CN104382999A - Yin-nourishing and heat-clearing preparation for treating aplastic anemia caused by deficiency of liver-yin and kidney-yin and preparation method of yin-nourishing and heat-clearing preparation for treating aplastic anemia caused by deficiency of liver-yin and kidney-yin - Google Patents
Yin-nourishing and heat-clearing preparation for treating aplastic anemia caused by deficiency of liver-yin and kidney-yin and preparation method of yin-nourishing and heat-clearing preparation for treating aplastic anemia caused by deficiency of liver-yin and kidney-yin Download PDFInfo
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Abstract
The invention discloses a yin-nourishing and heat-clearing preparation for treating aplastic anemia caused by deficiency of liver-yin and kidney-yin. The yin-nourishing and heat-clearing preparation for treating aplastic anemia caused by deficiency of liver-yin and kidney-yin is mainly prepared from the following medicinal raw materials in parts by weight: 6-12 parts of turtle shells (decocted earlier), 5-10 parts of russula nigricans, 15-20 parts of roots of kudzu vine, 6-15 parts of fructus forsythiae, 2-5 parts of artemisia anomala, 6-9 parts of stachys geobombycis, 8-16 parts of poria cocos, 3-6 parts of manchurian walnuts and 6-15 parts of radix platycodi. According to the principle of the traditional Chinese medicine science, yin-nourishing and heat-clearing preparation for treating aplastic anemia caused by deficiency of liver-yin and kidney-yin is prepared through years of research, has the effects of invigorating spleen-stomach, replenishing qi, nourishing yin, suppressing the excessive yang and resolving hard lump, is exact and reliable in clinical curative effect and high in cure rate.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of nourishing YIN and clearing away heat preparation for the treatment of liver-kidney yin deficiency aplastic anemia and preparation method thereof.
Background technology
Aplastic anemia is hypoplastic anemia again, is called for short aplastic anemia, refers to that bone marrow fails to produce the situation that enough or new cell carrys out supplemental blood cell.In general, anemia refers to low erythrocyte statistics, but the situation of low statistics all can appear in the patient suffering from hypoplastic anemia in three kinds of blood cell kinds (erythrocyte, leukocyte and platelet).Congenital and acquired two large classes can be divided into, most with acquired residence, congenital aplastic anemia is very rare, its main Types is Fanconi anemia, and acquired aplastic anemia can divide former and Secondary cases amphitypy, and the former is agnogenio person, account for 50% of acquired aplastic anemia, again can by clinical manifestation, the different comprehensive classification of Hemogram, is divided into acute and chronic amphitypy." aplastic anemia " clinical manifestation is mainly anemia, hemorrhage, and infect, the weight of clinical manifestation depends on hemoglobin, leukocyte, thrombocytopenic degree, also relevant with Clinical types.Aplastic anemia belongs to the categories such as " asthenia ", " mass formed by blood stasis " of the traditional Chinese medical science.Suffering from a deficiency of the kidney is its main pathogenesis, is generally dialectically divided into deficiency of the kidney yin, insufficiency of kidney-YANG, kidney insufficiency three type, wherein common with kidney yin deficiency type, and the Kidney-Nourishing for the treatment of mainly with growing water replenishing essence is main.Main manifestations is Anemia, hemorrhage and infect, heating slighter.Publication number CN 102274417 A(application number 201110213694.3) Chinese patent literature disclose a kind of Chinese patent medicine for the treatment of aplastic anemia, mainly contain the compositions such as crude drug Radix Rehmanniae Preparata, Radix Scrophulariae, Radix Ophiopogonis, Rhizoma Alismatis, Folium Mori, Radix Rubiae, Fructus Gardeniae, Cortex Moutan, Rhizoma Imperatae.Publication number CN 102727749 A(application number 201210233455.9) Chinese patent literature disclose a kind of medicine for the treatment of aplastic anemia, raw material has Radix Astragali 6-10 part, Rhizoma Polygonati 8-15 part, Fructus Ligustri Lucidi 8-15 part, Cacumen Securinegae Suffruticosae 6-10 part, Bos taurus domesticus Gmelin 6-10 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Radix Angelicae Sinensis 6-10 part, nine layers of wind 8-15 part, Herba Euphorbiae Humifusae 3-6 part.Publication number CN 102772685 A(application number 201210243793.0) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of aplastic anemia, consist of: Radix Rehmanniae 10-30 part, Cortex Moutan 10-30 part, Radix Glycyrrhizae 10-25 part, Rhizoma Imperatae 10-30 part, Herba Cirsii 10-30 part, Cornu Bubali 10-30 part, Radix Notoginseng 10-30 part, Radix Angelicae Sinensis 10-30 part, Radix Codonopsis 10-30 part, Herba Agrimoniae 10-30 part, Flos Carthami 10-30 part, Radix Isatidis 10-30 part.
