CN102772779A - 一种治疗痛经的药物及其制备方法 - Google Patents
一种治疗痛经的药物及其制备方法 Download PDFInfo
- Publication number
- CN102772779A CN102772779A CN2012102980791A CN201210298079A CN102772779A CN 102772779 A CN102772779 A CN 102772779A CN 2012102980791 A CN2012102980791 A CN 2012102980791A CN 201210298079 A CN201210298079 A CN 201210298079A CN 102772779 A CN102772779 A CN 102772779A
- Authority
- CN
- China
- Prior art keywords
- gram
- radix
- rhizoma
- clean
- choose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drugs Substances 0.000 title claims abstract description 43
- 208000005171 Dysmenorrhea Diseases 0.000 title claims abstract description 18
- 206010013935 Dysmenorrhoea Diseases 0.000 title claims abstract description 18
- 238000002360 preparation methods Methods 0.000 title claims abstract description 6
- 229940079593 drugs Drugs 0.000 title claims description 21
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 11
- 235000008434 ginseng Nutrition 0.000 claims abstract description 11
- 235000005035 ginseng Nutrition 0.000 claims abstract description 11
- 239000011901 water Substances 0.000 claims description 29
- 238000005202 decontamination Methods 0.000 claims description 22
- 230000003588 decontaminative Effects 0.000 claims description 22
- 210000002216 Heart Anatomy 0.000 claims description 14
- 241000208340 Araliaceae Species 0.000 claims description 10
- 241000756943 Codonopsis Species 0.000 claims description 10
- 241000218176 Corydalis Species 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 10
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 239000009636 Huang Qi Substances 0.000 claims description 8
- 239000003570 air Substances 0.000 claims description 8
- 238000005520 cutting process Methods 0.000 claims description 8
- 210000003165 Abomasum Anatomy 0.000 claims description 4
- 235000014676 Phragmites communis Nutrition 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 230000001429 stepping Effects 0.000 claims description 4
- 241000202807 Glycyrrhiza Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 239000002956 ash Substances 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 238000001764 infiltration Methods 0.000 claims description 2
- 239000007788 liquids Substances 0.000 claims description 2
- 239000002245 particles Substances 0.000 claims description 2
- 239000002994 raw materials Substances 0.000 claims description 2
- 230000000717 retained Effects 0.000 claims description 2
- 239000007921 sprays Substances 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 abstract description 45
- 230000036407 pain Effects 0.000 abstract description 45
- 210000004185 Liver Anatomy 0.000 abstract description 26
- 230000001737 promoting Effects 0.000 abstract description 12
- 230000001105 regulatory Effects 0.000 abstract description 11
- 230000017531 blood circulation Effects 0.000 abstract description 9
- 210000004914 menses Anatomy 0.000 abstract description 3
- 230000005906 menstruation Effects 0.000 abstract description 2
- 229940107666 ASTRAGALUS ROOT Drugs 0.000 abstract 1
- 240000001992 Angelica archangelica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 240000005801 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 235000004310 Cinnamomum zeylanicum Nutrition 0.000 abstract 1
- 241000510667 Conioselinum Species 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 240000008259 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 240000004678 Panax pseudoginseng Species 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- 210000004369 Blood Anatomy 0.000 description 37
- 239000008280 blood Substances 0.000 description 37
- 239000000796 flavoring agents Substances 0.000 description 30
- 235000019634 flavors Nutrition 0.000 description 30
- 210000000952 Spleen Anatomy 0.000 description 25
- 210000001015 Abdomen Anatomy 0.000 description 15
- 210000002784 Stomach Anatomy 0.000 description 15
- 235000009508 confectionery Nutrition 0.000 description 13
- 206010012735 Diarrhoea Diseases 0.000 description 12
- 210000004072 Lung Anatomy 0.000 description 12
- 206010001928 Amenorrhoea Diseases 0.000 description 11
- 206010007247 Carbuncle Diseases 0.000 description 11
- 201000000736 amenorrhea Diseases 0.000 description 11
- 231100000540 amenorrhea Toxicity 0.000 description 11
- 206010000087 Abdominal pain upper Diseases 0.000 description 10
- 201000010099 diseases Diseases 0.000 description 10
- 206010022114 Injuries Diseases 0.000 description 9
- 210000003734 Kidney Anatomy 0.000 description 9
- 206010027514 Metrorrhagia Diseases 0.000 description 9
- 208000006820 Arthralgia Diseases 0.000 description 7
- 210000000481 Breast Anatomy 0.000 description 7
- 206010011224 Cough Diseases 0.000 description 7
- 208000002173 Dizziness Diseases 0.000 description 7
- 206010027327 Menstrual diseases Diseases 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 208000001848 Dysentery Diseases 0.000 description 6
