CN104436046A - Medicine for treating hyperplasia of mammary glands and preparation method thereof - Google Patents

Medicine for treating hyperplasia of mammary glands and preparation method thereof Download PDF

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CN104436046A
CN104436046A CN201410703961.9A CN201410703961A CN104436046A CN 104436046 A CN104436046 A CN 104436046A CN 201410703961 A CN201410703961 A CN 201410703961A CN 104436046 A CN104436046 A CN 104436046A
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medicine
citri reticulatae
tablet
radix
pill
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顾蔷怡
高春娟
冷盛君
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Abstract

The invention provides a medicine for treating hyperplasia of mammary glands and a preparation method thereof. The medicine is prepared from radix bupleuri, pericarpium citri reticulatae, achyranthes bidentata, semen litchi, fried pericarpium citri reticulatae viride, scorpions, curcuma rcenyujin, poria cocos, salt tangerine seeds, cynanchum paniculatum, epimedium and rhizoma chuanxiong in a certain proportion compatibly. The medicine has the effects of treating breast distending pains, mammary nodules and acute mastitis, activating blood, relieving pains, clearing away heart fire, cooling blood, promoting the circulation of qi, removing stasis, eliminating inflammation, counteracting toxic substances and activating meridians to stop pains, can be effectively used for treating hyperplasia and has few side effects.