This disease of western medical treatment there is no good therapeutic scheme, operation risk is large, drug price is expensive, general family is difficult to bear, and the traditional Chinese medical science is lower relative to medical expense, and safe toxic and side effects is little, treatment for this disease has unique advantage, but effective Chinese medicine formula is actually rare, therefore, be necessary to continue to send out to output more effectively formula.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation of a kind of taking convenience, easily clothes of a specified duration and preparation method thereof.
Technical scheme of the present invention is:
Liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation, is prepared from primarily of following bulk drugs, is weight portion: Carapax Trionycis (being decocted first) 6-12, dark red mushroom 5-10, Radix Puerariae 15-20, Fructus Forsythiae 6-15, Herba Artemisiae Anomalae 2-5, Stachys geobombycis C. Y. Wu 6-9, Poria 8-16, Fructus Juglandis mandshuricae 3-6, Radix Platycodonis 6-15.
In preferred scheme, Carapax Trionycis (being decocted first) 8-10, dark red mushroom 6-9, Radix Puerariae 16-19, Fructus Forsythiae 8-13, Herba Artemisiae Anomalae 3-4, Stachys geobombycis C. Y. Wu 7-8, Poria 10-14, Fructus Juglandis mandshuricae 4-5, Radix Platycodonis 8-13.
Be more preferably, Carapax Trionycis (being decocted first) 9, dark red mushroom 7.5, Radix Puerariae 17.5, Fructus Forsythiae 10.5, Herba Artemisiae Anomalae 3.5, Stachys geobombycis C. Y. Wu 7.5, Poria 12, Fructus Juglandis mandshuricae 4.5, Radix Platycodonis 10.5.
Described liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation, be made into pharmaceutically acceptable pill, the preparation method of described pill is:
(1) getting Carapax Trionycis is placed in steamer, and big fire is steamed 30-50 minute (preferred, 35-45 minute is steamed in big fire, and be more preferably, big fire steams 40 minutes), takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and big fire is boiled 10-20 minute (preferred, 12-18 minute is boiled in big fire, is more preferably, and big fire boils 15 minutes) and taken out, and dries in the air cool;
(3) by Radix Puerariae, Fructus Forsythiae and Radix Platycodonis decontamination, dry, pulverize 80-140 mesh sieve (preferred, to pulverize 100-120 mesh sieve, and be more preferably, pulverized 110 mesh sieves);
(4) Carapax Trionycis processed in step (1) is placed in marmite, after decocting with water 30 minutes, add dark red mushroom, Stachys geobombycis C. Y. Wu, Poria and step (2) made medical material again, after big fire is boiled, turn little fire decoct 40-80 minute (preferred, turn a little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter;
(5) by step (4) gained filtrate, heating is concentrated, and then spraying dry, pulverizes 100 mesh sieves, and with step (3) made powder, mix homogeneously, adds refined honey, makes honeyed pill.
Described liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation pill, the 5-8 that step (4) amount of water is boiled total medical material weight is (preferred, to be 6-7 times of boiled total medical material weight, to be more preferably, 6.5 times for boiled total medical material weight) doubly.
The preparation method of described decoction is:
(1) getting Carapax Trionycis is placed in steamer, and big fire is steamed 30-50 minute (preferred, 35-45 minute is steamed in big fire, and be more preferably, big fire steams 40 minutes), takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and big fire is boiled 10-20 minute (preferred, 12-18 minute is boiled in big fire, is more preferably, and big fire boils 15 minutes) and taken out, and dries in the air cool;
(3) Carapax Trionycis processed in step (1) is placed in marmite, add the soak by water of institute's decoct medicinal herbs material gross weight 6 times after 30 minutes, add dark red mushroom, Radix Puerariae, Fructus Forsythiae, Stachys geobombycis C. Y. Wu, Poria, Radix Platycodonis and step (2) made medical material again, after big fire is boiled, turn little fire decoct 40-80 minute (preferred, turn a little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter;
(4) by step (3) gained filtrate, heating is concentrated into 1/3rd of original volume, adds Mel, stirs evenly, and leaves standstill, and filter, sterilizing, obtains decoction.
Described liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation decoction, the volume ratio of step (4) Mel and concentrated solution is 1:50.
