CN104435881A - 一种治疗肾病综合症的药物 - Google Patents

一种治疗肾病综合症的药物 Download PDF

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CN104435881A
CN104435881A CN201410661082.4A CN201410661082A CN104435881A CN 104435881 A CN104435881 A CN 104435881A CN 201410661082 A CN201410661082 A CN 201410661082A CN 104435881 A CN104435881 A CN 104435881A
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Abstract

一种治疗治疗肾病综合症的药物。它由黄芪、益母草、蝉蜕、茯苓、淮山、薏米、枣皮、女贞子、桑椹子、泽泻、赤芍、甘草组成，将上述原料焙干后，研磨成粉剂即可。本发明缩短了疗程，减轻了病人的痛苦，特别是消除了肾上腺皮质激素的副作用。

Description

一种治疗肾病综合症的药物
技术领域
本发明属于中药领域，特别是涉及一种治疗肾病综合症的药物。
背景技术
肾病综合症是临床较为常见、难治的疾病。肾病综合症的病因、病机可用湿、毒、淤、虚、郁五字概括，疫毒借外湿而入，内则是湿以滋生、复制、演变酿化，湿毒贯穿于始终，由浅及深，究其病位在血、肾，肾为先天之本，由于肾之病，以气郁为先，继之体周同病。肾病传脾，相继而出现湿热、郁、血瘀等病理变化，以至湿壅塞，与现代医学低蛋白血症、全身浮肿相符。
现代医学对肾病综合症虽有较深入地研究，但在治疗上仍然无更大突破。目前国内外主要采用免疫抑制剂治疗肾病综合症，但该治疗手段毒副作用大、时间长、疗效欠佳，复发率高。国内外目前对中医中药治疗肾病综合症前景乐观，但进展不大；国内虽有少数中药制剂，但其效果尚不理想。
发明内容
本发明的目的是为弥补现有技术的不足，提供一种疗效好、疗程短、无毒副作用的治疗肾病综合症的药物。
本发明的目的是这样实现的：
本发明由以下原料组成：黄芪26-32克、益母草12-16克、蝉蜕5-7克、茯苓8-12克、淮山10-14克、薏米10-14克、枣皮5-8克、女贞子10-14克、桑椹子14-16克、泽泻8-12克、赤芍18-22克、甘草4-6克。
本发明的最优原料配方为：
黄芪30克、益母草15克、蝉蜕6克、茯苓10克、淮山12克、薏米12克、枣皮6克、女贞子12克、桑椹子15克、泽泻10克、赤芍20克、甘草5克。
本发明将上述原料焙干后，研磨成粉剂即可。
使用本发明后均在1-3个月内症状消失。本发明缩短了疗程，减轻了病人的痛苦，特别是消除了肾上腺皮质激素的副作用。
具体实施方式
取黄芪30克、益母草15克、蝉蜕6克、茯苓10克、淮山12克、薏米12克、枣皮6克、女贞子12克、桑椹子15克、泽泻10克、赤芍20克、甘草5克，将上述原料焙干后，研磨成粉剂，按每次10克、每日2次的用法用量，饭后温开水冲服即可。
临床资料
    1、病例选择
病例选择符合中华肾病学会拟定的肾病综合症标准。此前1月内未服用抗病毒、免疫调节剂。排除心脏、内分泌及造血系统损害和其它影响疗效的评价因素，随机分为治疗组（A组）和对照组（B组），两组的年龄、性别及病程见表1。
表1 ：两组病例的年龄、性别及病程
 2、疗效标准
治愈：主要症状消失，血压正常，浮肿、蛋白尿消失，双肾区无扣痛、压痛，肾功能正常，随访1年以上无异常改变。
基本治愈：自觉症状消失，无浮肿，双肾区无扣痛、压痛，尿蛋白（+～++），肾功能正常，以上各项指标稳定1年以上。
好转：主要症状消失，双肾区扣痛、压痛消失，浮肿消退，血浆蛋白仍低，尿蛋白（++），肾功能正常。
无效：未达到上述标准。
3、治疗方法
采用双盲给药，A组服用本发明，B组服用另一种治疗肾病综合症中药，两组病人的基础治疗相同，其服药时间及次数均相同，均在每天上午8时、下午4时服药。
4、观察指标
临床症状及体征治疗前后观察，以临床痊愈、显效、有效、无效表示，治疗3、6、12月后各追踪观察1次，并于3、6、12月后各追踪观察记录1次。
5、观察结果
计数资料采用x检验，计量资料采用π检验，两组的疗效见表2、3、4、5。
表2：两组疗效比较（例（%））
注：与对照组比较△P＜0.005
表3：两组治疗前后主要临床症状及体征变化
注：与对照组比较＊P＞0.05, ＊＊P＞0.005
表4：两组治疗前后肾功能变化（X±）
注：与治疗组作配对比较△P＞0.05, △P＜0.005
与对照组比较※P＜0.005, ※P＜0.005
表5：血液流学改善情况（X±S）
 注：与治疗组作配对比较△P＜0.05, △△P＜0.005
与对照组比较※P＜0.05, ※P＜0.005
6、典型病例介绍
例1：邹某，女，28岁。患者反复浮肿，蛋白尿2年余，曾在湖南省医科大学二医院住院，诊断为肾病综合症，经服用药物后蛋白尿仍有（++～+++）、全身浮肿。使用本发明治疗38天，浮肿及蛋白尿均消失，肾功能正常。后随访2年4个月症状无复发。
例2：张某，女，24岁。患者因颜面浮肿，蛋白尿5年余，患者曾先后在多家医院住院服药治疗，经肾穿刺病理检查诊断为狼疮性肾炎。浮肿、面部红斑反复发作，尿蛋白持续为（+++）。使用本发明后，尿蛋白、浮肿消失。后追踪观察2年余，症状未再复发。
例3：邓某，男，27岁。患者因肾小球肾炎浮肿、腰痛，尿蛋白（+++）。使用本发明后症状消失，蛋白尿（-）。追踪观察1年余，复查蛋白尿（-）；追踪观察1年8个月，症状无特殊变化，蛋白尿（-）。

Claims (2)

1.一种治疗治疗肾病综合症的药物，其特征在于：由以下原料组成：黄芪26-32克、益母草12-16克、蝉蜕5-7克、茯苓8-12克、淮山10-14克、薏米10-14克、枣皮5-8克、女贞子10-14克、桑椹子14-16克、泽泻8-12克、赤芍18-22克、甘草4-6克。
2.根据权利要求1所述的一种治疗治疗肾病综合症的药物，其特征在于：本发明的最优原料配方为：黄芪30克、益母草15克、蝉蜕6克、茯苓10克、淮山12克、薏米12克、枣皮6克、女贞子12克、桑椹子15克、泽泻10克、赤芍20克、甘草5克。
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108186823A (zh) * 2018-02-05 2018-06-22 浙江中医药大学 一种用于治疗肾病综合征的药物组合物
CN108186823B (zh) * 2018-02-05 2021-04-06 浙江中医药大学 一种用于治疗肾病综合征的药物组合物

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