004.
实施例5 Example 5
迷迭香足浴粉,包括迷迷迭香22份;天竺葵8份;广藿香7份;杜仲叶8份;葡萄籽2份;玫瑰花4份;生姜粉5份。 Rosemary foot bath powder, including 22 parts of rosemary; 8 parts of geranium; 7 parts of patchouli; 8 parts of Eucommia leaves; 2 parts of grape seed; 4 parts of rose; 5 parts of ginger powder.
其制备方法包括除杂、风干、发酵、灭菌、酶解、干燥、复配、粉碎步骤。具体操作方法为: The preparation method includes the steps of impurity removal, air drying, fermentation, sterilization, enzymolysis, drying, compounding and crushing. The specific operation method is:
(1)除杂:原料除去树枝、杂草、树叶等杂质,清水清洗干净,备用; (1) Impurity removal: Remove impurities such as branches, weeds and leaves from raw materials, wash them with clean water, and set aside;
(2)风干:将所需原料风干至含水量为10%以下; (2) air-drying: the required raw materials are air-dried until the water content is below 10%;
(3)发酵:除杂后的迷迭香20份;天竺葵6份;广藿香6份;杜仲叶7份混合均匀,粉碎至20目,喷洒无菌水,调整水分含量至30%,按质量比0.10%接入EM菌剂,恒温恒湿发酵15h; (3) Fermentation: 20 parts of rosemary after impurity removal; 6 parts of geranium; 6 parts of patchouli; 0.10% mass ratio was added to EM bacterial agent, and fermented at constant temperature and humidity for 15 hours;
(4)灭菌:将步骤(3)中发酵完的物质微波灭菌25min,灭菌温度为90℃,备用; (4) Sterilization: Microwave sterilize the fermented material in step (3) for 25 minutes, the sterilization temperature is 90°C, and set aside;
(5)酶解:将灭菌完的物料冷却后调节pH至中性,加入纤维素酶、中性蛋白酶,32℃ 酶解3h,灭酶,备用; (5) Enzymolysis: After cooling the sterilized material, adjust the pH to neutral, add cellulase and neutral protease, enzymatically hydrolyze for 3 hours at 32°C, inactivate the enzyme, and set aside;
(6)干燥:将酶解完成后的物质采用微波干燥,微波剂量为0.027kw/kg,干燥温度为55℃,微波有效时间占总作用时间的50%,干燥至水分含量为10%以下停止干燥; (6) Drying: The material after the enzymolysis is completed is dried by microwave, the microwave dose is 0.027kw/kg, the drying temperature is 55°C, the effective time of microwave is 50% of the total action time, and the drying is stopped until the moisture content is below 10%. dry;
(7)复配:干燥后的物质与葡萄籽2份;玫瑰花3份;生姜粉4份混合均匀,备用; (7) compounding: the dried substance and 2 parts of grape seeds; 3 parts of roses; 4 parts of ginger powder are mixed evenly and set aside;
(8)粉碎:复配后的物料置于粉碎机中,粉碎至300目后即得迷迭香足浴粉。 (8) Pulverization: the compounded material is placed in a pulverizer, and pulverized to 300 mesh to obtain rosemary foot bath powder.
本实施例足浴粉水溶物溶出量高,具有杀菌去脚气、净心安神、改善睡眠、保健护肤等功能,产品各项指标符合;其各项指标符合QB/T 1859-2004的标准。 The foot bath powder of this example has a high dissolution rate of water-soluble matter, and has the functions of sterilizing and removing beriberi, calming the mind, improving sleep, health care and skin care, etc., and all indicators of the product meet the standards of QB/T 1859-2004.
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| CN105233227A (en) * | 2015-11-13 | 2016-01-13 | 韦慧芳 | Bacteriostatic foot bath powder and preparation method thereof |
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| CN105079097A (en) * | 2015-08-20 | 2015-11-25 | 黔南龙海特种植物开发有限公司 | Rosemary foot-bathing powder and manufacture method thereof |
| CN105233227A (en) * | 2015-11-13 | 2016-01-13 | 韦慧芳 | Bacteriostatic foot bath powder and preparation method thereof |
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