CN104382972A - Composition of paecilomyces hepialid, ginseng and pseudo-ginseng and preparation method of composition - Google Patents
Composition of paecilomyces hepialid, ginseng and pseudo-ginseng and preparation method of composition Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61K9/4825—Proteins, e.g. gelatin
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Abstract
The invention provides a composition of paecilomyces hepialid, ginseng and pseudo-ginseng and a preparation method of the composition. The composition comprises the following raw materials in parts by mass: 40%-60% of paecilomyces hepialid, 10%-30% of ginseng and 10%-30%of pseudo-ginseng. Mixed with added auxiliary materials, the composition can be prepared into traditional Chinese medicine preparations, such as traditional Chinese medicine tablets, granules, hard capsules and soft capsules. According to the composition disclosed by the invention, the paecilomyces hepialid, the ginseng and the pseudo-ginseng are matched and combined according to the individual functional characteristics. An animal function test proves that the prepared drug has the health functions of enhancing the immunity and relieving physical fatigue.
Description
Technical field
The present invention relates to Chinese medicine composition, especially relate to a kind of compositions be made up of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng three kinds of Chinese medicines and Chinese medicinal tablet, granule, soft capsule and the hard capsule prepared by said composition.
Background technology
Peacilomyce hepiahi bacterium powder is the succedaneum of natural cordyceps in pharmacy industry and food industry, be separated from natural cordyceps and obtain Cordyceps mycelium, through fermentation culture, the mycelial effect of gained is substantially identical with natural cordyceps, and effect is stronger, therefore replace expensive natural product with artificial fermented product, natural cs medicine source can be relaxed few, the present situation that supply falls short of demand.Cordyceps powder formal name used at school peacilomyce hepiahi bacterium powder.
Hepialus armoricanus oberthur cordyceps sinensis mycelium powder is rich in adenosine, polysaccharide isoreactivity material, and not only rich content and ratio are suitable, effectively can strengthen human body constitution, improve immune function and anti-fatigue ability comprehensively.Containing HH2 in hepialus armoricanus oberthur cordyceps sinensis mycelium powder, be the important component of women's biological clock, the antibody-secreting amount of human body can be impelled to increase, activate the immunologically competent cell of body, especially have obvious facilitation to lymphocyte transformation and abdominal cavity macrophage phagocytosis.
Radix Ginseng is a kind of plant of Araliaceae Panax, have the good reputation of " king of BAICAO " since ancient times, the superfine product of " YIN nourishing is mended raw; strengthening the body resistance " is more described as by oriental medicine circle, in China and other areas, it is used as Chinese medicine the history having had more than 2000 year, for the collapse for the treatment of vigour, lung heart spleen deficiency of kidney-QI etc.Modern study proves, Radix Ginseng have the activity of central nervous system, immunoregulatory activity, anti-fatigue active, antioxidant activity, arteriosclerosis active, improve cardiovascular disease activity, improve climacteric syndrome activity, improve the activity of osteoporosis, activity of fighting against senium and improve the various active such as organism adaptation ability.
Radix Notoginseng is Umbellales Araliaceae Radix Ginseng, and belong to herbaceos perennial, Radix Notoginseng is used as medicine with its root, and it is warm in nature, acrid in the mouth, has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Because Radix Notoginseng is all panax species, and its effective active matter is higher than Radix Ginseng, is therefore called " king in ginseng " by modern Chinese medicine medicine scholar again; Radix Notoginseng dissipating blood stasis stops blooding, the pharmacological action that subduing swelling and relieving pain effect is relevant is very extensive, comprise hemostasis, antithrombotic, promotion hemopoietic, expand blood vessel, blood pressure lowering, resist myocardial ischemia, anti-cerebral ischemia, arrhythmia, atherosclerosis, antiinflammatory, protect the liver, antitumor, the effect such as analgesia, principle active component is PNS, PDS, PTS and Radix Notoginseng propylhomoserin.
