CN104383067A - Traditional Chinese medicine preparation for treating all kinds of tinea and cutaneous pruritus and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating all kinds of tinea and cutaneous pruritus and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention provides a traditional Chinese medicine preparation for treating all kinds of tinea and cutaneous pruritus and a preparation method thereof. The traditional Chinese medicine preparation disclosed by the invention is prepared by carefully selecting purely natural Chinese herbal medicines including fructus cnidii, radix sophorae flavescentis, gallnut, cortex phellodendri, dried alum, sulphur, borax, camphor, borneol and the like as the raw materials. All the drugs in the formula are combined, and altogether have the effects of clearing heat, eliminating dampness, dispelling wind, relieving itching, detoxifying and promoting tissue regeneration, so that wind, dampness and heat are removed; and thus, the traditional Chinese medicine preparation disclosed by the invention has the obvious anti-inflammatory and antipruritic effects to tinea corporis and cruris, tinea versicolor, tinea of feet and hands, onychomycosis, acute and chronic eczema, neurodermatitis, allergic dermatitis, all kinds of cutaneous pruritus and the like.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind ofly treat Chinese medicine preparation of various tinea diseases and skin pruritus and preparation method thereof.
Background technology
Tinea has dividing of broad sense, narrow sense.Broad sense person refers to pachyderma, with squama or the dermatosis having sepage.As psoriasis, infantile eczema etc.The chat tinea that is narrow sense herein, means and occurs in epidermis, hair, refers to the superficial mycosis of (toe) first.As fungal infection of hand and foot, tinea alba, tinea versicolor etc., though not with tinea name, belong to the category of doctor trained in Western medicine superficial mycosis." General Treatise on the Cause and Symptoms of Diseases tinea time " cloud: " shape of tinea, skin and flesh urticaria, as money literary composition, increases gradually, round or oblique, and pain of itching, rectify Guo.Because of the difference of its happening part, and title is different.Tinea common clinically has: send out in tinea capitis, the tinea favosa of head, sends out in the fungal infection of hand and foot of hand, sends out in the tinea pedis etc. of foot.Tinea has chronicity, popularity, communicable feature, and it is the emphasis of preventing and treating skin diseases work always.Because life, daily life are careless, diseases caused by exogenous pathogenic factor are wet, heat, worm, poison, or the infection that contacts with each other, infection superficial mycosis, all heresies are harmonious, strongly fragrant in space between skin and muscles; Excessive caused by the skin.Send out in top person, ailment said due to cold or exposure of holding concurrently more, and send out as tinea capitis, tinea favosa, fungal infection of hand and foot etc.; Send out in bottom person, mostly be wet and contain, and send out as tinea pedis etc.Wind heat is Sheng person partially, then show as has dealt with rash, pruritus desquamation more; Damp and hot Sheng person, then many sepages stream taste, pruritus incrustation; Hot and suffocating dryness-transformation, qi-blood disharmony, failure of skin and muscle to be nourished, then pachyderma, crack from dryness, pruritus.Above-mentioned disease, be with in inconvenience, and all kinds of skin disorder is often more obstinate, is difficult to cure to the routine work of many people and life.
Summary of the invention
The technical problem that the present invention solves: provide a kind of and treat Chinese medicine preparation of various tinea diseases and skin pruritus and preparation method thereof, the pure natural Chinese herbal medicine such as Fructus Cnidii, Radix Sophorae Flavescentis, Galla Chinensis, Cortex Phellodendri, dried Alumen, prunus mume (sieb.) sieb.et zucc. sulphur, Borax, Camphora and Borneolum Syntheticum are meticulously selected to be raw material, be the external preparation of disinfection, there is obvious antiinflammatory, itching-relieving efficacies.
