CN104398594A - Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof - Google Patents

Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof Download PDF

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CN104398594A
CN104398594A CN201410601255.3A CN201410601255A CN104398594A CN 104398594 A CN104398594 A CN 104398594A CN 201410601255 A CN201410601255 A CN 201410601255A CN 104398594 A CN104398594 A CN 104398594A
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刘诚聪
赵彩虹
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Abstract

The invention relates to a pharmaceutical composition for treating children's inguinal hernia and its preparation method and use in drug preparation. The pharmaceutical composition comprises an oral administration component comprising 3-100 parts of honey-fried licorice root, 3-100 parts of spatholobus stem, 3-100 parts of achyranthes root, 3-100 parts of rhizoma corydalis and 1-50 parts of giant knot weed and also comprises an external application component comprising 10-120 parts of white pepper, 10-120 parts of lychee seed and 1-20 parts of camphor. The pharmaceutical composition utilizes traditional Chinese medicines as raw materials, has the advantage of low toxic or side effects of the traditional Chinese medicines, realizes treatment on children's hernia by combination of traditional Chinese medicine oral administration and external application, provides a safe, effective, cheap and simple treatment method for young patients, can be widely popularized and has a high clinical application value.

Description

A kind ofly treat pharmaceutical composition of children inguinal hernia gas and preparation method thereof
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof and pharmaceutical applications, particularly relate to and a kind ofly treat pharmaceutical composition of children inguinal hernia gas and preparation method thereof and pharmaceutical applications.
Background technology
Hernia is that abdominal visceral browser or tissue enter another position by congenital or that formed the day after tomorrow weak spot, defect or hole, abdominal visceral browser or tissue are abdominal external hernia together with the hernia that parietal peritoneum is outstanding to body surface, its content mostly is small intestinal, and abdominal external hernia is common with inguinal hernia again.
Children inguinal hernia is common congenital abnormal development, can be divided into indirect inguinal hernia and straight hernia, and that sees clinically is almost oblique hernia, straight hernia is very rare, its sickness rate is higher, is 0.8% ~ 4.4% according to the literature, and the sickness rate of premature infant is 4.8%, male is in the great majority, M-F is 15:1, and site of pathological change is common with right side, accounts for 60%, left side is 25%, and bilateral is 15%.Pathogenic factor is mainly the congenital processus vaginalis patent of infant or inadequacy forms hole, the weakness that abdominal wall muscle hypoplasia and spermatic cord or round ligament of uterus are formed by inguinal canal and defect make local defense ability decline, when children's cry and scream intra-abdominal pressure is increased time abdomen content outstanding and send out primary disease to body surface since then, clinical manifestation is for crying, falling inflation sense, touch a tender spot and groin or scrotal mass, but do not hinder activity, standing, the thing that swells when crying and screaming or exert oneself occurs or increases, flat sleeping, after sleep, swollen thing diminishes or disappears, swollen thing gently upwardly can be made also to receive abdominal cavity with have gentle hands.
High ligation of hernial sac traditional is clinically its treatment " goldstandard " at present, but there is the complication such as hematoma of scrotum, infection of incisional wound, postoperative pain, scrotum or atrophy of testis, peritoneal free cancer cells and hernia recurrence in operative treatment, also likely causes harmful effect to the psychology of infant; In addition, the clinical hernia truss that also often uses is treated, and has certain curative effect, but for child more than one full year of life, because it is often movable, easily produce displacement when wearing, affect therapeutic effect ewborn infant.Therefore, need a kind of safe and effective, toxic and side effects is little, low cost and operation and the easy medicine of preparation method and Therapeutic Method.
Summary of the invention
In order to solve above technical problem, inventor has created GANTENG soup and the loose two kinds of Chinese prescriptions of hernia core, close external application compression method treatment infantile hernia by oral medicinal herb, significant therapeutical effect can be played, and there is the advantages such as evident in efficacy, side effect is little, cost is low, operational approach is easy.
