CN104415052A - External composition for skin and preparation method of external composition for skin - Google Patents
External composition for skin and preparation method of external composition for skin Download PDFInfo
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- CN104415052A CN104415052A CN201310396042.7A CN201310396042A CN104415052A CN 104415052 A CN104415052 A CN 104415052A CN 201310396042 A CN201310396042 A CN 201310396042A CN 104415052 A CN104415052 A CN 104415052A
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- 239000000203 mixture Substances 0.000 title claims abstract description 127
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 84
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 52
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 41
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 41
- 239000002562 thickening agent Substances 0.000 claims abstract description 26
- 239000002270 dispersing agent Substances 0.000 claims abstract description 12
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 21
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 18
- 235000010413 sodium alginate Nutrition 0.000 claims description 18
- 239000000661 sodium alginate Substances 0.000 claims description 18
- 229940005550 sodium alginate Drugs 0.000 claims description 18
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 17
- 239000002904 solvent Substances 0.000 claims description 16
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 10
- 229930006000 Sucrose Natural products 0.000 claims description 10
- 239000005720 sucrose Substances 0.000 claims description 10
- 235000010418 carrageenan Nutrition 0.000 claims description 7
- 229920001525 carrageenan Polymers 0.000 claims description 7
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 7
- 241000416162 Astragalus gummifer Species 0.000 claims description 6
- 241000065610 Cotinus Species 0.000 claims description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- 239000005715 Fructose Substances 0.000 claims description 6
- 229930091371 Fructose Natural products 0.000 claims description 6
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- 229920000161 Locust bean gum Polymers 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- 229920001615 Tragacanth Polymers 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- 235000010420 locust bean gum Nutrition 0.000 claims description 6
- 239000000711 locust bean gum Substances 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- 239000000600 sorbitol Substances 0.000 claims description 6
- 235000010356 sorbitol Nutrition 0.000 claims description 6
- 235000010491 tara gum Nutrition 0.000 claims description 6
- 239000000213 tara gum Substances 0.000 claims description 6
- 235000010487 tragacanth Nutrition 0.000 claims description 6
- 239000000196 tragacanth Substances 0.000 claims description 6
- 229940116362 tragacanth Drugs 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- 235000010447 xylitol Nutrition 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 5
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims description 5
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims description 5
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 5
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 5
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 abstract description 37
- 230000000694 effects Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- 239000002250 absorbent Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 38
- 210000000245 forearm Anatomy 0.000 description 34
- 238000002156 mixing Methods 0.000 description 31
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical class CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 29
- 230000015572 biosynthetic process Effects 0.000 description 29
- 239000001768 carboxy methyl cellulose Substances 0.000 description 23
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 23
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 23
- 235000019437 butane-1,3-diol Nutrition 0.000 description 15
- 239000004745 nonwoven fabric Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 206010056474 Erythrosis Diseases 0.000 description 6
- 210000000981 epithelium Anatomy 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000007665 sagging Methods 0.000 description 2
- 230000003796 beauty Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a carbon dioxide-containing external composition for skin and a preparation method of the carbon dioxide-containing external composition for skin. The composition contains a component A and a component B, wherein the component A is carbon dioxide aqueous solution obtained by dissolving carbon dioxide in water to reach a saturated state, and the component B is a mixture composed of a thickener and a dispersant. When the component A and the component B are mixed, the viscosity of the mixture is rapidly increased to generate a sticky object, and thus carbon dioxide is stored in the sticky object. The obtained sticky object can be used for external application for the skin, and has the beautifying and treatment effects of carbon dioxide. The use method of the composition can be the direct mixed use of the component A and the component B, or the component B can be uniformly coated on a water-absorbent supporter and used by contacting with the component A.
Description
Technical field
The present invention relates to composition for external application containing carbon dioxide with beauty and skin care and therapeutic effect and preparation method thereof.
