CN104422779B - Automatic lmunoassays analyzer - Google Patents
Automatic lmunoassays analyzer Download PDFInfo
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- CN104422779B CN104422779B CN201310370502.9A CN201310370502A CN104422779B CN 104422779 B CN104422779 B CN 104422779B CN 201310370502 A CN201310370502 A CN 201310370502A CN 104422779 B CN104422779 B CN 104422779B
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 49
- 230000000712 assembly Effects 0.000 claims abstract description 42
- 238000000429 assembly Methods 0.000 claims abstract description 42
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 38
- 238000004140 cleaning Methods 0.000 claims abstract description 35
- 238000010521 absorption reaction Methods 0.000 claims abstract description 16
- 230000004044 response Effects 0.000 claims abstract description 4
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 17
- 244000273618 Sphenoclea zeylanica Species 0.000 claims description 15
- 238000001179 sorption measurement Methods 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 11
- 210000004369 blood Anatomy 0.000 claims description 11
- 238000010926 purge Methods 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 5
- 238000000034 method Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 2
- 230000009471 action Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000005622 photoelectricity Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of automatic lmunoassays analyzer, it comprises Control Component, frame, absorption transfer assembly, for the placing modules of placing response cup and TIP head, transfer assembly, application of sample assembly, reaction tray, cleaning assembly and light quantity pick-up unit, transfer assembly is between placing modules and application of sample assembly, application of sample assembly comprises Sample assemblies, reagent assembly, inhale sample assembly, inhale sample assembly and be positioned at reaction tray, the centre of Sample assemblies and reagent assembly, Control Component controls absorption transfer assembly and is placed in reaction tray by reaction cup, by transfer assembly, TIP head is arranged on suction sample assembly, by inhaling sample assembly, sample and reagent are added in the reaction cup of reaction tray, cleaned by cleaning device again, then control light quantity pick-up unit to detect.This contrive equipment is completed by instrument from application of sample completely automatically to the overall process going out result, easy to operate, and automaticity is high.
Description
Technical field
The present invention relates to medical instruments field, be specifically related to a kind of automatic lmunoassays analyzer.
Background technology
Biochemical immunity analyser (HF) is the instrument for detecting, analyzing life chemistry material, gives and provides information foundation to the diagnosis of disease, treatment and prevention and health status clinically.The existing domestic kind overwhelming majority developed voluntarily is semi-automatic, and analysis speed is slow, reagent consumption is large, and automaticity, precision, processing quality, reliability and stability, compared with external product, also exist sizable gap.
Summary of the invention
The object of the present invention is to provide a kind of easy to operate full-automatic analyser.
For achieving the above object, the present invention is by the following technical solutions:
A kind of automatic lmunoassays analyzer, for detecting the biochemical indicator of analyzing blood, it comprises Control Component, be provided with the frame of crossbeam, absorption transfer assembly, for the placing modules of placing response cup and TIP head, transfer assembly, application of sample assembly, reaction tray, cleaning assembly and light quantity pick-up unit, described Control Component, absorption transfer assembly, placing modules, transfer assembly, application of sample assembly, reaction tray, cleaning assembly and light quantity pick-up unit are located in described frame, and described transfer assembly is between described placing modules and application of sample assembly, and described application of sample assembly comprises Sample assemblies, reagent assembly, inhale sample assembly, described suction sample assembly is positioned at described reaction tray, the centre of Sample assemblies and reagent assembly, reaction cup is placed in described reaction tray by the absorption transfer assembly described in described Control Component controls, by described transfer assembly, TIP head is arranged on suction sample assembly, by described suction sample assembly, sample and reagent are added in the reaction cup of described reaction tray, cleaned by described cleaning device again, then control described light quantity pick-up unit and detect.
Described absorption transfer assembly comprises the first slide assemblies be positioned on crossbeam, the second slide assemblies of surface level is positioned at perpendicular to crossbeam, the 3rd slide assemblies of vertical plane is positioned at perpendicular to crossbeam, some contiguous blocks and adsorption head, described contiguous block is for connecting each slide assemblies, and described adsorption head is positioned at the 3rd slide assemblies bottom.
Described placing modules comprises placement cabinet, vertical mobile Control Component, move horizontally Control Component and some TIP head placing frames of being accommodated in placement cabinet and reaction cup placing frame, described vertical mobile Control Component is positioned at placement cabinet side, and the described Control Component that moves horizontally is positioned at placement cabinet lower end.
Described transfer assembly comprises pedestal, slide bar and slide block, and described pedestal is fixed in frame, and described slide bar is fixed on pedestal, and described slide block through slide bar, and can move freely on slide bar.