Primary disease belongs to motherland's medical science " inguinal hernia " scope, thinks " all hernias cloudy conception vessel of fainting is sick, the evil coacervation of exopathogenic factor wind and cold; endogenous cause of ill wets heat stagnated by cold ", namely hernia be conception vessel and JUE YIN meridian two through pathological changes, interior because children's's congenital defect, body constitution is poor, in addition affection of exogenous wind-cold or internal injury diet, or due to damp and hot interior strongly fragrant, the with the passing of time turbid poison of accumulateing, invaded by outside cold-evil again, inflow is fainted cloudy Liver Channel, is detained not all right, so that ecchymosis condensation and herniae.Primary disease is dialectical is QI and blood deficiency, caused by the stagnant liver network of malicious stasis blocking.Therefore, for primary disease pathogenesis, should adopt vigorate qi and replenish the blood, stasis-dispelling and pain-killing, dispelling toxins and dredging collaterals is main Therapeutic Principle, fundamentally treats infantile hernia.
Pharmaceutical composition of the present invention comprises (parts by weight):
GANTENG soup: Radix Glycyrrhizae Preparata 3-100 part, Caulis Spatholobi 3-100 part, Radix Achyranthis Bidentatae 3-100 part, Rhizoma Corydalis 3-100 part, Rhizoma Polygoni Cuspidati 1-50 part;
Hernia core falls apart: Radix orixae japonicae 10-120 part, Semen Litchi 10-120 part, Camphora 1-20 part.
Material medicine preferred weight number is:
GANTENG soup: Radix Glycyrrhizae Preparata 5-50 part, Caulis Spatholobi 5-50 part, Radix Achyranthis Bidentatae 5-50 part, Rhizoma Corydalis 5-50 part, Rhizoma Polygoni Cuspidati 1-25 part;
Hernia core falls apart: Radix orixae japonicae 20-60 part, Semen Litchi 20-60 part, Camphora 1-10 part.
Material medicine is more preferably parts by weight:
GANTENG soup: Radix Glycyrrhizae Preparata 10 parts, Caulis Spatholobi 10 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Corydalis 10 parts, Rhizoma Polygoni Cuspidati 3 parts;
Hernia core falls apart: Radix orixae japonicae 25 parts, Semen Litchi 25 parts, Camphora 2 parts.
In square GANTENG soup for oral administration, Radix Glycyrrhizae Preparata is monarch, its sweet in the mouth, and property is put down, and returns 12 warps, has QI invigorating invigorating middle warmer, relieving spasm to stop pain, eliminating fire and detoxication, the merit of coordinating the actions of various ingredients in a prescription; Caulis Spatholobi is minister, and its sweet in the mouth is warm in nature, returns liver, kidney channel, enriches blood, invigorate blood circulation, the merit of dredging collateral; Radix Glycyrrhizae Preparata and Caulis Spatholobi are harmonious, the purport of ancestor's " capable then blood of gas ", and gas promoting the circulation of blood is lived, blood vessels tonneau, stasis of blood hernia of faling apart disappears; Radix Achyranthis Bidentatae is minister, its bitter in the mouth, acid, and property is put down, and return liver, kidney channel, have the merit of promoting blood circulation to restore menstrual flow, sweet in the mouth can be mended, and can puckeryly can hold back, and under hardship of holding concurrently is straight, enters kidney with it; Rhizoma Corydalis, its acrid in the mouth is bitter, and warm in nature, enter the heart, spleen, liver, lung, have blood circulation promoting and blood stasis dispelling, the merit of promoting the circulation of QI to relieve pain, be adjuvant drug, it can enter blood system, enters edema caused by disorder of QI again, can gas in promoting the circulation of blood, again can blood in circulation of qi promoting, the smooth blood of gas, and general rule is not bitterly; Rhizoma Polygoni Cuspidati, its bitter in the mouth, acid, property is put down, and returns liver, gallbladder meridian, and enter blood and fall apart, promoting blood circulation to remove blood stasis, expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling, is adjuvant, embodies vigorate qi and replenish the blood, stasis-dispelling and pain-killing, and the Therapeutic Principle of dispelling toxins and dredging collaterals is just in step with the pathogenesis of hernia.
During external application side's hernia core is loose, Radix orixae japonicae, its acrid in the mouth, warm in nature, return stomach warp, large intestine channel, have warming spleen and stomach for dispelling cold, the merit of the therapeutic method to keep the adverse QI flowing downwards, expectorant; Semen Litchi, its sweet in the mouth, warm in nature, return liver, kidney channel, have promoting QI to circulate and dispersing the agglomeration of the pathogens, the merit of cold-dispelling pain-relieving, for colic of cold type stomachache, painful and swollen testis; Camphora, its acrid in the mouth, hot in nature, GUIXIN, spleen channel, have orifice opening, qi stagnation removing, wards off foul, killing parasites for relieving itching, the merit of reducing swelling and alleviating pain; Three is harmonious, and make through beniol, ecchymosis is gone, and hernia is multiple.
