CN104435053A - Composition with effect of preventing multiple infections and preparation method of composition - Google Patents
Composition with effect of preventing multiple infections and preparation method of composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention relates to a composition with an effect of preventing multiple infections. The composition comprises the active ingredients of indigowoad root, dandelion, honeysuckle flower and sweet tea in the weight ratio of (5-20):(2-10):(1-5):(1-2). The composition provided by the invention combines indigowoad root, dandelion, honeysuckle flower and sweet tea for using together. On the one aspect, through the effects of clearing away heat and toxic materials, relieving pain, relieving fever, resisting inflammation, calming mind, promoting blood circulation, removing blood stasis, inducing diuresis, eliminating swelling and the like, the immune function of a human body is regulated, the anti-infection ability of the human body is strengthened and the inflammation is eliminated. On the other aspect, the anti-infection effect is realized by direct sterilization, bacteriostasis and anti-viral action, so that the composition is effective for viral influenza, measles, mumps, cold and influenza and can also be used for treating the inflammation caused by bacteria and part of other microbial infections. The composition can treat both manifestation and root cause and has obvious effects on inhibiting and killing a variety of viruses and pathogenic bacteria. The invention further provides a method for preparing the composition with the effect of preventing multiple infections.
Description
Technical field
The present invention relates to viral infection and bacteriological infection, be specifically related to the composition and method of making the same with anti-multi-infection effect.
Background technology
Infection causes inflammation, thus makes the biological tissue with vascular system to damage factor generation defense reaction.
Infection has viral infection and bacteriological infection.Antimicrobial drug has suppression or killing action to antibacterial, and it comprises the antibacterials of antibiotic and synthetic.Antimicrobial drug is only applicable to the inflammation caused by antibacterial and other microorganisms of part, gives antimicrobial drug treatment do harm rather than good patients such as viral influenza, measles, parotitis, cold, influenzas.Antimicrobial drug is the microorganism for causing inflammation, and is killing microorganisms.Do not have the effect of prevention infection, on the contrary, life-time service antimicrobial drug can cause bacterial resistance.The abuse of antimicrobial drug can impel generation fastbacteria on the one hand, and these medicines enter after in human body and will constrain and kill flora useful in human body on the other hand, cause dysbacteriosis, cause resistance to decline.In addition the system of defense of human body can be made to can not get taking exercise, and defense response weakens, and defense reaction (namely produce inflammation, cry inflammation again) is slight, once the factor that sustains damage is attacked, health will collapse very soon.
Utilize Chinese medicine or meet Chinese traditional medicine principle food reply infect (comprising viral infection and bacteriological infection), a kind of good method of promoting what is beneficial and abolish what is harmful of can yet be regarded as.Traditional Chinese Medicine experts analysis is pointed out, Chinese medicine all has good therapeutical effect to multi-infection disease, its cure mechanism, have plenty of by directly sterilizing, antibacterial, antiviral and play anti-infectious function, more then be regulate human immunologic function by the effect such as clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling, strengthen the anti-infection ability of human body.
Summary of the invention
In order to solve the problem of antimicrobial drug abuse, giving full play to Chinese medicine and meeting the effect of food in resistance infection of Chinese traditional medicine principle, the invention provides a kind of compositions with anti-multi-infection effect.
The compositions with anti-multi-infection effect of the present invention, its active component comprises Radix Isatidis, Herba Taraxaci, Flos Lonicerae and Folium hydrangeae strigosae, and the weight ratio of Radix Isatidis/Herba Taraxaci/Flos Lonicerae/Folium hydrangeae strigosae is 5 ~ 20/2 ~ 10/1 ~ 5/1 ~ 2.
Further, the gross weight of active component accounts for more than 10% of whole composition.
Further, the gross weight of active component accounts for more than 30% of whole composition.
Implement as one, also comprise appropriate adjuvant, but do not comprise monosaccharide, disaccharide.
The form of compositions of the present invention comprises: active component mixture of raw materials, and granule, liquid, capsule, sheet or ball that active component extract is made.
