CN104435100A - Anti-depression composition - Google Patents
Anti-depression composition Download PDFInfo
- Publication number
- CN104435100A CN104435100A CN201410835529.5A CN201410835529A CN104435100A CN 104435100 A CN104435100 A CN 104435100A CN 201410835529 A CN201410835529 A CN 201410835529A CN 104435100 A CN104435100 A CN 104435100A
- Authority
- CN
- China
- Prior art keywords
- juice
- folic acid
- composition
- depression
- abelmoschi manihot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Abstract
The invention belongs to the technical field of preparation of medicines, and relates to a composition with drug effect, which is an anti-depression composition and is prepared by adopting zinc, folic acid and probiotics as main materials, and natural components as auxiliaries; the anti-depression composition includes the materials of: zinc oxide, folic acid, probiotics, okra juice, perilla leaf juice and water caltrop starch; the materials are prepared into oral liquid by common processing technologies or made into powder capsule by a spray drying method; unusual conditions of depressive patients can be improved by taking the composition for a long time; the composition is mature in preparation technology, easy to control preparation method, significant in curative effect, free from side effect, safe and reliable, low in processing cost and environmental friendly during eating.
Description
Technical field:
The invention belongs to pharmaceutical compounding techniques field, relating to one with zinc, folic acid and probiotic bacteria for main material preparation has pharmaceutically-active compositions, particularly a kind of antidepressant composition, for improving the depressive symptom of depressed crowd.
Background technology:
Depression is caused by multiple uncertain reason, with the low one group of mood disorders for principal character of mood or affective disorder syndrome, be one of affective disorder mental sickness of the most easily disabling in the world, have investigation display, the suicide of 50-70% is relevant to depression.The related statistical display of Chinese Association for Mental Hygiene: China at present existing 2,600 ten thousand people suffers from depression, and the financial burden brought to China every year reaches 621.91 hundred million yuan.In the middle of the crowd of more than 15 years old, Beijing community, depression lifetime prevalence is 6.87%, and investigation point prevalence 3.31%, in prediction on such basis, the number that depression is being suffered from Beijing area may reach 300,000.In addition, Beijing area general hospital depressive disorder epidemiology survey result shows, and general hospital depressive disorder prevalence is 5.2%.Suicide is died from the whole nation every year nearly 250,000 people, and would-be suicide has 200 ten thousand to 250 ten thousand people, in suicide crowd because depression do not obtain in time, systematic treating finally cause death account for 40%.Along with the development of society, the increase of social pressure, the sickness rate of depression is in ascendant trend year by year.The change of the aspects such as social environment, economy, education, personal character and life style all can inspire depression, some serious physical diseases, as apoplexy, heart disease etc. also can cause depression.According to World Health Organization's statistics, the sickness rate of global depression is about 11%.Depression has become the fourth-largest disease in the world at present, will become the primary factor disabled except cardiovascular disease to the year two thousand twenty depression.
Zinc is the necessary trace element of human body, and play a significant role in the stability process maintaining cell membrane, and participate in more than 300 kind of enzymes metabolism, the zinc in human body is mainly present in brain, especially Hippocampus and cerebral cortex.When in human body during zinc deficiency, various harmful effect may be caused, as emotional lability, suspicious, depressed, emotional stability decline and cognitive impairment etc.Domestic and international many research shows, patients with depression exists obvious zinc deficiency phenomenon, and in body, zinc level height is closely related with depression, dietary int ake zinc number develop with the generation of depressive syndrome be negative correlation, supplementary zinc can effective alleviate depression symptom.In addition, take in the observation of curative effect of antidepressants imipramine and escitalopram giving the depression rat of zinc deficiency forage feed, under zinc deficiency state, two kinds of antidepressant effects of medicine obviously reduce, illustrate that zinc not only can alleviate depression symptom, when zinc deficiency, the curative effect of antidepressants can also be reduced.