- 210000001624 Hip Anatomy 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 6
- 206010037660 Pyrexia Diseases 0.000 description 6
- 206010047700 Vomiting Diseases 0.000 description 6
- 239000010839 body fluid Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 206010019233 Headaches Diseases 0.000 description 5
- 231100000614 Poisons Toxicity 0.000 description 5
- 206010042674 Swelling Diseases 0.000 description 5
- 206010068760 Ulcers Diseases 0.000 description 5
- 230000000202 analgesic Effects 0.000 description 5
- 210000000038 chest Anatomy 0.000 description 5
- 231100000869 headache Toxicity 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 5
- 239000002574 poisons Substances 0.000 description 5
- 230000002522 swelling Effects 0.000 description 5
- 231100000397 ulcers Toxicity 0.000 description 5
- 208000004998 Abdominal Pain Diseases 0.000 description 4
- 210000001124 Body Fluids Anatomy 0.000 description 4
- 208000001780 Epistaxis Diseases 0.000 description 4
- 206010016256 Fatigue Diseases 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 206010033557 Palpitations Diseases 0.000 description 4
- 230000036528 appetite Effects 0.000 description 4
- 235000019789 appetite Nutrition 0.000 description 4
- 201000008286 diarrhea Diseases 0.000 description 4
- 230000003419 expectorant Effects 0.000 description 4
- 239000003172 expectorant agents Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000001717 pathogenic Effects 0.000 description 4
- 230000003014 reinforcing Effects 0.000 description 4
- 230000002269 spontaneous Effects 0.000 description 4
- 206010003549 Asthenia Diseases 0.000 description 3
- 210000001142 Back Anatomy 0.000 description 3
- 206010013990 Dysuria Diseases 0.000 description 3
- 210000003414 Extremities Anatomy 0.000 description 3
- 210000003128 Head Anatomy 0.000 description 3
- 206010021118 Hypotonia Diseases 0.000 description 3
- 206010022437 Insomnia Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 230000001914 calming Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 230000003203 everyday Effects 0.000 description 3
- 230000002175 menstrual Effects 0.000 description 3
- 230000003821 menstrual periods Effects 0.000 description 3
- 239000000203 mixtures Substances 0.000 description 3
- 230000025627 positive regulation of urine volume Effects 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 210000000988 Bone and Bones Anatomy 0.000 description 2
- 208000001387 Causalgia Diseases 0.000 description 2
- 206010009866 Cold sweat Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010015037 Epilepsy Diseases 0.000 description 2
- 210000000232 Gallbladder Anatomy 0.000 description 2
- 206010060891 General symptom Diseases 0.000 description 2
- 208000001786 Gonorrhea Diseases 0.000 description 2
- 206010018612 Gonorrhoea Diseases 0.000 description 2
- 206010018830 Haematemesis Diseases 0.000 description 2
- 206010018836 Haematochezia Diseases 0.000 description 2
- 208000006750 Hematuria Diseases 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- 210000003127 Knee Anatomy 0.000 description 2
- 208000009856 Lung Diseases Diseases 0.000 description 2
- 210000003205 Muscles Anatomy 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 206010057071 Rectal tenesmus Diseases 0.000 description 2
- 206010040943 Skin ulcer Diseases 0.000 description 2
- 210000001138 Tears Anatomy 0.000 description 2
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 230000001684 chronic Effects 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 201000009541 complex regional pain syndrome Diseases 0.000 description 2
- 230000001276 controlling effects Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 230000009247 menarche Effects 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 244000052769 pathogens Species 0.000 description 2
- 231100000486 side effect Toxicity 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 230000004206 stomach function Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000002588 toxic Effects 0.000 description 2
- 231100000820 toxicity tests Toxicity 0.000 description 2
- 230000002936 tranquilizing Effects 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000269 Abscess Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010002156 Anal fistula Diseases 0.000 description 1
- 206010002383 Angina pectoris Diseases 0.000 description 1
- 208000006673 Asthma Diseases 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010061428 Decreased appetite Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 210000000188 Diaphragm Anatomy 0.000 description 1
- 206010013781 Dry mouth Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241000371997 Eriocheir sinensis Species 0.000 description 1
- 206010015137 Eructation Diseases 0.000 description 1
- 206010016029 Face oedema Diseases 0.000 description 1
- 206010016286 Febrile diseases Diseases 0.000 description 1
