CN104382885A - Hydrogel plaster and production method thereof - Google Patents
Hydrogel plaster and production method thereof Download PDFInfo
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- CN104382885A CN104382885A CN201410613326.1A CN201410613326A CN104382885A CN 104382885 A CN104382885 A CN 104382885A CN 201410613326 A CN201410613326 A CN 201410613326A CN 104382885 A CN104382885 A CN 104382885A
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Abstract
The invention relates to the field of medical products, and particularly relates to a hydrogel plaster which consists of a backing layer, a hydrogel layer and a protective film layer, wherein the hydrogel layer comprises the following components in percentage by mass: 5-12% of framework material, 1-3% of an excipient, 25-30% of a wetting agent, 0.2-1.1% of a crosslinking agent, 0.1-1% of a pH regulator, 0.1-1% of a chelating agent, 0.1-0.2% of main drug and the balance of water. The hydrogel plaster is good in heat absorption and relatively strong in heat dissipation capacity of surface layer; and when in use, the hydrogel plaster is strong in slow release capacity and good in stability. Moreover, the hydrogel plaster is not easy to oxidize, relatively long in shelf life, long in storage time and relatively low in requirement on the environment condition of storage.
Description
Technical field
The present invention relates to medical product field, especially a kind of hydrogel plaster and production method thereof.
Background technology
Hydrogel take water as the gel of disperse medium.Hydrogel introduces a part of hydrophobic group and hydrophilic residue, hydrophilic residue wherein and water molecules having in cancellated water soluble polymer, thus hydrone is connected to netted inside, and hydrophobic residue water-swellable wherein.It is a kind of cross linked polymer with macromolecule network system, and character is soft, can keep certain shape, can absorb a large amount of water.
As the high water-keeping material of a kind of high water suction, hydrogel is widely used in multiple fields, as the water blockoff in the condensation preventing agent in: facial film, defervescence plaster used, pain easing plaster, agricultural film, building, conditioning agent, petrochemical industry adjust, the dehydration of crude oil or product oil, the dust suppressant in mining industry, the antistaling agent in food, thickening agent, pharmaceutical carrier in medical treatment etc.
But existing hydrogel still exists some problems, as short in the storage time of effective ingredient in hydrogel, the problems such as slow release effect is poor, unstable and oxidizable, make effective ingredient can not play due effect.
Summary of the invention
The object of the invention is the deficiency in order to solve above-mentioned technology and provide a kind of storage time and the shelf-life longer, the hydrogel plaster of had good sustained release effect and production method thereof.
In order to achieve the above object, the hydrogel plaster designed by the present invention, it is made up of backing layer, hydrogel layer and protective film, and described hydrogel layer is made up of framework material, excipient, wetting agent, cross-linking agent, acid-base modifier, chelating agen and water; Wherein shared by each component, the percentage ratio of gross mass is: framework material 5-12%, excipient 1-3%, wetting agent 25-30%, cross-linking agent 0.2-1.1%, acid-base modifier 0.1-1%, chelating agen 0.1-1%, principal agent 0.1%-0.2%, and all the other are water; Wherein principal agent is by Mentholum and borneol composition or be Fructus Capsici extract.
As optimization, described hydrogel layer is made up of framework material 8%, excipient 2%, wetting agent 26%, cross-linking agent 0.8%, acid-base modifier 0.2%, chelating agen 0.3%, principal agent 0.2% and excess water.
As preferably, described hydrogel layer is made up of framework material 11%, excipient 2.5%, wetting agent 28%, cross-linking agent 1.1%, acid-base modifier 0.4%, chelating agen 0.6%, principal agent 0.1% and excess water.
The hydrogel plaster that the present invention obtains, its heat absorption is good, and the heat-sinking capability on top layer is relatively strong simultaneously, and in use, its slow-release capability is strong, and good stability.It is not easily oxidized in addition, and the shelf-life is relatively long, and the storage time is of a specified duration, and relatively low to the requirement of the environmental condition stored.
