CN104383417A - 一种治疗乳腺癌的药物 - Google Patents

一种治疗乳腺癌的药物 Download PDF

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CN104383417A
CN104383417A CN201410706234.8A CN201410706234A CN104383417A CN 104383417 A CN104383417 A CN 104383417A CN 201410706234 A CN201410706234 A CN 201410706234A CN 104383417 A CN104383417 A CN 104383417A
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radix
rhizoma
fructus
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root
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高敏
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Shandong Provincial Hospital
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Abstract

本发明公开了一种治疗乳腺癌的药物。它由下述原料药制成:柴胡、水飞蓟、龙胆、佛手、酸枣仁、石菖蒲、远志、黄精、白术、陈皮、山药、砂仁、山楂、人参、黄芪、红景天、川芎、牛膝、红花、牡丹皮、鸦胆子、穿心莲、大黄、玄参、枳实、昆布、没药和甘草。以本发明的药物治疗乳腺癌,总有效率为100%。

Description

一种治疗乳腺癌的药物
技术领域
本发明涉及一种治疗乳腺癌的药物,属于医药技术领域。
背景技术
乳腺癌是女性最常见的恶性肿瘤之一,据资料统计,其发病率占全身各种恶性肿瘤的7-10%。在妇女中乳腺癌仅次于子宫癌,是一种严重影响妇女身心健康甚至危及生命的最常见的恶性肿瘤之一。在中国乳腺癌发病率为11.61/10万人口,其发病率比较高。据相关数据表明,每两分钟就有一名女性被诊断出患有乳腺癌。在我国,乳腺癌是导致40~50岁的女性死亡的主要原因。乳腺癌通常发生在乳房腺上皮组织,无痛性肿块、乳头乳晕改变、皮肤改变和乳头溢液是乳腺癌的典型表现。
目前乳腺癌的主要治疗方法为手术切除、放疗、化疗等。手术切除给患者身心带来巨大的伤害,放疗、化疗等对人体的危害极大。
发明内容
本发明克服了上述现有技术的不足,提供了一种治疗乳腺癌的药物。该药物采用中草药为原料,可以有效治疗乳腺癌。
本发明的技术方案是:一种治疗乳腺癌的药物,其特征是,由下述重量的原料药制成:柴胡20-30g、水飞蓟12-18g、龙胆12-18g、佛手15-20g、酸枣仁15-20g、石菖蒲10-15g、远志8-12g、黄精12-18g、白术10-15g、陈皮15-20g、山药12-18g、砂仁10-15g、山楂10-15g、人参15-20g、黄芪18-22g、红景天15-20g、川芎15-20g、牛膝18-22g、红花15-20g、牡丹皮10-15g、鸦胆子18-22g、穿心莲15-20g、大黄15-20g、玄参10-15g、枳实10-15g、昆布10-15g、没药5-10g和甘草3-8g。
优选配比:柴胡25g、水飞蓟15g、龙胆15g、佛手18g、酸枣仁18g、石菖蒲12g、远志10g、黄精15g、白术12g、陈皮17g、山药15g、砂仁12g、山楂12g、人参17g、黄芪20g、红景天17g、川芎17g、牛膝20g、红花17g、牡丹皮12g、鸦胆子20g、穿心莲18g、大黄17g、玄参12g、枳实12g、昆布12g、没药8g和甘草5g。
配制及服用方法:水煎煮,每日一剂,分两次早晚服用。1个月为1个疗程。
各中药药理作用:
柴胡:辛、苦,微寒。归肝、胆、肺经。功能与主治:疏散退热,疏肝解郁,升举阳气。用于感冒发热,寒热往来,胸胁胀痛,月经不调,子宫脱垂,脱肛。
水飞蓟:苦,凉。归肝、胆经。功能与主治:清热解毒,舒肝利胆。用于肝胆湿热,胁痛,黄疸。