Folic acid is a kind of water solublity B bunch vitamin, there are six kinds of forms: folate, folinic acid, formyl tetrahydrofolic acid, tetrahydrofolate, methene tetrahydrofolic acid and methyl tetrahydrofolate salt, the latter, also known as methopterin salt, is a kind of available folic acid form, can passes through blood brain barrier and enter cerebrospinal fluid.Methylenetetrahydrofolate reductase makes folic acid be converted into methyl tetrahydrofolate salt, the latter combines homocysteine, be converted into methionine, final synthesis S--adenosine-L--methionine, work as methyl donor, participate in brain dopamine (DA), 5-HT and NE synthesis, methyl tetrahydrofolate salt also promotes that tetrahydrobiopterin synthesizes, and participates in DA, 5-HT and NE synthesis.During folic acid deficiency, cause methyl tetrahydrofolate to decline, homocysteine is not because being put aside too much by using, SAM synthesis declines, and causes 5-HT, DA and NE to synthesize not enough, thus causes depression.Research finds, the oral fluoxetine of 189 routine depressive patients 8 weeks, and the probability that folic acid deficiency person antidepressant is invalid is the normal person of folic acid 2.2 times; Folic acid deficiency can also reduce the effective percentage of antidepressants intensive treatment, and postpones antidepressants onset.The behavior depression change that folic acid deficiency causes reduces relevant with the expression of hippocampus BDNF.
Intestinal is closely related as " the second brain " and the depression of the mankind, wherein, 1000 various bacteria in intestinal especially with the relation having countless ties of depression, enteric microorganism plays the effect that can not be ignored in various mental illness; Enteric microorganism affects the brain behavior and mentality state of host by intestinal-brain axle, is exchanged by nerve pathway, endosecretory pathway by means of neurotransmitter, metabolite, immune signal, even gene expression etc. with immunization route etc. with the central nervous system of host.At present, although the probiotic bacteria of regulating intestinal canal flora is mainly used to treatment and the health diet of various digestive tract disease in the world, the improvement of beneficial microbe to depressive emotion comes into one's own just day by day.The existing compositions improving depressive symptom mostly is Chinese medicine formula or nutritious food formula, because its prescription eats, there is numerous and diverse collocation, so unsatisfactory to the improvement effect of depression, therefore, a kind of edible simple, that curative effect is quick, drug effect is clear and definite, safety is high combined type composition of medicine of design preparation is used for the treatment of depression and the auxiliary treatment as antidepressant drug, has very important economic worth and social value to the generation and development controlling depression.
Summary of the invention:
The object of the invention is to the shortcoming overcoming prior art existence, seek to design provide a kind of have improve depressive symptom effect containing the antidepressant composition of zinc, folic acid and probiotic bacteria, the compositions adopting natural component adjuvant to make has the effect significantly reducing depressive symptom, and long-term taking can improve the unusual condition of depression crowd.
To achieve these goals, the components in weight percent of each raw material of the antidepressant composition containing zinc, folic acid and probiotic bacteria that the present invention relates to is zinc oxide 10-60%, folic acid 10-60%, probiotic bacteria 5-65%, Flos abelmoschi manihot juice 10-20%, Folium Perillae juice 2-5% and Pedicellus et Pericarpium Trapae hay powder 5-10%, the total amount of each material composition is 100%; Adopt traditional machining processes to be mixed with oral liquid or adopt spray drying method to make Powdered capsulation; Be no less than 20mg and folic acid is no less than 0.2mg containing zinc in its every gram antidepressant composition, total probiotic bacteria is no less than 1 × 10
10cfu.
Probiotic bacteria involved in the present invention comprises bifidus bacillus, lactobacillus, Streptococcus lactis (Lister) Lohnis 1909.554., streptococcus thermophilus, acetolactate diplostreptococcus and yeast, adopts commercially available prod; It is that 80-100 DEG C of hot water digestion is pulled out after 10-30 minute and drained that Pedicellus et Pericarpium Trapae hay powder used puts into temperature by the fresh Pedicellus et Pericarpium Trapae hay of maturation, and kernel is placed on after drying in the isoperibol of 40-60 DEG C and clays into power by peeling shell.
Flos abelmoschi manihot juice preparation technology of the present invention is: pluck fresh Flos abelmoschi manihot and clean up, put into 80-100 DEG C of boiled water digestion 5-10 minute, put into 5-15 DEG C of cold water after pulling out immediately to soak and within 1-3 minute, pull to obtain ripe Flos abelmoschi manihot again out, then undertaken squeezing rear filtering solids by the weight ratio of ripe Flos abelmoschi manihot and pure water 1:1 and obtain Flos abelmoschi manihot juice.