In the present invention, active component refers to the plant playing anti-multi-infection effect containing effective ingredient, comprises the root of plant, stem, Ye Heguo.
Adjuvant refers to the adjuvant entered in product.As be conducive to the water etc. in the dextrin of solid product molding, fluid product.
Refer in right amount and meet product specification and the amount of adding.As being deployed into the water yield required for certain concentration, or be convenient to requirement making product pelletize etc.
The form of compositions refers to the form of product, and such as raw material fragmentation mixes pack afterwards and becomes the product form that teabag is exactly a kind of mixture of raw materials.
The form of compositions of the present invention is from product form.As from commodity classification, compositions of the present invention can be food, beverage, health product, also can be medicine.
Radix Isatidis (conventional another name: indigo-blue, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) root, Radix Clerodenri Cyrtophylli) Isatis indigotica Fort. that has another name called, mountain indigo plant, great Lan root, rhizoma et radix baphicacanthis, Lan Longgen, Lumbricus root, greatly indigo etc., be a kind of Chinese crude drug.All produce all over China.Radix Isatidis is divided into northern Radix Isatidis and Rhizoma Et Radix Baphicacanthis Cusiae, and northern Radix Isatidis source is the root of cruciferae isatis (Isatis tinctoria L.); Rhizoma Et Radix Baphicacanthis Cusiae is rhizome and the root of acanthaceous vegetable acanthaceous indigo (Baphicacanthus cusia (Nees) Brem.).
In efficacy effect, Radix Isatidis bitter in the mouth, cold in nature, there is the effects such as heat-clearing and toxic substances removing, removing heat from blood, speckle removing, sore-throat relieving, be mainly used in the treatment of the disease such as epidemic febrile disease heating, headache, laryngalgia, macule, mumps, carbuncle sore tumefacting virus, cure mainly pharyngolaryngitis, acute tonsillitis, influenza, mumps, acute infectious hepatitis etc.It has inhibitory action to cold virus.Radix Isatidis has external broad-spectrum antibacterial action (comprising dysentery antibacterial, salmonella bacteria, hemolytic rope-forming bacteria), be anti-inflammation, pain relieving, the Chinese traditional herbs of bringing down a fever.
Containing multiple antiviral substance in Radix Isatidis, there are stronger suppression and killing action to cold virus, mumps virus, hepatitis virus and epidemic encephalitis virus etc.Radix Isatidis and Rhizoma Osmundae, Flos Lonicerae, Flos Chrysanthemi Indici etc. share, and are used for the treatment of some infectious disease and febrile disease.
Radix Isatidis clinically clearing away heat and cooling blood, antiviral antibacterial action is obvious, and consumption is large, can be rated as Chinese patent medicine.Result of study shows, Radix Isatidis has in significant purged body the pyrogen effect that body temperature can be caused to raise, and has been separated and obtains this active substance.The effect of bringing down a fever of Radix Isatidis namely by killing the pathogen such as virus and bacteria in body, remove and cause the factors such as the peroxy radical of fever and pyrogen to realize.When low grade fever, take the Chinese patent medicines such as Radix Isatidis, not only can effectively bring down a fever, meanwhile, the rehabilitation of health and the enhancing of immunity resistance can also be promoted.Early stage application, coordinates anti symptom treatment simultaneously, greatly can improve therapeutic effect.
Although Radix Isatidis has above-mentioned many good effects, if the time also had has been grown, the quantity of eating is many, will amass " medicine " and become disease, lead to future trouble.The case causing children's's anaphylaxis, digestive system and hemopoietic system to damage in clinical middle use Radix Isatidis granules is of common occurrence.
