CN104435983A - Traditional Chinese medicine for treating habitual abortion - Google Patents

Traditional Chinese medicine for treating habitual abortion Download PDF

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CN104435983A
CN104435983A CN201410683396.4A CN201410683396A CN104435983A CN 104435983 A CN104435983 A CN 104435983A CN 201410683396 A CN201410683396 A CN 201410683396A CN 104435983 A CN104435983 A CN 104435983A
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habitual abortion
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traditional chinese
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何朋飞
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

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Abstract

The invention relates to a traditional Chinese medicine for treating habitual abortion. The traditional Chinese medicine is prepared from the following bulk drugs in parts by weight: 9 parts of Taiwan dangshen, 6 parts of bighead atractylodes rhizome, 9 parts of poria cocos, 6 parts of madarin orange peel, 3 parts of fructus amomi, 6 parts of eucommia ulmoides, 6 parts of desert cistanche, 6 parts of ramie roots and 3 parts of panax ginseng. A clinical experiment proves that habitual abortion can be safely and effectively treated.

Description

A kind of Chinese medicine being used for the treatment of habitual abortion
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of habitual abortion.
Background technology
Definition
Continuous more than the 3 times persons of spontaneous abortion, each miscarriage often occurs in same gestation month, is called " habitual abortion ".Habitual abortion is mainly because of congenital defect, excess of sexual intercourse, pregnant rear fleshliness damage kidney qi, and tire is become homeless and is; Or ferritic insufficiency of vital energy and blood, serious disease prolonged illness is lost blood consumption gas, and tire is become homeless foster; Or ferritic yin asthenia generating intrinsic heat, collaterals of the uterus is solid etc. causes.It is equivalent to the habitual abortion of doctor trained in Western medicine.
Etiology and pathogenesis
Dominant mechanism is the impairment of chong and ren channels, liability to abortion, or embryo's defect, can not be shaped, and falls repeatly so pregnant repeatly.Common typing has kidney qi loss and QI and blood deficiency etc.
1. kidney qi loss
Natural endowment is not enough, and kidney qi is not filled, or because of pregnant rear intemperate sexual intercourse, indulges in sensual pleasures and hindered, so that kidney qi virtual loss, the debility of CHONG and REN meridians, and tire is become homeless and is, and to cause repeatly pregnant falling repeatly be habitual abortion then.
2. QI and blood deficiency
Ferritic is weak, insufficiency of vital energy and blood, or diet, overstrain impairing the spleen, and QI and blood source is not enough, or serious disease prolonged illness, and consumption impairment of QI blood, all can cause QI and blood deficiency, punching is appointed not enough, can not carry fetal cultivation tire, therefore makes repeatly pregnant falling repeatly and be habitual abortion.
3. ferritic yin asthenia generating intrinsic heat, collaterals of the uterus is not solid.
Medical material present Research involved in the present invention is as follows:
Platform Radix Codonopsis [source] this product is the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Autumn excavates, and cleans, dries.[nature and flavor] are sweet, flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.[usage and dosage] 9 ~ 30g.[attention] should not with Rhizoma et radix veratri (Radix Rhizoma Veratri) with using.
The Rhizoma Atractylodis Macrocephalae [source] this product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Excavate when withered and yellow, the upper leaf of inferior leads in winter becomes fragile, removing silt, dries or dries, then remove fibrous root.[nature and flavor] are bitter, sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.[usage and dosage] 6 ~ 12g.
Poria [source] this product is the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Excavate more than 7 ~ JIUYUE, dig out rear removing silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now scatter and disappear in wrinkle, the large portion of internal moisture for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed different parts cutting, dry in the shade, be called " Cortex Sclerotii Poriae " and " Poria block ".[nature and flavor] are sweet, light, flat.[return through] GUIXIN, lung, spleen, kidney channel.[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.[usage and dosage] 9 ~ 15g.
