CN104436089A - Traditional Chinese medicine composition for treating bronchial asthma as well as preparation method and application - Google Patents

Traditional Chinese medicine composition for treating bronchial asthma as well as preparation method and application Download PDF

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Publication number
CN104436089A
CN104436089A CN201410281521.9A CN201410281521A CN104436089A CN 104436089 A CN104436089 A CN 104436089A CN 201410281521 A CN201410281521 A CN 201410281521A CN 104436089 A CN104436089 A CN 104436089A
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parts
bronchial asthma
chinese medicine
medicine composition
treat
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陈军
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Wide Informational Inquiry Centre Of Nanjing China
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Wide Informational Inquiry Centre Of Nanjing China
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides a traditional Chinese medicine composition for treating bronchial asthma. The traditional Chinese medicine composition for treating bronchial asthma is prepared by extracting the following raw material medicines in parts by weight: 10-20 parts of affine cudweed, 10-20 parts of thomson creeper, 4-8 parts of rhizoma pinellinae praeparata, 4-8 parts of radix peucedani, 10-20 parts of platycodon grandiflorum, 10-15 parts of fructus evodiae and 2-4 parts of ginger. The traditional Chinese medicine composition for treating bronchial asthma is capable of clearing heat and relieving cough, warming liver and harmonizing stomach, and treating bronchial asthma. The invention further discloses a preparation method and an application.

Description

A kind of Chinese medicine composition and preparation method and application treating bronchial asthma
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that are used for the treatment of bronchial asthma.
Background technology
Bronchial asthma participates in chronic airway inflammation illness by various kinds of cell (as eosinophilic granulocyte, mastocyte, T lymphocyte, neutrophilic granulocyte, human airway epithelial cells etc.) and cellular component.This chronic inflammatory disease causes the generation of airway hyperreactivity, the reversible airflow limitation that usual appearance is extensively changeable, and causing the symptoms such as the panting of recurrent exerbation, out of breath, uncomfortable in chest or cough, be everlasting night and (or) outbreak in morning, most of patients can spontaneous remissions or alleviate through treatment.The treatments such as current use expansion bronchus medicine (beta 2 receptor agonist, theophylline class) or anti-inflammatory drug (glucocorticoid, leukotrienes regulator, sodium cromoglicate and Buddhist nun's polyacid sodium, anti-lgE monoclonal antibody, antihistamine drug), side effect is comparatively large, market lacks real effective Chinese patent medicine.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that treat bronchial asthma.
Technical scheme: the object of the invention is by following scheme realize:
Treat a Chinese medicine composition for bronchial asthma, it is extracted by the crude drug of following parts by weight and prepares: Herba Gnaphalii Affinis 10-20 part, five skin wind 10-20 parts, Rhizoma Pinelliae Preparatum 4-8 part, Radix Peucedani 4-8 part, Radix Platycodonis 10-20 part, Fructus Evodiae 10-15 part, Rhizoma Zingiberis Recens 2-4 part.
The Chinese medicine composition of described treatment bronchial asthma, it is extracted by the crude drug of following parts by weight and prepares: Herba Gnaphalii Affinis 15 parts, five skin wind 15 parts, Rhizoma Pinelliae Preparatum 6 parts, Radix Peucedani 6 parts, Radix Platycodonis 15 parts, Fructus Evodiae 12 parts, 3 parts, Rhizoma Zingiberis Recens.
The Chinese medicine composition of described treatment bronchial asthma, preparation method comprises the steps: to get Herba Gnaphalii Affinis, five skin wind, Rhizoma Pinelliae Preparatum, Radix Peucedani, Radix Platycodonis, Fructus Evodiae, Rhizoma Zingiberis Recens medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
The application of Chinese medicine composition in preparation treatment bronchial asthma medicine of described treatment bronchial asthma.
The Chinese medicine composition of described treatment bronchial asthma, in described preparation method, spray drying condition is: inlet temperature is 80-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
Raw Herba Gnaphalii Affinis of the present invention is the herb of Compositae cottonweed spire Herba Gnaphalii Affinis Gnaphalium japonicum Thunb., and five skin wind are herb or the whole herb with root of rosaceous plant Herba potentillae kleinianae, and all the other are pharmacopeia kind.
Beneficial effect:
From theory of Chinese medical science, in we, Herba Gnaphalii Affinis, five skin wind clearing and antitussives are monarch drug, Rhizoma Pinelliae Preparatum, Radix Peucedani, Radix Platycodonis, Fructus Evodiae warming the liver stomach function regulating, be ministerial drug altogether, Rhizoma Zingiberis Recens is adjuvant, and all medicines are harmonious, play clearing and antitussive altogether, the effect of warming the liver stomach function regulating, is used for the treatment of bronchial asthma.Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, and determined curative effect.Consist of Chinese crude drug, have no side effect, low price.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
One, preparation embodiment 1: get Herba Gnaphalii Affinis 15g, five skin wind 15g, Rhizoma Pinelliae Preparatum 6g, Radix Peucedani 6g, Radix Platycodonis 15g, Fructus Evodiae 12g, Rhizoma Zingiberis Recens 3g medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add starch and make capsule.
Preparation embodiment 2: get Herba Gnaphalii Affinis 15g, five skin wind 15g, Rhizoma Pinelliae Preparatum 6g, Radix Peucedani 6g, Radix Platycodonis 15g, Fructus Evodiae 12g, Rhizoma Zingiberis Recens 3g medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add starch, pelletizing press sheet makes tablet.
Two, the present invention is to the clinical trial data of bronchial asthma
The physical data of experimental subject: adopt the present invention to treat 30 examples altogether, the oldest person 42 years old, age reckling 16 years old, male 18 example, women 12 example.
Diagnostic criteria: 1, the panting of recurrent exerbation, dyspnea, uncomfortable in chest or cough, how with to contact allergen, cold air, physics, chemical irritation, viral upper respiratory tract infection, motion etc. relevant.2, during outbreak at two lung audible and be dispersed in diffusivity, the wheezing sound based on expiratory phase, expiratory phase prolongation.3, can obvious relief of symptoms by anti-asthmatic.Or above-mentioned symptom can spontaneous remission.Panting except 4 caused by other diseases, out of breath, uncomfortable in chest and cough.5 its atypical clinical manifestations persons (as without obviously panting or sign) at least should have one: 1 brinchial provocation test in following three or exercise test positive; The 2 Bronchodilation Test positives 3 round the clock PEF aberration rate are more than or equal to 20%.Meet 1-4 bar or 45 persons can diagnose bronchial asthma.By meeting the rule of asthma with the reaction after diagnosis and treatment treatment, diagnosis can be determined.
Therapeutic Method: usage and dosage: adopt capsule prepared by the embodiment of the present invention 1, its usage and consumption are each 8, and every day 3 times, warm water takes, Zhou Weiyi course for the treatment of, treated for 4 courses for the treatment of altogether.
The standard of curative effect evaluation: effective: patient's clinical symptom disappearance in 7d, cough stops; Effective: patient's clinical symptom disappearance in 10d, invalid: >10d, patient fails to reach above-mentioned standard or exacerbation of symptoms.
Experimental result: in accept for medical treatment 30 routine cases, through treatment in 1 month, wherein effective 18 examples, effective 9 examples, invalid 3 examples, total effective rate reached 90%.Show that the present invention has extremely significant effect to treatment Bronchial Asthmas.

