CN104435834B - A kind of Chinese medicine for being used to treat acute icteric hepatitis - Google Patents
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Abstract
The present invention relates to a kind of Chinese medicine for being used to treat acute icteric hepatitis, it is prepared by the raw medicinal material of following weight proportion：15 30 parts of oriental wormwood, 10 15 parts of cape jasmine, 6 10 parts of rheum officinale, 15 30 parts of the radix paeoniae rubrathe, 15 30 parts of hypericum japonicum, 15 30 parts of Radix Isatidis, 15 30 parts of Poria cocos, 6 10 parts of dried orange peel, 6 10 parts of the leaf of bamboo, 36 parts of the stem pith of the rice-paper plant.Clinical experiments have proved that the present invention can safely and effectively be used to treat acute icteric hepatitis caused by a variety of causes.
Description
Technical field
The present invention relates to a kind of Chinese medicine, and in particular to a kind of Chinese medicine for being used to treat acute icteric hepatitis.
Background technology
Definition
Jaundice is due to experience the exopathogens such as epidemic disease caused by damp-heat pathogen poison, causes wet turbid retardance, the imbalance of taste hepato-biliary function, and bile does not follow often
Road, with blood overflow caused by using mesh is yellow, body is yellow, yellow urine as main clinical manifestation a kind of disease of liver-gallbladder.Jaundice is clinical common
One of disease, men and women, old and young can all suffer from, but between twenty and fifty in the majority.Evil, the injury due to diet when cause of disease of yellow subcutaneous ulcer mainly has diseases caused by external factors, spleen
Stomach weakness and liver and bile stone, long-pending block stasis blocking etc., its morbidity are often internal and external reasonses mutually because of trouble.Acute icteric hepatitis is diseases caused by external factors
When heresy diseases caused by external factors it is wet it is turbid, damp and hot, when epidemic disease is malicious etc. heresy from mouth and people, pent up it is not normal in middle Jiao, transporting and transforming function of the spleen and stomach, it is damp and hot to fumigate in taste,
Involve liver and gall, so that liver dysfunction, bile Bu Xunchang roads, overflow with blood, excessive skin, upper note eyes, flow down bladder, makes body mesh
Urine is all yellow, into jaundice.If epidemic disease poison can injure ying blood, cave in pericardium, sends out as acute febrile compared with severe one.
Acute icteric hepatitis is to destroy liver cell by hepatitis viruse, makes degeneration of liver cells, necrosis and inflammatory reaction and draws
A series of this diseases of the disease of clinical symptoms such as the weak, yellow urine that rises, poor appetite, skin and mucosa xanthochromia belong to traditional Chinese medicine " jaundice "
Category, ancient times are also known as " jaundice ".《Interior warp》The name of existing jaundice, and the cause of disease to jaundice, the interpretation of the cause, onset and process of an illness, symptom etc. have tentatively
Understanding.《The Treatise on Fevrile Diseases》It also proposed the bright jaundice of sun and lunar jaundice, and the more detailed clinical manifestation for describing jaundice, initiative
The how first prescription such as Yinchenhao Tang, Oriental Wormwood Decoction, Yinchen Wuling San, Powder of Oriental Wormwood and Five Drugs with Poria, embody under rushing down, inducing diaphoresis, Qinghua, Wen Hua, by a variety of removing jaundices such as the stasis of blood, diuresis it
Method, these therapies and prescription still like use by today.Written by Yuan Dynasty's Luo Tianyi《The precious mirror of hygiene turns to be yellow》Summarize the warp of forefathers
Test, further clear and definite conversion of dampness into heat is yang jaundice, and conversion of dampness into old is yin jaundice, by the diagnosis and treatment systematization of yang jaundice and yin jaundice, holds letter
Drive it is numerous, it is larger to clinical practice guidelines meaning, be still used so far.China is virus hepatitis hotspot, annual Acute Hepatic
Scorching patient's incidence of disease is about 15.52/10 ten thousand, at present to use western medicine more, but medical expense is expensive mostly and cures the symptoms, not the disease,
Toxic side effect is obvious.
