CN104435250A - 一种治疗精索静脉曲张的药物 - Google Patents
一种治疗精索静脉曲张的药物 Download PDFInfo
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Abstract
一种治疗精索静脉曲张的药物，是将柴胡、川牛膝、当归、橘核、乌药、小茴香、川楝子、元胡、路路通、王不留行加水煎煮得到煎液，浓缩后加入常规辅料，加纯化水至含生药量为1g/ml，灌封、灭菌制成口服液制剂。本发明能疏肝理气、补中益气，对精索静脉曲张患者有特殊治疗效果，该药物天然纯净、安全无毒，没有副作用。经临床观察其有效率为88%。
Description
技术领域
本发明涉及一种治疗精索静脉曲张的药物，特别涉及一种以中药为原料药制备的治疗精索静脉曲张的中药。
背景技术
精索静脉曲张是指精索里的静脉因回流受阻，而出现的盘曲扩张。是青壮年常见的疾病，是指因精索静脉血流淤积而造成精索蔓状丛（静脉血管丛）血管扩张，迂曲和变长。发病率为男性人群为10－15%。由于精索静脉曲张导致局部温度升高、缺氧、pH值改变、毒性物质滞留等原因导致精子数量减少，精子活动能力下降和畸形精子比例的升高，从而降低了男性的生育力，导致男性不育。
目前对于精索静脉曲张患者的治疗，中度以上大多是采用手术或介入方法治疗。
发明内容
本发明的目的是提供一种治疗精索静脉曲张的中药，本发明能疏肝理气、补中益气，对精索静脉曲张患者有特殊治疗效果，该药物天然纯净、安全无毒，没有副作用。
本发明的药物是由以下重量份数的中药为原料药制备得到的：
柴胡10～12 川牛膝10～15 当归10～15
橘核10～15 乌药10～12 小茴香10～12
川楝子10～15 元胡10～12 路路通10～15
王不留行10～15。
可以将上述药物制成药剂学上任何一种剂型如片剂、丸剂、散剂、胶囊，本发明优选的是口服液。
将上述各组份制成本发明所述口服液的具体制备方法是：
将上述重量份的药物混合均匀，加水煎煮2～4次，每次1～2小时，合并煎液，过滤，将滤液浓缩成70℃相对密度1.15～1.18的清膏，冷藏静置，取上清液滤过，滤液中加入常规辅料，混匀，加纯化水至含生药量为1g/ml，灌封、灭菌制成口服液制剂。
使用方法：口服，每次1袋，每袋500ml，每日三次。
中医认为精索静脉曲张主要是因为血瘀阻络，情志失和，肝气郁滞，气滞而淤血，或者气虚下陷，素体虚弱，气虚不足而引起。因此，疏肝理气、温中助阳是治疗精索静脉曲张的主要大法。本方中柴胡有疏散退热，升阳舒肝之功效；川牛膝能逐瘀通经，利尿通淋；当归补血益气；橘核行肝气，消肿散毒，专攻睾丸肿痛；乌药用于行气止痛，温肾散寒；小茴香有散寒止痛，理气和中的功效；川楝子主要入肝经，疏泄肝热，行气止痛，有除湿热、清肝火、止痛的功能；王不留行能活血通经，利尿通淋。
以上诸药合用，用于治疗精索静脉曲张治愈率高，无手术之恐惧感，无西药制剂对人体脏器损害等副作用，也无抗生素等耐药性。
为进一步考察本发明的药物的临床疗效和安全性,选择8例精索静脉曲张患者对本发明药物的疗效进行临床观察。
疗效标准：根据《中药新药治疗精索静脉曲张的临床研究指导原则》规定，疗效判定以症状消失为主，并参考体征等改变情况，分为治愈、显效、有效、无效四级。治愈：症状及体征全部消失。显效：症状及体征明显改善。有效：症状及体征有一定改善。无效：症状及体征均无改善。
经治疗观察，患者连用三十天。8例患者，5例治愈，有效2例，无效1例，总有效率88%。没有任何副作用和不良反应。
具体实施方式
实施例：
取柴胡12 kg、川牛膝15 kg、当归15 kg、橘核15 kg、乌药12 kg、小茴香12 kg、川楝子15 kg、元胡12 kg、路路通15 kg、 王不留行15 kg，以清水洗净，加水煎煮3次，每次1～2小时，合并煎液，过滤，将滤液浓缩成70℃相对密度1.15～1.18的清膏，冷藏静置，取上清液滤过，滤液中加入常规辅料，混匀，加纯化水至含生药量为1g/ml，灌封、灭菌制成口服液制剂。
使用方法：口服，每次1袋，每袋500ml，每日三次。
病历一：刘某，男， 18岁。2007年9月11日来诊。精索静脉曲张1年余，有沉重及坠胀感，行走时疼痛加重，经常感到不适，一受凉坠胀感加重，多药无效，经用本方9剂后疼痛十去八九，再服20剂病愈。
病历二：郑某，男，21岁。2009年10月15日就诊。精索静脉曲张2年，有沉重及坠胀感，向腹股沟放射，行走及劳动时加重，平卧休息后减轻。影响休息和工作。经用本方加减10剂后症减，再服19剂病愈。
Claims (3)
1.一种治疗精索静脉曲张的药物，其特征在于：
本发明所述药物是由以下重量份数的中药为原料制备得到的：
柴胡10～12 川牛膝10～15 当归10～15
橘核10～15 乌药10～12 小茴香10～12
川楝子10～15 元胡10～12 路路通10～15
王不留行10～15。
2.根据权利要求1所述的治疗精索静脉曲张的药物，其特征在是将所述的药物制成口服液。
3.权利要求2所述的治疗精索静脉曲张的药物的制备方法是：将上述重量份的药物混合均匀，加水煎煮2～4次，每次1～2小时，合并煎液，过滤，将滤液浓缩成70℃相对密度1.15～1.18的清膏，冷藏静置，取上清液滤过，滤液中加入常规辅料，混匀，加纯化水至含生药量为1g/ml，灌封、灭菌制成口服液制剂。
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213699A (zh) * | 2015-11-02 | 2016-01-06 | 济南知尔医药科技有限公司 | 一种治疗精索静脉曲张的中药组合物 |
| CN109646468A (zh) * | 2019-01-31 | 2019-04-19 | 王书利 | 一种静脉曲张药剂的制备方法 |
| CN111529643A (zh) * | 2020-06-12 | 2020-08-14 | 深圳市中医院 | 一种橘核活精药剂制备方法及其装置 |
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| CN102309588A (zh) * | 2011-09-22 | 2012-01-11 | 长治市郊区黄碾镇中心卫生院 | 一种治疗精索静脉曲张的药物 |
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| CN102309588A (zh) * | 2011-09-22 | 2012-01-11 | 长治市郊区黄碾镇中心卫生院 | 一种治疗精索静脉曲张的药物 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213699A (zh) * | 2015-11-02 | 2016-01-06 | 济南知尔医药科技有限公司 | 一种治疗精索静脉曲张的中药组合物 |
| CN109646468A (zh) * | 2019-01-31 | 2019-04-19 | 王书利 | 一种静脉曲张药剂的制备方法 |
| CN111529643A (zh) * | 2020-06-12 | 2020-08-14 | 深圳市中医院 | 一种橘核活精药剂制备方法及其装置 |
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