Described transfer assembly also comprises and being fixed on pedestal, and leads to the hollow stem bottom frame through pedestal, and described slide block is provided with groove, and time above described skid to hollow stem, described groove is corresponding with hollow stem position.
Described cleaning assembly comprises cleaning arm, purge pipe and cleaning disc group, and described cleaning arm is positioned on beam guideway and can move freely, and described purge pipe and cleaning disc group are positioned at below cleaning arm.
Described Sample assemblies and reagent assembly include swivel base, application of sample block and some sample inserted blocks, be provided with chute and sliding part in described application of sample block, described sample inserted block is placed on application of sample block, and can move on swivel base along chute direction under the effect of sliding part.
Preferably, described suction sample assembly lower end is provided with the unidirectional force (forcing) pump that be connected pneumatic with it, and it is for controlling the adsorbance of inhaling sample assembly.
Preferably, described reagent assembly also comprises lid, and described lid is placed in the periphery of swivel base.
After adopting technique scheme, the present invention is compared with existing background technology, and tool has the following advantages:
1. this contrive equipment is completed by instrument from application of sample completely automatically to the overall process going out result.Operator only need be placed on the application of sample block of analyser sample, and Procedure for selection starts instrument etc. and gets survey report.Easy to operate, automaticity is high.
2. inhale the center that sample assembly is positioned at reaction tray, Sample assemblies and reagent assembly, inhale the operation that sample assembly completes sampling and draws reagent, unidirectional force (forcing) pump controls the adsorbance of inhaling sample assembly, and connection and reasonable arrangement, structure is simple.
3. placing modules comprises the mobile Control Component of both direction, and only need be arranged in placement cabinet by TIP head placing frame, reaction cup placing frame, namely adjust to suitable position by mobile Control Component, precision is high, and improves detection efficiency.
4. the slide block of transfer assembly is provided with groove, when above skid to hollow stem, groove is corresponding with hollow stem position, inhales sample assembly and discarded TIP head is left behind the dustbin directly falling in hollow stem and lead to below frame from groove, ensure that the clean of environment.
5. Sample assemblies and reagent assembly include swivel base, application of sample block and some sample inserted blocks, sample inserted block is placed on application of sample block, and can move on swivel base along chute direction under the effect of sliding part, because sample inserted block is detachable, the sample inserted block of different size and different open-work number can be adopted to place blood sample or reagent sample.
6. reagent assembly peripheral hardware has the peripheral lid being positioned at swivel base, can prevent reagent from being polluted.
Accompanying drawing explanation
Fig. 1 is front view of the present invention;
Fig. 2 is perspective view of the present invention;
Fig. 3 is absorption transfer assembly structural representation of the present invention;
Fig. 4 is placing modules structural representation of the present invention;
Fig. 5 is Sample assemblies structural representation of the present invention;
Fig. 6 is transfer assembly structural representation of the present invention.
Primary clustering symbol description:
100: frame, 110: crossbeam, 200: light quantity pick-up unit, 300: absorption transfer assembly, 310: the first slide assemblies, 311: the first slip rails, 312: the first belt gear parts, 320: the second slide assemblies, 321: the second slip rails, 322: the second belt gear parts, 330: the three slide assemblies, 331: the three slip rails, 332: the three belt gear parts, 341: the first contiguous blocks, 342: the second contiguous blocks, 350: adsorption head, 400: placing modules, 410: placement cabinet, 420: vertical mobile Control Component, 430: move horizontally Control Component, 440:TIP head placing frame, 450: reaction cup placing frame, 500: transfer assembly, 510: pedestal, 520: slide bar, 530: slide block, 531: groove, 540: hollow stem, 610: Sample assemblies, 611: swivel base, 612: sample inserted block, 613: application of sample block, 614: chute, 615: sliding part, 620: reagent assembly, 630: inhale sample assembly, 640: unidirectional force (forcing) pump, 700: reaction tray, 800: cleaning assembly, 810: cleaning arm, 820: purge pipe, 830: cleaning disc group, 910: reaction cup, 920:TIP head.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Biochemical immunity analyser, is mainly used in measuring the various biochemical indicators in human body fluid, comprises the routine biochemistry indexs such as routine blood test, myocardial enzymes, blood pressure and blood lipoid, liver function, immunoglobulin (Ig).