Pericarpium citri reticuatae chachiensis [source] this product is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or cold drying.[nature and flavor] are bitter, pungent, temperature.[return through] returns lung, spleen channel.[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.[usage and dosage] 3 ~ 9g.
Fructus Amomi [source] this product is the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T. L. Wu.Gather during fruit maturation between summer, autumn, dry or cold drying.[nature and flavor] are pungent, temperature.[return through] returns spleen, stomach, kidney channel.[function cures mainly] removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.[usage and dosage] 3 ~ 6g.
The Cortex Eucommiae [source] this product is the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..4 ~ June strips, and scrapes off rough bark, and " diaphoresis " to endothelium of banking up is puce, dries.[nature and flavor] are sweet, temperature.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.[usage and dosage] 6 ~ 9g.
Herba Cistanches [source] this product is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C.Ma.Excavate when Seedling is not unearthed or is just unearthed more than spring, removing inflorescence, cutting, dries.Nature and flavor] sweet, salty, temperature.[return through] returns kidney, large intestine channel.[function cures mainly] kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.[usage and dosage] 6 ~ 9g.
Radix Boehmeriae [source] is contrayerva Boehmeria Boehmeria nivea(L..) root of Gaud..Winter-spring season is excavated, and cleans, dries.Nature and flavor] sweet; Cold in nature; [return through] liver; The heart; Urinary bladder channel [function cures mainly] cooling blood for hemostasis; Clearing heat and preventing abortion; Diuresis; Removing toxic substances.Spitting of blood caused by main bleeding due to blood-heat; Spit blood; Epistaxis; Stranguria with blood; Have blood in stool; Metrorrhagia; Purpura; Frequent fetal movement; Vaginal bleeding during pregnancy hematochezia; Dribbling urination; Carbuncle pyogenic infections from tumour or sore; Worm venom [usage and dosage] 5-30g.
Not directly join the dry root that [source] this product is Araliaceae Radix Ginseng Panax ginseng C. A. Mey..Grower is " Park Ginseng ", and wild survivor is " SHANSHEN ".Excavate more than autumn, clean; Park Ginseng, through drying or drying, claims " Radix Ginseng "; SHANSHEN, through drying, claims " dried wild ginseng "; Through having one's hair waved, dry after leaching sugar, claim " white sugar ginseng "; Dry after cooking or dry, claiming " Radix Ginseng Rubra ".[nature and flavor] sweet, micro-hardship, flat.[return through] returns spleen, lung, heart channel.[function cures mainly] strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.[usage and dosage] 3 ~ 9g.[attention] should not with Rhizoma et radix veratri (Radix Rhizoma Veratri) with using.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of habitual abortion, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing habitual abortion.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine being used for the treatment of habitual abortion, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: platform Radix Codonopsis 9 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, 9 parts, Poria, Pericarpium citri reticuatae chachiensis 6 parts, Fructus Amomi 3 parts, the Cortex Eucommiae 6 parts, Herba Cistanches 6 parts, Radix Boehmeriae 6 parts, not directly ginseng 3 parts.
Inventor thinks that habitual abortion is weak by taste, and nausea loses foster or deficiency of the liver and kindey tire is originally solid.Control method, first adjust taste, continue strong Liver and kidney, and tire is obtained support this and solid, therefore assembly is our.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
It is object of study that inventor collects 90 routine habitual abortion patients between in August, 2011 ~ in February, 2013 altogether, and all patients all meet the diagnostic criteria of " gynecological's science " relevant habitual abortion, and it is divided into treatment group and matched group at random.Treatment group patient 44 example, the age 20 ~ 38 (28.8 ± 1.5) year, abortion times 2 ~ 4 (3.0 ± 0.8) is secondary; Matched group patient 46 example, the age 22 ~ 35 (27.9 ± 2.5) year, abortion times 2 ~ 5 (3.1 ± 0.9) is secondary.Two groups of patients compare in age, abortion times etc., and no significant difference (P>0.05), has comparability
