CN104435126A - Traditional Chinese medicine preparation for improving rheumatic arthralgia and resisting fatigue and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for improving rheumatic arthralgia and resisting fatigue and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention provides a traditional Chinese medicine preparation for improving rheumatic arthralgia and resisting fatigue and a preparation method thereof. According to the traditional Chinese medicine preparation, the alcohol extracts of a traditional Chinese medicine composition serve as active ingredients, the traditional Chinese medicine composition comprises the following components: 20-50 parts of beautiful millettia root, 0.5-5 parts of philippine flemingia root, 0.5-5 parts of radix fici simplicissimae, 0.1-2 parts of lucid ganoderma and 0.1-4 parts of schisandra chinensis, and the traditional Chinese medicine preparation is obtained by extracting the traditional Chinese medicine composition in the first aspect by using wine according to cold-maceration, hot dipping, percolation or reflux hot dipping. The traditional Chinese medicine preparation disclosed by the invention has good curative effects on symptoms such as cough of deficiency lung, deficiency of the kidney, spermatorrhea, leucorrhea, rheumatic arthralgia, waist and knee pain and fatigue and is small in toxic and side effects and safe to use.
Description
Technical field
The present invention relates to and field of medicaments, specifically, the present invention relates to a kind of for bone and muscle strengthening, relaxing muscles and tendons and activating QI and blood in the collateral, improve the Chinese medicine preparation and preparation method thereof of rheumatic arthralgia, soreness of waist and knee joint, resisting fatigue.
Background technology
Millettia Speciosa (Millettia speciosa Champ.) has another name called beautiful millettia, for pulse family (Leguminosae) Millettia (Millettia Wight et Arn.) plant, medicine name Millettia Speciosa, also known as cattle energetically (" the SHENGCAO property of medicine is standby to be wanted "), Radix Millettiae Speciosae (" Luchuan book on Chinese herbal medicine "), slope Rhizoma Nelumbinis (" Luchuan book on Chinese herbal medicine "), Rhizoma Nelumbinis (" Nanning City's medicine will "), Caulis seu Radix Schisandrae Henryi, large Rhizoma Nelumbinis (" Medicinal Plants of Guangxi register ").Be distributed in China Fujian, Hunan, Guangdong, Guangxi, Yunnan and Guizhou.Its root is used as medicine, and nature and flavor are sweet, cold.There is effect that tonify deficiency lung moistening, cough-relieving, strong muscle are active.Millettia Speciosa medication is with a long history, records as far back as " the SHENGCAO property of medicine standby will ": " reason internal injury, controls traumatic injury, infusing drugs in wine nourishing kidney for strengthening bone and muscle, relieving heat toxin." " Luchuan book on Chinese herbal medicine " record: " clearing away lung-heat to relieve cough, refreshing and detoxicating.Control hemoptysis, dysentery, epidemic febrile disease fever of the body is thirsty, dizzy." " Guangdong Chinese herbal medicine " record: " control cough due to deficiency of the lung, puerperal asthenia, limbs fatigue, carbuncle skin ulcer.”）。The cough due to deficiency of the lung of being used for the treatment of among the people, hemoptysis, breath with cough, the disease such as lumbar muscle strain, rheumatism paralysis, traumatic injury; Clinically confirm that it has therapeutical effect to multiple chronic disease, be mainly used in the diseases (" national Chinese herbal medicine compilation ") such as treatment rheumatic arthritis, pulmonary tuberculosis, chronic bronchitis, chronic hepatitis, lumbar muscle strain.Modern study shows, Millettia Speciosa root is mainly containing saccharide, alkaloid, flavones ingredient.Interleukin-2 is produced to experiment mice B lymphocytic emiocytosis specific antibody and T lymphocyte there is immunoregulation effect; Millettia Speciosa polysaccharide is one of main active of Millettia Speciosa immunity moderation function, has dual regulation to mouse T lymphocyte propagation.Millettia Speciosa Aqueous extracts has multiple biological activity, is desirable immunostimulant, and does not have toxic and side effects to normal cell, is used for antitumor, antiviral, anti-ageing drug research of waiting for a long time.