Background technology
Water containing carbon dioxide can just be known by blood circulation promoting for a long time, develops carbonated hot spring thus.Utilized the technology that the skin preparations for extenal use of the skin/hair cleaning supplies of this functional development of carbon dioxide containing carbon dioxide, spray and epithelium class is relevant afterwards.The external preparation of the epithelium class wherein containing carbon dioxide is because have very strong carbon dioxide percutaneous absorption, and it is remarkable that skin improves function, is the most widely used external carbon dioxide series products.
The known epithelium class skin preparations for extenal use containing carbon dioxide has two kinds.One uses carbon dioxide as raw material, to be stored in sticking material obtained through pressurization, such as: Japanese Patent Laid-Open 2002-255831, but this skin preparations for extenal use containing carbon dioxide not only preparation method program is complicated, and the skin preparations for extenal use made needs strict airtight preserving type just can avoid the volatilization of carbon dioxide.Another kind is the compositions containing carbonate and acid, by carbonate and acid mixing before using, generate carbon dioxide by carbonate and acid reaction and obtain skin preparations for extenal use, wherein widely used is the water soluble mixt of carbonate and the compositions of the granule of acid, but the carbonate water soluble mixture in this compositions has strong basicity, the granule of acid has highly acid, can cause the instability of other compositions in compositions, thus have the restricted problem of gradation composition.
Summary of the invention
The technical problem to be solved in the present invention be develop method for making simple, store and easy to use, components matching extensively, the product of the epithelium class skin preparations for extenal use containing carbon dioxide of excellent effect is target.
Technological means of the present invention and effect: a kind of composition for external application, be made up of A, B two kinds of components, wherein: component A is the water-soluble arbon dioxide solution to saturation of carbon dioxide, B component is the mixture of thickening agent and dispersant composition, and the weight ratio of A, B two kinds of components is selected from one or more the mixture in sodium alginate, Carboxymethyl cellulose sodium, ten smoke tree seeds, carrageenin, Tragacanth, tara gum, xanthan gum or locust bean gum for the thickening agent in B component described in 0.8:1-10.4:1..Dispersant in described B component can be solvent, also can be sugar.Described solvent is selected from one or more the mixture in diethylene glycol, propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol or hexanediol, and the weight ratio of described solvent and described thickening agent is 1.3:1-12.5:1.Described sugar to be selected from sucrose, glucose, fructose, lactose, xylitol, Sorbitol or mannitol one or more mixture, and the weight ratio of described sugar and described thickening agent is 3.3:1-33.7:1.
A preparation method for composition for external application, comprises the following steps:
(1) by water-soluble for carbon dioxide to saturation, obtained arbon dioxide solution, obtains component A;
(2) thickening agent and dispersant are obtained B component, wherein: thickening agent is selected from one or more the mixture in sodium alginate, Carboxymethyl cellulose sodium, ten smoke tree seeds, carrageenin, Tragacanth, tara gum, xanthan gum or locust bean gum, dispersant can be solvent also can be sugar;
(3) component A is mixed homogeneously according to weight ratio 0.8:1-10.4:1 with B component, obtained described compositions.
When being selected from one or more the mixture in diethylene glycol, propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol or hexanediol when the described solvent in step (2), the weight ratio of described solvent and thickening agent is 1.3:1-12.5:1.
When sugar described in step (2) to be selected from sucrose, glucose, fructose, lactose, xylitol, Sorbitol or mannitol one or more mixture, the weight ratio of described sugar and described thickening agent is 3.3:1-33.7:1.
Except A, B two kinds of components directly mix, also B component can be spread evenly across on water absorption carrier, then make B component contact obtained described compositions with component A.