Folium Perillae juice preparation technology of the present invention is: win fresh Folium Perillae, putting into weight percent concentration is that the common salt aqueous solution of 5-10% soaks to pull out for 5-10 minute and drains surface moisture, then by the weight ratio that Folium Perillae and aqueous sucrose solution are 1:2 mix squeeze after filtering solids obtain Folium Perillae juice; Wherein in aqueous sucrose solution, sucrose weight percent concentration is 15-20%.
Compared with prior art, the raw materials such as zinc, folic acid and probiotic bacteria are easy to get, mature preparation process, and preparation method is easily controlled in the present invention, and curative effect is obvious, and have no side effect, safe and reliable, processing cost is low, edible environmental friendliness.
Detailed description of the invention:
Below by embodiment, the present invention is described further:
Embodiment 1:
The components in weight percent of each raw material of the antidepressant composition containing zinc, folic acid and probiotic bacteria prepared by the present embodiment is zinc oxide 10%, folic acid 10%, probiotic bacteria 63%, Flos abelmoschi manihot juice 10%, Folium Perillae juice 2% and Pedicellus et Pericarpium Trapae hay powder 5%, adopt traditional machining processes to be mixed with oral liquid; Containing zinc 20mg and folic acid 0.2mg in its every gram antidepressant composition, total probiotic bacteria is no less than 1 × 10
10cfu.
Embodiment 2:
The components in weight percent of each raw material of the antidepressant composition containing zinc, folic acid and probiotic bacteria that the present embodiment relates to is zinc oxide 30%, folic acid 18%, probiotic bacteria 35%, Flos abelmoschi manihot juice 10%, Folium Perillae juice 2% and Pedicellus et Pericarpium Trapae hay powder 5%, adopt conventional spray drying methods to make powder and shape capsulation; Be greater than 20mg and folic acid is greater than 0.2mg containing zinc in its every gram antidepressant composition, total probiotic bacteria is no less than 1 × 10
10cfu.
Embodiment 3:
The components in weight percent of each raw material of the antidepressant composition containing zinc, folic acid and probiotic bacteria that the present embodiment relates to is zinc oxide 30%, folic acid 20%, probiotic bacteria 31%, Flos abelmoschi manihot juice 10%, Folium Perillae juice 3% and Pedicellus et Pericarpium Trapae hay powder 6%, adopt traditional machining processes to be mixed with oral liquid, containing zinc 20mg and folic acid 0.2mg in its every gram antidepressant composition, total probiotic bacteria is no less than 1 × 10
10cfu.
Embodiment 4:
The crowd of depression in various degree that the present embodiment is amounting to 120 people to three groups carries out within 3 months, intervening rear discovery, and compared with before intervention, crowd's depressive symptom of 87% has clear improvement or alleviates, particularly evident to the effect of mild depression.
Claims (4)
1. an antidepressant composition, is characterized in that the components in weight percent of each raw material is zinc oxide 10-60%, folic acid 10-60%, probiotic bacteria 5-65%, Flos abelmoschi manihot juice 10-20%, Folium Perillae juice 2-5% and Pedicellus et Pericarpium Trapae hay powder 5-10%, and the total amount of each material composition is 100%; Adopt traditional machining processes to be mixed with oral liquid or adopt spray drying method to make Powdered capsulation; Be no less than 20mg and folic acid is no less than 0.2mg containing zinc in its every gram antidepressant composition, total probiotic bacteria is no less than 1 × 10
10cfu.
2. antidepressant composition according to claim 1, is characterized in that the probiotic bacteria related to comprises bifidus bacillus, lactobacillus, Streptococcus lactis (Lister) Lohnis 1909.554., streptococcus thermophilus, acetolactate diplostreptococcus and yeast; It is that 80-100 DEG C of hot water digestion is pulled out after 10-30 minute and drained that Pedicellus et Pericarpium Trapae hay powder used puts into temperature by the fresh Pedicellus et Pericarpium Trapae hay of maturation, and kernel is placed on after drying in the isoperibol of 40-60 DEG C and clays into power by peeling shell.