Meanwhile, application strengthens on the one hand the intensity of stomach wall by external force, hernical sac can be made to stick together and short hernical sac closes hernia ring and reduces gradually, finally completely closed because of the growth of health; On the other hand by the osmotic absorption of abdominal skin to Chinese medicine, produce warming the meridian in vivo by cold, the merit of regulating QI to relieve pain, finally reach effect of the logical conception vessel of temperature and Liver Channel.
The preparation method of above-mentioned side for oral administration is: get the mixing of described material medicine and put into marmite, add water and do not have powder to soak 30 minutes, big fire changes slow fire boiling 30 minutes after boiling, leach medicinal liquid, then decocts with water 20 minutes, leaches medicinal liquid, and twice filtrate merges and get final product;
Or get material medicine in proportion to decoct with water, filter and obtain filtrate 1, filtering residue decocts with water again, filter and obtain filtrate 2, merge twice filtrate, concentrated, precipitate with ethanol, filtering supernatant, reclaim ethanol, concentrate and obtain extractum, add adjuvant common on pharmaceutics and be prepared into oral liquid or granule.
The preparation method that above-mentioned hernia core is loose is: by described material medicine grind into fine powder, mixed by powder and get final product, getting appropriate powder and appropriate Oleum Sesami furnishing pasty state, spread on sufferer place during use, covers gauze and fixes.
The invention has the beneficial effects as follows: take Chinese medicine as raw material, play the advantage that herbal toxic effect is low, closed application treatment infantile hernia by oral medicinal herb, for young patient provides safety, effective, cheap, easy Therapeutic Method, be easy to extensive popularization, there is higher clinical value.
Detailed description of the invention
In order to understand the present invention further, below in conjunction with embodiment, the preferred embodiment of the invention is described, but should be appreciated that these describe just for further illustrating the features and advantages of the present invention, instead of limiting to the claimed invention.
embodiment 1:
Prescription:
GANTENG soup: Radix Glycyrrhizae Preparata 20g, Caulis Spatholobi 20g, Radix Achyranthis Bidentatae 20g, Rhizoma Corydalis 20g, Rhizoma Polygoni Cuspidati 6g;
Hernia core falls apart: Radix orixae japonicae 50g, Semen Litchi 50g, Camphora 5g.
Preparation method:
GANTENG soup: get the mixing of described material medicine and put into marmite, add water and do not have powder to soak 30 minutes, big fire changes slow fire boiling 30 minutes after boiling, leach medicinal liquid, then decocts with water 20 minutes, leaches medicinal liquid, and twice filtrate merges and get final product;
Hernia core falls apart: by described material medicine grind into fine powder, mixed by powder and get final product.
Instructions of taking: GANTENG soup every day 2 times, point sooner or later twice one after each meal, taking drug withdrawal in 2 weeks 1 week, 3 weeks was 1 course for the treatment of, treated 3 courses for the treatment of; Hernia core is loose to be got appropriate powder and appropriate Oleum Sesami furnishing pasty state, spreads on sufferer place once a day during use, cover gauze and fix.
embodiment 2:
Prescription:
GANTENG soup: Radix Glycyrrhizae Preparata 30g, Caulis Spatholobi 30g, Radix Achyranthis Bidentatae 30g, Rhizoma Corydalis 30g, Rhizoma Polygoni Cuspidati 10g;
Hernia core falls apart: Radix orixae japonicae 40g, Semen Litchi 40g, Camphora 4g.
Preparation method:
GANTENG soup: get above-mentioned raw materials medicament mixed, add material medicine 6 times of water gagings, first time decocts 30min, filtration obtains filtrate 1, filtering residue adds material medicine 4 times amount soak by water 30min, filtration obtains filtrate 2, merge twice filtrate, being concentrated into relative density under room temperature is the concentrated solution of 1.1-1.2, add mass percent concentration be more than 95% alcoholic solution make concentrated solution alcohol content reach 60% to carry out precipitate with ethanol, precipitate with ethanol is filtering supernatant after 48 hours, reclaim ethanol, being concentrated to relative density under room temperature is the extractum of 1.3-1.4, adding purified water makes crude drug amount be 2g/ml, adjust ph is 7.5, add 0.1% strawberry essence, 0.1% aspartame, after mix homogeneously, fill becomes 10ml oral liquid, 100 DEG C of sterilizings 45 minutes, obtain oral liquid,
Hernia core falls apart: by described material medicine grind into fine powder, mixed by powder and get final product.
