CN104398906A - 一种治疗急性胰腺炎的中药制剂及其制备方法 - Google Patents
一种治疗急性胰腺炎的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗急性胰腺炎的中药制剂及其制备方法,由下列重量份数的中药制成:华凤仙31-49份,小蓟26-37份,竹沥21-30份,大黄23-29份,蒲公英18-26份,芒硝15-27份,小九节铃11-18份,旋覆花9-14份,甘草7-15份,柴胡9-16份。本发明的中药具有健脾益肺、舒肝解郁、活血化瘀、清热燥湿的功效,其治疗急性胰腺炎疗效显著,作用可靠,其组分药源广、配制简便、无毒副作用。本发明制得的药物能够安全有效治愈急性胰腺炎。
Description
技术领域
本发明公开了一种治疗急性胰腺炎的中药制剂及其制备方法,属于中药制备技术领域。
背景技术
急性胰腺炎是由多种因素参与的复杂的病理生理过程,各因素之间既相互独立又相互渗透,共同促进疾病的发生发展,可造成全身性多器官细胞广泛受损,对血管张力和渗透性产生影响,导致循环系统障碍,发生休克和全身性炎症反应综合征,多器官功能障碍综合征,重症急性胰腺炎发病急,进展快,临床表现凶险,其死亡率可高达40%,并发症多,是一种病死率较高的急腹症。
发现胰腺炎应及时治疗,中药调理治疗是最好的辅助治疗办法,可大大提高胰腺炎的治愈率及缩短恢复时间。目前治疗急性胰腺炎的中药制剂以泻下、理气、清热、活血为主,应用最多的是大黄,应用频率达到90%以上,其次是芒硝、柴胡、厚朴等。常用处方为:黄芩、银花、连翘、山栀、枳实、广木香、生大黄、玄明粉等。食积者另加保和丸;针刺及耳针亦可达止痛效果。但目前治疗急性胰腺炎的中药制剂方剂庞杂,大多数服用后不能治本,复发率高,限制其进一步推广应用。
发明内容
本发明所要解决的技术问题是提供一种治愈率高且不复发的急性胰腺炎中药配方,并提供一种制备方法。
为解决上述技术问题,本发明采用的技术方案是:
本发明提供的治疗急性胰腺炎的中药制剂,由下列重量份数的中药制成:华凤仙31-49份,小蓟26-37份,竹沥21-30份,大黄23-29份,蒲公英18-26份,芒硝15-27份,小九节铃11-18份,旋覆花9-14份,甘草7-15份,柴胡9-16份。
优选的,所述的治疗急性胰腺炎的中药制剂由下列重量份数的中药制成:华凤仙40份,小蓟31份,竹沥26份,大黄25份,蒲公英22份,芒硝23份,小九节铃16份,旋覆花12份,甘草11份,柴胡12份。
优选的,所述的治疗急性胰腺炎的中药制剂由下列重量份数的中药制成:华凤仙45份,小蓟35份,竹沥28份,大黄27份,蒲公英24份,芒硝25份,小九节铃14份,旋覆花10份,甘草14份,柴胡14份。
优选的,所述的治疗急性胰腺炎的中药制剂由下列重量份数的中药制成:华凤仙31份,小蓟26份,竹沥21份,大黄23份,蒲公英18份,芒硝15份,小九节铃11份,旋覆花9份,甘草7份,柴胡9份。
本发明还提供了一种上述治疗急性胰腺炎的中药制剂的制备方法,包括下列步骤:
(1)按照重量配比取所述药材,加入重量为药材总重量5-8倍的水,50-60摄氏度浸泡10-18个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态20-30分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)2-5次,合并所得的药液。
优选的,浸泡之前将步骤(1)中的药材研磨成300-500目的粉末。
本发明提供了一种步骤(2)中的水温梯度升高到沸腾的方式,具体是:水温每3-5分钟升高10摄氏度,并且每升高10摄氏度保持10分钟。
下面结合临床实验数据说明本发明的有益效果:
一、一般性资料:
本中药应用于临床观察病例75例,其中男45例,女30例,年龄18-69岁。病程最短者半个月,最长者达半年。
二、诊断标准:
1、实验室检查:(1)胰酶测定:血清淀粉酶值明显升高>500U/dl。包括白细胞增高,高血糖,肝功能异常,低血钙、血气分析及DIC指标异常等.