Description

A kind of medicine for the treatment of cyclomastopathy and preparation method thereof
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to a kind of medicine for the treatment of cyclomastopathy and preparation method thereof specifically.
Background technology
Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue.It is the modal cystic hyperplasia of breast of women.Clinically with mastalgia and lump in breast for principal character, how because spirit is too nervous, emotion is too exciting, long-term taking causes containing undesirable elements such as estrogenic health product, contraceptive, abortion times are too much, along with the continuous change of people's philosophy of life and mode, the sickness rate of female mammary gland proliferation is obvious ascendant trend in recent years, account for mastotic first place, endanger the Health and Living of women.And because cyclomastopathy is a kind of precancerosis, early discovery cyclomastopathy, prevents in advance, seeks medical advice in time particularly important.
Summary of the invention
The present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes a kind of medicine for the treatment of cyclomastopathy and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: HERBA BUPLEURL 8-12g, Pericarpium Citri Reticulatae 4-8g, Radix Achyranthis Bidentatae 8-12g, Semen Litchi 8-12g, parch skin 8-12g, Scorpio 3-7g, Radix Curcumae 8-12g, Poria 8-12g, stir-baked SEMEN CITRI RETICULATAE with salt solution 8-12g, Radix Cynanchi Paniculati 8-12g, Herba Epimedii 8-12g, Rhizoma Chuanxiong 8-12g.Optimum ratio is: HERBA BUPLEURL 10g, Pericarpium Citri Reticulatae 6g, Radix Achyranthis Bidentatae 10g, Semen Litchi 10g, parch skin 10g, Scorpio 5g, Radix Curcumae 10g, Poria 10g, stir-baked SEMEN CITRI RETICULATAE with salt solution 10g, Radix Cynanchi Paniculati 10g, Herba Epimedii 10g, Rhizoma Chuanxiong 10g.Described medicament is capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by HERBA BUPLEURL, Pericarpium Citri Reticulatae, Radix Achyranthis Bidentatae, Semen Litchi, parch skin, Scorpio, Radix Curcumae, Poria, stir-baked SEMEN CITRI RETICULATAE with salt solution, Radix Cynanchi Paniculati, Herba Epimedii, Rhizoma Chuanxiong;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
beneficial effect
The crude drug pharmacology of compatibe drug of the present invention is as follows:
HERBA BUPLEURL: have reconciling superficies and interior, soothing the liver, effect of yang invigorating, can control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, and bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse;
Pericarpium Citri Reticulatae: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm;
Radix Achyranthis Bidentatae: have the effectiveness such as eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome;
Semen Litchi: promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving;
Parch skin: soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant, the distending pain over the hypochondrium of main stagnation of QI due to depression of the liver, distending pain of the breast, nodule in the breast, acute mastitis;
Scorpio: there is " spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain " function, enhancing immunity;
Radix Curcumae: the use with regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire;
Poria: there is promoting diuresis to eliminate damp pathogen, invigorating middle warmer spleen invigorating, mind tranquilizing and the heart calming effect;
Stir-baked SEMEN CITRI RETICULATAE with salt solution: regulate the flow of vital energy, pain relieving, controls acute mastitis;
Radix Cynanchi Paniculati: wind-expelling pain-stopping, removing toxic substances and promoting subsidence of swelling, promoting the flow of QI in the collateral by warming the meridian
Herba Epimedii: kidney invigorating and YANG supporting, expelling wind and removing dampness;
Rhizoma Chuanxiong: for blood-activating and qi-promoting, wind-expelling pain-stopping;
The present invention is with parch skin, stir-baked SEMEN CITRI RETICULATAE with salt solution, Radix Curcumae, Rhizoma Chuanxiong, Semen Litchi, and for controlling distending pain of the breast, nodule in the breast, acute mastitis, promoting blood circulation and stopping pain, clear away heart-fire removing heat from blood, promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving; With HERBA BUPLEURL, Radix Achyranthis Bidentatae, Poria, Radix Cynanchi Paniculati, Herba Epimedii, for controlling alternate attack of chill and fever, reconciling superficies and interior, soothing the liver, yang invigorating, eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, invigorating middle warmer spleen invigorating, mind tranquilizing and the heart calming, kidney invigorating and YANG supporting, expelling wind and removing dampness; With Pericarpium Citri Reticulatae, Scorpio, for fullness in the epigastrium and chest, the spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain, enhancing immunity.
Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
Chinese medicine composition of the present invention has controls distending pain of the breast, nodule in the breast, acute mastitis, promoting blood circulation and stopping pain, and clear away heart-fire removing heat from blood, promoting QI to circulate and dispersing the agglomeration of the pathogens, antiinflammatory counteracting toxic substances, and effect of removing obstruction in the collateral to relieve pain, has and enough effectively treat cyclomastopathy, and side effect is little.
Clinical trial::
1, case is selected
2011-2013 clinical women's case 107 example (except anemia of pregnant woman), age 22-65 year;
2, diagnostic criteria
Breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue, with mastalgia, lump in breast.
3, therapeutic scheme
Capsule of controlling in embodiment 2, takes medicine for after menstruation one week, every day 4, every 0.3g, 15 days courses for the treatment of, withdrawal before menstrual onset, 2-4 the course for the treatment of;
4, the standard of curative effect evaluation
Cure: mastalgia disappears, lump in breast disappears, and the minimal disease in ultrasound diagnosis mammary gland disappears;
Alleviate: lump in breast obviously disappears, pain relief;
Effective: mastalgia alleviates, tumor regression;
Invalid: lump in breast, pain are not improved;
Total effective rate=cure rate+remission rate+effective percentage.
5, data statistics
Case load Cure Alleviate Effectively Invalid Cure rate Alleviation+cure rate Total effective rate
107 68 19 9 11 63.55% 81.31% 89.72%
6, result
2011-2013 clinical women's case 107 example (except anemia of pregnant woman), age 22-65 year, cure rate 63.55%, alleviates above 81.31%, and total effective rate reaches 89.72%, has remarkable effect.
Compatibility Chinese medicine composition of the present invention is to healing or alleviate cyclomastopathy lump in breast, mastalgia has remarkable effect.
Acute toxicity test: larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this drug toxicity is very little.
Detailed description of the invention
embodiment 1:a kind of medicine for the treatment of cyclomastopathy and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: HERBA BUPLEURL 8-12g, Pericarpium Citri Reticulatae 4-8g, Radix Achyranthis Bidentatae 8-12g, Semen Litchi 8-12g, parch skin 8-12g, Scorpio 3-7g, Radix Curcumae 8-12g, Poria 8-12g, stir-baked SEMEN CITRI RETICULATAE with salt solution 8-12g, Radix Cynanchi Paniculati 8-12g, Herba Epimedii 8-12g, Rhizoma Chuanxiong 8-12g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials,
HERBA BUPLEURL 8-12g, Pericarpium Citri Reticulatae 4-8g, Radix Achyranthis Bidentatae 8-12g, Semen Litchi 8-12g, parch skin 8-12g, Scorpio 3-7g, Radix Curcumae 8-12g, Poria 8-12g, stir-baked SEMEN CITRI RETICULATAE with salt solution 8-12g, Radix Cynanchi Paniculati 8-12g, Herba Epimedii 8-12g, Rhizoma Chuanxiong 8-12g.
The preparation method step of described capsule, tablet, pill is following,
(1) in the side of getting, screen analysis pulverized by HERBA BUPLEURL, Pericarpium Citri Reticulatae, Radix Achyranthis Bidentatae, Semen Litchi, parch skin, Scorpio, Radix Curcumae, Poria, stir-baked SEMEN CITRI RETICULATAE with salt solution, Radix Cynanchi Paniculati, Herba Epimedii, Rhizoma Chuanxiong;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) make capsule, pill time,
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
During making tablet,
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2,a kind of medicine for the treatment of cyclomastopathy and preparation method thereof.It is prepared from by the crude drug of following parts by weight proportioning medicament, Radix Astragali 13-17g, Rhizoma Zingiberis 7-11g, Herba Ephedrae 4-8g, Pheretima 8-12g processed, Radix Glycyrrhizae 2-4g, Radix Codonopsis 8-12g, Ramulus Cinnamomi 8-12g, Fructus Schisandrae Chinensis (processed with vinegar) 8-12g, vinegar Fructus Mume 8-12g, Herba Ecliptae 8-12g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials,
Radix Astragali 13-17g, Rhizoma Zingiberis 7-11g, Herba Ephedrae 4-8g, Pheretima 8-12g processed, Radix Glycyrrhizae 2-4g, Radix Codonopsis 8-12g, Ramulus Cinnamomi 8-12g, Fructus Schisandrae Chinensis (processed with vinegar) 8-12g, vinegar Fructus Mume 8-12g, Herba Ecliptae 8-12g.
The preparation method step of described capsule, tablet, pill is following,
(1) in the side of getting, screen analysis pulverized by HERBA BUPLEURL, Pericarpium Citri Reticulatae, Radix Achyranthis Bidentatae, Semen Litchi, parch skin, Scorpio, Radix Curcumae, Poria, stir-baked SEMEN CITRI RETICULATAE with salt solution, Radix Cynanchi Paniculati, Herba Epimedii, Rhizoma Chuanxiong;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) make capsule, pill time,
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
During making tablet,
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Embodiment 3: medicine of the present invention can also be decoction, oral liquid, granule etc.