2, test method
2.1 Therapeutic Method
Two groups of patients give immediately after clear and definite pregnancy allylestrenol (Pharmaceutical Co Ltd, Changzhou Pharmaceutical Factory No.4. the accurate word H20113293 of traditional Chinese medicines) oral medication .10mg/ time, 1 time/d, until crisis after date 4w, decrement is 5mg/ time, 1 time/d, continued treatment is to pregnant 20w end.
The decoct that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 3 times.Oral medicine treatment time determines with uterine contraction situation:
Matched group oral hydrochloride ritodrine sheet (Xianqiang Pharmaceutical Co., Ltd., Guangdong, the accurate word H20093480 of traditional Chinese medicines) is treated.10mg/ time, 2h/ time, change 15 ~ 20mg/ time into after 6h, 1d terminates, and oral medicine treatment time determines with uterine contraction situation
3, therapeutic outcome
3.1 criterion of therapeutical effect
Effective: after treatment, patient's clinical symptoms and sign disappear completely. blood samples of patients detects its peripheral blood anti-endometrial antibodies (EMAb) and (or) anticardiolipin antibody (ACA) is all turned out cloudy;
Effective: patient clinical symptom and sign disappear substantially, EMAb and (or) ACA turns out cloudy;
Invalid: patient clinical symptom and sign are not improved. during check, EMAb and ACA turns and does not all turn out cloudy.
Therapeutic outcome is in table 1.
Table 1 liang group comparitive study
Group n Effective Effectively Invalid Total effective rate (%) Success rate of preventing miscarriage [n (%)]
Treatment group 46 21 19 6 87.0% 35（76.1）
Matched group 44 10 14 20 54.5% 23（52.3）
Visible, the medicine that the present invention obtains can safe and effective treatment habitual abortion, has promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: platform Radix Codonopsis 9 grams, the Rhizoma Atractylodis Macrocephalae 6 grams, 9 grams, Poria, Pericarpium citri reticuatae chachiensis 6 grams, Fructus Amomi 3 grams, the Cortex Eucommiae 6 grams, Herba Cistanches 6 grams, Radix Boehmeriae 6 grams, not directly ginseng 3 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of habitual abortion.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: platform Radix Codonopsis 9 grams, the Rhizoma Atractylodis Macrocephalae 6 grams, 9 grams, Poria, Pericarpium citri reticuatae chachiensis 6 grams, Fructus Amomi 3 grams, the Cortex Eucommiae 6 grams, Herba Cistanches 6 grams, Radix Boehmeriae 6 grams, not directly ginseng 3 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of habitual abortion.Oral, daily once.
Specific embodiment 3
Take: platform Radix Codonopsis 9 grams, the Rhizoma Atractylodis Macrocephalae 6 grams, 9 grams, Poria, Pericarpium citri reticuatae chachiensis 6 grams, Fructus Amomi 3 grams, the Cortex Eucommiae 6 grams, Herba Cistanches 6 grams, Radix Boehmeriae 6 grams, not directly ginseng 3 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of habitual abortion.Oral, every bu is taken for twice sooner or later.

Claims (1)

1. one kind is used for the treatment of the Chinese medicine of habitual abortion, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: platform Radix Codonopsis 9 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, 9 parts, Poria, Pericarpium citri reticuatae chachiensis 6 parts, Fructus Amomi 3 parts, the Cortex Eucommiae 6 parts, Herba Cistanches 6 parts, Radix Boehmeriae 6 parts, not directly ginseng 3 parts.
CN201410683396.4A 2014-11-25 2014-11-25 Traditional Chinese medicine for treating habitual abortion Pending CN104435983A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003277278A (en) * 2002-03-20 2003-10-02 Fancl Corp Oxytocin antagonist
CN102698184A (en) * 2012-06-26 2012-10-03 刘天岐 Vomiting-arresting miscarriage-prevention fructus amomi pill

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003277278A (en) * 2002-03-20 2003-10-02 Fancl Corp Oxytocin antagonist
CN102698184A (en) * 2012-06-26 2012-10-03 刘天岐 Vomiting-arresting miscarriage-prevention fructus amomi pill

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
杜惠芳等: "《名医名家用药心得汇讲》", 30 November 2007 *
王存兰: "自拟安胎饮治疗习惯性流产62例", 《实用中医药杂志》 *

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Application publication date: 20150325

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