Production method: first weigh up wetting agent, in succession add framework material, excipient, cross-linking agent, chelating agen, mixing speed is turned down, speed is about 25r/min, slowly stir, after powder is all moistening by wetting agent, gradually improve mixing speed to 250r/min, rapid stirring mixing time about 10 minutes, to being uniformly dispersed; In advance acid-base modifier is added to the water dissolving stand-by; Separately principal agent is dissolved in a solvent; Add in above-mentioned dispersion, rapid stirring, treat that sizing material is swelling, reduce rotating speed when viscosity obviously increases to 75r/min, continue stir about discharging after 15 minutes.
Gained gel, according to principal agent characteristic, is divided into warming type and cool feeling type, and warming type has invigorates blood circulation, antiinflammatory, analgesic efficacy, for the pain that articular sprain and cold-damp cause.Cool feeling type is used for Physical temperature-lowering, the cold therapy for the treatment of swelling and pain by traumatic injury.
Detailed description of the invention
The present invention is further described by the following embodiment.
Embodiment 1:
The hydrogel plaster that the present embodiment describes, it is made up of backing layer, hydrogel layer and protective film, and described hydrogel layer is made up of framework material, excipient, wetting agent, cross-linking agent, acid-base modifier, chelating agen and water; Wherein shared by each component, the percentage ratio of gross mass is: framework material 8%, excipient 2%, wetting agent 26%, cross-linking agent 0.8%, acid-base modifier 0.2%, chelating agen 0.3%, principal agent 0.1% and excess water; Wherein principal agent is by Mentholum and borneol composition.
Production method: first weigh up wetting agent, in succession add framework material, excipient, cross-linking agent, chelating agen, mixing speed is turned down, speed is about 25r/min, slowly stir, after powder is all moistening by wetting agent, gradually improve mixing speed to 250r/min, rapid stirring mixing time about 10 minutes, to being uniformly dispersed; In advance acid-base modifier is added to the water dissolving stand-by; Separately principal agent is dissolved in a solvent; Add in above-mentioned dispersion, rapid stirring, treat that sizing material is swelling, reduce rotating speed when viscosity obviously increases to 75r/min, continue stir about discharging after 15 minutes.
Embodiment 2:
The hydrogel plaster that the present embodiment describes, it is made up of backing layer, hydrogel layer and protective film, and described hydrogel layer is made up of framework material, excipient, wetting agent, cross-linking agent, acid-base modifier, chelating agen and water; Wherein shared by each component, the percentage ratio of gross mass is: framework material 11%, excipient 2.5%, wetting agent 28%, cross-linking agent 1.1%, acid-base modifier 0.4%, chelating agen 0.6%, principal agent 0.1% and excess water; Principal agent is Fructus Capsici extract.
Embodiment 3:
The hydrogel plaster that the present embodiment describes, it is made up of backing layer, hydrogel layer and protective film, and described hydrogel layer is made up of framework material, excipient, wetting agent, cross-linking agent, acid-base modifier, chelating agen and water; Wherein shared by each component, the percentage ratio of gross mass is: framework material 5%, excipient 1%, wetting agent 25%, cross-linking agent 0.2-%, acid-base modifier 0.1%, chelating agen 0.1%, principal agent 0.1%, all the other are water.
Embodiment 4:
The hydrogel plaster that the present embodiment describes, it is made up of backing layer, hydrogel layer and protective film, and described hydrogel layer is made up of framework material, excipient, wetting agent, cross-linking agent, acid-base modifier, chelating agen and water; Wherein shared by each component, the percentage ratio of gross mass is: framework material 12%, excipient 3%, wetting agent 30%, cross-linking agent 1.1%, acid-base modifier 1%, chelating agen 1%, principal agent 0.1%, all the other are water.
