CN104435033A - Notoginseng flower and ginseng effervescent tablets and preparation method - Google Patents
Notoginseng flower and ginseng effervescent tablets and preparation method Download PDFInfo
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- CN104435033A CN104435033A CN201410623997.6A CN201410623997A CN104435033A CN 104435033 A CN104435033 A CN 104435033A CN 201410623997 A CN201410623997 A CN 201410623997A CN 104435033 A CN104435033 A CN 104435033A
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- radix notoginseng
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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Abstract
The invention relates to notoginseng flower and ginseng effervescent tablets, which are prepared from the following raw materials in parts by weight: 120-140 parts of fine notoginseng flower powder, 50-80 parts of fine ginseng powder, 2-5 parts of xylitol, 15-30 parts of citric acid, 15-30 parts of fumaric acid, 65-90 parts of sodium hydrogen carbonate, 4-7 parts of micro-powder silica gel and 10-15 parts of PEG (polyethylene glycol) 400. A preparation method of the effervescent tablets comprises: performing superfine grinding on the raw materials to obtain fine powder, mixing the fine powder uniformly in parts by weight to obtain a fine powder mixture, and directly tabletting the fine powder mixture to obtain the notoginseng flower and ginseng effervescent tablets. The notoginseng flower and ginseng effervescent tablets have the effects of clearing heat, calming the liver, reducing blood pressure and nourishing. Moreover, the notoginseng flower and ginseng effervescent tablets prepared by using the method are immediately dissolved in water to facilitate absorption, and have the characteristics of rich nutrition and obvious health-care effect.
Description
Technical field
The present invention relates to a kind of prepared slices of Chinese crude drugs and preparation method, particularly relate to a kind of flower of Radix Notoginseng Radix Ginseng effervescent tablet and preparation method.
Background technology
Flower of Radix Notoginseng, also known as Radix Notoginseng, has very high nutritive value and good health-care effect, the arasaponin containing high-load.Flower of Radix Notoginseng, nature and flavor are sweet cool, have heat clearing away, suppressing the hyperactive liver, blood pressure lowering, the effect such as sleeping, are applicable to giddy, dizzy, tinnitus, the disease such as hypertension and acute pharyngolaryngitis.Be generally used for and make tea, fry meat, Baoshang or use with other drug matchings.
Radix Ginseng is also a kind of health-care good product, YIN nourishing can mend raw, strengthening the body resistance.The ginsenoside contained in Radix Ginseng and polysaccharide, can effectively treat the diseases such as hypertension, heart disease, diabetes.
Effervescent tablet is an a kind of tablet containing disintegrating agent, and compared with common buccal tablet, effervescent tablet tool has the following advantages: disintegrate fast, taking convenience, onset be rapid; Bioavailability is high, can improve clinical efficacy; Be specially adapted to child, old people and the patient of pill difficulty of swallowing; Effervescent tablet after seasoning, taste is better, and good medicine is no longer bitter to the taste, and patient is more taken like a shot.Prepare effervescent tablet subject matter to be at present that an appearance is sticky and to fill, DeGrain water-soluble when effervescent tablet is eaten, especially utilize direct compression to make the requirement of technology to formula, technique of effervescent tablet stricter.
Summary of the invention
Technical problem to be solved by this invention is, in view of the deficiency that prior art exists, a kind of flower of Radix Notoginseng Radix Ginseng effervescent tablet and preparation method are provided, obtain formula of the present invention and technology of preparing by many experiments, to overcome in prior art easily stickyly to fill, problem that solute effect is undesirable.
The technical scheme that the present invention solves the problems of the technologies described above is as follows:
A kind of flower of Radix Notoginseng Radix Ginseng effervescent tablet, is made up of the component of following weight portion: flower of Radix Notoginseng 120-140 part, Radix Ginseng 50-80 part, xylitol 2-5 part, citric acid 15-30 part, fumaric acid 15-30 part, sodium bicarbonate 65-90 part, micropowder silica gel 4-7 part, PEG40010-15 part.
A kind of flower of Radix Notoginseng Radix Ginseng effervescent tablet preparation method, comprises the following steps:
1), by the flower of Radix Notoginseng roguing wash clean of fresh harvesting, after lyophilization, micronizing (grinding particle size is 5-10um) is carried out;
2) Radix Ginseng is carried out micronizing (grinding particle size is 5-10um), wear into fine powder, dry;
3) respectively xylitol, citric acid, fumaric acid, sodium bicarbonate, micropowder silica gel, PEG400 are carried out micronizing (grinding particle size is 5-10um), cross 30 mesh sieves;
4) by following weight portion: flower of Radix Notoginseng 120-140 part, Radix Ginseng 50-80 part, xylitol 2-5 part, citric acid 15-30 part, fumaric acid 15-30 part, sodium bicarbonate 65-90 part, micropowder silica gel 4-7 part, PEG40010-15 part, mix homogeneously, obtains fine powder mixture;
5) step 4) in fine powder mixture compression molding, 50-60 DEG C of oven drying at low temperature obtains finished product.