The modulation compositions of the epithelium class skin preparations for extenal use containing carbon dioxide of the present invention, the arbon dioxide solution be easy to get is used to be raw material, mix with the mixture containing thickening agent before using, generating rapidly sticky matter at short notice makes carbon dioxide storage in sticky matter, this sticky matter after making immediately for external preparation for skin, gas concentration lwevel is high, and skin absorbs strong.The using method of compositions is simple, two parts directly can be mixed to get the skin preparations for extenal use containing carbon dioxide, or be first spread evenly across by Part II on absorptive carrier, then contacts the skin preparations for extenal use generated containing carbon dioxide with Part I.
Arbon dioxide solution used in the present invention has and faintly acid like skin, is suitable for coordinating each constituents, and effect of these gradation compositions combines with the blood circulation promotion functions of carbon dioxide, has better implementation result.
Therefore the preparation compositions raw material of the epithelium class skin preparations for extenal use containing carbon dioxide of the present invention is easy to get, preparation method is simple, storage package that need not be special, carbon dioxide percutaneous absorbtion Be very effective, the stability of compositions is high, the components matching scope of application is extensive, can be widely used in aesthetic nursing and the treatment field of known carbon dioxide skin.
Detailed description of the invention
Carbon dioxide absorbs through skin, blood circulation promoting, unique creeping chill/excitement and erythrosis phenomenon can be produced, when the skin preparations for extenal use containing carbon dioxide is after skin removing, skin can recover normal color in several minutes, by this phenomenon, R&D Professional has judged whether that carbon dioxide skin absorbs.
When skin absorbs enough carbon dioxide, skin can produce obvious creeping chill/excitement, and skin obviously reddens, as embodiment 1 simultaneously; When the absorbtivity of carbon dioxide is more weak, have more weak creeping chill/excitement, erythrosis degree is medium simultaneously, embodiment 13; When not having carbon dioxide in goo, but goo can make skin produce indistinct creeping chill skin can not redden, embodiment 11.The sensation of skin and the slightly difference such as body constitution of situation because of people that reddens, test in the crowd of tuerculoderma of the present invention more than at least 5 people, draw consistent result.
Carbon dioxide is soluble in water, 20 DEG C, 1 atmospheric pressure time, dissolubility is about 0.17g/100ml water, and be dissolved in carbon dioxide in water and water and react and generate carbonic acid, thus solution is in acid, and pH value is about 3.89.Along with the meltage of carbon dioxide reduces, the pH value of solution raises.When the pH of aqueous solution is 4.80, the carbon dioxide percutaneous absorption of the sticky matter modulated with this arbon dioxide solution is more weak, and the creeping chill/excitement of skin and erythrosis are not too obvious, experiment 14.In order to ensure to provide enough carbon dioxide, the pH value of aqueous solution should not higher than 4.50 at 20 DEG C, experiment 13.The arbon dioxide solution used in the present invention is not when stating, pH value is not higher than 4.0.
The thickening agent generating rapidly sticky matter upon contact with water used in the present invention is one or more mixture formed of sodium alginate, Carboxymethyl cellulose sodium, ten smoke tree seeds, carrageenin, Tragacanth, tara gum, xanthan gum, locust bean gum.
The use level of thickening agent is determined according to the performance of different thickening agent, and after coating skin with the sticky matter made, not sagging is bottom line.