Folium hydrangeae strigosae (formal name used at school: Rubus Suatrssimus S.Lee, English name Sweet tea) is Rosaceae rubus, and having another name called sweet leaf Fructus Rubi corchorifolii Immaturus, is perennial wait-a-bit, and Guangxi is among the people is often used as tea-drinking, and leaf taste is sweet, therefore named Folium hydrangeae strigosae.Main product in Guilin, Liuzhou, the area such as Wuzhou, be Endemic Plants From Guangxi.Folium hydrangeae strigosae is cool in nature, sweet in the mouth is flat, has the effects such as heat clearing away, moistening lung and nourishing throat, expelling phlegm for arresting cough.Folium hydrangeae strigosae have blood pressure lowering, blood sugar lowering, enhances metabolism, treats the effects such as hyperchlorhydria.Folium hydrangeae strigosae element or the low-calorie non-sugar sweetener of a kind of high sugariness, sugariness is 300 times of sucrose, and calorific value is only 1% of sucrose, can be used as the succedaneum of glucide and sucrose, for the industry such as food, medicine.The patients such as cardiovascular, obesity, diabetes are all drinkable.Effect that Folium hydrangeae strigosae possesses common green tea also has the drug effects such as prevention and cure of cardiovascular disease, prevention of stroke, protective effect on cancer risk, prophylaxis of teeth disease outward simultaneously, there is heat-clearing and toxic substances removing, moistening the lung and resolving phlegm cough-relieving, cancer-resisting, antiallergic, anti-fat lipid-lowering and blood-pressure-lowing, reduction cholesterolemia, suppress and delay sclerosis of blood vessels, prevent and treat numerous health care such as coronary heart disease and diabetes, can melanin be decomposed, suppress the formation of black speck and chloasma.Folium hydrangeae strigosae also has good analgesia, antiinflammatory, sedation.
In Folium hydrangeae strigosae except the effective ingredient such as the antioxidative tea polyphenols containing common green tea, also be rich in 18 seed amino acids, every 100 grams of dry products containing total amino acid content 331.54 milligrams, be particularly rich in Folium hydrangeae strigosae human body necessary, human body can not generate, 8 seed amino acids that can only absorb from food.Folium hydrangeae strigosae is containing abundant nutrient substance and the necessary trace element of human body, mainly contain calcium 0.84%, zinc 105.5mg/kg, germanium 5.5 μ g/kg, selenium 17.94 μ g/kg, and the multiple element such as potassium, magnesium, phosphorus, ferrum, sodium, copper, chromium, strontium, lithium, not containing noxious substances such as arsenic aluminum, except above-mentioned contained trace element, be also rich in vitamin C, B
1, B
2, B
3, superoxide dismutase, in fresh and sweet tea, ascorbic content is up to 115mg/100g.Selenium can eliminate harmful free radical, changes the metabolism direction of carcinogen, reduces the oxidative damage of human body cell and cell membrane component, improves body resistivity.Germanium can strengthen erythrocytic band oxygen ability, thus ensures the oxygen-supplying amount of body, is conducive to metabolic carrying out.Bioflavonoids can strengthen blood capillary, antioxidation, blood pressure lowering.
Folium hydrangeae strigosae plays the effect improving immunity of organisms (resistivity) from the following aspects:
(1) selenium in Folium hydrangeae strigosae can eliminate harmful free radical, changes the metabolism direction of carcinogen, reduces the oxidative damage of human body cell and cell membrane component, improves body resistivity, thus can delay the life-span of people;
(2) germanium in Folium hydrangeae strigosae can strengthen erythrocytic band oxygen ability, thus ensures the oxygen-supplying amount of body, is conducive to metabolic carrying out.
(3) Folium hydrangeae strigosae is containing zinc.Zinc is the indispensable trace element of human body, and in human body, many kinds of enzymes must have zinc to participate in competence exertion effect, and zinc is very important to adjustment immunologic function.In addition, zinc can also infection.Take in the zinc of 50 ~ 100 milligrams every day, just can flu-prevention.Zinc is the constituent of a lot of important enzyme in human body, has catalytic action to vital movement, improves autoimmunity, and participates in the metabolism of vitamin A.