The very heavy group of property of medicine is sweet, tepor, flat.Return lung, kidney, urinary bladder channel, have expelling wind and removing dampness, effect of repercussive removing toxic substances.Cure mainly rheumatic arthralgia, extremity are aching and limp unable, traumatic injury, can relaxing muscles and tendons and activating QI and blood in the collateral.Normal with Millettia Speciosa compatibility, the relaxing muscles and tendons and activating QI and blood in the collateral contributing to monarch drug Millettia Speciosa treats effect of rheumatic arthralgia.Pharmacological research shows, Radix Flemingiae Philippinensis has analgesia, antiinflammatory, protective effect to peripheral nerve injury and cerebral tissue.
Ganoderma nature and flavor are sweet, flat; GUIXIN, lung, liver, kidney channel.Useful essence, the kidney invigorating, the effect of dispeling the wind, cure mainly asthenia, cough, asthma, insomnia, dyspepsia etc., also has hepatoprotective, improves immunologic function, antibacterially waits effect.The merit of the kidney invigorating of Millettia Speciosa, remove rheumatism arthralgia pain can not only be helped, raising immune function of human body can also be reached, strengthen effect of resistance of human body.
Herba Fici Simplicissimae nature and flavor are sweet, tepor.There is invigorating the spleen for eliminating dampness, promoting the circulation of QI and reducing phlegm, effect of relaxing muscles and tendons and activating QI and blood in the collateral.For pulmonary tuberculosis cough, chronic bronchitis, rheumatic arthritis, lumbago and skelalgia, insufficiency of the spleen edema, after being ill night sweat, leucorrhea.After its decoct of research discovery, ethanol extraction, alcohol reflux, the water extract of residue, all has obvious antitussive action to mouse gavaging to the cough that ammonia spraying causes respectively.Test tubes also has good bacteriostasis to staphylococcus aureus, alpha streptococcus.
The acid of Fructus Schisandrae Chinensis nature and flavor, temperature; Return lung, kidney channel.Astringe the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, effect of arresting seminal emission.Cure mainly the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Modern study shows, Fructus Schisandrae Chinensis contains abundant organic acid, vitamin, flavonoid, phytosterol and has the lignan of potent reactivation (such as schisandrin, schisandrin B or Fructus Schisandrae Chinensis fat element), the strong liver of energy QI invigorating, the efficiency of promoting cells exclude refuse, supply more oxygen, construction and utilization energy, raising memory and property endurance.
At present, although having with Millettia Speciosa is the report of other medical material of principal agent compatibility, there is not yet above-mentioned five kinds of Chinese medicine jointly for bone and muscle strengthening, relaxing muscles and tendons and activating QI and blood in the collateral, the relevant report improving the aspects such as rheumatic arthralgia, soreness of waist and knee joint, resisting fatigue and research.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition improving rheumatic arthralgia, resisting fatigue, may be used for bone and muscle strengthening, relaxing muscles and tendons and activating QI and blood in the collateral, improve rheumatic arthralgia, soreness of waist and knee joint, resisting fatigue etc.Another object of the present invention is to provide and adopts the ethanol extract of described Chinese medicine composition to be the Chinese medicine preparation of active substance.Another object of the present invention is to provide the preparation method of described Chinese medicine preparation.
First aspect of the present invention is to provide a kind of Chinese medicine composition improving rheumatic arthralgia, resisting fatigue, and according to weight parts, its composition comprises Millettia Speciosa 20 ~ 50 parts, Radix Flemingiae Philippinensis 0.5 ~ 5 part, Herba Fici Simplicissimae 0.5 ~ 5 part, Ganoderma 0.1 ~ 2 part and Fructus Schisandrae Chinensis 0.1 ~ 4 part.
Preferably, according to weight parts, the composition of described Chinese medicine composition comprises Millettia Speciosa 30 ~ 40 parts, Radix Flemingiae Philippinensis 1 ~ 4 part, Herba Fici Simplicissimae 1 ~ 4 part, Ganoderma 0.3 ~ 1 part and Fructus Schisandrae Chinensis 0.5 ~ 2 part.
Preferably, according to weight parts, the composition of described Chinese medicine composition comprises Millettia Speciosa 34.5 parts, Radix Flemingiae Philippinensis 2 parts, Herba Fici Simplicissimae 2 parts, Ganoderma 0.5 part and Fructus Schisandrae Chinensis 1 part.
Second aspect of the present invention is to provide a kind of Chinese medicine preparation improving rheumatic arthralgia, resisting fatigue, the ethanol extract that the active component of described Chinese medicine preparation is the Chinese medicine composition described in the present invention first aspect.
Described Chinese medicine preparation can be prepared into any oral drugs, such as powder, medicated wine, pill, tablet etc.