The preparation method of described tablet is:
(1) getting Carapax Trionycis is placed in steamer, and big fire is steamed 30-50 minute (preferred, 35-45 minute is steamed in big fire, and be more preferably, big fire steams 40 minutes), takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and big fire is boiled 10-20 minute (preferred, 12-18 minute is boiled in big fire, is more preferably, and big fire boils 15 minutes) and taken out, and dries in the air cool;
(3) by Radix Puerariae, Fructus Forsythiae and Radix Platycodonis decontamination, dry, pulverize 80-140 mesh sieve (preferred, to pulverize 100-120 mesh sieve, and be more preferably, pulverized 110 mesh sieves);
(4) Carapax Trionycis processed in step (1) is placed in marmite, add institute's decoct medicinal herbs material gross weight 6 times of soak by water after 30 minutes, add dark red mushroom, Stachys geobombycis C. Y. Wu, Poria and step (2) made medical material again, after big fire is boiled, turn little fire and decoct 40-80 minute (preferably, turn little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter, filtering residue adds water and again decocts (water surface did not have medical material 2cm), merges twice filtrate;
(5) step (4) gained filtrate is concentrated, dry, pulverize 100 mesh sieves, and mixed with step (3) made powder, add appropriate amount of auxiliary materials, mixing, dry, be pressed into tablet dosage form according to the preparation for processing of tablet.
Described liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat formulation tablet, it is after big fire is boiled that step (4) filtering residue decocts again, turns little fire and decocts 30-50 minute (preferred, to turn little fire and decoct 40 minutes).
The preparation method of described unguentum is:
(1) getting Carapax Trionycis is placed in steamer, and big fire is steamed 30-50 minute (preferred, 35-45 minute is steamed in big fire, and be more preferably, big fire steams 40 minutes), takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and big fire is boiled 10-20 minute (preferred, 12-18 minute is boiled in big fire, is more preferably, and big fire boils 15 minutes) and taken out, and dries in the air cool;
(3) Carapax Trionycis processed in step (1) is placed in marmite, add the soak by water of institute's decoct medicinal herbs material gross weight 6 times after 30 minutes, add dark red mushroom, Radix Puerariae, Fructus Forsythiae, Stachys geobombycis C. Y. Wu, Poria, Radix Platycodonis and step (2) made medical material again, after big fire is boiled, turn little fire and decoct 40-80 minute (preferably, turn little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter, filtering residue adds water and again decocts (water surface did not have medical material 2cm), after big fire is boiled, turn little fire and decoct 40 minutes, merge twice filtrate;
(4) by step (3) gained filtrate, heating is concentrated into clear paste, obtains unguentum.
Described liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation unguentum, the relative density of step (4) clear paste is 1.21-1.26(70 DEG C) (preferred, the relative density of clear paste is 1.22-1.25(70 DEG C), be more preferably, the relative density of clear paste is 1.23(70 DEG C)).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Carapax Trionycis: base is former: be the carapace of Trionychidae animal Trionyx sinensis Wiegmann.Nature and flavor: salty, are slightly cold.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.
Dark red mushroom: base is former: be the sporophore of the dark red mushroom of Russulaceae Russula fungus.Composition: sporophore contains ergosterol, 5,7-Ergota steroid diene-3 β-ol.The property of medicine: " national Chinese herbal medicine compilation ": " micro-salty, temperature." function cures mainly: functions dispelling wind and clearing away cold, removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly anemofrigid-damp arthralgia, lumbago and skelalgia, arthralgia, numb hand and foot, tic of the limbs.
Radix Puerariae: base is former: be the tuber of pulse family Pueraria Herba Gelsemii Elegantis or Radix Puerariae rattan.Composition: Radix Puerariae is containing flavonoid: daidzein, daiazi, puerarin, 4 '-methoxy puerarin, daidzein-4 ', 7-diglucoside, daidzein-7-glucoside etc.The property of medicine: sweet, pungent, flat.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles is delivered, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Cure mainly fever caused by exogenous pathogens, rigidity pain on the head and nape, measles goes out smooth from the beginning of, rash, epidemic febrile disease is thirsty, diabetes, has loose bowels, dysentery.