(4) Folium hydrangeae strigosae is containing vitamin C.Vitamin can strengthen body immunity, and vitamin C is that human body is indispensable, and it can reduce capillary permeability, makes it to become a barrier, stops cell entry tissue, protection biological organs.Collagen protein is a kind of extracellular protein, and it twists into spiral fibrous proteins by 3 peptide chains, and collagen protein is the most rich in protein of people's in-vivo content, accounts for more than 30% of whole body gross protein.Be rich in the aminoacid such as glycine, proline, hydroxyproline that human body needs.Collagen protein is most important ingredient in extracellular matrix.The synthesis of collagen protein needs vitamin C to participate in, so VC lacks, collagen protein just can not normally synthesize.VC can promote the synthesis of human collagen albumen, and has stronger reproducibility.The generation of energy check melanin.Meanwhile, all right vat black pigment, makes it desalinate.Skin and muscles are fair in order.Anti-aging effects is remarkable.
(5) Folium hydrangeae strigosae is containing flavone and superoxide dismutase.They all have Scavenging ability.Free radical is called as the source of ten thousand diseases, is chemically called " free radical ", is the atomic group containing a unpaired electron.Owing to lacking electronics, therefore free radical just captures an electronics of other materials everywhere, makes oneself to form stable material.In chemistry, this phenomenon is called " oxidation ".Reactive oxygen free radical is by activation c-Jun kinases, and NF-kappaB etc., make insulin receptor substrate (IRS) protein phosphorylation, accelerate the degraded of IRS-1, cause insulin resistant.The hyperfunction PKC that causes of polyhydric alcohol metabolism activates in addition, and Advanced glycation end products increases, and protein function changes, and intracellular transport obstacle, trigger cell apoptosis etc., cause diabetes nerve dysfunction.Remove unnecessary free radical, reduce oxidized cell, recover normal cell function, fall three fat, blood sugar lowering, resisting fatigue, thus can immunity of organisms be improved.
(6) Folium hydrangeae strigosae is containing aminoacid.Particularly 8 kinds of essential amino acids.
(7) tea polyphenols that Folium hydrangeae strigosae contains has obvious antioxidation.
Herba Taraxaci is the whole herb with root of feverfew Herba Taraxaci, containing taraxasterol, choline, inulin and fruit acid etc.; Its decoct has resisting pathogenic microbes effect; Have again protect the liver, the effect of function of gallbladder promoting and raising immune function of human body.The traditional Chinese medical science is thought, it is cold in nature, sweet in the mouth, hardship, function heat-clearing and toxic substances removing, and dispersing swelling and dissipating binds, is applicable to acute mastitis, and lymphadenitis carries adenitis on the shoulder, gastritis, hepatitis, cholecystitis, urinary tract infection etc.Experiment proves that Herba Taraxaci decocting liquid has broad-spectrum antiseptic and obvious biocidal efficacies.It all has significant curative effect to acute tonsillitis, conjunctivitis, urinary tract infection, mastitis, tracheitis, gastritis etc.
Flos Lonicerae is the alabastrum of caprifoliaceae plant Radix Ophiopogonis, containing chlorogenic acid, and inositol, flavones ingredient etc.; Pharmacological testing proves: Flos Lonicerae has antiinflammatory and refrigeration function, and infected by influenza and various pathogens, skin pathomycete have inhibitory action, reflect the heat-clearing toxin-expelling functions of Flos Lonicerae.The traditional Chinese medical science is thought, it is cold in nature, sweet in the mouth, function heat clearing away, removing toxic substances, is applicable to epidemic febrile disease heating, toxic-heat and blood stasis, the disease of the hyperactivity of toxic heat such as skin ulcer, carbuncle, furuncle and phyma.Flos Lonicerae cures mainly upper respiratory tract infection, pneumonia, pulmonary abscess, acute appendicitis, leptospirosis, bacillary dysentery, furuncle, carbuncle, erysipelas, uterine erosion etc.