Claims (4)
1. a hydrogel plaster, it is made up of backing layer, hydrogel layer and protective film, it is characterized in that: described hydrogel layer is made up of framework material, excipient, wetting agent, cross-linking agent, acid-base modifier, chelating agen and water; Wherein shared by each component, the percentage ratio of gross mass is: framework material 5-12%, excipient 1-3%, wetting agent 25-30%, cross-linking agent 0.2-1.1%, acid-base modifier 0.1-1%, chelating agen 0.1-1%, principal agent 0.1%-0.2%, all the other are water; Wherein principal agent is by Mentholum and borneol composition or be Fructus Capsici extract.
2. a kind of hydrogel plaster according to claim 1, is characterized in that: described hydrogel layer is made up of framework material 8%, excipient 2%, wetting agent 26%, cross-linking agent 0.8%, acid-base modifier 0.2%, chelating agen 0.3%, principal agent 0.1% and excess water.
3. a kind of hydrogel plaster according to claim 1, is characterized in that: described hydrogel layer is made up of framework material 11%, excipient 2.5%, wetting agent 28%, cross-linking agent 1.1%, acid-base modifier 0.4%, chelating agen 0.6%, principal agent 0.2% and excess water.
4. the production method of a hydrogel plaster, it is characterized in that: first weigh up wetting agent, in succession add framework material, excipient, cross-linking agent, chelating agen, mixing speed turned down, speed is about 25r/min, slowly stirs, after powder is all moistening by wetting agent, gradually improve mixing speed to 250r/min, rapid stirring mixing time about 10 minutes, to being uniformly dispersed; In advance acid-base modifier is added to the water dissolving stand-by; Separately principal agent is dissolved in a solvent; Add in above-mentioned dispersion, rapid stirring, treat that sizing material is swelling, reduce rotating speed when viscosity obviously increases to 75r/min, continue stir about discharging after 15 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410613326.1A CN104382885A (en) | 2014-11-05 | 2014-11-05 | Hydrogel plaster and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410613326.1A CN104382885A (en) | 2014-11-05 | 2014-11-05 | Hydrogel plaster and production method thereof |
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| Publication Number | Publication Date |
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| CN104382885A true CN104382885A (en) | 2015-03-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410613326.1A Pending CN104382885A (en) | 2014-11-05 | 2014-11-05 | Hydrogel plaster and production method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297834A (en) * | 2020-04-19 | 2020-06-19 | 田文超 | Cooling paste |
| CN111821336A (en) * | 2020-07-13 | 2020-10-27 | 明亮芯动(成都)健康科技有限公司 | Refreshing hydrogel patch and production process and production equipment thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864753A (en) * | 2005-05-17 | 2006-11-22 | 株式会社盛本医药 | Plaster |
| CN103083282A (en) * | 2011-11-03 | 2013-05-08 | 杭州炬九生物科技有限公司 | Novel hydrogel scar patch and its preparation process |
| CN103191184A (en) * | 2013-04-16 | 2013-07-10 | 王怀伟 | Novel nasal strip gel layer, novel nasal strip and preparation method of nasal strip |
-
2014
- 2014-11-05 CN CN201410613326.1A patent/CN104382885A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864753A (en) * | 2005-05-17 | 2006-11-22 | 株式会社盛本医药 | Plaster |
| CN103083282A (en) * | 2011-11-03 | 2013-05-08 | 杭州炬九生物科技有限公司 | Novel hydrogel scar patch and its preparation process |
| CN103191184A (en) * | 2013-04-16 | 2013-07-10 | 王怀伟 | Novel nasal strip gel layer, novel nasal strip and preparation method of nasal strip |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297834A (en) * | 2020-04-19 | 2020-06-19 | 田文超 | Cooling paste |
| CN111297834B (en) * | 2020-04-19 | 2023-05-26 | 田文超 | Defervescing plaster |
| CN111821336A (en) * | 2020-07-13 | 2020-10-27 | 明亮芯动(成都)健康科技有限公司 | Refreshing hydrogel patch and production process and production equipment thereof |
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Application publication date: 20150304 |