- 210000003754 Fetus Anatomy 0.000 description 1
- 208000002513 Flank Pain Diseases 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010018987 Haemorrhages Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 210000003026 Hypopharynx Anatomy 0.000 description 1
- 208000004356 Hysteria Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 210000004705 Lumbosacral Region Anatomy 0.000 description 1
- 210000004080 Milk Anatomy 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010029410 Night sweats Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 210000004417 Patella Anatomy 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 206010034568 Peripheral coldness Diseases 0.000 description 1
- 210000003800 Pharynx Anatomy 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N Picric acid Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300' height='300' x='0' y='0'> </rect>
<path class='bond-0' d='M 237.79,148.022 L 221.598,148.022' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0' d='M 221.598,148.022 L 205.406,148.022' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1' d='M 205.406,148.022 L 180.685,190.84' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1' d='M 193.134,149.501 L 175.83,179.473' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15' d='M 205.406,148.022 L 180.685,105.205' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2' d='M 180.685,190.84 L 188.504,204.383' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2' d='M 188.504,204.383 L 196.323,217.925' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5' d='M 180.685,190.84 L 131.244,190.84' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3' d='M 194.039,253.346 L 191.74,257.328' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3' d='M 191.74,257.328 L 189.44,261.311' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4' d='M 230.578,238.602 L 234.499,238.602' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4' d='M 234.499,238.602 L 238.42,238.602' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4' d='M 230.578,228.714 L 234.499,228.714' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4' d='M 234.499,228.714 L 238.42,228.714' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6' d='M 131.244,190.84 L 106.523,148.022' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6' d='M 136.099,179.473 L 118.795,149.501' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7' d='M 106.523,148.022 L 94.3881,148.022' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7' d='M 94.3881,148.022 L 82.2533,148.022' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10' d='M 106.523,148.022 L 131.244,105.205' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8' d='M 47.9982,132.29 L 45.7317,128.364' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8' d='M 45.7317,128.364 L 43.4652,124.438' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9' d='M 41.4328,165.238 L 39.1333,169.221' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9' d='M 39.1333,169.221 L 36.8339,173.204' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9' d='M 49.9963,170.182 L 47.6969,174.165' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9' d='M 47.6969,174.165 L 45.3974,178.148' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11' d='M 131.244,105.205 L 180.685,105.205' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11' d='M 138.66,115.093 L 173.269,115.093' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12' d='M 180.685,105.205 L 187.362,93.6398' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12' d='M 187.362,93.6398 L 194.039,82.0749' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13' d='M 230.578,62.387 L 234.499,62.387' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13' d='M 234.499,62.387 L 238.42,62.387' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14' d='M 200.605,44.1824 L 198.338,40.2567' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14' d='M 198.338,40.2567 L 196.072,36.331' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14' d='M 192.041,49.1265 L 189.775,45.2008' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14' d='M 189.775,45.2008 L 187.508,41.2752' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='248.915' y='157.911' class='atom-0' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='262.561' y='157.911' class='atom-0' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='199.473' y='243.546' class='atom-3' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='213.119' y='235.635' class='atom-3' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='174.752' y='286.364' class='atom-4' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='188.398' y='278.453' class='atom-4' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='248.915' y='243.546' class='atom-5' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='51.1484' y='157.911' class='atom-8' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='64.7942' y='150' class='atom-8' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='26.4276' y='115.093' class='atom-9' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='40.0735' y='107.182' class='atom-9' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='26.4276' y='200.728' class='atom-10' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='199.473' y='72.2753' class='atom-13' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='213.119' y='64.3647' class='atom-13' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='248.915' y='72.2753' class='atom-14' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='262.561' y='64.3647' class='atom-14' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='174.752' y='29.4577' class='atom-15' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85' height='85' x='0' y='0'> </rect>
<path class='bond-0' d='M 69.5566,41.4397 L 63.6275,41.4397' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0' d='M 63.6275,41.4397 L 57.6984,41.4397' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1' d='M 57.6984,41.4397 L 50.6942,53.5713' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1' d='M 54.2214,41.8586 L 49.3185,50.3507' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15' d='M 57.6984,41.4397 L 50.6942,29.308' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2' d='M 50.6942,53.5713 L 53.5756,58.5621' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2' d='M 53.5756,58.5621 L 56.457,63.5528' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5' d='M 50.6942,53.5713 L 36.6857,53.5713' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3' d='M 55.7641,69.0532 L 53.822,72.4172' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3' d='M 53.822,72.4172 L 51.8798,75.7812' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4' d='M 62.3105,67.1038 L 65.9912,67.1038' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4' d='M 65.9912,67.1038 L 69.6719,67.1038' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4' d='M 62.3105,64.3022 L 65.9912,64.3022' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4' d='M 65.9912,64.3022 L 69.6719,64.3022' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6' d='M 36.6857,53.5713 L 29.6815,41.4397' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6' d='M 38.0614,50.3507 L 33.1585,41.8586' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7' d='M 29.6815,41.4397 L 24.9833,41.4397' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7' d='M 24.9833,41.4397 L 20.2851,41.4397' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10' d='M 29.6815,41.4397 L 36.6857,29.308' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8' d='M 14.4316,39.2895 L 12.4994,35.9428' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8' d='M 12.4994,35.9428 L 10.5672,32.5961' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9' d='M 12.5256,44.0895 L 10.5834,47.4534' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9' d='M 10.5834,47.4534 L 8.64125,50.8174' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9' d='M 14.952,45.4903 L 13.0098,48.8543' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9' d='M 13.0098,48.8543 L 11.0676,52.2183' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11' d='M 36.6857,29.308 L 50.6942,29.308' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11' d='M 38.787,32.1097 L 48.5929,32.1097' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12' d='M 50.6942,29.308 L 53.2292,24.9173' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12' d='M 53.2292,24.9173 L 55.7641,20.5265' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13' d='M 62.3105,17.1763 L 65.9912,17.1763' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13' d='M 65.9912,17.1763 L 69.6719,17.1763' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14' d='M 57.6701,14.3257 L 55.7379,10.979' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14' d='M 55.7379,10.979 L 53.8057,7.63237' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14' d='M 55.2438,15.7265 L 53.3116,12.3799' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14' d='M 53.3116,12.3799 L 51.3794,9.03321' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='69.9068' y='44.4397' class='atom-0' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='74.0468' y='44.4397' class='atom-0' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='55.8984' y='68.703' class='atom-3' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='60.0384' y='66.303' class='atom-3' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='48.8942' y='80.8347' class='atom-4' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='53.0342' y='78.4347' class='atom-4' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='69.9068' y='68.703' class='atom-5' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='13.8731' y='44.4397' class='atom-8' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='18.0131' y='42.0397' class='atom-8' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='6.86883' y='32.308' class='atom-9' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='11.0088' y='29.908' class='atom-9' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='6.86883' y='56.5713' class='atom-10' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='55.8984' y='20.1763' class='atom-13' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='60.0384' y='17.7763' class='atom-13' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='69.9068' y='20.1763' class='atom-14' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='74.0468' y='17.7763' class='atom-14' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='48.8942' y='8.04465' class='atom-15' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 210000002826 Placenta Anatomy 0.000 description 1
- 206010036018 Pollakiuria Diseases 0.000 description 1
- 208000008425 Protein Deficiency Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 210000004915 Pus Anatomy 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010062104 Renal mass Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010072736 Rheumatic diseases Diseases 0.000 description 1
- 208000005687 Scabies Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040872 Skin infection Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010042772 Syncope Diseases 0.000 description 1
- 210000002435 Tendons Anatomy 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 210000003932 Urinary Bladder Anatomy 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 239000002253 acids Substances 0.000 description 1
- 230000003213 activating Effects 0.000 description 1
- 230000001166 anti-perspirant Effects 0.000 description 1
- 239000003213 antiperspirants Substances 0.000 description 1
- 231100000319 bleeding Toxicity 0.000 description 1
- 230000000740 bleeding Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 201000009030 carcinoma Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000000295 complement Effects 0.000 description 1
- 201000002574 conversion diseases Diseases 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 230000003247 decreasing Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 201000000297 erysipelas Diseases 0.000 description 1
- 230000001605 fetal Effects 0.000 description 1
- 235000019525 fullness Nutrition 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000001976 improved Effects 0.000 description 1
- 230000001939 inductive effects Effects 0.000 description 1
- 230000004054 inflammatory processes Effects 0.000 description 1
- 239000004615 ingredients Substances 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000003211 malignant Effects 0.000 description 1
- 239000000463 materials Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000000034 methods Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000003020 moisturizing Effects 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001314 paroxysmal Effects 0.000 description 1
- 230000036961 partial Effects 0.000 description 1
- 229940114148 picric acid Drugs 0.000 description 1
- 230000003389 potentiating Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002035 prolonged Effects 0.000 description 1
- 230000002829 reduced Effects 0.000 description 1
- 230000035812 respiration Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000552 rheumatic Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 230000001502 supplementation Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- 229950002929 trinitrophenol Drugs 0.000 description 1
Abstract
本发明公开了一种治疗痛经的药物及其制备方法，它主要是由党参、黄芪、当归、川芎、香附、红花、侧柏叶、赤芍、牛膝、人参、白术、苏木、肉桂等按一定重量配比制备而成，本发明药物具有行气活血，疏肝解郁，调经止痛的功效，用于治疗痛经疗程短，见效快，治愈率高。
Description
一种治疗痛经的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗痛经的药物及其制备方法，属中药领域。
技术背景
[0002] 痛经是指女性在经期及其前后，出现小腹或腰部疼痛，甚至痛及腰骶。痛经是妇科常见病和多发病，病因多，病机复杂，反复性大，治疗棘手，尤其是未婚女青年及月经初期少女更为普遍，表现为女性经期或行经前后，周期性发生下腹部胀痛、冷痛、灼痛、刺痛、隐痛、坠痛、绞痛、痉挛性疼痛、撕裂性疼痛，疼痛蔓延至骶腰背部，甚至涉及大腿及足部，常伴有全身症状：乳房胀痛、肛门坠胀、胸闷烦躁、悲伤易怒、心惊失眠、头痛头晕、恶心呕吐、胃痛腹泻、倦怠乏力、面色苍白、四肢冰凉、冷汗淋漓、虚脱昏厥等症状。其发病之高、范围之广、周期之近、痛苦之大，严重影响了广大女性的工作和学习，降低了生活的质量。目前，由于 西药无法有效治疗痛经，且有较多副作用，因此，人们对有效治疗痛经的中药存在很大的需求。
发明内容
[0003] 本发明人依据中医理论的研究及临床反复的试验和验证，终于找到了有效治疗痛经的药物，从而完成了本发明。
[0004] 本发明的目的就是提供一种治疗痛经的组合药物。
