CN104383273B - A kind of Chinese medical extract for treating stress hyperglycemia and its preparation method and application - Google Patents
A kind of Chinese medical extract for treating stress hyperglycemia and its preparation method and application Download PDFInfo
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- A61K2236/30—Extraction of the material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of Chinese medical extract for treating stress hyperglycemia and its preparation method and application, which is prepared by the traditional Chinese medicinal material raw materials of following parts by weight：Fry 20 32 parts of waxgourd seed, 50 80 parts of cherokee rose root, 50 80 parts of dried orange peel, 20 40 parts of wilsonii, 59 parts of the coptis, 18 36 parts of radix polygonati officinalis.The Chinese medical extract of the present invention can improve the blood sugar level under abnormal carbohydrate metabolism state caused by the hormones such as adrenaline by way of oral, it can be the generation clinically reduced to the pathologic effect of original disease, patient is recovered earlier, and the medical expense of patient can be reduced.
Description
Technical field
The invention belongs to technical field of extraction of Chinese traditional medicine, is carried in particular to a kind of Chinese medicine for treating stress hyperglycemia
Take thing and its preparation method and application.
Background technology
Stress hyperglycemia be in various urgent patients, such as high fever, acute myocardial infarction AMI, cerebral hemorrhage or cerebral thrombosis,
Major operation, wound are such as fractured, severe burn due to increasing than usual in stress situation, glycemic hormone such as adrenaline secretion
More than 10 times, hyperglycemic factor, catecholamine, growth hormone etc., which are also secreted, to be increased, hyperglycaemia, glucose in urine and the sugar temporarily occurred
The pathological phenomenon of Tolerance.
Adrenaline belongs to the hormone of strong rise blood glucose, is combined with the beta receptor on liver, muscle cell membrane, passes through G-protein
Activated adenyl cyclase, increase intracellular cAMP concentration, and protein kinase cascades activating phosphatase enzyme, suppress Glycogensynthase, from
And accelerate decomposition of glycogen, suppress Glycogen synthesis.Clinically outstanding behaviours is pathologic hyperglycaemia, sugar tolerance to stress hyperglycemia
Decline, the increase of body catabolism, negative nitrogen balance, fat-free mass group is reduced, Wound healing is bad and infection rate raises etc..This
The pathologic effect of original disease can be aggravated by planting acute-property hyperglycaemia excessively, influenced or delayed rehabilitation, it is for example tight to induce multiple complications
Double infection dye, polyneuropathy, multiple organ failure or even death etc., seriously affect body homeostasis, the high blood of irritability
Sugar can reflect the state of an illness and the prognosis of critical patient to a certain extent.In addition, in ICU, stress hyperglycemia is very universal, should
The incidence of patient's infection and multiple organ dysfunction can be improved by swashing property hyperglycaemia, and ICU number of days and case fatality rate are moved in so as to increase.
At present, patient is persistently raised for stress hyperglycemia, its treatment method is usually to carry out intravenous insulin instillation
It is controlled.The pain for not only increasing patient is treated however, instiling using intravenous insulin, and medical expense is high.
The content of the invention
In view of the deficiencies in the prior art, it is an object of the invention to provide a kind of traditional Chinese medicine extraction for treating stress hyperglycemia
Thing and its preparation method and application.The Chinese medical extract can control the level of stress hyperglycemia, while medicine by taking orally
Production cost it is low, alleviate patient medication burden.
In order to achieve the object of the present invention, inventor is finally obtained as follows by a large number of experiments research and persistent exploration
Technical solution：
A kind of Chinese medical extract for treating stress hyperglycemia, the Chinese medical extract by following parts by weight traditional Chinese medicinal material raw materials
It is prepared：Fry 20-32 parts of waxgourd seed, 50-80 parts of cherokee rose root, 50-80 parts of dried orange peel, 20-40 parts of wilsonii, 5-9 parts of the coptis, jade
18-36 parts of bamboo.
It is further preferred that the Chinese medical extract of stress hyperglycemia is treated as described above by the Chinese medicine of following parts by weight
Material raw material is prepared：Fry 24-27 parts of waxgourd seed, 58-65 parts of cherokee rose root, 56-68 parts of dried orange peel, 28-32 parts of wilsonii, coptis 6-
8 parts, 26-32 parts of radix polygonati officinalis.