The technical solution used in the present invention: the Chinese medicine preparation for the treatment of various tinea diseases and skin pruritus, be made up of the crude drug of following weight parts: Fructus Cnidii 1 ~ 4, Radix Sophorae Flavescentis 0.5 ~ 1.5, Galla Chinensis 0.5 ~ 1.5, Cortex Phellodendri 1 ~ 3, dried Alumen 0.25 ~ 0.75, sulfur 0.125 ~ 0.375, Borax 0.25 ~ 0.75, Camphora 0.125 ~ 0.375, Borneolum Syntheticum 0.06 ~ 0.18.
A kind of preparation method for the treatment of the Chinese medicine preparation of various tinea diseases and skin pruritus is also provided, comprises the steps:
1) Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Phellodendri and Galla Chinensis are put into 2 times amount vinegars and soak 24h, then heating leaches to obtain the first filtrate after decocting 30min;
2) in the first filtrate, add dried Alumen, sulfur and Borax, heating leaches to obtain the second filtrate after decocting 30min again;
3) Camphora and Borneolum Syntheticum are added in 2 times amount ethanol make it to dissolve to obtain lysate;
4) the second filtrate and lysate are merged, filtration gets product.
The present invention's advantage compared with prior art:
1, we follow the theory and means of external treatment with Chinese medicine, the Chinese medicine external use lotion of development by Fructus Cnidii, Radix Sophorae Flavescentis, Galla Chinensis, Cortex Phellodendri, dried Alumen, sulfur, Borax, Camphora, Borneolum Syntheticum totally nine herbal medicines form, there is the effect of heat clearing and damp drying, dispelling wind for relieving itching;
2, in we, all medicines share, play heat clearing and damp drying, dispelling wind for relieving itching altogether, the merit of removing toxic substances and promoting granulation, make wind, wet, hot three heresies all remove, to tinea corporis and cruris, tinea versicolor, tinea manus and pedis, tinea unguium and acute and chronic eczema, neurodermatitis, allergic dermatitis and various skin pruritus etc., there is obvious inflammation-resisting itch-stopping effect.
Detailed description of the invention
Three kinds of embodiments of the present invention are described below.
Embodiment one: the Chinese medicine preparation for the treatment of various tinea diseases and skin pruritus, get Fructus Cnidii 1g, Radix Sophorae Flavescentis 0.5g, Galla Chinensis 0.5g, Cortex Phellodendri 1g, dried Alumen 0.25g, sulfur 0.125g, Borax 0.25g, Camphora 0.125g, Borneolum Syntheticum 0.06g, its preparation method is as follows:
1) by Fructus Cnidii 1g, Radix Sophorae Flavescentis 0.5g, Galla Chinensis 0.5g, Cortex Phellodendri 1g put into 2 times amount vinegars and soak 24h, and then heating leaches to obtain the first filtrate after decocting 30min;
2) in the first filtrate, add dried Alumen 0.25g, sulfur 0.125g, Borax 0.25g, heating leaches to obtain the second filtrate after decocting 30min again;
3) by Camphora 0.125g, Borneolum Syntheticum 0.06g adds in 2 times amount ethanol to be made it to dissolve to obtain lysate;
4) the second filtrate and lysate are merged, filtration gets product.
Embodiment two: the Chinese medicine preparation for the treatment of various tinea diseases and skin pruritus, get Fructus Cnidii 4g, Radix Sophorae Flavescentis 1.5g, Galla Chinensis 1.5g, Cortex Phellodendri 3g, dried Alumen 0.75g, sulfur 0.375g, Borax 0.75g, Camphora 0.375g, Borneolum Syntheticum 0.18g, its preparation method is as follows:
1) by Fructus Cnidii 4g, Radix Sophorae Flavescentis 1.5g, Galla Chinensis 1.5g, Cortex Phellodendri 3g put into 2 times amount vinegars and soak 24h, and then heating leaches to obtain the first filtrate after decocting 30min;
2) in the first filtrate, add dried Alumen 0.75g, sulfur 0.375g, Borax 0.75g, heating leaches to obtain the second filtrate after decocting 30min again;
3) Camphora Camphora 0.375g, Borneolum Syntheticum 0.18g are added in 2 times amount ethanol make it to dissolve to obtain lysate;
4) the second filtrate and lysate are merged, filtration gets product.