Should be understood that, described Chinese medicine preparation also comprises pharmaceutically acceptable adjuvant, such as correctives, antioxidant, filler, stabilizing agent etc.
3rd aspect of invention is to provide the preparation method of Chinese medicine preparation of improvement rheumatic arthralgia described in the present invention second aspect, resisting fatigue, carries out extraction obtain with wine according to cold-maceration, hot dipping, percolation or backflow hot dipping to the Chinese medicine composition described in the present invention first aspect.
Wherein, cold-maceration refers to and medical material and appropriate wine is placed in altogether in hermetic container, at room temperature floods, periodic agitation, general dipping more than 30 days.Get supernatant, squeezing medicinal residues, pressed liquor and supernatant merge, and stir, and leave standstill, and filter, get filtrate and get final product.
Wherein, hot dipping refers to and medical material and appropriate wine is placed in container with lid, and water-bath or be steam heated to stops heating after boiling immediately, then in another container with lid of impouring, airtight, at room temperature flood one to several months, periodic agitation, Aspirate supernatant again, squeezing medicinal residues, merge supernatant and pressed liquor, leave standstill, filter, get filtrate and get final product.
Wherein, percolation refers to the medical material got and suitably pulverize, and by percolation operation, collects percolate, leaves standstill, filter, to obtain final product.
Wherein, backflow hot dipping refers to and is immersed in wine by medical material, and after reflux, extracting liq, to obtain final product.
Wherein the processing time of cold-maceration, hot dipping, percolation or backflow hot dipping can carry out determining and adjusting according to actual needs.
Adopt said method to obtain product directly as medicated wine, can to add the correctives such as sugar or honey as required and carry out taste masking.As required said method can also be obtained product to concentrate, powder is made in drying, or pill, or film-making etc., make various oral formulations.
Wherein, described wine for any edible ethanol can be adopted, such as rice wine, yellow wine, Chinese liquor etc.
Preferably, in described wine, the content of ethanol is 15 ~ 70%(v/v).
In prescription, Millettia Speciosa is monarch drug, there is tonify deficiency lung moistening, cough-relieving, strong muscle is active, effect of enhancing immunity, Radix Flemingiae Philippinensis can promote effect of the relaxing muscles and tendons and activating QI and blood in the collateral treatment rheumatic arthralgia of Millettia Speciosa, Ganoderma not only helps the kidney invigorating of Millettia Speciosa, the merit of remove rheumatism arthralgia pain, raising immune function of human body can also be reached, strengthen effect of resistance of human body, compatibility has invigorating the spleen for eliminating dampness again, promoting the circulation of QI and reducing phlegm, effect Herba Fici Simplicissimae of relaxing muscles and tendons and activating QI and blood in the collateral, and there is nourishing kidney, the Fructus Schisandrae Chinensis of the effect such as to promote the production of body fluid, there is good bone and muscle strengthening, relaxing muscles and tendons and activating QI and blood in the collateral and antifatigue effect, to cough due to deficiency of the lung, suffer from a deficiency of the kidney, seminal emission, leucorrhea, rheumatic arthralgia, soreness of waist and knee joint, the diseases such as fatigue have good curative effect.Meanwhile, prescription Chinese crude drug of the present invention, by compatibility, can regulate inherent internal organs function, enhancing body body constitution, improves immunity of organisms, reaches the object for the treatment of both the principal and the secondary aspects of a disease at the same time.In addition, the medical material used in prescription of the present invention all derives from natural plants, and effect relaxes lasting, and toxic and side effects is little, use safety, and relapse rate is low.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further, to understand the present invention better.
In order to the property of medicine of more each embodiment better, each embodiment adopts identical preparation method cold-maceration, and preparation process condition is identical, should be understood that, those skilled in the art can carry out suitable adjustment to preparation process condition, or other preparation methoies can also be adopted, such as hot dipping, percolation or backflow hot dipping etc.
embodiment 1
By 34.5 grams of Millettia Speciosa, 2 grams of Radix Flemingiae Philippinensis, 2g Herba Fici Simplicissimae and 0.5g Ganoderma medical material sections, add 1g Fructus Schisandrae Chinensis, add yellow wine (purchased from Guyuelongshan Shaoxing Wine Co Ltd, Zhejiang) to 1L, sealing preservation 1 year.Then sterilizing, canned in 100 bottles for oral use, both.