The content of the invention
The present invention is intended to provide a kind of be used to treat the Chinese medicine of acute icteric hepatitis, by select suitable medicinal material and its
Proportioning, reach the purpose of safely and effectively treatment acute icteric hepatitis.
In order to achieve the above object, the present invention uses following technical scheme：
A kind of Chinese medicine for being used to treat acute icteric hepatitis, it is characterised in that it is by the raw material of following weight proportion
Medicinal material is prepared：Oriental wormwood 15-30 parts, cape jasmine 10-15 parts, rheum officinale 6-10 parts, radix paeoniae rubrathe 15-30 parts, hypericum japonicum 15-30 parts, plate
Blue root 15-30 parts, Poria cocos 15-30 parts, dried orange peel 6-10 parts, leaf of bamboo 6-10 parts, stem pith of the rice-paper plant 3-6 parts.
It is preferred that：20 parts of oriental wormwood, 12 parts of cape jasmine, 8 parts of rheum officinale, 25 parts of the radix paeoniae rubrathe, 20 parts of hypericum japonicum, 25 parts of Radix Isatidis, Poria cocos 20
Part, 8 parts of dried orange peel, 8 parts of the leaf of bamboo, 5 parts of the stem pith of the rice-paper plant.
Illustrate beneficial effects of the present invention with reference to theory of traditional Chinese medical science：
It has been recognised by the inventors that the category of icteric hepatitis category traditional Chinese medicine " jaundice " disease, clinically, patient often show as body it is yellow,
Mesh is yellow, red yellow urine is primary symptom, is common clinical, frequently-occurring disease wherein especially with mesh Huang for this sick principal character.Acute icteric
When hepatitis is diseases caused by external factors heresy diseases caused by external factors it is wet it is turbid, damp and hot, when epidemic disease is malicious etc. heresy from mouth and people, pent up it is not normal in middle Jiao, transporting and transforming function of the spleen and stomach, it is damp and hot
Fumigate in taste, involve liver and gall, so that liver dysfunction, bile Bu Xunchang roads, overflow with blood, excessive skin, upper note eyes, flow down
Bladder, make body mesh urine all yellow, into jaundice.If epidemic disease poison can injure ying blood, cave in pericardium, sends out as acute febrile compared with severe one.《Element
Ask that wind discusses a piece the 42nd》Middle theory：" general mood with sun it is bright enter stomach, follow arteries and veins and up to inner canthus, then general mood must not leak its people's fertilizer,
Then to hanker and mesh is yellow, " understand singly to enter stomach by ailment said due to cold or exposure, it must not leak, jaundice can be caused.Oriental wormwood, hypericum japonicum have clearing heat and promoting diuresis
The work(of removing jaundice；Cape jasmine clearing heat-fire；Rheum officinale leads to internal organs and rushes down turbid removing jaundice；The soft liver of radix paeoniae rubrathe clearing heat and cooling blood promoting blood circulation；Poria cocos, dried orange peel, radix glycyrrhizae profit
Wet relieving QI stagnancy in the stomach, the leaf of bamboo, stem pith of the rice-paper plant reducing fever and causing diuresis, enables damp and hot heresy to be solved from urine, and all medicines play clearing heat and promoting diuresis removing toxic substances removing jaundice altogether
Work(.
The beneficial effects of the present invention will now be described with reference to clinical experimental data：
1st, diagnostic criteria
Revised according to the Xi'an of in September, 2000 whole nation virus hepatitis and hepatopathy academic conference《Virus hepatitis preventing and treating side
Case》Diagnostic criteria.
2nd, clinical data
（One）Research object：The 2 months acute jaundices being in hospital in infectious hospital of Yantai City in selection in March, 2010 ~ 2013 year
The patient of type hepatitis, totally 162, it is randomly divided into treatment group and control group.