In the most preferred embodiment of the present invention, the Chinese medical extract as described above for treating stress hyperglycemia
It is prepared by the traditional Chinese medicinal material raw materials of following parts by weight：25 parts of waxgourd seed of stir-fry, 60 parts of cherokee rose root, 60 parts of dried orange peel, 30 parts of wilsonii,
7 parts of the coptis, 30 parts of radix polygonati officinalis.
It should be noted that traditional Chinese medicinal material raw materials of the present invention employed in preparation process have following source：Fry wax gourd
Son is the dry mature seed of wax gourd, cleans and dries, fries to yellow；Cherokee rose root is rosaceous plant fruit of Cherokee rose Rosa
The dry root skin of laevigata Michx.；Dried orange peel is being dried to for rutaceae orange Citrus reticulata Blanco
Ripe pericarp；Wilsonii is Araliaceae wilsonii Acanthopanax senticosus（Rupr. et Maxim.）
The dry root of Harms；The coptis is ranunculaceae plant triangle leaf coptis Coptis deltoidea C. Y. Cheng et
The dry rhizome of Hsiao；Radix polygonati officinalis is liliaceous plant radix polygonati officinalis Polygonatum odoratum（Mill.）The dry root of Druce
Stem.
Present invention also offers a kind of preparation method of Chinese medical extract as described above, this method comprises the following steps：Press
Weight ratio weighs each traditional Chinese medicinal material raw materials, merges, and with 90-95% ethanol heating and refluxing extractions, filters extracting solution, filtrate decompression concentration
Ethyl acetate is added afterwards to be extracted, and is concentrated into below medicinal extract, then 62 DEG C and is dried after the recovered solvent of gained acetic acid ethyl acetate extract
It is dry, obtain Chinese medical extract.
The technological parameter of above-mentioned Chinese medical extract preparation method is done further preferably, wherein the extraction step is
Equal-volume extraction；It is aided with ultrasonic vibration when ethyl acetate is extracted, supersonic frequency is frequency 15-30kHz.
The present inventor has investigated Chinese medical extract to stress hyperglycemia mouse caused by adrenaline by animal experiment
Influence, result of the test shows：The Chinese medical extract of high and low dose can reduce the sky of stress hyperglycemia animal model in various degree
Abdomen blood glucose, has more obvious hypoglycemic activity to the fasting blood-glucose of stress hyperglycemia mouse.Therefore, the present invention also provides upper
Application of the Chinese medical extract stated in the medicine for preparing treatment stress hyperglycemia.
Compared with prior art, Chinese medical extract of the invention can improve sugar caused by the hormones such as adrenaline by oral
Blood sugar level under metabolic disorder state, can be the generation clinically reduced to the pathologic effect of original disease, make patient more
It is early to recover, and the medical expense of patient can be reduced.
Embodiment
It is the preparation embodiment of Chinese medical extract of the present invention below, and by the form of animal experiment example to the upper of the present invention
Technique effect is stated to be described in further detail again, but the scope that this should not be interpreted as to the above-mentioned theme of the present invention be only limitted to it is following
Example, the techniques implemented on the basis of the foregoing are all within the scope of the present invention.
The preparation of 1 Chinese medical extract of embodiment
1060g raw medicinal herbs is taken (to fry waxgourd seed 125g, cherokee rose root 300g, dried orange peel 300g, wilsonii 150g, coptis 35g, jade
Bamboo 150g), suitably shred, add 95% ethanol 8.5L, heating and refluxing extraction 2 times (each 2h) merges extracting solution, filtering, and filtrate subtracts
Pressure is concentrated into 500ml, adds 500ml ethyl acetate, ultrasound thereto（Frequency 26.4kHz）10min is extracted, and is repeated with method
Extraction 2 times, combined ethyl acetate extract, recycling design, is concentrated into medicinal extract, and (60 DEG C) drying into vacuum drying chamber, crush,
100 mesh sieves are crossed, obtain Chinese medical extract.
Influence experiment of 2 Chinese medical extract of embodiment to adrenaline induced hyperglycemia mice blood glucose
SPF grades of Kunming mouses, weight 20-24g, male and female dual-purpose, puts same laboratory observation for 3 days before experiment and raises
Support, freely ingest and drink water, each group feed is identical with drinking water.After on-test, all mouse are randomly divided into five groups（It is female
It is male fifty-fifty）, every group 10:Normal group, model control group (distilled water 15ml/kg)；Positive controls (melbine
0.75g/kg)；Chinese medical extract high and low dose group (Chinese medical extract 540, the 270mg/kg of the preparation of embodiment 1).Each group is equal
Gastric infusion, 1 time/d, continuous use 10d.After fasting for solids but not liquids 2h after fasting for solids but not liquids 8h, administration before last dose, except just
Outside normal control group, the equal Injection of Adrenaline 0.5mg/kg of other groups of every mouse peritoneals, Normal group, which is then injected intraperitoneally etc., to be held
Product physiological saline.Socket of the eye veniplex capillary glass-tube takes blood 0.2ml after 30min, after blood clotting separate out serum after, 3500r/min from
Heart 15min, separates serum, takes serum to survey fasting blood sugar.