As shown in Figure 1, 2, automatic lmunoassays analyzer disclosed in this invention comprises Control Component, be provided with the frame 100 of crossbeam 110, be positioned at the absorption transfer assembly 300 on crossbeam 110, for placing modules 400, transfer assembly 500, application of sample assembly, reaction tray 700, cleaning assembly 800, the light quantity pick-up unit 200 of placing response cup 910 and TIP 920.Control Component, absorption transfer assembly 300, placing modules 400, transfer assembly 500, application of sample assembly, reaction tray 700, cleaning assembly 800 and light quantity pick-up unit 200 are located in frame 100.
As shown in Figure 3: absorption transfer assembly 300 comprises the first slide assemblies 310 be positioned on crossbeam 110, be positioned at the second slide assemblies 320 of surface level, be positioned at the 3rd slide assemblies 330 of vertical plane, first contiguous block 341, second contiguous block 342 and adsorption head 350, the first belt gear part 312, first contiguous block 341 that first slide assemblies 310 comprises the first slip rail 311 and is fixed on its lower end to be fixed on the first belt gear part 312 and to be connected with the second slide assemblies 320.The second belt gear part 322, second contiguous block 342 that second slide assemblies 320 comprises the second slip rail 321 and is fixed on its side to be fixed on the second belt gear part 322 and to be connected with the 3rd slide assemblies 330.3rd slide assemblies 330 comprises the 3rd slip rail 331 and is fixed on the 3rd belt gear part 332 of the second contiguous block 342 lower end.Adsorption head 350 is positioned at the 3rd slip rail 331 bottom.
As shown in Figure 4: placing modules 400 comprises placement cabinet 410, vertical mobile Control Component 420, move horizontally Control Component 430 and some TIP head placing frames 440 of being accommodated in placement cabinet 410 and reaction cup placing frame 450, vertical mobile Control Component 420 is positioned at placement cabinet 410 side, moves horizontally Control Component 430 and is positioned at placement cabinet 410 lower end.
Application of sample assembly comprises Sample assemblies 610, reagent assembly 620, inhales sample assembly 630.Inhale the centre that sample assembly 630 is positioned at reaction tray 700, Sample assemblies 610 and reagent assembly 620.The control of all controlled assembly of reaction tray 700, Sample assemblies 610 and reagent assembly 620 can axial rotation, and inhaling sample assembly 630 can 360 degree of rotation.As shown in Figure 5, Sample assemblies 610 and reagent assembly 620 include swivel base 611, application of sample block 613 and some sample inserted blocks 612.Be provided with chute 614 and sliding part 615 in application of sample block 613, sample inserted block 612 is placed on application of sample block 613, and can move on swivel base 611 along chute 614 direction under the effect of sliding part 615.
As Fig. 2, inhale sample assembly 630 lower end and be provided with the unidirectional force (forcing) pump 640 that be connected pneumatic with it, it is for controlling the adsorbance of inhaling sample assembly 630.Reagent assembly 620 also comprises lid (not shown in FIG.), and lid is placed in the periphery of swivel base 611, plays buffer action, prevents reagent from being polluted.
As Fig. 6, transfer assembly 500 is between placing modules 400 and application of sample assembly, and transfer assembly 500 comprises pedestal 510, slide bar 520, slide block 530, to be fixed on pedestal 510 and to lead to the hollow stem 540 bottom frame 100 through pedestal 510.Slide block 530 is provided with groove 531, and pedestal 510 is fixed in frame 100, and slide bar 520 is fixed on pedestal 510, and slide block 530 through slide bar 520, and can move freely on slide bar 520.
Cleaning assembly 800 comprises cleaning arm 810, purge pipe 820 and cleaning disc group 830, and cleaning arm 810 is positioned on crossbeam 110 and can move freely, and purge pipe 820 and cleaning disc group 830 are positioned at below cleaning arm 810.
Open instrument after collecting blood sample, select test item and corresponding reagent; Run and detect, analyser will carry out the steps such as application of sample, reagent adding, incubation reaction, photoelectricity test, washing automatically, and its main workflow is as follows:
The first step: be placed in reaction cup placing frame 450 by the reaction cup 910 of sky, is placed in TIP head placing frame 440, by two kinds of placing frame longitudinal arrangements in placement cabinet 410 by TIP 920.Placing frame is displaced downwardly to and moves horizontally on Control Component 430 by vertical mobile Control Component 420 from placement cabinet 410, and move horizontally Control Component 430 by one group of TIP head placing frame 440, reaction cup placing frame 450 is transferred to below crossbeam 110.