Fructus Forsythiae: base is former: be the dry fruit of Oleaceae plants Fructus Forsythiae.Nature and flavor: bitter, are slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Herba Artemisiae Anomalae: base is former: be the herb of feverfew artemisia anomalas.Nature and flavor: acrid in the mouth; Micro-hardship; Warm in nature.Gui Jing: GUIXIN; Liver; Spleen channel.Function cures mainly: dissipating blood stasis to promote menstruationg; Hemostasia and detumescence; Promoting digestion and removing stagnation.Main warp closes; ' dysmenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lochiorrhea, lump in the abdomen; Traumatic injury; Incised wound is hemorrhage; Rheumatic arthralgia; Have blood in stool; Hematuria; Carbuncle pyogenic infections from tumour or sore; Scald; Abdominal pain due to retention of food; Dysentery.
Stachys geobombycis C. Y. Wu: base is former: Labiatae betony Stachys geobombycis C. Y. Wu, is used as medicine with tuber.Nature and flavor: sweet in the mouth; Property is put down.Gui Jing: lung; Kidney channel.Function cures mainly: kidney tonifying lung moistening; To enrich blood the infantile malnutrition that disappears.Main pulmonary tuberculosis cough is spitted blood; Night sweat; The deficiency of the lung is panted; Blood deficiency is weak; Infantile malnutrition.
Poria: base is former: be the dry sclerotia of On Polyporaceae Poria.Nature and flavor: sweet, light are flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Fructus Juglandis mandshuricae: base is former: be Juglandaceae walnut Juglans mandshurica immature fruit or peel.Composition: kernel is containing oils and fats, and protein, sugar and vitamin C, containing juglone in Fructus Canarii skin.The property of medicine: " national Chinese herbal medicine compilation ": " pungent, flat, poisonous." function cures mainly: promoting the circulation of QI to relieve pain, killing parasites for relieving itching.Cure mainly abdominal distention, psoriasis.
Radix Platycodonis: base is former: be the dry root of Campanulaceae Radix Platycodonis A.DC..Nature and flavor: bitter, pungent are flat.Gui Jing: return lung meridian.Function cures mainly: lung qi dispersing, and sore-throat relieving eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Liver-kidney yin deficiency provided by the invention " aplastic anemia " nourishing YIN and clearing away heat preparation not only scientific formula, and the preparation method of various dosage form is simple.In addition, excellent results of the present invention also shows:
1, formula of the present invention has invigorating the spleen and replenishing QI, nourishing YIN for attracting YANG, hard masses softening and resolving effect;
2, this prescription is according to Chinese medicine principle, and research is obtained for many years, and clinical efficacy is definitely reliable;
3, raw material is cheaply easy to get, and cost of manufacture is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation, is prepared from primarily of following bulk drugs: Carapax Trionycis (being decocted first) 6g, dark red mushroom 5g, Radix Puerariae 15g, Fructus Forsythiae 6g, Herba Artemisiae Anomalae 2g, Stachys geobombycis C. Y. Wu 6g, Poria 8g, Fructus Juglandis mandshuricae 3g, Radix Platycodonis 6g.
The preparation method of above-mentioned liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation pill is:
(1) getting Carapax Trionycis is placed in steamer, and big fire steams 35 minutes, takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and taking-up in 12 minutes is boiled in big fire, dries in the air cool;
(3) by Radix Puerariae, Fructus Forsythiae and Radix Platycodonis decontamination, dry, pulverize 100 mesh sieves;
(4) Carapax Trionycis processed in step (1) is placed in marmite, adds the soak by water of 6 times of boiled total medical material weight after 30 minutes, then add dark red mushroom, Stachys geobombycis C. Y. Wu, Poria and step (2) made medical material, after big fire is boiled, turn little fire and decoct 50 minutes, filter;
(5) by step (4) gained filtrate, heating is concentrated, and then spraying dry, pulverizes 100 mesh sieves, and with step (3) made powder, mix homogeneously, adds refined honey, makes honeyed pill.
The instructions of taking of pill of the present invention: pill is 15 days courses for the treatment of, and every day takes twice, each 3-5.
embodiment 2liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation, is prepared from primarily of following bulk drugs: Carapax Trionycis (being decocted first) 12g, dark red mushroom 10g, Radix Puerariae 20g, Fructus Forsythiae 15g, Herba Artemisiae Anomalae 5g, Stachys geobombycis C. Y. Wu 9g, Poria 16g, Fructus Juglandis mandshuricae 6g, Radix Platycodonis 15g.