龙胆:苦,寒。归肝、胆经。功能与主治:清热燥湿,泻肝胆火。用于湿热黄疸,阴肿阴痒,带下,湿疹瘙痒,肝火目赤,耳呜耳聋,胁痛口苦,强中,惊风抽搐。
佛手:辛、苦、酸,温。归肝、脾、肺经。功能与主治:舒肝理气,和胃止痛。用于肝胃气滞,胸胁胀痛,胃脘痞满,食少呕吐。
酸枣仁:甘、酸,平。归肝、胆、心经。功能与主治:养心补肝,宁心安神,敛汗,生津。用于虚烦不眠,惊悸多梦,体虚多汗,津伤口渴。
石菖蒲:辛、苦,温。归心、胃经。功能与主治:开窍豁痰,醒神益智,化湿开胃。用于神昏癫痫,健忘失眠,耳鸣耳聋,脘痞不饥,噤口下痢。
远志:苦、辛,温。归心、肾、肺经。功能与主治:安神益智,交通心肾,祛痰,消肿。用于心肾不交引起的失眠多梦,健忘惊悸,神志恍惚,咳痰不爽,疮疡肿毒,乳房肿痛。
郁金:辛、苦,寒。归肝、心、肺经。功能与主治:活血止痛,行气解郁,清心凉血,利胆退黄。用于胸胁刺痛,胸痹心痛,经闭痛经,乳房胀痛,热病神昏,癫痫发狂,血热吐衄,黄疸尿赤。
黄精:甘,平。归脾、肺、肾经。功能与主治:补气养阴,健脾,润肺,益肾。用于脾胃气虚,体倦乏力,胃阴不足,口干食少,肺虚燥咳,劳嗽咳血,精血不足,腰膝酸软,须发早白,内热消渴。
白术:苦、甘,温。归脾、胃经。功能与主治:健脾益气,燥湿利水,止汗,安胎。用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。
陈皮:苦、辛,温。归肺、脾经。功能与主治:理气健脾,燥湿化痰。用于脘腹胀满,食少吐泻,咳嗽痰多。
山药:甘,平。归脾、肺、肾经。功能与主治:补脾养胃,生津益肺,补肾涩精。用于脾虚食少,久泻不止,肺虚喘咳,肾虚遗精,带下,尿频,虚热消渴。
砂仁:辛,温。归脾、胃、肾经。功能与主治:化湿开胃,温脾止泻,理气安胎。用于湿浊中阻,脘痞不饥,脾胃虚寒,呕吐泄泻,妊娠恶阻,胎动不安。
山楂:酸、甘,微温。归脾、胃、肝经。功能与主治:消食健胃,行气散瘀,化浊降脂。用于肉食积滞,胃脘胀满,泻痢腹痛,瘀血经闭,产后瘀阻,心腹刺痛,胸痹心痛,疝气疼痛,高脂血症。
人参:大补元气,复脉固脱,补脾益肺,生津养血,安神益智。用于体虚欲脱,肢冷脉微,脾虚食少,肺虚喘咳,津伤口渴,内热消渴,气血亏虚,久病虚赢,惊悸失眠,阳痿宫冷。
黄芪:补气升阳、益精固表、利水退肿,适用于自汗、盗汗、浮肿、内伤劳倦、脾虚、泄泻、脱肛及一切气衰血虚之症。但有高热、大渴、便秘等实热症者忌用。
红景天:甘、苦,平。归肺、心经。功能与主治:益气活血,通脉平喘。用于气虚血瘀,胸痹心痛,中风偏瘫,倦怠气喘。
川芎:辛,温。归肝、胆、心包经。功能与主治:活血行气,祛风止痛。用于胸痹心痛,胸胁刺痛,跌扑肿痛,月经不调,经闭痛经,癥瘕腹痛,头痛,风湿痹痛。
牛膝:苦、甘、酸,平。归肝、肾经。功能与主治:逐瘀通经,补肝肾,强筋骨,利尿通淋,引血下行。用于经闭,痛经,腰膝酸痛,筋骨无力,淋证,水肿,头痛,眩晕,牙痛,日疮,吐血,衄血。
红花:辛,温。归心、肝经。功能与主治:活血通经,散瘀止痛。用于经闭,痛经,恶露不行,癥瘕痞块,胸痹心痛,瘀滞腹痛,胸胁刺痛,跌扑损伤,疮疡肿痛。
牡丹皮:苦、辛,微寒。归心、肝、肾经。功能与主治:清热凉血,活血化瘀。用于热入营血,温毒发斑,吐血衄血,夜热早凉,无汗骨蒸,经闭痛经,跌扑伤痛,痈肿疮毒。
鸦胆子:苦,寒;有小毒。归大肠、肝经。功能与主治:清热解毒,截疟,止痢,腐蚀赘疣。用于痢疾,疟疾;外治赘疣,鸡眼。
穿心莲:苦,寒。归心、肺、大肠、膀胱经。功能与主治:清热解毒,凉血,消肿。用于感冒发热,咽喉肿痛,口舌生疮,顿咳劳嗽,泄泻痢疾,热淋涩痛,痈肿疮疡,蛇虫咬伤。
大黄:味苦,寒。入胃、大肠、肝经。泻热通肠,凉血解毒,逐瘀通经。泻热毒,破积滞,行瘀血。治实热便秘,谵语发托,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,痈疡肿毒,疔疮,汤火伤。
玄参:甘、苦、咸,微寒。归肺、胃、肾经。功能与主治:清热凉血,滋阴降火,解毒散结。用于热入营血,温毒发斑,热病伤阴,舌绛烦渴,津伤便秘,骨蒸劳嗽,目赤,咽痛,白喉,瘰疬,痈肿疮毒。
枳实:苦、辛、酸,微寒。归脾、胃经。功能与主治:破气消积,化痰散痞。用于积滞内停,痞满胀痛,泻痢后重,大便不通,痰滞气阻,胸痹,结胸,脏器下垂。
昆布:咸,寒。归肝、胃、肾经。功能与主治:消痰,软坚散结,利水消肿。用于瘿瘤,瘰疬,睾丸肿痛,痰饮水肿。