Claims (4)

1. treat the Chinese medicine composition of bronchial asthma for one kind, it is characterized in that, it is extracted by the crude drug of following parts by weight and prepares: Herba Gnaphalii Affinis 10-20 part, five skin wind 10-20 parts, Rhizoma Pinelliae Preparatum 4-8 part, Radix Peucedani 4-8 part, Radix Platycodonis 10-20 part, Fructus Evodiae 10-15 part, Rhizoma Zingiberis Recens 2-4 part.
2. treat the Chinese medicine composition of bronchial asthma as claimed in claim 1, it is characterized in that, it is extracted by the crude drug of following parts by weight and prepares: Herba Gnaphalii Affinis 15 parts, five skin wind 15 parts, Rhizoma Pinelliae Preparatum 6 parts, Radix Peucedani 6 parts, Radix Platycodonis 15 parts, Fructus Evodiae 12 parts, 3 parts, Rhizoma Zingiberis Recens.
3. treat the Chinese medicine composition of bronchial asthma as claimed in claim 1, it is characterized in that, preparation method comprises the steps: to get Herba Gnaphalii Affinis, five skin wind, Rhizoma Pinelliae Preparatum, Radix Peucedani, Radix Platycodonis, Fructus Evodiae, Rhizoma Zingiberis Recens medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
4. described in claim 1, treat the application of Chinese medicine composition in treatment bronchial asthma medicine of bronchial asthma.
CN201410281521.9A 2014-06-22 2014-06-22 Traditional Chinese medicine composition for treating bronchial asthma as well as preparation method and application Pending CN104436089A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1386516A (en) * 2001-05-18 2002-12-25 王建立 Chinese-medicinal capsule for treating cough asthma
CN101972468A (en) * 2010-11-16 2011-02-16 于淑萍 Traditional Chinese medicine for treating bronchial asthma
CN103920106A (en) * 2014-01-17 2014-07-16 赵庆军 Traditional Chinese medicinal composition for treating bronchitis and bronchial asthma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1386516A (en) * 2001-05-18 2002-12-25 王建立 Chinese-medicinal capsule for treating cough asthma
CN101972468A (en) * 2010-11-16 2011-02-16 于淑萍 Traditional Chinese medicine for treating bronchial asthma
CN103920106A (en) * 2014-01-17 2014-07-16 赵庆军 Traditional Chinese medicinal composition for treating bronchitis and bronchial asthma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张晓雷: "延年半夏汤运用体会", 《中国中医药信息杂志》 *

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Application publication date: 20150325