CN104415084A - Preparation method of ligusticum wallichii and dalbergia wood volatile oil for Kuanxin capsules - Google Patents
Preparation method of ligusticum wallichii and dalbergia wood volatile oil for Kuanxin capsules Download PDFInfo
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- CN104415084A CN104415084A CN201310395160.6A CN201310395160A CN104415084A CN 104415084 A CN104415084 A CN 104415084A CN 201310395160 A CN201310395160 A CN 201310395160A CN 104415084 A CN104415084 A CN 104415084A
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- preparation
- volatile oil
- ligusticum wallichii
- rhizoma chuanxiong
- dalbergia wood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of ligusticum wallichii and dalbergia wood volatile oil for Kuanxin capsules. The preparation process comprises the following steps: weighing a certain amount of ligusticum wallichii and dalbergia wood according to a formula, mixing and then conveying into an extraction tank, adding ethyl alcohol for soaking, extracting by supercritical carbon dioxide during a process of heating and pressurizing the mixed solution, and collecting the extract. Compared with the prior art, the preparation method disclosed by the invention is simpler, environmental friendly in technology and short in time, thus saving water resources and the energies consumed by water distillation. A component analysis is carried out on the prepared ligusticum wallichii and dalbergia wood volatile oil, and the result displays that the yield of the contained basic ingredients is increased by more than 20%, thus the quality of the prepared Kuanxin capsule products is greatly improved, the efficacy is easier to exert, and the curative effect for curing the sickness to save the patients is obvious.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to the preparation method of Rhizoma Chuanxiong, volatile oil of Lignum Dalbergiae Odoriferae in a kind of relieved soft capsule prescription.
Background technology
Relieved soft capsule has effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is used for the treatment of qi stagnation and blood stasis type angina pectoris, can reduce anginal seizure frequency, improve blood supply of cardiac muscle, rehabilitation ischemic myocardium.Confirm through clinical trial, soft capsule treatment patients with coronary heart disease of feeling relieved, angina pectoris attacks number of times, TCM syndrome, nitroglycerin stop the curative effect such as lapse rate, electrocardiogram and are all significantly better than similar reference product, and have obvious dose-effect relationship.And the extracting method that the patent No. is Rhizoma Chuanxiong, volatile oil of Lignum Dalbergiae Odoriferae in the patent of ZL03125289.3 is: get Rhizoma Chuanxiong and Lignum Dalbergiae Odoriferae, adds 4-8 times of water gaging, use water distillation and extraction 3-10h, collect volatile oil.Also exist that to extract the temperature of volatile oil high, the time is long, and yield is low, and heavy damage effective ingredient, directly affects the open defect of relieved soft capsule quality.
Summary of the invention
The object of the invention is to overcome above-mentioned defect, to former technique reform, advanced in China's Chinese medicine and modern times pharmaceutical technology is combined, adopt advanced supercritical carbon dioxide extraction method, while economizing on resources, reach Rhizoma Chuanxiong, a kind of relieved soft capsule Rhizoma Chuanxiong of volatile oil of Lignum Dalbergiae Odoriferae fundamental component yield raising, the preparation method of volatile oil of Lignum Dalbergiae Odoriferae.It is characterized in that: its preparation technology is: send into extractor after taking a certain amount of Rhizoma Chuanxiong, Lignum Dalbergiae Odoriferae mixing by formula, add soak with ethanol, in the process to mixed liquor temperature-pressure, with supercritical carbon dioxide extraction, collect extract,
The 40%-95% soak with ethanol of described soak with ethanol 0.5-2 times amount, the time between 0.5-5h,
Heating in described extraction process, temperature within the scope of 40-90 DEG C,
Pressurize in extractor in described extraction process, pressure within the scope of 0-50MPa,
Use the time of supercritical carbon dioxide extraction in described extraction process between 0.5-4h.