没药:辛、苦,平。归心、肝、脾经。功能与主治:散瘀定痛,消肿生肌。用于胸痹心痛。胃脘疼痛,痛经经闭。产后瘀阻,癥瘕腹痛,风湿痹痛,跌打损伤,痈肿疮疡。
甘草:甘,平。归心、肺、脾、胃经。补脾益气,滋咳润肺,缓急解毒,调和百药。主治咽喉肿痛,痛疽疮疡,胃肠道溃疡以及解药毒、食物中毒等。
《外科正宗》曰:“乳岩由于忧思郁结,所愿不遂,肝脾气逆,以致经络阻塞,结积成核”。因妇女乳头属肝,乳房属胃,脾胃互为表里,忧思郁怒则肝脾两伤,肝失疏泻,气郁化火,脾失健运,痰浊内生,以致痰热搏结,经络痞塞,阻滞日久,结滞乳中或气机郁久化火成毒,以致热毒壅盛,瘀毒内结而成本病。本发明以上述药物组方,舒肝解郁安神、活血行气、健脾益胃、补气血,以扶正;通过祛淤通络、清热解毒、燥湿祛痰、软坚散结、消肿止痛以祛邪,通过扶正祛邪达到有效治疗乳腺癌的效果。以本发明的药物治疗乳腺癌,总有效率为100%。
以下结合临床资料及典型病例来进一步说明其有益效果。
一、临床资料:
1、临床数据:随机选取2012年1月-2013年1月,经医院诊断为原发性乳腺癌的患者150例进行临床观察。患者年龄35-56岁,平均44.6岁;其中早期乳腺癌62人,其余为中晚期乳腺癌患者。
2、诊断标准:乳房内摸到肿块、质硬,表面不平或乳房内摸不到明显肿块(To),但病理或细胞学检查查到了癌细胞,均可确诊为乳腺癌。
3、治疗方法:服用本发明的药物,水煎煮,每日1剂,分两次早晚服用,1个月为1个疗程。
4、疗效评定标准:完全缓解(CR):所有可见病灶完全消失,至少维持4周以上;部分缓解(PR):肿瘤最大直径及最大垂直径的乘积减少50%以上,无其他病灶进展,无任何新病灶出现;疾病稳定无变化(SD):肿瘤最大直径及最大垂直径的乘积减少小于50%,或增大不超过25%,无任何新病灶出现;进展(PD):肿瘤最大直径及最大垂直径的乘积增大大于25%;CR+PR为总有效率。
5、治疗结果:CR 73例,PR77例,SD及PD均为0。总有效率(CR+PR)为100%。说明本发明药物治疗原发性乳腺癌的有效率高,具有抑制乳腺癌发展,稳定瘤体的作用。
二、典型病例
病例1:王某,女,51岁。患者右乳肿块1年,入院前1个月内感觉明显增大。经医院检查,发现右乳肿块6*4.5cm,不规则、质硬、活动度差,乳晕呈橘皮样皱缩,色黑暗。诊断为乳腺癌。经服用本发明的药物6个月后,肿块消失,随访1年无复发。
病例2:吴某,女,40岁。因右乳腺包块6月余入院。检查发现右乳腺外上象限包块,约5×4cm,质硬。穿刺活检诊断为乳腺癌。经服用本发明的药物5个月后,肿块消失,随访1年无复发。
病例3:田某,女,45岁。患者在体检时发现左侧乳房有一核桃大小肿块,于医院就医。经医院病理诊断为乳腺癌。经服用本发明的药物5个月后,肿块消失,随访1年无复发。
具体实施方式
实施例1
配比:柴胡25g、水飞蓟15g、龙胆15g、佛手18g、酸枣仁18g、石菖蒲12g、远志10g、黄精15g、白术12g、陈皮17g、山药15g、砂仁12g、山楂12g、人参17g、黄芪20g、红景天17g、川芎17g、牛膝20g、红花17g、牡丹皮12g、鸦胆子20g、穿心莲18g、大黄17g、玄参12g、枳实12g、昆布12g、没药8g和甘草5g。
配制及服用方法:水煎煮,每日一剂,分两次早晚服用。1个月为1个疗程。
实施例2
配比:柴胡30g、水飞蓟18g、龙胆18g、佛手20g、酸枣仁20g、石菖蒲15g、远志12g、黄精18g、白术15g、陈皮20g、山药18g、砂仁15g、山楂15g、人参20g、黄芪22g、红景天20g、川芎15g、牛膝18g、红花15g、牡丹皮10g、鸦胆子18g、穿心莲15g、大黄15g、玄参10g、枳实10g、昆布10g、没药5g和甘草5g。
配制及服用方法:水煎煮,每日一剂,分两次早晚服用。1个月为1个疗程。
实施例3
配比:柴胡20g、水飞蓟12g、龙胆12g、佛手15g、酸枣仁15g、石菖蒲10g、远志8g、黄精12g、白术10g、陈皮15g、山药12g、砂仁10g、山楂10g、人参15g、黄芪18g、红景天15g、川芎20g、牛膝22g、红花20g、牡丹皮15g、鸦胆子22g、穿心莲20g、大黄20g、玄参15g、枳实15g、昆布15g、没药10g和甘草8g。
配制及服用方法:水煎煮,每日一剂,分两次早晚服用。1个月为1个疗程。