The preparation method of liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation decoction is:
(1) getting Carapax Trionycis is placed in steamer, and big fire steams 40 minutes, takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and taking-up in 15 minutes is boiled in big fire, dries in the air cool;
(3) Carapax Trionycis processed in step (1) is placed in marmite, add the soak by water of institute's decoct medicinal herbs material gross weight 6 times after 30 minutes, then add dark red mushroom, Radix Puerariae, Fructus Forsythiae, Stachys geobombycis C. Y. Wu, Poria, Radix Platycodonis and step (2) made medical material, after big fire is boiled, turn little fire and decoct 60 minutes, filter;
(4) by step (3) gained filtrate, heating is concentrated into 1/3rd of original volume, adds Mel (volume ratio of Mel and concentrated solution is 1:50), stirs evenly, and leaves standstill, and filter, sterilizing, obtains decoction.
Model case: xxx, female, 36 years old.Main suit: often dizziness and blurred vision, delayed period, amount is few, within nearest one week, start to occur pharyngoxerosis, feverish sensation in the palms and soles, evening night sweat, with low grade fever, feel very uncomfortable, so household accompanies it to carry out examination in hospital, time medical, pale complexion, pale tongue, few tongue, thready and rapid pulse, hemogram checking result, hemoglobin 65g/L, leukocyte 2.6 × 109/L, erythrocyte 1.7 × 10HL, platelet 54 × 109/L, be finally diagnosed as YIN-deficiency type aplastic anemia.
Take the present embodiment gained liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation decoction, every day 2 times, 15 days courses for the treatment of.After taking a course for the treatment of, each symptom obviously alleviates, and continues to take a course for the treatment of, and menstrual cycle is normal, and all malaise symptoms all disappear, and patient feels recovery from illness, follows up a case by regular visits to, do not recur after half a year.
embodiment 3liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation, is prepared from primarily of following bulk drugs: Carapax Trionycis (being decocted first) 8g, dark red mushroom 6g, Radix Puerariae 16g, Fructus Forsythiae 8g, Herba Artemisiae Anomalae 3g, Stachys geobombycis C. Y. Wu 7g, Poria 10g, Fructus Juglandis mandshuricae 4g, Radix Platycodonis 8g.
The preparation method of liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat formulation tablet is:
(1) getting Carapax Trionycis is placed in steamer, and big fire steams 40 minutes, takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and taking-up in 15 minutes is boiled in big fire, dries in the air cool;
(3) by Radix Puerariae, Fructus Forsythiae and Radix Platycodonis decontamination, dry, pulverize 110 mesh sieves;
(4) Carapax Trionycis processed in step (1) is placed in marmite, add institute's decoct medicinal herbs material gross weight 6 times of soak by water after 30 minutes, add dark red mushroom, Stachys geobombycis C. Y. Wu, Poria and step (2) made medical material again, after big fire is boiled, turn little fire and decoct 60 minutes, filter, filtering residue adds water and again decocts (water surface did not have medical material 2cm), after big fire is boiled, turn little fire and decoct 40 minutes, merge twice filtrate;
(5) step (4) gained filtrate is concentrated, dry, pulverize 100 mesh sieves, and mixed with step (3) made powder, add appropriate amount of auxiliary materials, mixing, dry, be pressed into tablet dosage form according to the preparation for processing of tablet.
Model case: xxx, male, 49 years old.Main suit: think that the whole body is weak for nearly 1 year, but nearest two months, especially seriously, with dizziness and tinnitus, then arrive examination in hospital, time medical, shallow complexion, dysphoria with feverish sensation in the chest palms and soles, hectic fever night sweat, soreness of waist and knee, light red tongue limit point is red, thin fur, thready and rapid pulse, have a blood test conventional leukocyte 2.4 × 109/L, hemoglobin 53g/L, platelet 49 × 109/L, Chinese medical discrimination is deficiency of the kidney yin aplastic anemia.
Take the present embodiment gained liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat formulation tablet, adopt twice daily, each 4-6 sheet, with warm boiled water, 15 days courses for the treatment of.After taking two weeks, each symptom is comparatively front obviously to be improved, and rear continuation takes two courses for the treatment of, and self-induction is fully recovered, check routine blood test, leukocyte 4.2 × 109/L, hemoglobin 118g/L, platelet 115 × 109/L.
embodiment 4liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation, is prepared from primarily of following bulk drugs: Carapax Trionycis (being decocted first) 10g, dark red mushroom 9g, Radix Puerariae 19g, Fructus Forsythiae 13g, Herba Artemisiae Anomalae 4g, Stachys geobombycis C. Y. Wu 8g, Poria 14g, Fructus Juglandis mandshuricae 5g, Radix Platycodonis 13g.