3. antidepressant composition according to claim 1, it is characterized in that the preparation technology of described Flos abelmoschi manihot juice is: pluck fresh Flos abelmoschi manihot and clean up, put into 80-100 DEG C of boiled water digestion 5-10 minute, put into 5-15 DEG C of cold water after pulling out immediately to soak and within 1-3 minute, pull to obtain ripe Flos abelmoschi manihot again out, then undertaken squeezing rear filtering solids by the weight ratio of ripe Flos abelmoschi manihot and pure water 1:1 and obtain Flos abelmoschi manihot juice.
4. antidepressant composition according to claim 1, it is characterized in that the preparation technology of described Folium Perillae juice is: win fresh Folium Perillae, putting into weight percent concentration is that the common salt aqueous solution of 5-10% soaks to pull out for 5-10 minute and drains surface moisture, then by the weight ratio that Folium Perillae and aqueous sucrose solution are 1:2 mix squeeze after filtering solids obtain Folium Perillae juice; Wherein in aqueous sucrose solution, sucrose weight percent concentration is 15-20%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410835529.5A CN104435100B (en) | 2014-12-29 | 2014-12-29 | A kind of antidepressant composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410835529.5A CN104435100B (en) | 2014-12-29 | 2014-12-29 | A kind of antidepressant composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104435100A true CN104435100A (en) | 2015-03-25 |
| CN104435100B CN104435100B (en) | 2016-01-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410835529.5A Expired - Fee Related CN104435100B (en) | 2014-12-29 | 2014-12-29 | A kind of antidepressant composition |
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| Country | Link |
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| CN (1) | CN104435100B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106806384A (en) * | 2017-01-10 | 2017-06-09 | 青岛大学 | A kind of Synergistic treats the composition of depression |
| CN109789171A (en) * | 2016-08-10 | 2019-05-21 | 波比奥泰克股份公司 | For treating the composition of major depressive disorder |
| CN111685328A (en) * | 2019-07-23 | 2020-09-22 | 河北一然生物科技有限公司 | Naqu 4580 probiotics and application of preparation thereof in food for regulating emotion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307889A (en) * | 2000-12-29 | 2001-08-15 | 南京大学 | Depression treating medicine and its preparation |
| CN103200830A (en) * | 2010-09-03 | 2013-07-10 | N·V·努特里奇亚 | Method and preparation for the treatment or prevention of anxiety or neurogenesis |
-
2014
- 2014-12-29 CN CN201410835529.5A patent/CN104435100B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307889A (en) * | 2000-12-29 | 2001-08-15 | 南京大学 | Depression treating medicine and its preparation |
| CN103200830A (en) * | 2010-09-03 | 2013-07-10 | N·V·努特里奇亚 | Method and preparation for the treatment or prevention of anxiety or neurogenesis |
Non-Patent Citations (3)
| Title |
|---|
| 刘朝军，等: "叶酸对抑郁症的辅助治疗", 《中国行为学医学科学》, vol. 13, no. 02, 31 December 2004 (2004-12-31), pages 169 - 170 * |
| 摘自食品伙伴网: "台湾研究称乳酸菌有助于改善抑郁情绪", 《饮料工业》, vol. 17, no. 4, 30 April 2014 (2014-04-30), pages 25 * |
| 白琳，等: "锌与抑郁症研究进展", 《安徽医学》, vol. 33, no. 08, 31 August 2012 (2012-08-31), pages 1095 - 1096 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109789171A (en) * | 2016-08-10 | 2019-05-21 | 波比奥泰克股份公司 | For treating the composition of major depressive disorder |
| US11298384B2 (en) | 2016-08-10 | 2022-04-12 | Probiotical S.P.A. | Composition for use in the treatment of major depressive disorder |
| US11969449B2 (en) | 2016-08-10 | 2024-04-30 | Probiotical S.P.A. | Composition for use in the treatment of major depressive disorder |
| CN106806384A (en) * | 2017-01-10 | 2017-06-09 | 青岛大学 | A kind of Synergistic treats the composition of depression |
| CN111685328A (en) * | 2019-07-23 | 2020-09-22 | 河北一然生物科技有限公司 | Naqu 4580 probiotics and application of preparation thereof in food for regulating emotion |
| CN111685328B (en) * | 2019-07-23 | 2022-10-21 | 河北一然生物科技股份有限公司 | Naqu 4580 and application of Naqu 4580 preparation in food for regulating emotion |
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| Publication number | Publication date |
|---|---|
| CN104435100B (en) | 2016-01-06 |
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