[0005] 本发明的另一个目的就是提供了该组合药物的制备方法。本发明药物是选择党参、黄苗、当归、川；、香附、青皮、牡丹皮、积壳、生地黄、艾叶、生姜、白苟、熟地黄、泽兰、续断、红花、侧柏叶、赤芍、牛膝、延胡索、麦冬、三棱、丹参、通草、莪术、茯苓、甘草、大枣、人参、白术、苏木、肉桂药物进行组合的，将这些药物组合使得各药物功效产生协同作用，从而能够有效的治疗痛经。其中选用党参是因为其性味甘，平，入手、足太阴经气分，有补中益气，生津的功能，治脾胃虚弱，气血两亏，体倦无力，食少，口渴，久泻，脱肛。选用黄芪是因为其性味甘，微温，入肺、脾经，生用有益卫固表，利水消肿，托毒，生肌的功能，治自汗，盗汗，血痹，浮肿，痈疽不溃或溃久敛；炙用有补中益的功能，治内伤劳倦，脾虚泄泻，脱肛，气虚血脱，崩带及一切气衰血虚之症。选用当归是因为其性味甘辛，温，入心、肝、脾经，有补血和血，调经止痛，润燥滑肠的功能，治月经不调，经闭腹痛，癥瘕结聚，崩漏，血虚头痛，眩晕，痿痹，肠燥难便，赤痢后重，痈疽疮疡，金疮，跌扑损伤。选用川芎是因为其性味辛，温，入肝、胆经，有行气开郁，祛风燥湿，活血止痛的功能，治风冷头痛旋晕，胁痛腹疼，寒痹筋挛，经闭，难产，产后瘀阻块痛，痈疽疮疡。选用香附是因为其性味辛微苦干，平，入肝、三焦经，有理气解郁，止痛调经的功能，治肝胃不和，气郁不舒，胸腹胁肋胀痛，痰饮痞满，月经不调，崩漏带下。选用青皮是因为其性味苦辛，微温，入肝、胆经，有疏肝破气，散结消痰的功能，治胸胁胃脘疼痛，疝气，食积，乳肿，乳核，久疟癖块。选用牡丹皮是因为其性味辛苦，凉，入心、肝、肾经，有清热，凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血，骨蒸劳热,经闭，癥瘕，痈疡，扑损。选用枳壳是因为其性味苦辛，凉，入肺、脾、大肠经，有破气，行痰，消积的功能，治胸膈痰滞，胸痞，胁胀，食积，噫气，呕逆，下痢后重，脱肛，子宫脱垂。选用生地黄是因为其性味甘，寒，归心、肝、肾经，有清热凉血，养阴，生津的功能，治热病烦渴，阴虚内热，骨蒸劳热，内热消渴，吐血，衄血，发斑发疹。艾叶是因为其性味苦辛，温。入脾、肝、肾经。理气血，逐寒湿；温经，止血，安胎。治心腹冷痛，泄泻转筋，久痢，吐衄，下血，月经不调，崩漏，带下，胎动不安，痈疡，疥癣。选用生姜是因为其性味辛，温，入肺、胃、脾经，有发表，散寒，止呕，开痰的功能，治感冒风寒，呕吐，痰饮，喘咳，胀满，泄湾，解半夏、天南星及鱼蟹、鸟兽肉毒。选用白芍是因为其性味苦酸，凉，入肝、脾经，有养血柔肝，缓中止痛，敛阴收汗的功能，治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。选用熟地黄是因为其性味甘，微温，入肝、肾经，有滋阴，补血的功能，治阴虚血少，腰膝痿弱，劳嗽骨蒸，遗精，崩漏，月经不调，消渴，溲数，耳聋，目昏。选用泽兰是因为其性味苦辛，微温，入肝、脾经，有活血，行水的功能，治经闭，癥瘕，产后瘀滞腹痛,身面浮肿,跌扑损伤,金疮,痈肿。选用续断是因为其性味苦辛，微温，入肝、肾经，有补肝肾，续筋骨，调血脉的功能，治腰背酸痛，足膝无力，胎漏，崩漏，带下，遗精，跌打损伤，金疮，痔漏，痈疽疮肿。选用红花是因为其性味辛，温，入心、肝经，有活血通经，去瘀止痛的功能，治经闭，癥瘕，难产，死胎，产后恶露不行，瘀血作痛，痈肿，跌扑损伤。选用侧柏叶是因为其性味苦涩，寒，入心、肝、大肠经，有凉血，止血,祛风湿,散肿毒的功能,治吐血,衄血,尿血,血痢,肠风,崩漏,风湿痹痛,细菌性痢疾,高血压，咳嗽，丹毒，痄腮，烫伤。选用赤芍是因为其性味苦，微寒，归肝经，有清热凉血，散瘀止 痛的功能，治温毒发狂，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，癎瘕腹痛，跌扑损伤，痈肿疮疡。选用牛膝是因为其性味甘苦酸，平，入肝、肾经，生用散瘀血，消痈肿的功能，治淋病，尿血，经闭，癥瘕，难产，胞衣不下，产后瘀血腹痛，喉痹，痈肿，跌打损伤，熟用补肝肾，强筋骨，治腰膝骨痛，四肢拘挛，痿痹。选用延胡索是因为其性味辛苦，温，入肝、胃经，有活血，散瘀，理气，止痛的功能，治心腹腰膝诸痛，月经不调，癥瘕，崩中，产后血晕，恶露不尽，跌打损伤。选用麦冬是因为其性味甘微苦，寒，入肺、胃、心经，有养阴润肺，清心除烦，益胃生津的功能，治肺燥干咳，吐血，咯血，肺痿，肺痈，虚劳烦热，清渴，热病津伤，咽干口燥，便秘。选用三棱是因为其性味苦辛，平，入肝、脾经，有破血，行气，消积，止痛的功能，治癥瘕积聚，气血凝带，心腹疼痛，胁下胀疼，经闭，产后瘀血腹痛，跌打损伤，疮肿坚硬。选用丹参是因为其性味苦，微温，入心、肝经，有活血去瘀，安神宁心，排脓，止痛的功能，治心胶痛，月经不调，痛经，以闭，血崩带下，癥瘕，积聚，瘀血腹痛，骨节疼痛，惊悸不眠，恶疮肿毒。选用通草是因为其性味甘淡，凉，入肺、胃经，有泻肺，利小便，下乳汁的功能，治小便不利，淋病，水肿，产妇乳汁不通，目昏，鼻塞。选用莪术是因为其性味辛、苦、温。归肝、脾经。行气破血，消积止痛。用于癥瘕痞块，瘀血经闭，食积胀痛，跌打肿痛，早期宫颈癌。选用茯苓是因为其性味甘淡，平，入心、脾、肺经，有渗湿利水，益脾和胃，宁心安神的功能，治小便不利水肿胀痛，痰饮咳逆，呕哕，泄泻，遗精，淋浊，惊悸，健忘。选用甘草是因为其性味甘平，入脾、胃、肺经，有和中缓急，润肺，解毒，调和诸药的功能，炙用治脾胃虚弱，食少，腹痛便溏，劳倦发热，肺痿咳嗽，心悸，惊痈，生用治咽喉肿痛，消化性溃疡，痈疽疮疡，解药毒及食物中毒。选用大枣是因为其性味甘，温，入脾、胃经，有补脾和胃，益气生津，调营卫，解药毒的功能，治胃虚食少，脾弱便溏，气血津液不足，营卫不和，心悸怔忡，妇人脏躁。选用人参是因为其性味甘微甘，温，入脾、肺经，有大补元气，固脱生津，安神的功能，治劳伤虚损，食少，倦怠，反胃吐食，大便滑泄，虚咳喘促，自汗暴脱，惊t季，健忘，眩晕头痛，阳萎，尿频，消渴，妇女崩漏，小儿慢惊及久虚不复，一切气血津液不足之症。选用白术是因为其性味苦甘，温，入脾、胃经，有补脾，益胃，燥湿，和中的功能，治脾胃气弱，不思饮食，倦怠少气，虚胀，泄泻，痰饮，水肿，黄疸，湿痹，小便不利，头晕，自汗，胎气不安。选用苏木是因为其性味甘咸，平，入心、肝经，有行轿，破瘀，消肿，止痛的功能，治妇人血气心腹痛，经闭，产后瘀血胀痛喘急，痢疾，破伤风，痈肿，扑损瘀滞作痛。选用肉桂是因为其性味辛甘，热，入肾、脾、膀胱经，有补元阳，暖脾胃，除积冷，通血脉的功能，治命门火衰，肢冷脉微，亡阳虚脱，腹痛泄泻，寒疝奔豚，腰膝冷痛，经闭癥瘕，阴疽，流注，及虚阳浮越，上热下寒。
具体实施方式
[0006] 本发明组合的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好疗效
党参 10-20克黄芪 10-20克当归 8-15克
川芎10-20克香附 10-20克青皮 8-15克
牡丹皮10-20克枳壳 10-20克生地黄 8-15克
艾叶 10-20克生姜 6-10克白芍 8-15克
熟地黄15-25克泽兰 6-10克续断 10-20克
红花 15-25克侧柏叶 8-12克赤芍 10-20克
牛膝10-25克延胡索 8-12克麦冬 8-12克
三棱 10-25克丹参 8-15克通草 6-10克
莪术15-25克茯苓 10-15克甘草 6-12克
大枣 10-25克人参 10-25克白术 6-12克
苏木 10-20克肉桂 10-20克 其中，优选为
党参15克黄芪 15克当归 12克
川芎15克香附 15克青皮 12克
牡丹皮15克枳壳 15克生地黄 12克
艾叶15克生姜 8克白芍 10克
熟地黄15克泽兰 8克续断 15克
红花20克侧柏叶 10克赤芍 15克
牛膝20克延胡索 10克麦冬 10克
三棱20克丹参 12克通草 8克
莪术20克茯苓 12克甘草 10克
大枣20克人参 20克白术 10克
苏木15克 肉桂 15克
本发明药物的制备方法如下 一、备料
1、党参：洗净泥沙后润透去芦，切片或切段，晒干；
2、黄芪：拣净杂质，除去残留的根头和空心较大者，用水浸泡，捞出，润透后及时切片，晒干；3、当归：拣去杂质，洗净，闷润，稍晾至内外湿度半干时，切片晒干；
4、川芎：拣去杂质，分开大、小个，用水浸泡，晒晾，闷润后切片，干燥；
5、香附：拣去杂质，碾成碎粒，簸去细毛及细末；
6、青皮：拣净杂质，用水浸泡，捞出，润透，切片，晒干；
7、牡丹皮：拣去杂质，除去木心，洗净，润透，切片，晾干；
8、枳壳：除去瓤、核，冼净，稍浸，捞出，润软，以手能捏对折为度，切片，晾干；
9、生地黄：取原药材，除去杂质，洗净，稍润，切厚片，干燥，筛去碎屑；
10、艾叶：拣去杂质，去梗，筛去灰屑；
11、生姜：拣去杂质，洗净泥土，用时切片；
12、白芍：拣去杂制裁，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥；
13、熟地黄：选干净熟地黄；
14、泽兰：拣去杂质，除去残根，喷水稍润，切段晒干； 15、续断：洗净泥沙，除去残留根头，润透后切片晒干，筛去屑；
16、红花：拣净杂质，除去茎叶、蒂头，晒干；
17、侧柏叶：拣净杂质，揉碎去梗，筛净灰屑；
18、赤芍：取原药材，除去杂质，大小分档，洗净，润透，切薄片，干燥，筛去碎屑；
19、牛膝：拣去杂质，洗净，润软，去芦，切段，晒干；
20、延胡索：拣去杂质，用水浸泡，洗净，晒晾，润至内外湿度均匀，切片或打碎；
21、麦冬：拣净杂质，用水浸泡，捞出，润透后抽去心，再洗净晒干；
22、三棱：拣净杂质,用水浸泡,捞出润透,切片，晒干；
23、丹参：拣净杂质，除去根茎，洗净，捞出，润透后切片，晾干；
24、通草：拣去杂质，切片；
25、莪术：取原药材，除去杂质，大小分档，洗净，略浸泡，取出，润透，切薄片，干燥，筛去碎屑；
26、茯苓：用水浸泡，洗净捞出，闷透后，切片，晒干；
27、甘草：拣去杂质，洗净，用水浸泡至八成透时，捞出，润透，切片，凉干；
28、大枣：拣净杂质，晒干；
29、人参：除去芦头，切段；
30、白术：拣净杂质,用水浸泡,泡后捞出，润透,切片，晒干；
31、苏木：取原药材，锯成短段，再劈成碎片或镑片；
32、肉桂：拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻，切片，晾干。
[0007] 二、制备
I、将所述重量的党参、黄芪、当归、川芎、香附、青皮、牡丹皮、枳壳、生地黄、艾叶、生姜、白芍、熟地黄、泽兰、续断、红花、侧柏叶、赤芍、牛膝、延胡索、麦冬、三棱、丹参、通草、莪术、茯苓、甘草、大枣、人参、白术、苏木、肉桂加水煎煮，第一次加水6倍量，浸泡120分钟，武火煎煮沸腾10分钟，再用文火煎煮30分钟，即得煎煮液。
[0008] 2、将煮液分为6齐U。
[0009] 本发明药物具有行气活血，疏肝解郁，调经止痛的功效，治疗痛经疗程短，见效快。[0010] 以下通过试验例来进一步阐述本发明药物的有益效果，这些试验包括本发明药物。
[0011] 以下为治疗痛经药物的动物毒性试验和临床观察试验。
[0012][试验例I]本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2. 0—2. 5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为30ml/kg，正常量为15ml/kg，给药方式为灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[0013][试验例2]本发明药物的临床观察资料
I、一般资料 收治门诊患者280例，年龄20— 30岁135例，30— 40岁95例，40— 45岁50例。
[0014] 2、诊断标准
痛经是妇科常见病和多发病，病因多，病机复杂，反复性大，治疗棘手，尤其是未婚女青年及月经初期少女更为普遍，表现为妇女经期或行经前后，大多开始于月经来潮或在阴道出血前数小时，周期性发生下腹部胀痛、冷痛、灼痛、刺痛、隐痛、坠痛、绞痛、痉挛性疼痛、撕裂性疼痛，疼痛延至骶腰背部，甚至涉及大腿及足部，历时O. 5〜2小时。疼痛部位多在下腹部，重者可放射至腰骶部或股内前侧。约有50%以上病人伴有全身症状：乳房胀痛、肛门坠胀、胸闷烦躁、悲伤易怒、心惊失眠、头痛头晕、恶心呕吐、胃痛腹泻、倦怠乏力、面色苍白、四肢冰凉、冷汗淋漓、虚脱昏厥等症状。在剧烈腹痛发作后，转为中等度阵发性疼痛，约持续12〜24小时。
[0015] 3、治疗方法
选用上述药剂，给患者服用，每次服用I剂，每天早、中、晚各服I次，15天为一个疗程，连续服用3个疗程。
[0016] 4、疗效评定标准
显效：治疗后临床症状消失，经期恢复正常，观察半年无复发者；
好转：临床症状明显改善，逐步恢复；
无效：临床部分症状消失或无改变，达不到好转标准者。
[0017] 5、治疗结果
(-—痛«治疗^显效I好鋳—^I * ^铃有效
类型总数时间—w—..............—«—......丽i..............«.......「哭丽.....