Treatment group 82, man 60, female 22,18 ~ 72 years old age, average age 35.70 ± 10.03 years old.Control group 80
Example, man 59, female 21,20 ~ 67 years old age, average age 36.8 ± 9.62 years old.Two groups before the treatment in sex, age, liver
Function no difference of science of statistics（P ＞ 0.05）.
3rd, research method：
The present invention gives according to decoction made from embodiment 1 in treatment group, twice daily.Combine reproducibility gluathione simultaneously
Peptide, compound glycyrrbizic acid intravenous injection and symptomatic treatment.
Control group is given only reductive glutathione, compound glycyrrbizic acid intravenous injection and symptomatic treatment.
Lain up as far as possible during medication, bland diet, avoid eating fatness, sweet, thick and oily.It is within 14 days a course for the treatment of, continuous application two
Comparing two groups of case clinical cure rates and liver function index after the individual course for the treatment of improves situation.
4th, clinical development standard：
It is fixed with reference to the Ministry of Public Health《The guideline of clinical investigations for the treatment of by Chinese herbs virus hepatitis》In efficacy of new drug it is comprehensive
Close evaluation criterion.
Clinical cure：（1）Cardinal symptom disappears（2）Hepatosplenomegaly disappears or retraction（3）It is basic that liver can detect 4 indexs
Recover normal（That is below ALT40U/L, total bilirubin 17.7 below umol/L, A/G are equal to or more than 1.4：1 similarly hereinafter）.
It is clinical effective：（1）Cardinal symptom is obviously improved or disappeared（2）Hepatosplenomegaly disappears or retraction（3）Liver function test
Take a turn for the better.
It is clinical invalid：（1）Clinical symptoms are without improvement（2）Hepatosplenomegaly bounces back or stablized constant（3）Liver function test is without good
Turn or aggravate.
5th, statistical method：Enumeration data usesх 2Examine, measurement data usestExamine.
6th, therapeutic effect
（One）The comparison of two groups of case clinical cure rates（It is shown in Table 1）
The comparison of 1 two groups of case clinical cure rates of table
* two groups compareP＜ 0.05
（Two）Two groups of pretherapy and post-treatment liver functions of case compare（It is shown in Table 2）
The comparison of 2 two groups of pretherapy and post-treatment liver functions of case of table（±s）
* with this group before treatmentP＜ 0.01,▲Compare compared with after control group treatmentP＜ 0.05
7th, conclusion
Acute icteric hepatitis is due to infect systemic, the acute biography caused by hepatitis viruse based on liver damage more
Infectious diseases.Belong to " jaundice " its " yang jaundice " in the traditional Chinese medical science, so that body is yellow, mesh is yellow, urine Huang is primary symptom.Jaundice office key be it is wet,
Damp retention in middle-jiao, taste disturbance in ascending and descending, and then influence the catharsis of liver and gall so that bile Bu Xunchang roads, penetrate into blood, overflow in white of the eye,
Skin, or bladder is leaked into, so as to form jaundice.If the strongly fragrant long intrinsic heat of damp evil, yellow is distinct, referred to as yang jaundice.For jaundice
Treatment,《The Treatise on Fevrile Diseases》Point out:" typhoid fever seven, eight days, body is yellow such as tangerine color, difficult urination, slight fullness in the abdomen person, tarragon soup master it." oriental wormwood
To treat the first choice of the yang jaundice of jaundice, there is heat-clearing, dampness removing, the work(of removing jaundice, particularly suitable for damp and hot yang jaundice.We are mainly by mattress
Old, cape jasmine, rheum officinale form, and it is monarch drug in a prescription that oriental wormwood is reused in side, and hardship lets out decline, are apt to energy clearing heat and promoting diuresis, are Yellow River harnessing subcutaneous ulcer key medicine;Minister with
Cape jasmine heat-clearing and fire-reducing, tonneau three is burnt, helps oriental wormwood to draw and damp and hot is gone from urine;Assistant is expelled the heat-evil by the stasis of blood with rheum officinale, tonneau stool, leads the stasis of blood
Heat is under stool.Three's collective effect, the effect of playing heat-clearing and dampness-resolving, hepatocyte function can be effectively improved, promote liver
Cytothesis, accelerate Rehabilitation.This item purpose Chinese medicinal formulae composition is by clinic application and observation proof is curative for effect, hence it is evident that
The cure rate of acute icteric hepatitis patient is improved, promotes liver function recovery.And this prescription composition is cheap, has produced
Good Social benefit and economic benefit.Its popularization and application undoubtedly can bring benefit to more acute icteric hepatitis patients
Place, while new treatment method also is added for liver disease worker, more preferable Social benefit and economic benefit will be produced.