Current above-mentioned various raw material all has folk prescription or the finished product processed with other raw material compound recipes or patent, and dosage form has tablet, capsule, granule, medicated wine, but has no the product and reported in literature that are made up of above-mentioned three kinds of raw materials.
Summary of the invention
For the problems referred to above that prior art exists, the invention provides a kind of peacilomyce hepiahi bacterium, Radix Ginseng and notoginseng composition and preparation method thereof.Compositions of the present invention is that the functional characteristics respectively had according to peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng carries out matched combined, and three supplements and complements each other, and has synergism for the function such as enhancing immunity and alleviating physical fatigue.
Technical scheme of the present invention is as follows:
A kind of peacilomyce hepiahi bacterium, Radix Ginseng and notoginseng composition, the mass fraction of contained raw material and each raw material is: peacilomyce hepiahi bacterium 40%-60%, Radix Ginseng 10%-30%, Radix Notoginseng 10%-30%.
Contained by described compositions, the mass fraction of raw material and each raw material is preferred: peacilomyce hepiahi bacterium 40%-60%, Radix Ginseng 15%-30%, Radix Notoginseng 20%-30%.
Described compositions Raw all or at the most two kinds be crude drug, all the other are crude drug extract.
The preparation method of described compositions is: take the peacilomyce hepiahi bacterium of respective amount, Radix Ginseng and Radix Notoginseng crude drug or medicinal substances extract, after pulverizing with jet mill respectively, cross 60 mesh sieves, after by the ground product of particle diameter 3 ~ 5 μm, put into three-dimensional mixer in the lump, mix 20-40min under 5-10r/min rotating speed, mixing discharging, obtains described compositions.
The Chinese medicine preparation prepared by described compositions, described Chinese medicine preparation is tablet, granule, hard capsule or soft capsule.
The preparation method of described tablet is: by the compositions 40%-85% of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng; starch 5%-30%, microcrystalline Cellulose 5%-20%, carboxymethylstach sodium 5%-10%; drop into mixing 5-20 minute in mixer-granulator; add ethanol as wetting agent, mixing 5-20 minute, mixed material pelletization, drying; add magnesium stearate; granulate, tabletting, obtains described tablet.
The preparation method of described granule is: by the compositions 20%-60% of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng; dextrin 30%-70%; sucrose 2%-10%; drop into mixing 5-20 minute in mixer-granulator; add ethanol as wetting agent, mixing 5-20 minute, mixed material pelletization, drying, screening; remove coarse granule and fine powder, obtain granule.
The preparation method of described hard capsule is: by the compositions 50%-92% of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng; carboxymethylstach sodium 1%-20%; conventional fillers 5%-35%, drops into mixing 5-20 minute in mixer-granulator, adds ethanol as wetting agent; mixing 5-20 minute; mixed material pelletization, drying, add magnesium stearate, granulate; capsule fill, obtains hard capsule.
The preparation method of described soft capsule is: by the compositions 20%-40% of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng, PEG400 35%-65%, tween 5%-15%, suspending agent 5%-10%, be mixed and made into composition solution, separately make capsule material glue with gelatin, arabic gum, glycerol, syrup, Purified Water q. s; Capsule material glue is made soft film, with encapsulating machine, composition solution is pressed into soft capsule.
The technique effect that the present invention is useful is:
1, in the present composition, peacilomyce hepiahi bacterium proves through animal function test, has the health care of enhancing immunity, alleviating physical fatigue;
2, in the present composition, Radix Ginseng has effect of strengthening by means of tonics, invigorating the spleen and replenishing QI;
3, in the present composition, Radix Notoginseng has blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain, strengthening by means of tonics, resisting fatigue, anoxia enduring, anti-ageing effect of waiting for a long time;
4, present composition three components supplements and complements each other, and has synergism for the function such as enhancing immunity and alleviating physical fatigue.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is specifically described.