embodiment 2
By 30 grams of Millettia Speciosa, 4 grams of Radix Flemingiae Philippinensis, 1g Herba Fici Simplicissimae and 0.3g Ganoderma medical material sections, add 2g Fructus Schisandrae Chinensis, add yellow wine to 1L, sealing preservation 1 year.The ratio adding 1 gram of Mel according to 20 grams of medicated wine adds Mel and carries out taste masking, then sterilizing, canned in 100 bottles for oral use, both.
embodiment 3
By 40 grams of Millettia Speciosa, 1 gram of Radix Flemingiae Philippinensis, 4g Herba Fici Simplicissimae and 1g Ganoderma medical material section, add 0.5g Fructus Schisandrae Chinensis, add yellow wine to 1L, sealing preservation 1 year.The ratio adding 1 gram of Mel according to 20 grams of medicated wine adds Mel and carries out taste masking, then sterilizing, canned in 100 bottles for oral use, both.
embodiment 4
By 20 grams of Millettia Speciosa, 5 grams of Radix Flemingiae Philippinensis, 5g Herba Fici Simplicissimae and 0.1g Ganoderma medical material sections, add 4g Fructus Schisandrae Chinensis, add yellow wine to 1L, sealing preservation 1 year.The ratio adding 1 gram of Mel according to 20 grams of medicated wine adds Mel and carries out taste masking, then sterilizing, canned in 100 bottles for oral use, both.
embodiment 5
By 50 grams of Millettia Speciosa, 0.5 gram of Radix Flemingiae Philippinensis, 0.5g Herba Fici Simplicissimae and 2g Ganoderma medical material section, add 0.1g Fructus Schisandrae Chinensis, add yellow wine to 1L, sealing preservation 1 year.The ratio adding 1 gram of Mel according to 20 grams of medicated wine adds Mel and carries out taste masking, then sterilizing, canned in 100 bottles for oral use, both.
comparative example 1
Prepare medicated wine according to the mode identical with embodiment 1, difference is not add the five fingers hair and Fructus Schisandrae Chinensis in medicated wine.
comparative example 2
Prepare medicated wine according to the mode identical with embodiment 1, difference is not add Radix Flemingiae Philippinensis in medicated wine.
comparative example 3
Prepare medicated wine according to the mode identical with embodiment 1, difference is not add Ganoderma in medicated wine.
improve rheumatic arthralgia test
The diagnostic criteria of rheumatic arthralgia judges according to the diagnosis basis of " Chinese medical disease diagnosis and treatment standard " rheumatism numbness: 1, walk to alter pain based on the large joint of extremity, and companion soreness of waist and knee joint, numbness, joint joint stuffiness, have the symptom such as aversion to cold, heating more; 2, there is pharyngalgia tonsillitis history before sick more, or paddle and drench with rain, occupy wetland history for a long time; 3, some patients can have low grade fever, extremity erythema iris, or erythema nodosum.Often can Cardiac Involvemant; 4, erythrocyte sedimentation rate speeds, and antistreptolysin " 0 " is greater than 500 units.
Case: choose patient 400 example meeting above-mentioned diagnostic criteria, the wherein each half of men and women, 40 years old mean age.Therapeutic Method: above-mentioned patient is divided into 8 groups, often organizes 50 routine patients, the situation no difference of science of statistics of the patient between each group.Use the medicated wine in embodiment 1 ~ 5 and comparative example 1 ~ 3 respectively, daily 3 times, each 30 grams.Continuous 6 weeks is a course for the treatment of.
Efficacy assessment standard, according to " guideline of clinical investigations for the treatment of by Chinese herbs arthromyodynia ", is drafted with reference to " arthromyodynia opinion is made a study of subjects ", " rheumatoid arthritis " related content, is divided into healing, improvement, does not heal.The situation of the traditional Chinese medical science being cured for medicated wine and take a turn for the better has the effect of " bone and muscle strengthening, relaxing muscles and tendons and activating QI and blood in the collateral " also referred to as medicated wine.
Cure: transference cure, joint motion is normal, and lab testing is normal;
Take a turn for the better: symptom is clearly better, and lab testing is improved;
Do not heal: symptom and lab testing are without progress.
Result of the test sees the following form 1.