Instructions of taking: GANTENG soup oral liquid every day 2 times, each 1, point sooner or later twice one after each meal, taking drug withdrawal in 2 weeks 1 week, 3 weeks was 1 course for the treatment of, treated 3 courses for the treatment of; Hernia core is loose to be got appropriate powder and appropriate Oleum Sesami furnishing pasty state, spreads on sufferer place once a day during use, cover gauze and fix.
embodiment 3: pharmaceutical composition is tested the therapeutic effect of infantile hernia:
a, samples selection:
Case collect: with do not accept surgical intervention 0.6-4 year children inguinal hernia infant for subjects.
Diagnostic criteria: inguinal region finds transmutability " pears shape " or " sausage shape " enclosed mass, enclosed mass is given prominence to from superficial inguinal ring, can reach in scrotum or in labium majus, the soft person of enclosed mass, also can receive to abdominal cavity during extruding, compressing internal ring can stop enclosed mass to occur, subcutaneous widening of the ring, has impulsion sense during infant cough, during enclosed mass incarceration, except local pain, stomachache is normal with vomiting, is diagnosed as inguinal hernia; Exclusion standard: have the infant of other serious diseases as serious hepatorenal disease, child with cancer, and to the method person that has serious adverse reaction.
Collect infant 524 example altogether, it is divided into 4 groups at random, often organize 131 examples, matched group wears hernia truss treatment.
Criterion of therapeutical effect:
Recovery from illness: transference cure after treatment, hernia mouth closes, and follows up a case by regular visits to and does not reaccess;
Effective: after treatment, attack times minimizing or hernia ring obviously diminish;
Invalid: before and after treatment, symptom is without change.
, clinical treatment:
Treatment group:
Endo-medicine: treatment group 1 and treatment group 2 take the decoction of embodiment 1 orally, every day 2 times, takes drug withdrawal in 2 weeks 1 week, within 3 weeks, is 1 course for the treatment of, treats 3 courses for the treatment of; Treatment group 3 takes the oral liquid of embodiment 2 orally, every day 2 times, takes drug withdrawal in 2 weeks 1 week, within 3 weeks, is 1 course for the treatment of, treats 3 courses for the treatment of.
Liniment: treatment group 1-3 respectively once a day, gets appropriate powder and appropriate Oleum Sesami furnishing pasty state, spreads on sufferer place during use, cover gauze and fix.
Matched group: wear hernia truss treatment.
, therapeutic effect observe:
Experimental result:
Visible, pharmaceutical composition of the present invention has obvious therapeutical effect for children inguinal hernia.
Content of the present invention merely illustrates some claimed specific embodiments; one of them or more described technical characteristic can be combined with arbitrary one or more technical scheme in technical scheme; these technical schemes obtained through combination also in the application's protection domain, just as these technical schemes obtained through combination in the disclosure of invention concrete record.

Claims (10)

1. be used for the treatment of a pharmaceutical composition for children inguinal hernia, it is characterized in that: comprise following medicine and be prepared from according to parts by weight: side for oral administration: Radix Glycyrrhizae Preparata 3-100 part, Caulis Spatholobi 3-100 part, Radix Achyranthis Bidentatae 3-100 part, Rhizoma Corydalis 3-100 part, Rhizoma Polygoni Cuspidati 1-50 part; External application side: Radix orixae japonicae 10-120 part, Semen Litchi 10-120 part, Camphora 1-20 part.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, the parts by weight of material medicine are: Radix Glycyrrhizae Preparata 5-50 part, Caulis Spatholobi 5-50 part, Radix Achyranthis Bidentatae 5-50 part, Rhizoma Corydalis 5-50 part, Rhizoma Polygoni Cuspidati 1-25 part, Radix orixae japonicae 20-60 part, Semen Litchi 20-60 part, Camphora 1-10 part.
3. pharmaceutical composition as claimed in claim 1, it is characterized in that, the parts by weight of material medicine are: Radix Glycyrrhizae Preparata 10 parts, Caulis Spatholobi 10 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Corydalis 10 parts, Rhizoma Polygoni Cuspidati 3 parts, Radix orixae japonicae 25 parts, Semen Litchi 25 parts, Camphora 2 parts.