After can be seen that administration 10d by the test statistics result of table 1, compared with Normal group, model control group is small
Mouse intraperitoneal injection adrenaline after fasting blood-glucose raise immediately (P＜ 0.01), illustrate adrenaline induced hyperglycemia mice modeling
Success.Compared with model control group, melbine group and extract high and low dose group can be significantly reduced caused by adrenaline
Mouse blood sugar rise (P＜ 0.05 orP＜ 0.01).
Table 1：The fasting blood-glucose of each group adrenaline induced hyperglycemia mice compares
| Packet | Sample size（Only） | Blood glucose value（mmol/L） |
| Normal group | 10 | 4.74±1.20 |
| Model control group | 10 | 15.26±2.79▼▼ |
| Positive controls | 10 | 10.95±2.56★★ |
| Extract low dose group | 10 | 12.77±1.91★ |
| Extract high dose group | 10 | 11.08±2.14★★ |
Model control group compared with Normal group,▼P ＜ 0.05,▼▼P ＜ 0.01；Administration group is compared with model control group
,★P ＜ 0.05,★★P ＜ 0.01.
Claims (6)
1. a kind of Chinese medical extract for treating stress hyperglycemia, it is characterised in that the Chinese medical extract is by following parts by weight
Traditional Chinese medicinal material raw materials be prepared：24-27 parts of waxgourd seed of stir-fry, 58-65 parts of cherokee rose root, 56-68 parts of dried orange peel, 28-32 parts of wilsonii,
6-8 parts of the coptis, 26-32 parts of radix polygonati officinalis；Preparation method is：Each traditional Chinese medicinal material raw materials are weighed by weight, are merged, are added with 90-95% ethanol
Circumfluence distillation, filters extracting solution, and adding ethyl acetate after filtrate decompression concentration is extracted, gained acetic acid ethyl acetate extract warp
It is concentrated into below medicinal extract, then 62 DEG C and dries after recycling design, obtains Chinese medical extract.
2. the Chinese medical extract for the treatment of stress hyperglycemia according to claim 1, it is characterised in that the Chinese medicine carries
Thing is taken to be prepared by the traditional Chinese medicinal material raw materials of following parts by weight：Fry 25 parts of waxgourd seed, 60 parts of cherokee rose root, 60 parts of dried orange peel, wilsonii
30 parts, 7 parts of the coptis, 30 parts of radix polygonati officinalis.
3. a kind of preparation method of Chinese medical extract according to claim 1 or 2, it is characterised in that this method includes as follows
Step：Each traditional Chinese medicinal material raw materials are weighed by weight, are merged, and with 90-95% ethanol heating and refluxing extractions, filter extracting solution, filtrate subtracts
Ethyl acetate is added after pressure concentration to be extracted, and medicinal extract, then 62 DEG C are concentrated into after the recovered solvent of gained acetic acid ethyl acetate extract
Dry below, obtain Chinese medical extract.
4. the preparation method of Chinese medical extract according to claim 3, it is characterised in that the extraction step is to wait body
Product extraction.
5. the preparation method of Chinese medical extract according to claim 3, it is characterised in that auxiliary when ethyl acetate is extracted
With ultrasonic vibration, supersonic frequency is frequency 15-30kHz.
6. application of the Chinese medical extract in the medicine for preparing treatment stress hyperglycemia described in claim 1 or 2.
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| CN103951551A (en) * | 2014-03-05 | 2014-07-30 | 北华大学 | Three new lignin compounds and their preparation method and medical purposes |
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| CN103951551A (en) * | 2014-03-05 | 2014-07-30 | 北华大学 | Three new lignin compounds and their preparation method and medical purposes |
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| Title |
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| 瓯柑橘皮和陈皮降血糖作用研究;马森;《武夷学院学报》;20100430;第29卷(第2期);第19页 * |
| 金樱根不同炮制品中总黄酮的含量测定;单于超等;《今日药学》;20110731;第21卷(第7期);第414-415页 * |
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