CN104399121B - 一种制备人工骨用材料及其制备方法 - Google Patents
一种制备人工骨用材料及其制备方法 Download PDFInfo
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- CN104399121B CN104399121B CN201410627542.1A CN201410627542A CN104399121B CN 104399121 B CN104399121 B CN 104399121B CN 201410627542 A CN201410627542 A CN 201410627542A CN 104399121 B CN104399121 B CN 104399121B
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- artificial bone
- hydroxyapatite
- chitin
- calcium hydroxide
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 50
- 239000000463 material Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 24
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 24
- 229920002101 Chitin Polymers 0.000 claims abstract description 23
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 23
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 23
- 239000000920 calcium hydroxide Substances 0.000 claims abstract description 23
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 23
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims abstract description 20
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims abstract description 20
- 229940112869 bone morphogenetic protein Drugs 0.000 claims abstract description 20
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 239000001913 cellulose Substances 0.000 claims description 22
- 229920002678 cellulose Polymers 0.000 claims description 22
- 239000008119 colloidal silica Substances 0.000 claims description 22
- 239000003517 fume Substances 0.000 claims description 22
- XQSFXFQDJCDXDT-UHFFFAOYSA-N hydroxysilicon Chemical compound [Si]O XQSFXFQDJCDXDT-UHFFFAOYSA-N 0.000 claims description 22
- 239000003921 oil Substances 0.000 claims description 22
- -1 vinylsiloxane Chemical class 0.000 claims description 22
- 238000002156 mixing Methods 0.000 claims description 10
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims description 7
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims description 7
- 102000008143 Bone Morphogenetic Protein 2 Human genes 0.000 claims description 3
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 3
- 238000000465 moulding Methods 0.000 abstract description 2
- 229920001046 Nanocellulose Polymers 0.000 abstract 1
- 238000005260 corrosion Methods 0.000 abstract 1
- 230000007797 corrosion Effects 0.000 abstract 1
- 229910021485 fumed silica Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229920002545 silicone oil Polymers 0.000 abstract 1
- 229920002379 silicone rubber Polymers 0.000 abstract 1
- 239000004945 silicone rubber Substances 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004820 osteoconduction Effects 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
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- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
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CN104399121A CN104399121A (zh) | 2015-03-11 |
CN104399121B true CN104399121B (zh) | 2016-04-13 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106310379A (zh) * | 2016-08-30 | 2017-01-11 | 谢秋艳 | 一种改性纳米仿生复合材料及其应用 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105148324B (zh) * | 2015-08-31 | 2018-02-16 | 中原工学院 | 一种由矿化的纳米纤维素晶须构建的骨仿生材料及其制备方法 |
CN105903083A (zh) * | 2016-04-20 | 2016-08-31 | 苏州蔻美新材料有限公司 | 一种人工骨复合材料及其制备方法 |
CN106237380A (zh) * | 2016-08-30 | 2016-12-21 | 覃华贤 | 一种医用纳米复合材料及其制备方法 |
CN106215235A (zh) * | 2016-08-31 | 2016-12-14 | 周飞燕 | 一种模拟人骨的材料及其制备方法 |
CN106267362A (zh) * | 2016-08-31 | 2017-01-04 | 阮丽丽 | 一种仿生医用复合材料及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4798606A (en) * | 1985-02-26 | 1989-01-17 | Corvita Corporation | Reinforcing structure for cardiovascular graft |
CN102363050A (zh) * | 2011-06-29 | 2012-02-29 | 大连林桥科技有限公司 | 一种医用生物材料及其制备方法 |
CN102580583A (zh) * | 2012-03-30 | 2012-07-18 | 中蓝晨光化工研究设计院有限公司 | 一种硅橡胶超薄渗透膜的制备方法 |
Family Cites Families (1)
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CN102389344B (zh) * | 2006-02-07 | 2015-12-16 | 脊柱赛特有限公司 | 采用机械应变使人皮肤成纤维细胞发生软骨形成分化的方法 |
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- 2014-11-10 CN CN201410627542.1A patent/CN104399121B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4798606A (en) * | 1985-02-26 | 1989-01-17 | Corvita Corporation | Reinforcing structure for cardiovascular graft |
CN102363050A (zh) * | 2011-06-29 | 2012-02-29 | 大连林桥科技有限公司 | 一种医用生物材料及其制备方法 |
CN102580583A (zh) * | 2012-03-30 | 2012-07-18 | 中蓝晨光化工研究设计院有限公司 | 一种硅橡胶超薄渗透膜的制备方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106310379A (zh) * | 2016-08-30 | 2017-01-11 | 谢秋艳 | 一种改性纳米仿生复合材料及其应用 |
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Inventor after: Luo Wei Inventor after: Luo Qing Inventor after: Li Yucheng Inventor after: Lei Guanghua Inventor after: He Hongbo Inventor after: Xiao Wenfeng Inventor before: Pan Lingen Inventor before: Qiu Dongcheng Inventor before: Liu Lefeng |
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Effective date of registration: 20160316 Address after: 410000 Hunan province Changsha Xiangya Road No. 87 Applicant after: XIANGYA HOSPITAL OF CENTRAL SOUTH University Address before: Wuzhong District town Suzhou city Jiangsu province 215128 gold Jinchang Road No. 360 Applicant before: SUZHOU VIVOTIDE BIOTECHNOLOGIES Co.,Ltd. |
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