Second step: the blood sample collected is inserted on the sample inserted block 612 of Sample assemblies 610, reagent bottle is placed on the sample inserted block 612 of reagent assembly 620.Being placed on by sample inserted block 612 in the chute 614 of application of sample block 613, matches with sliding part 615 in the bottom of sample inserted block 612, and sliding part 615 mobile application of sample block 613 that simultaneously drives in chute 614 enters and is clamped on swivel base 611.Swivel base 611 rotates an angle, makes blood sample and reagent bottle near inhaling sample assembly 630.
3rd step: adsorption head 350 moves along crossbeam 110 on the first slide assemblies 310, by the second slide assemblies 320 and the 3rd slide assemblies 330 along the horizontal plane and vertical plane move, be adjusted to above reaction cup placing frame 450 under the effect of Control Component, adsorption head 350 adsorbs reaction cup 910 wall, is moved and is placed in reaction tray 700.
4th step: adsorption head 350 is adjusted to above TIP head placing frame 440, adsorbs TIP 920.Slide block 530 simultaneously on transfer assembly 500 moves to pedestal 510 near absorption transfer assembly 300 one end along slide bar 520, and TIP 920 is placed on slide block 530 by adsorption head 350.
5th step: slide block 530 moves to above hollow stem 540 along slide bar 520, now groove 531 is corresponding with hollow stem 540 position.
6th step: inhale sample assembly 630 and rotate on slide block 530, capture TIP on it 920, then rotate on the sample inserted block 612 of Sample assemblies 610, and draw appropriate blood sample with TIP 920, unidirectional force (forcing) pump 640 can control the adsorbance of inhaling sample assembly 630.
7th step: inhale sample assembly 630 and rotate in TIP the 920 interior blood sample instillation reaction cup 910 drawn to reaction tray 700, then inhaling sample assembly 630 rotates above the groove 531 of slide block 530, TIP 920 after polluting is unclamped, makes the TIP after pollution 920 enter hollow stem 540 by groove 531 and lead in the dustbin of frame 100 bottom.
8th step: adsorption head 350 is adjusted to above TIP head placing frame 440 again, adsorbs new TIP 920, and places it on slide block 530.Inhale sample assembly 630 to rotate above slide block 530, adsorb clean TIP 920 and rotate on reagent assembly 620, draw the reagent in reagent bottles with TIP 920.
9th step: suction sample assembly 630 rotates and instilled in reaction cup 910 by TIP the 920 interior reagent drawn to reaction tray 700, makes the blood in reaction cup 910 and reagent reacting.Then inhale sample assembly 630 to rotate above the groove 531 of slide block 530 equally, the TIP after pollution 920 is unclamped, make the TIP after pollution 920 enter hollow stem 540 by groove 531 and lead in the dustbin of frame 100 bottom.
Tenth step: after having reacted, cleaning arm 810 captures in reaction cup 910 to the light quantity pick-up unit 200 in reaction tray 700 and detects.
11 step: after having detected, cleaning arm 810 captures reaction cup 910 to cleaning disc group 830, cleans reaction cup 910.
More than complete a work period, the time span of each work period is consistent.In each work period, each action component is according to the action sequence work of regulation, complete add blood sample, add reagent, photo-electronic data acquisition and the automatic cleaning action of reaction cup, so perform the work period continuously again and again, thus complete the test of multiple project continuously expeditiously.
The above; be only the present invention's preferably embodiment, but protection scope of the present invention is not limited thereto, is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (6)
1. an automatic lmunoassays analyzer, for detecting the biochemical indicator of analyzing blood, is characterized in that: it comprises Control Component, be provided with the frame of crossbeam, absorption transfer assembly, for the placing modules of placing response cup and TIP head, transfer assembly, application of sample assembly, reaction tray, cleaning assembly and light quantity pick-up unit, described Control Component, absorption transfer assembly, placing modules, transfer assembly, application of sample assembly, reaction tray, cleaning assembly and light quantity pick-up unit are located in described frame, and described transfer assembly is between described placing modules and application of sample assembly, and described application of sample assembly comprises Sample assemblies, reagent assembly, inhale sample assembly, described suction sample assembly is positioned at described reaction tray, the centre of Sample assemblies and reagent assembly, reaction cup is placed in described reaction tray by the absorption transfer assembly described in described Control Component controls, by described transfer assembly, TIP head is arranged on suction sample assembly, by described suction sample assembly, sample and reagent are added in the reaction cup of described reaction tray, cleaned by described cleaning device again, then control described light quantity pick-up unit and detect, described placing modules comprises placement cabinet, vertical mobile Control Component, move horizontally Control Component and some TIP head placing frames of being accommodated in placement cabinet and reaction cup placing frame, described vertical mobile Control Component is positioned at placement cabinet side, and the described Control Component that moves horizontally is positioned at placement cabinet lower end, described transfer assembly comprises pedestal, slide bar, slide block and is fixed on pedestal, and lead to the hollow stem bottom frame through pedestal, described pedestal is fixed in frame, described slide bar is fixed on pedestal, described slide block through slide bar, and can move freely on slide bar, and described slide block is provided with groove, time above described skid to hollow stem, described groove is corresponding with hollow stem position.