Claims (5)

1. treat a medicine for cyclomastopathy, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: HERBA BUPLEURL 8-12g, Pericarpium Citri Reticulatae 4-8g, Radix Achyranthis Bidentatae 8-12g, Semen Litchi 8-12g, parch skin 8-12g, Scorpio 3-7g, Radix Curcumae 8-12g, Poria 8-12g, stir-baked SEMEN CITRI RETICULATAE with salt solution 8-12g, Radix Cynanchi Paniculati 8-12g, Herba Epimedii 8-12g, Rhizoma Chuanxiong 8-12g.
2. the medicine for the treatment of cyclomastopathy according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: HERBA BUPLEURL 10g, Pericarpium Citri Reticulatae 6g, Radix Achyranthis Bidentatae 10g, Semen Litchi 10g, parch skin 10g, Scorpio 5g, Radix Curcumae 10g, Poria 10g, stir-baked SEMEN CITRI RETICULATAE with salt solution 10g, Radix Cynanchi Paniculati 10g, Herba Epimedii 10g, Rhizoma Chuanxiong 10g.
3. the medicine for the treatment of cyclomastopathy according to claim 1 and 2, is characterized in that: described medicament is capsule, tablet or pill.
4. the medicine for the treatment of cyclomastopathy according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by HERBA BUPLEURL, Pericarpium Citri Reticulatae, Radix Achyranthis Bidentatae, Semen Litchi, parch skin, Scorpio, Radix Curcumae, Poria, stir-baked SEMEN CITRI RETICULATAE with salt solution, Radix Cynanchi Paniculati, Herba Epimedii, Rhizoma Chuanxiong;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine for the treatment of cyclomastopathy according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
CN201410703961.9A 2014-11-30 2014-11-30 Medicine for treating hyperplasia of mammary glands and preparation method thereof Pending CN104436046A (en)

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