4. pharmaceutical composition as described in claim 1-3, is characterized in that, the preparation method of side for oral administration is: the material medicine getting corresponding weight, decocts with water to obtain decoction and take, every day potion, point sooner or later twice one after each meal; Or get material medicine in proportion to decoct with water, filter and obtain filtrate 1, filtering residue decocts with water again, filter and obtain filtrate 2, merge twice filtrate, concentrated, precipitate with ethanol, filtering supernatant, reclaim ethanol, concentrate and obtain extractum, add adjuvant common on pharmaceutics and be prepared into oral liquid or granule.
5. pharmaceutical composition as claimed in claim 4, it is characterized in that, get above-mentioned raw materials medicament mixed, add material medicine 6 times of water gagings, first time decocts 30min, filtration obtains filtrate 1, filtering residue adds material medicine 4 times amount soak by water 30min, filtration obtains filtrate 2, merge twice filtrate, being concentrated into relative density under room temperature is the concentrated solution of 1.1-1.2, add mass percent concentration be more than 95% alcoholic solution make concentrated solution alcohol content reach 60% to carry out precipitate with ethanol, precipitate with ethanol is filtering supernatant after 48 hours, reclaim ethanol, being concentrated to relative density under room temperature is the extractum of 1.3-1.4, adding purified water makes crude drug amount be 2g/ml, adjust ph is 7.5, add 0.1% strawberry essence, 0.1% aspartame, after mix homogeneously, fill becomes 10ml oral liquid, 100 DEG C of sterilizings 45 minutes, obtain oral liquid.
6. pharmaceutical composition as described in claim 1-3, is characterized in that, the preparation method of external application side is: by described material medicine grind into fine powder, powder is mixed and get final product, get appropriate powder and appropriate Oleum Sesami furnishing pasty state during use, spread on sufferer place, cover gauze and fix.
7. prepare a method for arbitrary pharmaceutical composition as described in claim 1-3, it is characterized in that, the preparation method of side for oral administration is: the material medicine getting corresponding weight, decocts with water to obtain decoction and take, every day potion, point sooner or later twice one after each meal; Or get material medicine in proportion to decoct with water, filter and obtain filtrate 1, filtering residue decocts with water again, filter and obtain filtrate 2, merge twice filtrate, concentrated, precipitate with ethanol, filtering supernatant, reclaim ethanol, concentrate and obtain extractum, add adjuvant common on pharmaceutics and be prepared into oral liquid or granule.
8. prepare the method for pharmaceutical composition as claimed in claim 7 for one kind, it is characterized in that: get the mixing of corresponding material medicine, add material medicine 6 times of water gagings, first time decocts 30min, filtration obtains filtrate 1, filtering residue adds material medicine 4 times amount soak by water 30min, filtration obtains filtrate 2, merge twice filtrate, being concentrated into relative density under room temperature is the concentrated solution of 1.1-1.2, add mass percent concentration be more than 95% alcoholic solution make concentrated solution alcohol content reach 60% to carry out precipitate with ethanol, precipitate with ethanol is filtering supernatant after 48 hours, reclaim ethanol, being concentrated to relative density under room temperature is the extractum of 1.3-1.4, adding purified water makes crude drug amount be 2g/ml, adjust ph is 7.5, add 0.1% strawberry essence, 0.1% aspartame, after mix homogeneously, fill becomes 10ml oral liquid, 100 DEG C of sterilizings 45 minutes, obtain oral liquid.
9. prepare a method for arbitrary pharmaceutical composition as described in claim 1-3, it is characterized in that, the preparation method of external application side is: by described material medicine grind into fine powder, powder is mixed and get final product, get appropriate powder and appropriate Oleum Sesami furnishing pasty state during use, spread on sufferer place, cover gauze and fix.
10. described in a claim 1-6, any combination thing is used for the treatment of the purposes of children inguinal hernia.
CN201410601255.3A 2014-11-01 2014-11-01 Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof Pending CN104398594A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840441A (en) * 2020-08-15 2020-10-30 唐钰暘 A Chinese medicinal powder for treating hernia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840441A (en) * 2020-08-15 2020-10-30 唐钰暘 A Chinese medicinal powder for treating hernia

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