Embodiment 1:
Take peacilomyce hepiahi bacterium 40% respectively, Radix Ginseng 30%, Radix Notoginseng 30%, after pulverizing with jet mill respectively, cross 60 mesh sieves, after by the ground product of particle diameter 3 ~ 5 μm, put into three-dimensional mixer in the lump, mix 40min under 5r/min rotating speed, mixing discharging, obtains described compositions;
Above-mentioned peacilomyce hepiahi bacterium is crude drug extract, and Radix Ginseng, Radix Notoginseng are crude drug;
Get above-mentioned composition 60%, starch 25%, microcrystalline Cellulose 10%; carboxymethylstach sodium 5%; drop in mixer-granulator and mix 10 minutes, add ethanol as wetting agent, mix 10 minutes; mixed material pelletization, drying; add magnesium stearate, granulate, tabletting; packaging, obtains tablet of the present invention.
Embodiment 2:
Take peacilomyce hepiahi bacterium 60% respectively, Radix Ginseng 20%, Radix Notoginseng 20%, after pulverizing with jet mill respectively, cross 60 mesh sieves, after by the ground product of particle diameter 3 ~ 5 μm, put into three-dimensional mixer in the lump, mix 20min under 10r/min rotating speed, mixing discharging, obtains described compositions;
Above-mentioned peacilomyce hepiahi bacterium, Radix Ginseng, Radix Notoginseng are crude drug;
Take above-mentioned composition 50%, starch 25%, microcrystalline Cellulose 15%; carboxymethylstach sodium 10%; drop in mixer-granulator and mix 5 minutes, add ethanol as wetting agent, mix 20 minutes; mixed material pelletization, drying; add magnesium stearate, granulate, tabletting; packaging, obtains tablet of the present invention.
Embodiment 3:
Take peacilomyce hepiahi bacterium 55% respectively, Radix Ginseng 25%, Radix Notoginseng 20%, after pulverizing with jet mill respectively, cross 60 mesh sieves, after by the ground product of particle diameter 3 ~ 5 μm, put into three-dimensional mixer in the lump, mix 30min under 6r/min rotating speed, mixing discharging, obtains described compositions;
Above-mentioned peacilomyce hepiahi bacterium, Radix Notoginseng are crude drug, Radix Ginseng is crude drug extract;
Take above-mentioned composition 50%, dextrin 45%, sucrose 5%, drop in mixer-granulator and mix 5 minutes; add ethanol as wetting agent, mix 20 minutes, mixed material pelletization, drying, screening; remove coarse granule and fine powder, packaging, obtains granule of the present invention.
Embodiment 4:
Take peacilomyce hepiahi bacterium 60% respectively, Radix Ginseng 10%, Radix Notoginseng 30%, after pulverizing with jet mill respectively, cross 60 mesh sieves, after by the ground product of particle diameter 3 ~ 5 μm, put into three-dimensional mixer in the lump, mix 25min under 8r/min rotating speed, mixing discharging, obtains described compositions;
Above-mentioned peacilomyce hepiahi bacterium, Radix Ginseng are crude drug, and Radix Notoginseng is crude drug extract;
Take combinations thereof compositions 90%; carboxymethylstach sodium 5%, filler (starch) 5%, drops in mixer-granulator and mixes 20 minutes; add ethanol as wetting agent; mix 5 minutes, mixed material pelletization, drying, add magnesium stearate; granulate; capsule fill, packaging, namely making content is heavily the hard capsule of 0.45g.
Embodiment 5:
Take peacilomyce hepiahi bacterium 50% respectively, Radix Ginseng 30%, Radix Notoginseng 20%, after pulverizing with jet mill respectively, cross 60 mesh sieves, after by the ground product of particle diameter 3 ~ 5 μm, put into three-dimensional mixer in the lump, mix 28min under 7r/min rotating speed, mixing discharging, obtains described compositions;
Above-mentioned peacilomyce hepiahi bacterium, Radix Ginseng, Radix Notoginseng are crude drug extract;
Take above-mentioned composition 60%; carboxymethylstach sodium 15%, filler (starch) 25%, drops in high-speed mixing granulating machine and mixes 10 minutes; add ethanol as wetting agent; mix 20 minutes, mixed material pelletization, drying, add magnesium stearate; granulate; capsule fill, packaging, namely making content is heavily the hard capsule of 0.45g.