2、放射影像学诊断:(1)胸部X线片:左肺下叶不张,左半膈肌升高,左侧胸水等反映膈肌周围及腹膜后的炎症。(2)腹部平片:可见十二指肠充气,表示近段空肠麻痹扩张。还可见结肠中断征,表示横结肠麻痹扩张,脾曲结肠和远段结肠内无气体影,或可见到胆结石影和胰管结石影,及腰大肌影消失等。(3)腹部B超:可帮助诊断,B超扫描能发现胰腺水肿和胰周液体的积聚。(4)增强CT扫描:胰腺的改变包括弥漫性或局灶性胰腺增大。水肿,坏死液化,胰腺周围组织变模糊,增厚,并可见积液。
三、用法用量:
取华凤仙40克,小蓟31克,竹沥26克,大黄25克,蒲公英22克,芒硝23克,小九节铃16克,旋覆花12克,甘草11克,柴胡12克。
研磨成400目的粉末,加入重量为药材总重量7倍的水,55摄氏度浸泡16个小时;
将水温梯度升高,水温每4分钟升高10摄氏度,并且每升高10摄氏度保持10分钟,到沸腾,保持沸腾状态25分钟,过滤得药液和药渣;将药渣重复上述步骤3次,合并所得的药液。
用量为每次300-400毫升,每天两次,分早、晚两次饭前半小时温热服用。7天为一个疗程。
四、疗效标准:
(1)治愈:临床主要症状及体征消失,炎症好转达轻度;
(2)显效:临床主要症状消失,次要症状基本消失,炎症好转;
(3)有效:主要症状明显减轻,炎症有所减轻;
(4)无效;主要症状无变化,也未恶化。
五、治疗效果:
临床观察病例中,服药7-30天,治愈63例,显效8例,有效2例,无效2例。治疗期间未发生其他副作用。
本发明的中药具有健脾益肺、舒肝解郁、活血化瘀、清热燥湿的功效,其治疗急性胰腺炎疗效显著,作用可靠,其组分药源广、配制简便、无毒副作用。本发明制得的药物能够安全有效治愈急性胰腺炎。
具体实施方式
实施例1
本实施例提供的治疗急性胰腺炎的中药制剂由下列重量克数的中药制成:华凤仙45克,小蓟35克,竹沥28克,大黄27克,蒲公英24克,芒硝25克,小九节铃14克,旋覆花10克,甘草14克,柴胡14克。
上述治疗急性胰腺炎的中药制剂的制备方法,包括下列步骤:
取上述中药,研磨成400目的粉末,加入重量为药材总重量8倍的水,55摄氏度浸泡18个小时;
将水温梯度升高,水温每5分钟升高10摄氏度,并且每升高10摄氏度保持10分钟,到沸腾,保持沸腾状态30分钟,过滤得药液和药渣;将药渣重复上述步骤3次,合并所得的药液。
用量为每次300-400毫升,每天两次,分早、晚两次饭前半小时温热服用。7天为一个疗程。
实施例2
本实施例提供的治疗急性胰腺炎的中药制剂由下列重量克数的中药制成:华凤仙31克,小蓟26克,竹沥21克,大黄23克,蒲公英18克,芒硝15克,小九节铃11克,旋覆花9克,甘草7克,柴胡9克。
上述治疗急性胰腺炎的中药制剂的制备方法,包括下列步骤:
取上述中药,研磨成400目的粉末,加入重量为药材总重量6倍的水,55摄氏度浸泡14个小时;
将水温梯度升高,水温每3分钟升高10摄氏度,并且每升高10摄氏度保持10分钟,到沸腾,保持沸腾状态25分钟,过滤得药液和药渣;将药渣重复上述步骤3次,合并所得的药液。
用量为每次300-400毫升,每天两次,分早、晚两次饭前半小时温热服用。7天为一个疗程。
实施例3
本实施例提供的治疗急性胰腺炎的中药制剂由下列重量克数的中药制成:华凤仙45克,小蓟35克,竹沥28克,大黄27克,蒲公英24克,芒硝25克,小九节铃14克,旋覆花10克,甘草14克,柴胡14克。