Embodiment three: the Chinese medicine preparation for the treatment of various tinea diseases and skin pruritus, get Fructus Cnidii 3g, Radix Sophorae Flavescentis 1g, Galla Chinensis 1g, Cortex Phellodendri 2g, dried Alumen 0.5g, sulfur 0.25g, Borax 0.5g, Camphora 0.25g, Borneolum Syntheticum 0.125g, its preparation method is as follows:
1) by Fructus Cnidii 3g, Radix Sophorae Flavescentis 1g, Galla Chinensis 1g, Cortex Phellodendri 2g put into 2 times amount vinegars and soak 24h, and then heating leaches to obtain the first filtrate after decocting 30min;
2) in the first filtrate, add dried Alumen 0.5g, sulfur 0.25g, Borax 0.5g, heating leaches to obtain the second filtrate after decocting 30min again;
3) Camphora Camphora 0.375g, Borneolum Syntheticum 0.18g are added in 2 times amount ethanol make it to dissolve to obtain lysate;
4) the second filtrate and lysate are merged, filtration gets product.
We's rubella of controlling, windy folder of eczema pruritus is damp and hot strongly fragrant caused by the flesh natural fibre line of meat.
External treatment is paid much attention in the treatment of eczema, is no matter that acute, subacute, chronic eczema all can use external treatment.Pruritus is its cardinal symptom, is also the main object for the treatment of, and method for the treatment of is that heat-clearing and toxic substances removing, dispeiling pathogenic wind and removing dampness are antipruritic.External therapy is by local topical medicine, and the efficacy of a drug is gone directly focus, and treatment has more specific aim and feasibility.Because its sick bit table is shallow, focus exposes, and external treatment medicine not only can go directly disease institute, by thoroughly reaching space between skin and muscles, dredge smooth passages through which vital energy circulates, QI and blood regulating, righting of getting rid of evils etc. are machine-processed and play local directly therapeutical effect, also by flesh natural fibre line of meat hair key, go deep into internal organs, play the effect of Chinese medicine.In addition, external used medicine is through percutaneous drug delivery, has not by the advantage of the many factors such as gastrointestinal enzyme, Digestive system, pH value.
We are instruct with Chinese medical theory, follows the theory and means of external treatment with Chinese medicine, the Chinese medicine external use lotion of development.We by Fructus Cnidii, Radix Sophorae Flavescentis, Galla Chinensis, Cortex Phellodendri, dried Alumen, sulfur, Borax, Camphora, Borneolum Syntheticum totally nine herbal medicines form, there is the effect of heat clearing and damp drying, dispelling wind for relieving itching, be mainly used in the treatment of eczema.In side, Fructus Cnidii is warm in nature, bitter in the mouth, returns kidney channel, has dampness and dispels the wind, effect of killing parasites for relieving itching." herbal classic " " ... the damp and hot sufferings of outer infections, all skin ulcers of contaminating, can wash as soup, can be end and apply, and produce effects very prompt, are not able to low-priced product and neglect it "; Dried Alumen puckery, cold in nature, return lung, spleen, liver, large intestine channel, there is removing toxic substances parasite killing, effect of dampness removing to stop itchin." Japan hanako materia medica ": " ... control apoplectic aphasia, scabies ...." Radix Sophorae Flavescentis bitter in the mouth is cold in nature, GUIXIN, liver, stomach, large intestine, urinary bladder channel, Cortex Phellodendri bitter in the mouth, cold in nature, returns kidney, urinary bladder channel, two medicines gather the antipruritic effect of heat clearing and damp drying altogether.Compendium of Material Medica: " bitter cold of Radix Sophorae Flavescentis, Cortex Phellodendri, all can the kidney invigorating, and lid gets its bitter dampness, and cold heat extraction also.Hot air wind producing, humidogene worm, therefore wind parasite killing can be controlled again ... "Fructus Cnidii, Radix Sophorae Flavescentis, dried Alumen, Cortex Phellodendri four medicine share, loose ailment said due to cold or exposure, and