Thickening agent in the present invention has the character generating rapidly sticky matter when mixed with water, and simultaneously because this characteristic, sticky matter can generate rapidly in local, and produces the phenomenon of caking.In order to avoid the generation of caking, we use and the miscible solvent of water or the sugar dispersant as thickening agent, as 1,3 butanediols, be scattered in advance wherein by thickening agent, form dispersion, this dispersion is when mixing with water, not only generate sticky matter rapidly, and generation of not luming.If solvent use level is too small, disperse uneven, desirable sticky matter can not be generated; If use level is excessive, the composition of water can be caused too low, be unfavorable for the dissolving of skin absorption and composition.Solvent is selected from one or more the mixture in diethylene glycol, propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol or hexanediol.The weight ratio of solvent and thickening agent is 1.3:1-12.5:1.When making dispersant with sugar, the sugar of use is selected from the saccharide of sucrose, glucose, fructose, lactose, xylitol, Sorbitol, mannitol etc., one or more mixture wherein.Sugar is 3.3:1-33.7:1. with the weight ratio of thickening agent
Embodiment
Embodiment 1:
By sodium alginate 0.25 gram, 1,3 butanediol 1.00 grams mix homogeneously, add carbonate aqueous solution 3.70 grams, mixing, there is bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 2:
By sodium carboxymethyl cellulose 0.15 gram, 1,3 butanediol 1.00 grams mix homogeneously, add carbonate aqueous solution 3.95 grams, mixing, there is bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 3:
By ten smoke tree seed 0.12 gram, 1,3 butanediol 1.20 grams mix homogeneously, add carbonate aqueous solution 3.30 grams, mixing, there is bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 4:
By sodium alginate 0.10 gram, sodium carboxymethyl cellulose 0.15 gram, sucrose 1.55 grams of mix homogeneously, add carbonate aqueous solution 5.20 grams, mixing, there is bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 5:
By carrageenin 0.25 gram, 1,3 butanediol 1.00 grams mix homogeneously, add carbonate aqueous solution 3.75 grams, mixing, there is bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 6:
By Tragacanth 0.20 gram, 1,3 butanediol 1.00 grams mix homogeneously, add carbonate aqueous solution 3.80 grams, mixing, there is bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 7:
By tara gum 0.21 gram, 1,3 butanediol 1.05 grams mix homogeneously, add carbonate aqueous solution 3.80 grams, mixing, there is bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 8:
By xanthan gum 0.25 gram, 1,3 butanediol 1.05 grams mix homogeneously, add carbonate aqueous solution 3.80 grams, mixing, there is bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 9:
By carrageenin 0.10 gram, locust bean gum 0.07 gram, 1,3 butanediol 1.00 grams mix homogeneously, add carbonate aqueous solution 5.20 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 10:
By sodium alginate 0.10 gram, sodium carboxymethyl cellulose 0.13 gram, 1,3 butanediol 1.00 grams mix homogeneously, add carbonate aqueous solution 3.70 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 11:
By sodium alginate 0.10 gram, sodium carboxymethyl cellulose 0.13 gram, 1,3BG1.50 gram of mix homogeneously, add 3.27 grams, tap water, mixing, have minute bubbles to generate, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, slightly cool feeling, without erythrosis phenomenon.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 12:
By sodium alginate 0.05 gram, sodium carboxymethyl cellulose 0.15 gram, 1,3 butanediol 2.50 grams mix homogeneously, add carbonate aqueous solution 2.50 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 13:
By sodium alginate 0.20 gram, sodium carboxymethyl cellulose 0.25 gram, 1,3BG1.50 gram of mix homogeneously, after carbonate aqueous solution takes out from container, be placed to pH4.50, get this carbonated water 8.05 grams and mix with mixture above, the sticky matter of generation is applied to the inner side of left hand forearm, there is creeping chill/excitement, medium, erythrosis in 5 minutes, redness is medium.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 14:
By sodium alginate 0.20 gram, CMCNa0.25 gram, 1,3BG1.00 gram of mix homogeneously, after carbonate aqueous solution takes out from container, place and stir and make bubble collapse, the pH4.80 of this solution, gets this carbonated water 8.00 grams and mixes with mixture above, the sticky matter of generation is applied to the inner side of left hand forearm, have creeping chill/excitement but strong, in 5 minutes, skin becomes micro-red.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 15:
By sodium alginate 0.10 gram, sodium carboxymethyl cellulose 0.13 gram, 1,3 butanediol 1.00 grams mix homogeneously, are spread evenly across on the non-woven fabrics of 5 centimetres x5 centimetre by this mixture, then water on coated non-woven fabrics and spill carbonate aqueous solution 3.70 grams, sticky matter is generated at non-woven fabrics upper surface, non-woven fabrics is placed in the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, remove on non-woven fabrics, clean skin with water.