Implement the obvious advantage after this technology and effect is: compared with prior art, the present invention is more simple, technology environmental protection, and the time is short, thus save water resource and water distillation institute's power consumption source.Obtained Rhizoma Chuanxiong, volatile oil of Lignum Dalbergiae Odoriferae carry out component analysis, and the contained fundamental component yield of result display improves more than 20%, and the relieved soft gel products quality made is greatly improved, and drug effect more easily plays, and the curative effect of curing the sickness to save the patient is obvious.
Detailed description of the invention
Be below example by 4 routine embodiments, the invention will be further described:
Embodiment 1
Take Rhizoma Chuanxiong, each 2500g of Lignum Dalbergiae Odoriferae, add the 40% soak with ethanol 5h of 2500g, in the environment of the temperature 90 DEG C ± 2 and 10MPa pressure, use supercritical carbon dioxide extraction 4h, collect extract, to obtain final product.
Embodiment 2
Take Rhizoma Chuanxiong, each 2500g of Lignum Dalbergiae Odoriferae, add the 60% soak with ethanol 2.5h of 5000g, in the environment of the temperature 70 DEG C ± 2 and 20MPa pressure, use supercritical carbon dioxide extraction 3h, collect extract, to obtain final product.
Embodiment 3
Take Rhizoma Chuanxiong, each 2500g of Lignum Dalbergiae Odoriferae, add the 80% soak with ethanol 1.5h of 7500g, in the environment of the temperature 55 DEG C ± 2 and 35MPa pressure, use supercritical carbon dioxide extraction 1.5h, collect extract, to obtain final product.Embodiment 4
Take Rhizoma Chuanxiong, each 2500g of Lignum Dalbergiae Odoriferae, add the 95% soak with ethanol 0.5h of 10000g, in the environment of the temperature 40 DEG C ± 2 and 50MPa pressure, use supercritical carbon dioxide extraction 0.5h, collect extract, to obtain final product.
Claims (5)
1. the preparation method of a relieved soft capsule Rhizoma Chuanxiong, volatile oil of Lignum Dalbergiae Odoriferae, it is characterized in that: its preparation technology is: after taking a certain amount of Rhizoma Chuanxiong, Lignum Dalbergiae Odoriferae mixing by formula, send into extractor, add soak with ethanol, in the process to mixed liquor temperature-pressure, with supercritical carbon dioxide extraction, collect extract.
2. according to the preparation method of the relieved soft capsule Rhizoma Chuanxiong of claim 1 one kind, volatile oil of Lignum Dalbergiae Odoriferae, it is characterized in that: the 40%-95% soak with ethanol of described soak with ethanol 0.5-2 times amount, the time is between 0.5-5h.
3., according to the preparation method of the relieved soft capsule Rhizoma Chuanxiong of claim 1 one kind, volatile oil of Lignum Dalbergiae Odoriferae, it is characterized in that: heating in described extraction process, temperature is within the scope of 40-90 DEG C.
4., according to the preparation method of the relieved soft capsule Rhizoma Chuanxiong of claim 1 one kind, volatile oil of Lignum Dalbergiae Odoriferae, it is characterized in that: pressurize in extractor in described extraction process, pressure is within the scope of 0-50MPa.
5. according to the preparation method of the relieved soft capsule Rhizoma Chuanxiong of claim 1 one kind, volatile oil of Lignum Dalbergiae Odoriferae, it is characterized in that: in described extraction process, use the time of supercritical carbon dioxide extraction between 0.5-4h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310395160.6A CN104415084A (en) | 2013-09-03 | 2013-09-03 | Preparation method of ligusticum wallichii and dalbergia wood volatile oil for Kuanxin capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310395160.6A CN104415084A (en) | 2013-09-03 | 2013-09-03 | Preparation method of ligusticum wallichii and dalbergia wood volatile oil for Kuanxin capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104415084A true CN104415084A (en) | 2015-03-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310395160.6A Pending CN104415084A (en) | 2013-09-03 | 2013-09-03 | Preparation method of ligusticum wallichii and dalbergia wood volatile oil for Kuanxin capsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104415084A (en) |
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2013
- 2013-09-03 CN CN201310395160.6A patent/CN104415084A/en active Pending
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150318 |