Embodiment 6
Take peacilomyce hepiahi bacterium 60% respectively, Radix Ginseng 30%, Radix Notoginseng 10%, after pulverizing with jet mill respectively, cross 60 mesh sieves, after by the ground product of particle diameter 3 ~ 5 μm, put into three-dimensional mixer in the lump, mix 20min under 10r/min rotating speed, mixing discharging, obtains described compositions;
Above-mentioned peacilomyce hepiahi bacterium, Radix Ginseng are crude drug, and Radix Notoginseng is crude drug extract;
Take above-mentioned composition 25%, PEG400 60%, tween 5%, suspending agent 10%, is mixed and made into composition solution; Another gelatin 35%, arabic gum 5%, glycerol 20%, syrup 5%, purified water 35%, mix homogeneously, makes capsule material glue; Capsule material glue is made soft film, composition solution is pressed into (be 0.3-0.75g containing composition weight) soft capsule with encapsulating machine.
Test example:
Experimental design: select the cleaning grade Kun Ming mice (body weight 20.0 ± 2.0g) 200 bought from Chinese Academy of Sciences's Shanghai Experimental Animal Center, swimming with a load attached to the body experiment uses male Mus entirely, other test male and female half and half, be divided into 5 groups at random, be respectively matched group, low dose group, middle dosage group, high dose group and commercially available matched group, in each group, every 10 are carried out a test.
Test daily ration: matched group gavage gives water for injection; Low dose group gavage gives embodiment 4 gained capsule 's content 225mg/ (kgd) (human body recommends 5 times of consumption); Middle dosage group gavage gives embodiment 4 gained capsule 's content 450mg/ (kgd) (human body recommends 10 times of consumption); High dose group gavage gives embodiment 4 gained capsule 's content 900mg/ (kgd) (human body recommends 20 times of consumption); Commercially available matched group gavage gives correction ginseng pills of sea dog (specification: 320mg/ grain) the content 320mg/ (kgd) (human body recommends 10 times of consumption) that Rongcheng Baihe Biological Technology Co., Ltd. produces.
Trial: cleaning grade Kun Ming mice purchase come after freely drink water, diet, animal is tested after observing 5d, and each test group content, is dissolved in distilled water and is settled to 200ml, matched group gives the water for injection of equal volume, gives tested mice lavage respectively; Once a day, continuous 30 days.
Mensuration project: Loaned swimming test, serum urea measure, blood lactase acid measures.Functional evaluation is carried out in experiment.Result is respectively as shown in table 1,2,3,4.
Table 1
| Group | Number of animals (only) | Swimming time ± S (second) |
| Matched group | 10 | 299.1±67.3 |
| Low dose group | 10 | 311.7±69.5 |
| Middle dosage group | 10 | 378.3±83.6 |
| High dose group | 10 | 389.3±84.1 |
| Commercially available matched group | 10 | 306.4±77.4 |
The walking weight load that swimming with a load attached to the body result can find out 450mg/ (kgd) listed by table 1,900mg/ (kgd) dosage can extend white mice, middle and high dosage group white mice walking weight load is apparently higher than matched group, and difference has significance (P < 0.05); Middle and high dosage group and the contrast of commercially available matched group, successful is better than commercially available matched group.
Table 2
| Group | Number of animals (only) | Serum urea ± S (mmol/L) | P value |
| Matched group | 10 | 10.12±1.31 | ---- |
| Low dose group | 10 | 9.31±1.61 | 0.393 |
| Middle dosage group | 10 | 9.19±1.32 | 0.177 |
| High dose group | 10 | 8.35±1.48 | 0.025 |
| Commercially available matched group | 10 | 9.46±1.24 | 0.412 |
Serum urea measurement result listed by table 2, high dose group mouse serum carbamide is starkly lower than matched group, and difference has significance (P < 0.05); Middle dosage group and the contrast of commercially available matched group, mouse serum carbamide is starkly lower than commercially available matched group, so middle and high dosage group can more effectively reduce mouse serum urea content.