The preparation method of liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation unguentum is:
(1) getting Carapax Trionycis is placed in steamer, and big fire steams 40 minutes, takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and taking-up in 15 minutes is boiled in big fire, dries in the air cool;
(3) Carapax Trionycis processed in step (1) is placed in marmite, add the soak by water of institute's decoct medicinal herbs material gross weight 6 times after 30 minutes, add dark red mushroom, Radix Puerariae, Fructus Forsythiae, Stachys geobombycis C. Y. Wu, Poria, Radix Platycodonis and step (2) made medical material again, after big fire is boiled, turn little fire and decoct 60 minutes, filter, filtering residue adds water and again decocts (water surface did not have medical material 2cm), after big fire is boiled, turn little fire and decoct 40 minutes, merge twice filtrate;
(4) by step (3) gained filtrate, heating is concentrated into clear paste, and the relative density of clear paste is 1.23(70 DEG C), obtain unguentum.
Model case: xxx, man, 32 years old.Main suit: occurred dizzy, weak before three months without obvious inducement, brush teeth hemorrhage, two is just normal, diet, sleep all normal, but can not do physical work, time medical, pale complexion is simple and unadorned, red tongue, thready and rapid pulse, blood routine examination: leukocyte 2.1 × 109/L, hemoglobin 39g/L, platelet 21 × 109/L, is finally diagnosed as YIN-deficiency type aplastic anemia.
Take the present embodiment gained liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation unguentum, twice daily, with warm boiled water, 15 days courses for the treatment of.After taking 10, malaise symptoms is alleviated gradually, after taking 20 days, patient without malaise symptoms, after again consolidate take 10 days, self-induction fully recover, check routine blood test, leukocyte, hemoglobin, platelet all rise to normal level.
embodiment 5liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation, is prepared from primarily of following bulk drugs: Carapax Trionycis (being decocted first) 9g, dark red mushroom 7.5g, Radix Puerariae 17.5g, Fructus Forsythiae 10.5g, Herba Artemisiae Anomalae 3.5g, Stachys geobombycis C. Y. Wu 7.5g, Poria 12g, Fructus Juglandis mandshuricae 4.5g, Radix Platycodonis 10.5g.
The preparation method of liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation pill is:
(1) getting Carapax Trionycis is placed in steamer, and big fire steams 40 minutes, takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and taking-up in 15 minutes is boiled in big fire, dries in the air cool;
(3) by Radix Puerariae, Fructus Forsythiae and Radix Platycodonis decontamination, dry, pulverize 110 mesh sieves;
(4) Carapax Trionycis processed in step (1) is placed in marmite, adds the soak by water of 6.5 times of boiled total medical material weight after 30 minutes, then add dark red mushroom, Stachys geobombycis C. Y. Wu, Poria and step (2) made medical material, after big fire is boiled, turn little fire and decoct 60 minutes, filter;
(5) by step (4) gained filtrate, heating is concentrated, and then spraying dry, pulverizes 100 mesh sieves, and with step (3) made powder, mix homogeneously, adds refined honey, makes honeyed pill.
test example 1the clinical practice of embodiment 5 gained liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation pill: according to the diagnostic criteria of country's the 4th aplastic anemia academic conference system in 1987,336 routine cases are filtered out in the outpatient service of hematology of hospital, wherein women 158 example, male 178 example, oldest 70 years old, minimal ages 8 years old, 47.3 years old mean age, the course of disease 3 months-2 years, average course of disease 1.2 years.
Patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes embodiment 5 products obtained therefrom, and every day takes twice, each 3-5 (adjusting to some extent depending on concrete condition), and 15 days courses for the treatment of, matched group takes the conventional medication such as Xue-bao capsules, ZAIZAOSHENGXUE PIAN, FUFANG ZAOFAN WAN.After taking 5 courses for the treatment of, carry out curative effect statistics.Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: cure: clinical anemia, infection, bleeding sign disappear, and blood routine examination platelet rises to 100 × 109/L, and leukocyte rises to 4.0 × 109/L and hemoglobin rises to 110g/L, the visible hematopoietic cell of bone marrow smear recovers normal; Effective: clinical anemia, infection, bleeding disappear substantially, blood routine examination leukocyte rises to 3.5 × 109/L, and hemoglobin rises to 100g/L, and platelet rises to 90 × 109/L, and the visible hematopoietic cell of bone marrow smear is close to normal; Invalid: before and after treatment, clinical malaise symptoms is unchanged, and blood routine examination, bone marrow smear are not improved.Two groups for the treatment of situations are as shown in table 1.