Radix Isatidis, Herba Taraxaci, Flos Lonicerae and Folium hydrangeae strigosae are used in combination by the present invention, on the one hand by heat-clearing and toxic substances removing, pain relieving, bring down a fever, antiinflammatory, calmness, blood circulation promoting and blood stasis dispelling, dampness removing, the effect such as detumescence regulate human immunologic function, strengthen the anti-infection ability of human body, diminish inflammation.On the other hand by directly sterilization, antibacterial, antiviral and play anti-infectious function, effective to viral influenza, measles, parotitis, cold, influenza, also can treat the inflammation that antibacterial and other infected by microbes of part cause.Not only take stopgap measures but also effect a permanent cure, and have obvious inhibitory or killing effect to multiple virus and pathogenic bacteria.
And the present invention utilizes the sweet taste of Folium hydrangeae strigosae to cover the bitterness of Radix Isatidis, does not use monosaccharide and disaccharidase, compositions of the present invention is made also to be suitable for diabetics.The antiallergic of Folium hydrangeae strigosae is utilized to cause anaphylaxis to what resist Radix Isatidis.Utilize Folium hydrangeae strigosae can improve the function of human body resistivity to make up the defect that Radix Isatidis may cause the decline of immune function of human body.Folium hydrangeae strigosae is utilized to treat the function of hyperchlorhydria to prevent and treat Radix Isatidis damage digestive tract.Utilize the selenium in Folium hydrangeae strigosae to eliminate harmful free radical, reduce the oxidative damage of human body cell and cell membrane component, and germanium can strengthen erythrocytic band oxygen ability, ensure the oxygen-supplying amount of body, be conducive to metabolic carrying out, can the effects such as blood capillary be strengthened with bioflavonoids, prevent Radix Isatidis to the infringement of hemopoietic system.
The present invention also provides a kind of method preparing the compositions with anti-multi-infection effect.
The described preparation method with the compositions of anti-multi-infection effect, comprises following step:
(1) airtight extraction pot is put into together by after active component fragmentation;
(2) hot water extraction;
(3) extracting solution is condensed into extractum;
(4) (3) gained is mixed with adjuvant, granulates;
(5) dry;
(6) interior subpackage and outer package.
In step (2), hot water temperature is 50 ~ 90 degree; Extract 3 ~ 5 times, be 3 ~ 10 times of L/kg of extract weight with hot water amount, each time is 1 ~ 3 hour at every turn; Hot water comprises the hot water that adds or is heated at extraction pot by cold water and obtain.
Step (2) described hot water temperature is 50 ~ 60 degree.
In step (3), temperature is no more than 60 degree, vacuum concentration; In step (4), granulation particle diameter be 0.1 ~ 2mm in step (5), vacuum drying is to product moisture 0.1 ~ 5%.
Said method is the method that preparation has the compositions extract particles of anti-multi-infection effect.The preparation method of a kind of form of the compositions that just the present invention relates to.
In production method, meet light, heat and oxygen because of various effective ingredient and easily decompose, lose effect and effect.And sweet tea polyphenols has obvious antioxidant effect, be with by various material together hot water extraction, can loss of effective components be reduced.The present invention uses airtight extraction equipment, can effectively prevent vitamin C thermo-labile and evaporate, the vitamin C with thermal evaporation can be flowed back to water droplet.
Sweet tea polyphenols yet stores product and plays the rotten effect of antioxidation in addition.Thus do not need in product of the present invention to add any antiseptic.
In fact, the compositions with anti-multi-infection effect of the present invention, by the technical scheme of existing various maturations, can be prepared into various forms.
Detailed description of the invention
Embodiment 1
Be 20/10/5/1 batching by the weight ratio of Radix Isatidis/Herba Taraxaci/Flos Lonicerae/Folium hydrangeae strigosae.
(1) Radix Isatidis, Herba Taraxaci, Flos Lonicerae are put into airtight extraction pot together with after Folium hydrangeae strigosae fragmentation;
(2) hot water extraction; Hot water temperature is 60 degree; Extract 3 times, be 10 times of L/kg of extract weight with hot water amount, each time is 2 hours at every turn.
(3) extracting solution is condensed into extractum; Temperature 60 degree, vacuum concentration.
(4) (3) gained is mixed with dextrin, granulates; Granulation particle diameter is 1mm.
(5) dry; Vacuum drying is to product moisture 5%.
(6) interior subpackage and outer package.