damp eliminating heat, eliminating rash and relieving itching is monarch drug altogether.The acid temperature of sulfur smoke, return kidney, large intestine channel, have effect of killing parasites for relieving itching, usual external treatment is used for scabies, tinea alba, carbuncle of yin nature malignant boil etc.Borneolum Syntheticum bitter in the mouth, cold nature, GUIXIN, spleen, lung meridian, external heat radiation erosion prevention and muscle growing, a surname's poison is antipruritic." medical center bun want ": " ... pox poison caves in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and do not keep, also can granulation promoting pain relieving ".Camphora taste is pungent hot in nature, has dehumidifying parasite killing, effect of antipruritic pain relieving." product remittance essence is wanted ": " main parasite killing, except scabies, treatment sore due to scald and burn ... " " detailed outline ": " ..., the disturbance of lower legs due to pathogenic cold and dampness, scabies, wind scabies, dental caries, parasite killing." sulfur, Borneolum Syntheticum, Camphora three taste be ministerial drug altogether, principal drug assistance is antipruritic.Galla Chinensis sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is removing toxic substances and promoting subsidence of swelling, removing dampness, effect of sore." Bencao Jingshu ": " ..., rheumatism tinea skin ulcer, and children's face nasal eczema person, all from external treatment, get its bitter energy parasite killing, acid is flat can hold back superficial heat, and property dry energy main air is wet, skin ulcer itches pus.Borax, sweet in the mouth, salty, cool in nature, attach to the lung and stomach meridians, there is heat-clearing and toxic substances removing, detumescence, anticorrosion, with Galla Chinensis altogether for monarch-minister drug damp eliminating assisted by adjuvant drug, and doublely can control because scratching that caused skin infection is routed for a long time not to be held back.
Assay one, acute oral toxicity test.
1, experimental animal: ICR strain white mice 20, male and female half and half, body weight 18-22g, is provided by Xian Medical Univ's animal feeding center;
2, tested material: yellow-green liquid;
3, test method: get white mice 20, mixed by tested material 25ml adding distil water to 100ml, forms outstanding mixed liquid, carries out a gavage, try the general state of Mus, poisoning manifestations and death condition after observing administration in 14 days by the dosage of 0.2ml/10g to white mice;
4, result of the test: in the observation period, examination Mus diet activity is normal, and have no poisoning manifestations, none is dead, LD
50> 5000mg/kg.
5, evaluation of result: the nontoxic level in our true border.
Assay two, single-use skin irritant test.
1, experimental animal: new zealand white rabbit three, body weight 2.5 ± 0.5kg, is provided by Xian Medical Univ's animal feeding center;
2, tested material: yellow-green liquid;
3, test method: get new zealand white rabbit three, first 24 hours of administration is by each unhairing 3*2cm in rabbit back spinal column both sides
2, only get tested material 1.0ml/, uniform application is at unhairing place, side, and opposite side is coated with distilled water as blank, within after coating 4 hours, remains tested material, observe 1,24,48,72 hour local skin response situation with warm water removing;
4, result of the test: see the following form
5, evaluation of result: according to upper table, we belong to nonirritant to skin.
Assay three, hypersensitive test.
1, experimental animal: Britain Cavia porcellus 30, body weight 200-220g, is provided by The Fourth Military Medical University's animal feeding center;
2, tested material: yellow-green liquid;
3, test method: taken off by guinea pig back diamond wool for first 24 hours in administration, the every side of unhairing scope is about 3*3cm
2.Test Cavia porcellus is divided into three groups at random by body weight, sex, often organizes 10, male and female half and half.First group to tested material, second group is negative control, and the 3rd group is positive control.