Table 1 liang component group situation and after taking medicine patient treat situation
As shown in Table 1: the experimental group patient taking embodiment 5 gained pill, malaise symptoms is all eliminated, it is 142 examples (60.2%) that routine blood test and bone marrow smear recover normal patient's number, and the patient that symptom is clearly better has 79 examples (33.5%), experimental group total effective rate 93.7%; The total effective rate of matched group is 86%, and therapeutic effect is not as experimental group.Visible embodiment 5 gained liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation pill has good therapeutic effect to liver-kidney yin deficiency aplastic anemia.
The therapeutic effect that the present invention is good, selection has close relationship with it, Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG in formula, hard masses softening and resolving; Radix Puerariae expelling pathogenic factors from muscles is delivered, promoting the production of body fluid to quench thirst; Fructus Forsythiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Herba Artemisiae Anomalae hemostasia and detumescence, dissipating blood stasis to promote menstruationg; The lung moistening of Stachys geobombycis C. Y. Wu kidney tonifying, the infantile malnutrition that disappears of enriching blood; Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, multi-medicament one works, and jointly plays effect of invigorating the spleen and replenishing QI, nourishing YIN for attracting YANG, hard masses softening and resolving, contributes to the healing of liver-kidney yin deficiency aplastic anemia.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation, is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Carapax Trionycis (being decocted first) 6-12, dark red mushroom 5-10, Radix Puerariae 15-20, Fructus Forsythiae 6-15, Herba Artemisiae Anomalae 2-5, Stachys geobombycis C. Y. Wu 6-9, Poria 8-16, Fructus Juglandis mandshuricae 3-6, Radix Platycodonis 6-15.
2. liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation as claimed in claim 1, is characterized in that, Carapax Trionycis (being decocted first) 8-10, dark red mushroom 6-9, Radix Puerariae 16-19, Fructus Forsythiae 8-13, Herba Artemisiae Anomalae 3-4, Stachys geobombycis C. Y. Wu 7-8, Poria 10-14, Fructus Juglandis mandshuricae 4-5, Radix Platycodonis 8-13(is preferred, Carapax Trionycis (being decocted first) 9, dark red mushroom 7.5, Radix Puerariae 17.5, Fructus Forsythiae 10.5, Herba Artemisiae Anomalae 3.5, Stachys geobombycis C. Y. Wu 7.5, Poria 12, Fructus Juglandis mandshuricae 4.5, Radix Platycodonis 10.5).
3. liver-kidney yin deficiency " aplastic anemia " the nourishing YIN and clearing away heat preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, the preparation method of described pill is:
(1) getting Carapax Trionycis is placed in steamer, and big fire is steamed 30-50 minute (preferred, 35-45 minute is steamed in big fire, and be more preferably, big fire steams 40 minutes), takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and big fire is boiled 10-20 minute (preferred, 12-18 minute is boiled in big fire, is more preferably, and big fire boils 15 minutes) and taken out, and dries in the air cool;
(3) by Radix Puerariae, Fructus Forsythiae and Radix Platycodonis decontamination, dry, pulverize 80-140 mesh sieve (preferred, to pulverize 100-120 mesh sieve, and be more preferably, pulverized 110 mesh sieves);
(4) Carapax Trionycis processed in step (1) is placed in marmite, after decocting with water 30 minutes, add dark red mushroom, Stachys geobombycis C. Y. Wu, Poria and step (2) made medical material again, after big fire is boiled, turn little fire decoct 40-80 minute (preferred, turn a little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter;
(5) by step (4) gained filtrate, heating is concentrated, and then spraying dry, pulverizes 100 mesh sieves, and with step (3) made powder, mix homogeneously, adds refined honey, makes honeyed pill.
4. the preparation method of liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation as claimed in claim 3, it is characterized in that, the 5-8 that step (4) amount of water is boiled total medical material weight is doubly (preferred, for 6-7 times of boiled total medical material weight, be more preferably, 6.5 times for boiled total medical material weight).