Table 1
As shown in Table 1, the medicated wine of the present invention containing Millettia Speciosa, Radix Flemingiae Philippinensis, Herba Fici Simplicissimae, Ganoderma and Fructus Schisandrae Chinensis is all better than the effect of comparative example, and illustrate that medicated wine of the present invention is by compatibility, its successful improving rheumatic arthralgia is better than 3 comparative examples.In addition, regular return visit is carried out to the patient after treatment, in 1 year, has no recidivist.
anti-fatigue test
Experiment content: the raising of exercise tolerance is that anti-fatigue ability is strengthened the most directly showing, and the length of swimming time can reflect the degree of fatigue of animal movement.By mice heavy burden (sheet lead of body weight 5%) swimming, by contrasting with matched group swimming time, determine the resisting fatigue effect of medicine.
Experimental technique: select bull kunming mice, body weight 18-22g.If a blank group and several tested material group, according to the every kg body weight daily intaking amount of human body of recommending, being converted into the every consumption per day of mice is 0.2ml, directly carries out gavage.Because administration is drinks, experimentally need, after administration 30min, the sheet lead of Mus root of the tail portion load 5% body weight, mice is placed in swimming trunk went swimming.The depth of water is no less than 30cm, water temperature 25 ± 0.5 DEG C, and mice starts to swimming the death time from swimming record.Medicated wine in embodiment 1 ~ 5 and comparative example 1 ~ 3 is tested, obtains result as shown in table 2.
Table 2
As shown in Table 2, medicated wine of the present invention, by compatibility, have good resisting fatigue effect, and resisting fatigue successful is better than 3 comparative examples.
Be described in detail specific embodiments of the invention above, but it is just as example, the present invention is not restricted to specific embodiment described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and substituting also all among category of the present invention.Therefore, equalization conversion done without departing from the spirit and scope of the invention and amendment, all should contain within the scope of the invention.
Claims (7)
1. improve a Chinese medicine composition for rheumatic arthralgia, resisting fatigue, it is characterized in that, according to weight parts, its composition comprises Millettia Speciosa 20 ~ 50 parts, Radix Flemingiae Philippinensis 0.5 ~ 5 part, Herba Fici Simplicissimae 0.5 ~ 5 part, Ganoderma 0.1 ~ 2 part and Fructus Schisandrae Chinensis 0.1 ~ 4 part.
2. the Chinese medicine composition improving rheumatic arthralgia, resisting fatigue according to claim 1, is characterized in that, according to weight parts, its composition comprises Millettia Speciosa 30 ~ 40 parts, Radix Flemingiae Philippinensis 1 ~ 4 part, Herba Fici Simplicissimae 1 ~ 4 part, Ganoderma 0.3 ~ 1 part and Fructus Schisandrae Chinensis 0.5 ~ 2 part.
3. the Chinese medicine composition improving rheumatic arthralgia, resisting fatigue according to claim 1, is characterized in that, according to weight parts, its composition comprises Millettia Speciosa 34.5 parts, Radix Flemingiae Philippinensis 2 parts, Herba Fici Simplicissimae 2 parts, Ganoderma 0.5 part and Fructus Schisandrae Chinensis 1 part.
4. improve a Chinese medicine preparation for rheumatic arthralgia, resisting fatigue, it is characterized in that, the ethanol extract that the active component of described Chinese medicine preparation is the Chinese medicine composition in claim 1 ~ 3 described in any one.
5. the Chinese medicine preparation improving rheumatic arthralgia, resisting fatigue according to claim 4, is characterized in that, the dosage form of described Chinese medicine preparation is medicated wine, powder, pill or tablet.
6. one kind is improved the preparation method of Chinese medicine preparation of rheumatic arthralgia, resisting fatigue as claimed in claim 4, it is characterized in that, according to cold-maceration, hot dipping, percolation or backflow hot dipping, extraction is carried out to the Chinese medicine composition in claim 1 ~ 3 described in any one with wine and obtain.
7. preparation method according to claim 6, is characterized in that, obtains powder by extracting the product concentrate drying obtained, or pill, or tabletting.
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| CN108295160A (en) * | 2018-04-20 | 2018-07-20 | 陈婷 | A kind of Traditional Chinese medicine foot bath side and preparation method thereof for improving immunity |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107468969A (en) * | 2017-08-31 | 2017-12-15 | 广西那坡县翠株园林业科技有限公司 | A kind of beautiful millettia root wine for treating cough and preparation method thereof |
| CN108295160A (en) * | 2018-04-20 | 2018-07-20 | 陈婷 | A kind of Traditional Chinese medicine foot bath side and preparation method thereof for improving immunity |
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