Sensitization contact: get tested material 0.2ml and be coated in depilation district in back on the left of animal, continues 6 hours, the 7th day and the 14th day, in kind repeats once, and negative control is coated with distilled water, and positive control is coated with 1%DNCB.
Excite contact: after last is to the thing sensitization that is put to the test 14 days, tested material 0.2ml is applied to district of losing hair or feathers on the right side of guinea pig back, tested material is removed after 6 hours, at once anaphylaxis situation is observed, then again observed in 1,24,48 hour, negative control group (distilled water) and positive controls (1%DNCB), operation and observational technique are with being subject to medicine group.
4, result of the test:
5, according to upper table, we belong to without sensitization.
In sum, in side, all medicines share, play heat clearing and damp drying, dispelling wind for relieving itching altogether, the merit of removing toxic substances and promoting granulation, make wind, wet, hot three heresies all remove, to tinea corporis and cruris, tinea versicolor, tinea manus and pedis, tinea unguium and acute and chronic eczema, neurodermatitis, allergic dermatitis and various skin pruritus etc., there is obvious inflammation-resisting itch-stopping effect.
Above-described embodiment, just preferred embodiment of the present invention, is not used for limiting the scope of the present invention, therefore all equivalence changes done with content described in the claims in the present invention, all should be included within the claims in the present invention scope.
Claims (2)
1. treat the Chinese medicine preparation of various tinea diseases and skin pruritus, it is characterized in that being made up of the crude drug of following weight parts: Fructus Cnidii 1 ~ 4, Radix Sophorae Flavescentis 0.5 ~ 1.5, Galla Chinensis 0.5 ~ 1.5, Cortex Phellodendri 1 ~ 3, dried Alumen 0.25 ~ 0.75, sulfur 0.125 ~ 0.375, Borax 0.25 ~ 0.75, Camphora 0.125 ~ 0.375, Borneolum Syntheticum 0.06 ~ 0.18.
2. the preparation method of the Chinese medicine preparation for the treatment of various tinea diseases as claimed in claim 1 and skin pruritus, is characterized in that comprising the steps:
1) Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Phellodendri and Galla Chinensis are put into 2 times amount vinegars and soak 24h, then heating leaches to obtain the first filtrate after decocting 30min;
2) in the first filtrate, add dried Alumen, sulfur and Borax, heating leaches to obtain the second filtrate after decocting 30min again;
3) Camphora and Borneolum Syntheticum are added in 2 times amount ethanol make it to dissolve to obtain lysate;
4) the second filtrate and lysate are merged, filtration gets product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106110121A (en) * | 2016-07-23 | 2016-11-16 | 孙茂志 | A kind of Chinese medicine composition treating tinea versicolor |
| CN113456755A (en) * | 2021-06-16 | 2021-10-01 | 北京圣永制药有限公司 | Ointment for treating skin itch and preparation method thereof |
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| CN1130534A (en) * | 1995-03-08 | 1996-09-11 | 朱海峰 | Medicinal sanitary rod |
| CN1116949A (en) * | 1995-04-11 | 1996-02-21 | 孔繁营 | Chinese herb medicine for external use of gynecopathy |
| CN1634248A (en) * | 2004-10-09 | 2005-07-06 | 玉桂才 | Chinese herbal formulation for treating venereal disease and skin disease |
| CN101167894A (en) * | 2007-11-09 | 2008-04-30 | 北京中科雍和医药技术有限公司 | Traditional Chinese medicinal washing lotion for treating dermatitis, vulvitis and vaginitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106110121A (en) * | 2016-07-23 | 2016-11-16 | 孙茂志 | A kind of Chinese medicine composition treating tinea versicolor |
| CN113456755A (en) * | 2021-06-16 | 2021-10-01 | 北京圣永制药有限公司 | Ointment for treating skin itch and preparation method thereof |
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Application publication date: 20150304 |