Embodiment 16:
By sodium alginate 0.10 gram, sodium carboxymethyl cellulose 0.13 gram, sucrose 1.55 grams of mix homogeneously, this mixture is spread evenly across on the non-woven fabrics of 5 centimetres x5 centimetre, then water on coated non-woven fabrics and spill carbonate aqueous solution 5.20 grams, generate sticky matter at non-woven fabrics upper surface, non-woven fabrics is placed in the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, remove on non-woven fabrics, clean skin with water.
Embodiment 17:
By sodium alginate 0.25 gram, propylene glycol 1.00 grams of mix homogeneously, add carbonate aqueous solution 3.70 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 18:
By sodium alginate 0.25 gram, pentanediol 1.00 grams of mix homogeneously, add carbonate aqueous solution 3.70 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 19:
By sodium carboxymethyl cellulose 0.15 gram, propylene glycol 1.00 grams of mix homogeneously, add carbonate aqueous solution 3.95 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 20:
By sodium carboxymethyl cellulose 0.15 gram, pentanediol 1.00 grams of mix homogeneously, add carbonate aqueous solution 3.95 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 21:
By sodium alginate 0.25 gram, glycerol 1.00 grams of mix homogeneously, add carbonate aqueous solution 3.70 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 22:
By sodium carboxymethyl cellulose 0.15 gram, glycerol 1.00 grams of mix homogeneously, add carbonate aqueous solution 3.95 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, have strong creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 23:
By sodium carboxymethyl cellulose 0.15 gram, 1,3 butanediol 1.00 grams mix homogeneously, add the viscosity of carbonate aqueous solution to sticky matter not sagging on skin, the carbonate aqueous solution added is 7.92 grams, has bubble formation, this sticky matter is applied to the inner side of left hand forearm, there is creeping chill/excitement but strong, erythrosis in 5 minutes.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 24:
By sodium carboxymethyl cellulose 0.15 gram, 1,3 butanediol 1.00 grams mix homogeneously, add carbonate aqueous solution 1.41 grams, mixing, has bubble formation, generates tough sticky matter, this sticky matter is applied to the inner side of left hand forearm, has faint creeping chill/excitement, in 5 minutes, skin becomes micro-red.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 25:
By sodium carboxymethyl cellulose 0.15 gram, sucrose 1.50 grams of mix homogeneously, add carbonate aqueous solution 4.03 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 26:
By sodium carboxymethyl cellulose 0.15 gram, sucrose 0.50 gram of mix homogeneously, adds carbonate aqueous solution 4.09 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 27:
By sodium carboxymethyl cellulose 0.15 gram, sucrose 5.06 grams of mix homogeneously, add carbonate aqueous solution 4.05 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 28:
By sodium alginate 0.05 gram, sodium carboxymethyl cellulose 0.15 gram, 1,3 butanediol 0.25 gram mix homogeneously, add carbonate aqueous solution 4.70 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 29:
By sodium carboxymethyl cellulose 0.15 gram, fructose 1.50 grams of mix homogeneously, add carbonate aqueous solution 4.02 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 30:
By sodium carboxymethyl cellulose 0.15 gram, glucose 1.50 grams of mix homogeneously, add carbonate aqueous solution 4.10 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 31:
By sodium carboxymethyl cellulose 0.15 gram, lactose 1.50 grams of mix homogeneously, add carbonate aqueous solution 4.07 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 32:
By sodium carboxymethyl cellulose 0.15 gram, xylitol 1.50 grams of mix homogeneously, add carbonate aqueous solution 4.10 grams, mixing, have bubble formation, mixture viscosity increases gradually, generates transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 33:
By sodium carboxymethyl cellulose 0.15 gram, Sorbitol 1.50 grams of mix homogeneously, add carbonate aqueous solution 4.01 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment 34:
By sodium carboxymethyl cellulose 0.15 gram, mannitol 1.50 grams of mix homogeneously, add carbonate aqueous solution 4.05 grams, mixing, have bubble formation, mixture viscosity increases gradually, generate transparent sticky matter, this sticky matter is applied to the inner side of left hand forearm, has creeping chill/excitement, in 5 minutes, skin obviously reddens.After 30 minutes, with a tablet, sticky matter is wiped off, clean skin with water.