Table 3
Result listed by table 3 is blood lactase acid measurement result, can find out 225mg/ (kgd) dosage from institute's column data, just can reduce the rear blood lactase acid value of white mice motion, obviously reduce the blood lactase acid area under curve of white mice, P < 0.05; High dose group white mice blood lactase acid area under the curve is starkly lower than matched group, and difference has significance (P < 0.05).
In sum, by carrying out Loaned swimming test to the white mice taking product of the present invention, directly embody resisting fatigue effect, in table 1, high dose group has exceeded 107S (25%) than matched group, has exceeded 83S than commercially available prod, (20%); Serum urea mensuration and blood lactase acid measure the size embodying tired rear recovery capability and side effect, and can find out that product composition of the present invention has the function of alleviating physical fatigue and tired rear recovery capability is strong, side effect is little.
Claims (9)
1. peacilomyce hepiahi bacterium, Radix Ginseng and a notoginseng composition, is characterized in that the mass fraction of contained raw material and each raw material is: peacilomyce hepiahi bacterium 40%-60%, Radix Ginseng 10%-30%, Radix Notoginseng 10%-30%.
2. compositions according to claim 1, is characterized in that the mass fraction of contained raw material and each raw material: peacilomyce hepiahi bacterium 40%-60%, Radix Ginseng 15%-30%, Radix Notoginseng 20%-30%.
3. compositions according to claim 1, it is characterized in that described compositions Raw all or at least one be crude drug, all the other are crude drug extract.
4. compositions according to claim 1, it is characterized in that the preparation method of described compositions is: take the peacilomyce hepiahi bacterium of respective amount, Radix Ginseng and Radix Notoginseng crude drug or medicinal substances extract, after pulverizing with jet mill respectively, cross 60 mesh sieves, after by the ground product of particle diameter 3 ~ 5 μm, put into three-dimensional mixer in the lump, under 5-10r/min rotating speed, mix 20-40min, mixing discharging, obtains described compositions.
5. the Chinese medicine preparation prepared by compositions described in claim 1, is characterized in that described Chinese medicine preparation is tablet, granule, hard capsule or soft capsule.
6. Chinese medicine preparation according to claim 5, is characterized in that the preparation method of described tablet is:
By the compositions 40%-85% of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng; starch 5%-30%, microcrystalline Cellulose 5%-20%, carboxymethylstach sodium 5%-10%; drop into mixing 5-20 minute in mixer-granulator; add ethanol as wetting agent, mixing 5-20 minute, mixed material pelletization, drying; add magnesium stearate; granulate, tabletting, obtains described tablet.
7. Chinese medicine preparation according to claim 5, is characterized in that the preparation method of described granule is:
By the compositions 20%-60% of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng; dextrin 30%-70%; sucrose 2%-10%; drop into mixing 5-20 minute in mixer-granulator; add ethanol as wetting agent, mixing 5-20 minute, mixed material pelletization, drying, screening; remove coarse granule and fine powder, obtain granule.
8. Chinese medicine preparation according to claim 5, is characterized in that the preparation method of described hard capsule is:
By the compositions 50%-92% of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng; carboxymethylstach sodium 1%-20%; conventional fillers 5%-35%, drops into mixing 5-20 minute in mixer-granulator, adds ethanol as wetting agent; mixing 5-20 minute; mixed material pelletization, drying, add magnesium stearate, granulate; capsule fill, obtains hard capsule.
9. Chinese medicine preparation according to claim 5, is characterized in that the preparation method of described soft capsule is:
By the compositions 20%-40% of peacilomyce hepiahi bacterium, Radix Ginseng and Radix Notoginseng, PEG400 35%-65%, tween 5%-15%, suspending agent 5%-10% are mixed and made into composition solution, separately make capsule material glue with gelatin, arabic gum, glycerol, syrup, Purified Water q. s; Capsule material glue is made soft film, with encapsulating machine, composition solution is pressed into soft capsule.
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Application publication date: 20150304 |