The invention has the beneficial effects as follows: flower of Radix Notoginseng Radix Ginseng preparation method provided by the invention, step is simple, raw material is few, by reasonably allocating formula and preparation process, effectively prevent sticky problem of filling, make the effervescent tablet obtained have solute effect good, be conducive to the advantage absorbed.Adopt flower of Radix Notoginseng and Radix Ginseng to be raw material in addition in formula, there is effect of heat clearing away, suppressing the hyperactive liver, blood pressure lowering, nourishing, nutritious, good health care effect.
Detailed description of the invention
Be described principle of the present invention and feature below, example, only for explaining the present invention, is not intended to limit scope of the present invention.
1), by the flower of Radix Notoginseng roguing wash clean of fresh harvesting, after lyophilization, micronizing (grinding particle size is 5-10um) is carried out;
2) Radix Ginseng is carried out micronizing (grinding particle size is 5-10um), wear into fine powder, dry;
3) respectively xylitol, citric acid, fumaric acid, sodium bicarbonate, micropowder silica gel, PEG400 are carried out micronizing (grinding particle size is 5-10um), cross 30 mesh sieves;
4) by following weight portion: flower of Radix Notoginseng 120-140 part, Radix Ginseng 50-80 part, xylitol 2-5 part, citric acid 15-30 part, fumaric acid 15-30 part, sodium bicarbonate 65-90 part, micropowder silica gel 4-7 part, PEG40010-15 part, mix homogeneously, obtains fine powder mixture;
5) step 4) in fine powder mixture compression molding, 50-60 DEG C of oven drying at low temperature obtains finished product.
Kilogram corresponding with embodiment of part described above.
Embodiment 1
1), by the flower of Radix Notoginseng roguing wash clean of fresh harvesting, after lyophilization, micronizing (granularity is 5um) is carried out;
2) Radix Ginseng is carried out micronizing (granularity is 5um), wear into fine powder, dry;
3) respectively xylitol, citric acid, fumaric acid, sodium bicarbonate, micropowder silica gel, PEG400 are carried out micronizing (granularity is 5um), cross 30 mesh sieves;
4) by following weight portion: flower of Radix Notoginseng 120 kilograms, Radix Ginseng 50 kilograms, xylitol 2 kilograms, citric acid 15 kilograms, fumaric acid 15 kilograms, sodium bicarbonate 65 kilograms, micropowder silica gel 4 kilograms, PEG40010 kilogram, mix homogeneously, obtains fine powder mixture;
5) step 4) in fine powder mixture compression molding, 50 DEG C of oven drying at low temperatures obtain finished product.
Embodiment 2
1), by the flower of Radix Notoginseng roguing wash clean of fresh harvesting, after lyophilization, micronizing (granularity is 7um) is carried out;
2) Radix Ginseng is carried out micronizing (granularity is 7um), wear into fine powder, dry;
3) respectively xylitol, citric acid, fumaric acid, sodium bicarbonate, micropowder silica gel, PEG400 are carried out micronizing (granularity is 7um), cross 30 mesh sieves;
4) by following weight portion: flower of Radix Notoginseng 130 kilograms, Radix Ginseng 60 kilograms, xylitol 3.5 kilograms, citric acid 20 kilograms, fumaric acid 20 kilograms, sodium bicarbonate 75 kilograms, micropowder silica gel 6 kilograms, PEG40013 kilogram, mix homogeneously, obtains fine powder mixture;
5) step 4) in fine powder mixture compression molding, 55 DEG C of oven drying at low temperatures obtain finished product.