2. automatic lmunoassays analyzer as claimed in claim 1, it is characterized in that: described absorption transfer assembly comprises the first slide assemblies be positioned on crossbeam, the second slide assemblies of surface level is positioned at perpendicular to crossbeam, the 3rd slide assemblies of vertical plane is positioned at perpendicular to crossbeam, some contiguous blocks and adsorption head, described contiguous block is for connecting each slide assemblies, and described adsorption head is positioned at the 3rd slide assemblies bottom.
3. automatic lmunoassays analyzer as claimed in claim 1, it is characterized in that: described cleaning assembly comprises cleaning arm, purge pipe and cleaning disc group, described cleaning arm is positioned on beam guideway and can move freely, and described purge pipe and cleaning disc group are positioned at below cleaning arm.
4. automatic lmunoassays analyzer as claimed in claim 3, it is characterized in that: described Sample assemblies and reagent assembly include swivel base, application of sample block and some sample inserted blocks, chute and sliding part is provided with in described application of sample block, described sample inserted block is placed on application of sample block, and can move on swivel base along chute direction under the effect of sliding part.
5. automatic lmunoassays analyzer as claimed in claim 4, is characterized in that: described suction sample assembly lower end is provided with the unidirectional force (forcing) pump that be connected pneumatic with it, and it is for controlling the adsorbance of inhaling sample assembly.
6. automatic lmunoassays analyzer as claimed in claim 5, it is characterized in that: described reagent assembly also comprises lid, described lid is placed in the periphery of swivel base.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310370502.9A CN104422779B (en) | 2013-08-22 | 2013-08-22 | Automatic lmunoassays analyzer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310370502.9A CN104422779B (en) | 2013-08-22 | 2013-08-22 | Automatic lmunoassays analyzer |
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| CN104422779A CN104422779A (en) | 2015-03-18 |
| CN104422779B true CN104422779B (en) | 2016-03-09 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105388314B (en) * | 2015-12-17 | 2017-09-12 | 嘉兴凯实生物科技有限公司 | A kind of full-automatic sample adding instrument |
| CN105628947B (en) * | 2016-02-02 | 2017-08-08 | 徐恩良 | Whole blood automatic luminous immunoassay instant detector |
| CN105784986B (en) * | 2016-04-29 | 2018-08-14 | 江苏扬新生物医药有限公司 | A kind of full-automatic sample detection immunity analysis instrument of strip formula |
| CN106093445A (en) * | 2016-08-17 | 2016-11-09 | 江苏英诺华医疗技术有限公司 | There is automatic clinical chemistry analyzer and the analysis method of noncontact air pressure agitating device |
| CN110823871B (en) * | 2018-08-14 | 2022-09-02 | 深圳市新产业生物医学工程股份有限公司 | Luminescence analyzer and analysis method thereof |
| CN109239018B (en) * | 2018-10-12 | 2023-10-27 | 武汉纺织大学 | Full-automatic coagulation analysis system |
| CN109917056A (en) * | 2019-04-04 | 2019-06-21 | 广东出入境检验检疫局检验检疫技术中心 | A kind of liquid phase autosampler and cleaning method |
| CN110286119B (en) * | 2019-06-28 | 2024-04-19 | 武汉明德生物科技股份有限公司 | TIP head detection frame, sample type detection module assembly and chemiluminescence immunoassay analyzer |
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| US7842504B2 (en) * | 2004-04-02 | 2010-11-30 | Siemens Healthcare Diagnostics Inc. | Method for increasing throughput in an automatic clinical analyzer by duplicating reagent resources |
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Effective date of registration: 20181116 Address after: 528400 East Third Floor, Building 6, Shennong Road, Zhongshan Torch Development Zone, Guangdong Province Patentee after: Songke Medical Instruments (Zhongshan) Co., Ltd. Address before: 518116 Room 605, Pioneering Building, Overseas Students Pioneering Park, Longgang Central City, Shenzhen City, Guangdong Province Patentee before: Zhong Weiming |