上述治疗急性胰腺炎的中药制剂的制备方法,包括下列步骤:
取上述中药,研磨成400目的粉末,加入重量为药材总重量7倍的水,55摄氏度浸泡13个小时;
将水温梯度升高,水温每3分钟升高10摄氏度,并且每升高10摄氏度保持10分钟,到沸腾,保持沸腾状态25分钟,过滤得药液和药渣;将药渣重复上述步骤3次,合并所得的药液。
用量为每次300-400毫升,每天两次,分早、晚两次饭前半小时温热服用。7天为一个疗程。
典型病例:
病例1:
王某,男,45岁,暴饮暴食后出现上腹痛,并伴有恶心感、有发热症状,诊断为急性胰腺炎。服用本发明的中药组合物制备的药剂7天,症状基本消失,偶有腹痛;继续巩固3天,诸症状均消失,治愈。
病例2:
钱某,男,51岁,酗酒后出现上腹钝痛、腹胀,不饥而呕,发热。诊断为急性胰腺炎,服用本发明的中药组合物制备的药剂2天,腹痛、腹胀稍减轻,不再呕吐,身体不再发热,续服10天,症状谐除,痊愈。
病例3:
刘某,男,54岁,饮酒膈出现腹痛、腹胀,伴有呕吐、恶心,有发热症状,经查体,确诊为急性胰腺炎。在辅以抗生素治疗的同时服用本发明的中药组合物制备的药剂,7天后,症状基本消失,偶有腹痛;停止抗生素治疗,继续巩固服用本发明的中药组合物制备的药剂6天,诸症状均消失,治愈。
Claims (7)
1. 一种治疗急性胰腺炎的中药制剂,由下列重量份数的中药制成:华凤仙31-49份,小蓟26-37份,竹沥21-30份,大黄23-29份,蒲公英18-26份,芒硝15-27份,小九节铃11-18份,旋覆花9-14份,甘草7-15份,柴胡9-16份。
2. 根据权利要求1所述的治疗急性胰腺炎的中药制剂,由下列重量份数的中药制成:华凤仙40份,小蓟31份,竹沥26份,大黄25份,蒲公英22份,芒硝23份,小九节铃16份,旋覆花12份,甘草11份,柴胡12份。
3. 根据权利要求1所述的治疗急性胰腺炎的中药制剂,由下列重量份数的中药制成:华凤仙45份,小蓟35份,竹沥28份,大黄27份,蒲公英24份,芒硝25份,小九节铃14份,旋覆花10份,甘草14份,柴胡14份。
4. 根据权利要求1所述的治疗急性胰腺炎的中药制剂,由下列重量份数的中药制成:华凤仙31份,小蓟26份,竹沥21份,大黄23份,蒲公英18份,芒硝15份,小九节铃11份,旋覆花9份,甘草7份,柴胡9份。
5. 上述任一项权利要求所述的治疗急性胰腺炎的中药制剂的制备方法,包括下列步骤:
(1)按照重量配比取所述药材,加入重量为药材总重量5-8倍的水,50-60摄氏度浸泡10-18个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态20-30分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)2-5次,合并所得的药液。
6. 根据权利要求5所述的制备方法,其特征在于,浸泡之前将步骤(1)中的药材研磨成300-500目的粉末。
7. 根据权利要求5所述的制备方法,其特征在于,步骤(2)中的水温梯度升高到沸腾的方式是:水温每3-5分钟升高10摄氏度,并且每升高10摄氏度保持10分钟。
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