Embodiment 3
1), by the flower of Radix Notoginseng roguing wash clean of fresh harvesting, after lyophilization, micronizing (granularity is 10um) is carried out;
2) Radix Ginseng is carried out micronizing (granularity is 10um), wear into fine powder, dry;
3) respectively xylitol, citric acid, fumaric acid, sodium bicarbonate, micropowder silica gel, PEG400 are carried out micronizing (granularity is 10um), cross 30 mesh sieves;
4) by following weight portion: flower of Radix Notoginseng 140 kilograms, Radix Ginseng 80 kilograms, xylitol 5 kilograms, citric acid 30 kilograms, fumaric acid 30 kilograms, sodium bicarbonate 90 kilograms, micropowder silica gel 7 kilograms, PEG40015 kilogram, mix homogeneously, obtains fine powder mixture;
5) step 4) in fine powder mixture compression molding, 60 DEG C of oven drying at low temperatures obtain finished product.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. a flower of Radix Notoginseng Radix Ginseng effervescent tablet, it is characterized in that, be made up of the component of following weight portion: flower of Radix Notoginseng 120-140 part, Radix Ginseng 50-80 part, xylitol 2-5 part, citric acid 15-30 part, fumaric acid 15-30 part, sodium bicarbonate 65-90 part, micropowder silica gel 4-7 part, PEG40010-15 part.
2. a flower of Radix Notoginseng Radix Ginseng effervescent tablet preparation method, is characterized in that, comprise the following steps:
1) by the flower of Radix Notoginseng roguing wash clean of fresh harvesting, after lyophilization, micronizing is carried out;
2) Radix Ginseng is carried out micronizing, wear into fine powder, dry;
3) respectively xylitol, citric acid, fumaric acid, sodium bicarbonate, micropowder silica gel, PEG400 are carried out micronizing, sieve;
4) above-mentioned raw materials of following weight portion is taken: flower of Radix Notoginseng 120-140 part, Radix Ginseng 50-80 part, xylitol 2-5 part, citric acid 15-30 part, fumaric acid 15-30 part, sodium bicarbonate 65-90 part, micropowder silica gel 4-7 part, PEG40010-15 part, mix homogeneously, obtains fine powder mixture;
5) by step 4) in fine powder mixture compression molding, dry obtain finished product.
3. a kind of flower of Radix Notoginseng Radix Ginseng effervescent tablet preparation method according to claim 2, is characterized in that, step 1) and step 2) in, the granularity of described micronizing is 5-10um.
4. a kind of flower of Radix Notoginseng Radix Ginseng effervescent tablet preparation method according to claim 2, is characterized in that, step 3) in, the granularity of described micronizing is 5-10um, described in the fineness degree that sieves be 30 orders.
5. a kind of flower of Radix Notoginseng Radix Ginseng effervescent tablet preparation method according to claim 2, is characterized in that, step 5) in, the temperature of described oven dry is 50-60 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410623997.6A CN104435033A (en) | 2014-11-07 | 2014-11-07 | Notoginseng flower and ginseng effervescent tablets and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410623997.6A CN104435033A (en) | 2014-11-07 | 2014-11-07 | Notoginseng flower and ginseng effervescent tablets and preparation method |
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| CN104435033A true CN104435033A (en) | 2015-03-25 |
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| CN201410623997.6A Pending CN104435033A (en) | 2014-11-07 | 2014-11-07 | Notoginseng flower and ginseng effervescent tablets and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036903A (en) * | 2016-06-08 | 2016-10-26 | 彭常安 | Preparation method of phallus indusiatus and panax notoginseng flower effervescent tablets |
| CN109985079A (en) * | 2017-12-29 | 2019-07-09 | 辽宁上药科技开发有限公司 | A kind of preparation method and application comprising ginseng and sanchi flower double-layer tablets |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296833A (en) * | 2000-11-20 | 2001-05-30 | 国家中药现代化工程技术研究中心 | Chinese medicinal composition for relieving fatigue |
-
2014
- 2014-11-07 CN CN201410623997.6A patent/CN104435033A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296833A (en) * | 2000-11-20 | 2001-05-30 | 国家中药现代化工程技术研究中心 | Chinese medicinal composition for relieving fatigue |
Non-Patent Citations (3)
| Title |
|---|
| 南京中医药大学编著: "《中药大辞典》", 30 March 2006 * |
| 张冰主编: "《临床中药学》", 30 September 2012 * |
| 高明菊等: "三七花的研究进展", 《人参研究》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036903A (en) * | 2016-06-08 | 2016-10-26 | 彭常安 | Preparation method of phallus indusiatus and panax notoginseng flower effervescent tablets |
| CN109985079A (en) * | 2017-12-29 | 2019-07-09 | 辽宁上药科技开发有限公司 | A kind of preparation method and application comprising ginseng and sanchi flower double-layer tablets |
| CN109985079B (en) * | 2017-12-29 | 2021-09-24 | 辽宁上药科技开发有限公司 | Preparation method and application of double-layer tablet containing ginseng and pseudo-ginseng flower |
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Application publication date: 20150325 |
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