To sum up, medicine produced by the present invention can safely and effectively treat acute icteric hepatitis, have certain promotion price
Value.
Embodiment
In order to more fully understand and implement the present invention, the present invention is further illustrated with reference to specific embodiment.
Specific embodiment 1
Weigh：20 grams of oriental wormwood, 12 grams of cape jasmine, 8 grams of rheum officinale, 25 grams of the radix paeoniae rubrathe, 20 grams of hypericum japonicum, 25 grams of Radix Isatidis, Poria cocos 20
Gram, 8 grams of dried orange peel, 8 grams of the leaf of bamboo, 5 grams of the stem pith of the rice-paper plant, add 8 times amount water, decoct 1.5 hours, filtering；Filter residue adds 6 times of amount water, and it is small to decoct 1
When, filtering；Merging filtrate, 120 grams are concentrated into, produce the decoction for meeting one day dosage of normal adult.
For treating acute icteric hepatitis.Orally, taken twice sooner or later per bu.
Specific embodiment 2
Weigh：15 grams of oriental wormwood, 10 grams of cape jasmine, 6 grams of rheum officinale, 15 grams of the radix paeoniae rubrathe, 15 grams of hypericum japonicum, 15 grams of Radix Isatidis, Poria cocos 15
Gram, 6 grams of dried orange peel, 6 grams of the leaf of bamboo, 3 grams of the stem pith of the rice-paper plant, add 10 times amount water, decoct 2 hours, filtering；Filter residue adds 8 times of amount water, and it is small to decoct 1.5
When, filtering；Merging filtrate, concentrate, dry, packaging, produce the powder for meeting one day dosage of normal adult.
For treating acute icteric hepatitis.Orally, taken three times in the morning, afternoon and evening per bu.
Specific embodiment 3
Weigh：30 grams of oriental wormwood, 15 grams of cape jasmine, 10 grams of rheum officinale, 30 grams of the radix paeoniae rubrathe, 30 grams of hypericum japonicum, 30 grams of Radix Isatidis, Poria cocos 30
Gram, 10 grams of dried orange peel, 10 grams of the leaf of bamboo, 6 grams of the stem pith of the rice-paper plant, add 6 times amount water, decoct 3 times, every time decoct 1 hour, merge decoction liquor, concentration,
Dry, load capsule shells, produce the capsule for meeting one day dosage of normal adult.
For treating acute icteric hepatitis.Orally, taken twice sooner or later per bu.
Claims (1)
1. a kind of Chinese medicine for being used to treat acute icteric hepatitis, it is characterised in that it is by the bulk drug of following weight proportion
Material is prepared：20 parts of oriental wormwood, 12 parts of cape jasmine, 8 parts of rheum officinale, 25 parts of the radix paeoniae rubrathe, 20 parts of hypericum japonicum, 25 parts of Radix Isatidis, 20 parts of Poria cocos,
8 parts of dried orange peel, 8 parts of the leaf of bamboo, 5 parts of the stem pith of the rice-paper plant.
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| 中药系列方治疗各种肝病的临床研究;王建伟等;《中国科技项目创新成果鉴定意见数据库（知网版）》;20081213 * |
| 茵陈蒿汤加减治疗急性黄疸型肝炎38例;何汶忠;《光明中医》;20110930;第26卷(第09期);1843-1844页 * |
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