5. liver-kidney yin deficiency " aplastic anemia " the nourishing YIN and clearing away heat preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, the preparation method of described decoction is:
(1) getting Carapax Trionycis is placed in steamer, and big fire is steamed 30-50 minute (preferred, 35-45 minute is steamed in big fire, and be more preferably, big fire steams 40 minutes), takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and big fire is boiled 10-20 minute (preferred, 12-18 minute is boiled in big fire, is more preferably, and big fire boils 15 minutes) and taken out, and dries in the air cool;
(3) Carapax Trionycis processed in step (1) is placed in marmite, add the soak by water of institute's decoct medicinal herbs material gross weight 6 times after 30 minutes, add dark red mushroom, Radix Puerariae, Fructus Forsythiae, Stachys geobombycis C. Y. Wu, Poria, Radix Platycodonis and step (2) made medical material again, after big fire is boiled, turn little fire decoct 40-80 minute (preferred, turn a little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter;
(4) by step (3) gained filtrate, heating is concentrated into 1/3rd of original volume, adds Mel, stirs evenly, and leaves standstill, and filter, sterilizing, obtains decoction.
6. the preparation method of liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation as claimed in claim 5, it is characterized in that, the volume ratio of step (4) Mel and concentrated solution is 1:50.
7. liver-kidney yin deficiency " aplastic anemia " the nourishing YIN and clearing away heat preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, the preparation method of described tablet is:
(1) getting Carapax Trionycis is placed in steamer, and big fire is steamed 30-50 minute (preferred, 35-45 minute is steamed in big fire, and be more preferably, big fire steams 40 minutes), takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and big fire is boiled 10-20 minute (preferred, 12-18 minute is boiled in big fire, is more preferably, and big fire boils 15 minutes) and taken out, and dries in the air cool;
(3) by Radix Puerariae, Fructus Forsythiae and Radix Platycodonis decontamination, dry, pulverize 80-140 mesh sieve (preferred, to pulverize 100-120 mesh sieve, and be more preferably, pulverized 110 mesh sieves);
(4) Carapax Trionycis processed in step (1) is placed in marmite, add institute's decoct medicinal herbs material gross weight 6 times of soak by water after 30 minutes, add dark red mushroom, Stachys geobombycis C. Y. Wu, Poria and step (2) made medical material again, after big fire is boiled, turn little fire and decoct 40-80 minute (preferably, turn little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter, filtering residue adds water and again decocts (water surface did not have medical material 2cm), merges twice filtrate;
(5) step (4) gained filtrate is concentrated, dry, pulverize 100 mesh sieves, and mixed with step (3) made powder, add appropriate amount of auxiliary materials, mixing, dry, be pressed into tablet dosage form according to the preparation for processing of tablet.
8. the preparation method of liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation as claimed in claim 7, it is characterized in that, it is after big fire is boiled that step (4) filtering residue decocts again, turns little fire and decocts 30-50 minute (preferred, to turn little fire and decoct 40 minutes).
9. liver-kidney yin deficiency " aplastic anemia " the nourishing YIN and clearing away heat preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, the preparation method of described unguentum is:
(1) getting Carapax Trionycis is placed in steamer, and big fire is steamed 30-50 minute (preferred, 35-45 minute is steamed in big fire, and be more preferably, big fire steams 40 minutes), takes out, puts into hot water, with firmly brushing peeling meat, cleaning, drying, smash to pieces;
(2) by Herba Artemisiae Anomalae and Fructus Juglandis mandshuricae decontamination, be placed in the marmite that wine is housed, wine face there just was not medical material, and big fire is boiled 10-20 minute (preferred, 12-18 minute is boiled in big fire, is more preferably, and big fire boils 15 minutes) and taken out, and dries in the air cool;
(3) Carapax Trionycis processed in step (1) is placed in marmite, add the soak by water of institute's decoct medicinal herbs material gross weight 6 times after 30 minutes, add dark red mushroom, Radix Puerariae, Fructus Forsythiae, Stachys geobombycis C. Y. Wu, Poria, Radix Platycodonis and step (2) made medical material again, after big fire is boiled, turn little fire and decoct 40-80 minute (preferably, turn little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter, filtering residue adds water and again decocts (water surface did not have medical material 2cm), after big fire is boiled, turn little fire and decoct 40 minutes, merge twice filtrate;
(4) by step (3) gained filtrate, heating is concentrated into clear paste, obtains unguentum.
10. the preparation method of liver-kidney yin deficiency " aplastic anemia " nourishing YIN and clearing away heat preparation as claimed in claim 9, it is characterized in that, the relative density of step (4) clear paste is 1.21-1.26(70 DEG C) (preferred, the relative density of clear paste is 1.22-1.25(70 DEG C), be more preferably, the relative density of clear paste is 1.23(70 DEG C)).
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| Title |
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| 周霭详: "再生障碍性贫血的中医治疗", 《新医药学杂志》 * |
| 孟宪宗: "周信有教授治疗再生障碍性贫血用药经验", 《中医儿科杂志》 * |
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