Embodiment experimental data:
The experimental data of table one: embodiment 1-11
The experimental data of table two: embodiment 12-22
The experimental data of table three: embodiment 23-34.
Claims (8)
1. a composition for external application, be made up of A, B two kinds of components, wherein: component A is the water-soluble arbon dioxide solution to saturation of carbon dioxide, B component is the mixture of thickening agent and dispersant composition, and the weight ratio of A, B two kinds of components is 0.8:1-10.4:1.
2. composition for external application according to claim 1, is characterized in that: the thickening agent in described B component is selected from one or more the mixture in sodium alginate, Carboxymethyl cellulose sodium, ten smoke tree seeds, carrageenin, Tragacanth, tara gum, xanthan gum or locust bean gum.
3. composition for external application according to claim 2, it is characterized in that: the dispersant in described B component is solvent, described solvent is selected from one or more the mixture in diethylene glycol, propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol or hexanediol, and the weight ratio of described solvent and described thickening agent is 1.3:1-12.5:1.
4. composition for external application according to claim 2, it is characterized in that: the dispersant in described B component is sugar, described sugar to be selected from sucrose, glucose, fructose, lactose, xylitol, Sorbitol or mannitol one or more mixture, and the weight ratio of described sugar and described thickening agent is 3.3:1-33.7:1.
5. a preparation method for composition for external application, comprises the following steps:
(1) by water-soluble for carbon dioxide to saturation, obtained arbon dioxide solution, obtains component A;
(2) thickening agent and dispersant are obtained B component, wherein: thickening agent is selected from one or more the mixture in sodium alginate, Carboxymethyl cellulose sodium, ten smoke tree seeds, carrageenin, Tragacanth, tara gum, xanthan gum or locust bean gum, dispersant can be solvent also can be sugar;
(3) component A is mixed homogeneously according to weight ratio 0.8:1-10.4:1 with B component, obtained described compositions.
6. the preparation method of a kind of composition for external application according to claim 5, it is characterized in that: described in step (2), solvent is selected from one or more the mixture in diethylene glycol, propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol or hexanediol, the weight ratio of described solvent and thickening agent is 1.3:1-12.5:1.
7. the preparation method of a kind of composition for external application according to claim 5, it is characterized in that: described in step (2), sugar to be selected from sucrose, glucose, fructose, lactose, xylitol, Sorbitol or mannitol one or more mixture, and the weight ratio of described sugar and thickening agent is 3.3:1-33.7:1.
8. the preparation method of a kind of composition for external application according to claim 5 ~ 7 any one, is characterized in that: B component be spread evenly across on water absorption carrier, then makes B component contact obtained described compositions with component A.
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| CN106266453A (en) * | 2016-08-31 | 2017-01-04 | 郑向东 | A kind of composition for external application and application thereof |
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| JP2000319187A (en) * | 1999-05-06 | 2000-11-21 | Medion Research Laboratories Inc | Carbon dioxide transcutaneous and transmucosal absorption composition |
| JP2002255831A (en) * | 2000-12-28 | 2002-09-11 | Medion Research Laboratories Inc | External preparation comprising carbon dioxide transdermal-transmucosal absorption composition filled in airtight container |
| CN1520305A (en) * | 2001-04-06 | 2004-08-11 | Ҳ | Compsns. for preparing external carbon dioxide agents |
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