Claims (2)

1.一种治疗乳腺癌的药物,其特征是,由下述重量的原料药制成:柴胡20-30g、水飞蓟12-18g、龙胆12-18g、佛手15-20g、酸枣仁15-20g、石菖蒲10-15g、远志8-12g、黄精12-18g、白术10-15g、陈皮15-20g、山药12-18g、砂仁10-15g、山楂10-15g、人参15-20g、黄芪18-22g、红景天15-20g、川芎15-20g、牛膝18-22g、红花15-20g、牡丹皮10-15g、鸦胆子18-22g、穿心莲15-20g、大黄15-20g、玄参10-15g、枳实10-15g、昆布10-15g、没药5-10g和甘草3-8g。
2.如权利要求1所述的一种治疗乳腺癌的药物,其特征是,由下述重量的原料药制成:柴胡25g、水飞蓟15g、龙胆15g、佛手18g、酸枣仁18g、石菖蒲12g、远志10g、黄精15g、白术12g、陈皮17g、山药15g、砂仁12g、山楂12g、人参17g、黄芪20g、红景天17g、川芎17g、牛膝20g、红花17g、牡丹皮12g、鸦胆子20g、穿心莲18g、大黄17g、玄参12g、枳实12g、昆布12g、没药8g和甘草5g。
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