Embodiment 2
Be 10/10/5/1 batching by the weight ratio of Radix Isatidis/Herba Taraxaci/Flos Lonicerae/Folium hydrangeae strigosae.
All the other are identical with embodiment 1.
Embodiment 3
Be 5/10/5/1 batching by the weight ratio of Radix Isatidis/Herba Taraxaci/Flos Lonicerae/Folium hydrangeae strigosae.
All the other are identical with embodiment 1.
Embodiment 4
Be 10/2/5/1 batching by the weight ratio of Radix Isatidis/Herba Taraxaci/Flos Lonicerae/Folium hydrangeae strigosae.
When preparing product, step (1) (2) (3) with embodiment 1, afterwards,
(4) (3) gained is mixed with dextrin.
(5) dry; Vacuum drying is to product moisture 5%.
(6) then according to after existing conventional techniques tabletting, interior subpackage and outer package is carried out.
Embodiment 5
Be 20/2/1/1 batching by the weight ratio of Radix Isatidis/Herba Taraxaci/Flos Lonicerae/Folium hydrangeae strigosae.
(1) Radix Isatidis, Herba Taraxaci, Flos Lonicerae are put into airtight extraction pot together with after Folium hydrangeae strigosae fragmentation;
(2) hot water extraction; Hot water temperature is 60 degree; Extract 3 times, be 10 times of L/kg of extract weight with hot water amount, each time is 2 hours at every turn.
Then liquid beverage or oral liquid is made according to existing conventional techniques.
Embodiment 6
Be 5/2/1/2 batching by the weight ratio of Radix Isatidis/Herba Taraxaci/Flos Lonicerae/Folium hydrangeae strigosae.
All the other are identical with embodiment 5.
Claims (9)
1. have the compositions of anti-multi-infection effect, its active component comprises Radix Isatidis, Herba Taraxaci, Flos Lonicerae and Folium hydrangeae strigosae, and the weight ratio of Radix Isatidis/Herba Taraxaci/Flos Lonicerae/Folium hydrangeae strigosae is 5 ~ 20/2 ~ 10/1 ~ 5/1 ~ 2.
2. the compositions with anti-multi-infection effect according to claim 1, is characterized in that the gross weight of active component accounts for more than 10% of whole composition.
3. the compositions with anti-multi-infection effect according to claim 1, is characterized in that the gross weight of active component accounts for more than 30% of whole composition.
4. the compositions with anti-multi-infection effect according to claim 1, is characterized in that: also comprise appropriate adjuvant, but does not comprise monosaccharide, disaccharide.
5. the compositions with anti-multi-infection effect according to claim 1, is characterized in that: the form of compositions comprises: active component mixture of raw materials, and granule, liquid, capsule, sheet or ball that active component extract is made.
6. the preparation method with the compositions of anti-multi-infection effect described in any one of Claims 1 to 5, comprises following step:
(1) airtight extraction pot is put into together by after active component fragmentation;
(2) hot water extraction;
(3) extracting solution is condensed into extractum;
(4) (3) gained is mixed with adjuvant, granulates;
(5) dry;
(6) interior subpackage and outer package.
7. preparation method according to claim 6, is characterized in that: in step (2), and hot water temperature is 50 ~ 90 degree; Extract 3 ~ 5 times, be 3 ~ 10 times of L/kg of extract weight with hot water amount, each time is 1 ~ 3 hour at every turn; Hot water comprises the hot water that adds or is heated at extraction pot by cold water and obtain.
8. the preparation method according to claim 6 or 7, is characterized in that: step (2) described hot water temperature is 50 ~ 60 degree.
9. preparation method according to claim 6, is characterized in that: in step (3), temperature is no more than 60 degree, vacuum concentration; In step (4), granulation particle diameter is 0.1 ~ 2mm; In step (5), vacuum drying is to product moisture 0.1 ~ 5%.
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| CN113350393A (en) * | 2020-03-06 | 2021-09-07 | 湖南诺泽生物科技有限公司 | Traditional Chinese medicine composition and feed composition containing same |
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