__"___数 % 1¾ 1I I 数 i %__
麵 280 45 天 1270 9“316 2:1414 1:43 98:57
在上述的治疗中，用本发明药物治疗痛经患者280例，结果显效270例，显效率为96. 43%，好转6例，好转率为2. 14%，无效4例，总有效率为98. 57%。
Claims (3)
1. 一种治疗痛经的药物，其特征在于：它是由下述重量范围内的原料药制成： 党参10-20克黄芪10-20克当归8-15克 川芎10-20克香附10-20克青皮8-15克 牡丹皮10-20克枳壳10-20克生地黄8-15克 艾叶10-20克生姜6-10克白芍8-15克 熟地黄15-25克泽兰6-10克续断10-20克 红花15-25克侧柏叶8-12克赤芍10-20克 牛膝10-25克延胡索8-12克麦冬8-12克 三棱10-25克丹参8-15克通草6-10克 莪术15-25克茯苓10-15克甘草6-12克 大枣10-25克人参10-25克白术6-12克 苏木10-20克肉桂10-20克。
2.根据权利要求I所述的药物，其中各原料药的用量为： 党参15克黄芪15克当归12克 川芎15克香附15克青皮12克 牡丹皮15克枳壳15克生地黄12克 艾叶15克生姜8克白芍10克 熟地黄15克泽兰8克续断15克 红花20克侧柏叶10克赤芍15克 牛膝20克延胡索10克麦冬10克 三棱20克丹参12克通草8克 莪术20克茯苓12克甘草10克 大枣20克人参20克白术10克 苏木15克肉桂15克。
3.根据权利要求I或2所述药物的制备方法，其特征在于：它包括下列步骤： (一）备料 (1)党参：洗净泥沙后润透去芦，切片或切段，晒干； (2)黄芪：拣净杂质，除去残留的根头和空心较大者，用水浸泡，捞出，润透后及时切片，晒干； (3)当归：拣去杂质，洗净，闷润，稍晾至内外湿度半干时，切片晒干； (4)川芎：拣去杂质,分开大、小个,用水浸泡,晒晾，闷润后切片,干燥； (5)香附：拣去杂质，碾成碎粒，簸去细毛及细末； (6)青皮：拣净杂质,用水浸泡,捞出，润透,切片，晒干； (7)牡丹皮：拣去杂质，除去木心，洗净，润透，切片，晾干； (8)枳壳：除去瓤、核，冼净，稍浸，捞出，润软，以手能捏对折为度，切片，晾干； (9)生地黄：取原药材，除去杂质，洗净，稍润，切厚片，干燥，筛去碎屑； (10)艾叶：拣去杂质，去梗，筛去灰屑； (11)生姜：拣去杂质，洗净泥土，用时切片； (12)白芍：拣去杂制裁，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥； (13)熟地黄：选干净熟地黄； (14)泽兰：拣去杂质，除去残根，喷水稍润，切段晒干； (15)续断：洗净泥沙，除去残留根头，润透后切片晒干，筛去屑； (16)红花：拣净杂质，除去茎叶、蒂头，晒干； (17)侧柏叶：拣净杂质，揉碎去梗，筛净灰屑； (18)赤芍：取原药材，除去杂质，大小分档，洗净，润透，切薄片，干燥，筛去碎屑； (19)牛膝：拣去杂质，洗净，润软，去芦，切段，晒干； (20)延胡索：拣去杂质，用水浸泡，洗净，晒晾，润至内外湿度均匀，切片或打碎； (21)麦冬：拣净杂质，用水浸泡，捞出，润透后抽去心，再洗净晒干； (22)三棱：拣净杂质,用水浸泡,捞出润透,切片，晒干； (23)丹参：拣净杂质，除去根茎，洗净，捞出，润透后切片，晾干； (24)通草：拣去杂质，切片； (25)莪术：取原药材，除去杂质，大小分档，洗净，略浸泡，取出，润透，切薄片，干燥，筛去碎屑； (26 )茯苓：用水浸泡，洗净捞出，闷透后，切片，晒干； (27)甘草：拣去杂质，洗净，用水浸泡至八成透时，捞出，润透，切片，凉干； (28)大枣：拣净杂质，晒干； (29)人参：除去芦头，切段； (30)白术：拣净杂质，用水浸泡，泡后捞出，润透，切片，晒干； (31)苏木：取原药材，锯成短段，再劈成碎片或镑片； (32)肉桂：拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片，晾干； (二）制备 (1)将所述重量的党参、黄芪、当归、川芎、香附、青皮、牡丹皮、枳壳、生地黄、艾叶、生姜、白苟、熟地黄、泽兰、续断、红花、侧柏叶、赤苟、牛膝、延胡索、麦冬、三棱、丹参、通草、莪术、茯苓、甘草、大枣、人参、白术、苏木、肉桂加水煎煮，第一次加水6倍量，浸泡120分钟，武火煎煮沸腾10分钟，再用文火煎煮30分钟，即得煎煮液； (2)将煮液分为6剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210298079.1A CN102772779B (zh) | 2012-08-21 | 2012-08-21 | 一种治疗痛经的药物及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210298079.1A CN102772779B (zh) | 2012-08-21 | 2012-08-21 | 一种治疗痛经的药物及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102772779A true CN102772779A (zh) | 2012-11-14 |
| CN102772779B CN102772779B (zh) | 2014-04-02 |
Family
ID=47118035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210298079.1A Expired - Fee Related CN102772779B (zh) | 2012-08-21 | 2012-08-21 | 一种治疗痛经的药物及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102772779B (zh) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656525A (zh) * | 2013-12-19 | 2014-03-26 | 王星月 | 一种治疗痛经的中药组合物 |
| CN103720901A (zh) * | 2013-11-30 | 2014-04-16 | 刘志方 | 一种治疗痛经的药酒 |
| CN103948903A (zh) * | 2014-05-14 | 2014-07-30 | 张少林 | 一种治疗妇科痛经症的中药组合物 |
| CN104274815A (zh) * | 2014-10-30 | 2015-01-14 | 刘小芳 | 一种治疗气血虚弱型痛经的中药组合物 |
| CN105169361A (zh) * | 2015-11-06 | 2015-12-23 | 周广禹 | 一种治疗痛经的中药制剂 |
| CN105214057A (zh) * | 2015-11-05 | 2016-01-06 | 赵红侠 | 一种治疗胃痛的药物及其制备方法 |
| CN105726859A (zh) * | 2016-04-27 | 2016-07-06 | 李博 | 一种治疗气滞血瘀型痛经的中药 |
| CN106266997A (zh) * | 2016-09-20 | 2017-01-04 | 四川兴聚焦医药科技有限责任公司 | 一种治疗经前期紧张综合征的胶囊剂药物及其制备方法 |
| CN107582791A (zh) * | 2017-10-29 | 2018-01-16 | 杨小丽 | 一种治疗闭经的药物及其制备方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342353A (zh) * | 2008-07-24 | 2009-01-14 | 王镇 | 治疗不孕症的中药制剂及其制备方法 |
| CN101543610A (zh) * | 2009-02-18 | 2009-09-30 | 曹莹莹 | 一种有效治疗痛经的药酒 |
| CN101623475A (zh) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | 一种参桂鹿茸口服固体制剂的制备方法 |
| CN101628101A (zh) * | 2009-05-13 | 2010-01-20 | 九芝堂股份有限公司 | 一种药物组合物及其在制备治疗卵巢早衰制剂中的应用 |
| CN101856492A (zh) * | 2010-06-09 | 2010-10-13 | 杨青 | 妇科用中药组合物 |
| CN103169928A (zh) * | 2013-04-16 | 2013-06-26 | 南京海思创新生物科技有限公司 | 治疗痛经的外用中药组合物及其制备方法和应用 |
-
2012
- 2012-08-21 CN CN201210298079.1A patent/CN102772779B/zh not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342353A (zh) * | 2008-07-24 | 2009-01-14 | 王镇 | 治疗不孕症的中药制剂及其制备方法 |
| CN101623475A (zh) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | 一种参桂鹿茸口服固体制剂的制备方法 |
| CN101543610A (zh) * | 2009-02-18 | 2009-09-30 | 曹莹莹 | 一种有效治疗痛经的药酒 |
| CN101628101A (zh) * | 2009-05-13 | 2010-01-20 | 九芝堂股份有限公司 | 一种药物组合物及其在制备治疗卵巢早衰制剂中的应用 |
| CN101856492A (zh) * | 2010-06-09 | 2010-10-13 | 杨青 | 妇科用中药组合物 |
| CN103169928A (zh) * | 2013-04-16 | 2013-06-26 | 南京海思创新生物科技有限公司 | 治疗痛经的外用中药组合物及其制备方法和应用 |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720901A (zh) * | 2013-11-30 | 2014-04-16 | 刘志方 | 一种治疗痛经的药酒 |
| CN103656525A (zh) * | 2013-12-19 | 2014-03-26 | 王星月 | 一种治疗痛经的中药组合物 |
| CN103948903A (zh) * | 2014-05-14 | 2014-07-30 | 张少林 | 一种治疗妇科痛经症的中药组合物 |
| CN104274815A (zh) * | 2014-10-30 | 2015-01-14 | 刘小芳 | 一种治疗气血虚弱型痛经的中药组合物 |
| CN105214057A (zh) * | 2015-11-05 | 2016-01-06 | 赵红侠 | 一种治疗胃痛的药物及其制备方法 |
| CN105169361A (zh) * | 2015-11-06 | 2015-12-23 | 周广禹 | 一种治疗痛经的中药制剂 |
| CN105726859A (zh) * | 2016-04-27 | 2016-07-06 | 李博 | 一种治疗气滞血瘀型痛经的中药 |
| CN106266997A (zh) * | 2016-09-20 | 2017-01-04 | 四川兴聚焦医药科技有限责任公司 | 一种治疗经前期紧张综合征的胶囊剂药物及其制备方法 |
| CN107582791A (zh) * | 2017-10-29 | 2018-01-16 | 杨小丽 | 一种治疗闭经的药物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102772779B (zh) | 2014-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102772779B (zh) | 一种治疗痛经的药物及其制备方法 | |
| CN103251792A (zh) | 一种治疗缺乳肝气郁结症的药物及其制备方法 | |
| CN105477614A (zh) | 一种治疗肥胖的药物及其制备方法 | |
| CN103263642B (zh) | 一种治疗经乱的药物及其制备方法 | |
| CN103736037A (zh) | 一种治疗慢性疲劳综合症的药物及其制备方法 | |
| CN103977306A (zh) | 一种治疗乙型肝炎的药物及其制备方法 | |
| CN102631655B (zh) | 一种治疗冠心病的药物及其制备方法 | |
| CN103735934B (zh) | 一种治疗腰部疼痛的药物及其制备方法 | |
| CN103285211B (zh) | 一种用于治疗病理肥胖的中药颗粒 | |
| CN102872443B (zh) | 一种治疗偏头痛的药物及其制备方法 | |
| CN103735916B (zh) | 一种治疗肾病综合症的药物及其制备方法 | |
| CN102872351A (zh) | 一种治疗甲状腺炎的药物及其制备方法 | |
| CN103263555B (zh) | 一种治疗功能失调性子宫出血的药物及其制备方法 | |
| CN102872405B (zh) | 一种治疗黄疸的药物及其制备方法 | |
| CN104056224A (zh) | 一种治疗习惯性流产的药物及其制备方法 | |
| CN101947303B (zh) | 一种根治高血压的药物及其制备方法 | |
| CN103638496A (zh) | 一种治疗妇女崩漏的药物及其制备方法 | |
| CN103735792A (zh) | 一种治疗月经不调的药物及其制备方法 | |
| CN103263575A (zh) | 一种治疗头痛的药物及其制备方法 | |
| CN103735833B (zh) | 一种治疗小儿脱发的药物及其制备方法 | |
| CN102670925A (zh) | 一种治疗月经不调的药物及其制备方法 | |
| CN105343863A (zh) | 一种治疗良性卵巢囊肿的药物及其制备方法 | |
| CN105343854A (zh) | 一种治疗胃脘痛的药物及其制备方法 | |
| CN106177857A (zh) | 一种治疗习惯性流产的药物及其制备方法 | |
| CN102988883B (zh) | 一种治疗肝炎的药物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| C06 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C10 | Entry into substantive examination | ||
| GR01 | Patent grant | ||
| C14 | Grant of patent or utility model | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140402 Termination date: 20140821 |
|
| EXPY | Termination of patent right or utility model |