CN104379589A - 抗血小板药剂的前药 - Google Patents
抗血小板药剂的前药 Download PDFInfo
- Publication number
- CN104379589A CN104379589A CN201380030644.9A CN201380030644A CN104379589A CN 104379589 A CN104379589 A CN 104379589A CN 201380030644 A CN201380030644 A CN 201380030644A CN 104379589 A CN104379589 A CN 104379589A
- Authority
- CN
- China
- Prior art keywords
- independently
- formula
- compound
- pharmaceutically acceptable
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(c1ccccc1*)=O Chemical compound CC(c1ccccc1*)=O 0.000 description 2
- ASUSBMNYRHGZIG-UHFFFAOYSA-N CNCCc1c[nH]c(cc2)c1cc2O Chemical compound CNCCc1c[nH]c(cc2)c1cc2O ASUSBMNYRHGZIG-UHFFFAOYSA-N 0.000 description 2
- CFJWVDOQJYPRQZ-LBPRGKRZSA-N CC([C@H](Cc1c[nH]c2c1cc(C)cc2)N)=O Chemical compound CC([C@H](Cc1c[nH]c2c1cc(C)cc2)N)=O CFJWVDOQJYPRQZ-LBPRGKRZSA-N 0.000 description 1
- JECYUBVRTQDVAT-UHFFFAOYSA-N CC(c1ccccc1O)=O Chemical compound CC(c1ccccc1O)=O JECYUBVRTQDVAT-UHFFFAOYSA-N 0.000 description 1
- YEJSPQZHMWGIGP-UHFFFAOYSA-N COC(CCC(C(OC)=O)N)=O Chemical compound COC(CCC(C(OC)=O)N)=O YEJSPQZHMWGIGP-UHFFFAOYSA-N 0.000 description 1
- MNWSGMTUGXNYHJ-UHFFFAOYSA-N COc1ccccc1C(N)=O Chemical compound COc1ccccc1C(N)=O MNWSGMTUGXNYHJ-UHFFFAOYSA-N 0.000 description 1
- WWJHSKHOCSUEHQ-SNVBAGLBSA-N C[C@]1(CCCCC(OC)=O)SSCC1 Chemical compound C[C@]1(CCCCC(OC)=O)SSCC1 WWJHSKHOCSUEHQ-SNVBAGLBSA-N 0.000 description 1
- UCMKMRPVPYBNHR-PAEJTBARSA-N O=C([C@H](c(cccc1)c1F)N(CCC1S)C/C1=C/C(I)=O)C1CC1 Chemical compound O=C([C@H](c(cccc1)c1F)N(CCC1S)C/C1=C/C(I)=O)C1CC1 UCMKMRPVPYBNHR-PAEJTBARSA-N 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N OC(c1ccccc1O)=O Chemical compound OC(c1ccccc1O)=O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1781CH2012 | 2012-05-07 | ||
| IN1781/CHE/2012 | 2012-05-07 | ||
| WOPCT/IB2012/053673 | 2012-07-19 | ||
| PCT/IB2012/053673 WO2013024376A1 (en) | 2011-08-16 | 2012-07-19 | Compositions and methods for the treatment of atherothrombosis |
| PCT/IB2013/052328 WO2013168024A1 (en) | 2012-05-07 | 2013-03-24 | Prodrugs of anti-platelet agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104379589A true CN104379589A (zh) | 2015-02-25 |
Family
ID=54193687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380030644.9A Pending CN104379589A (zh) | 2012-05-07 | 2013-03-24 | 抗血小板药剂的前药 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2847197A4 (https=) |
| JP (1) | JP2015519334A (https=) |
| CN (1) | CN104379589A (https=) |
| AU (1) | AU2013257745A1 (https=) |
| CA (1) | CA2873094A1 (https=) |
| SG (1) | SG11201407307YA (https=) |
| WO (1) | WO2013168024A1 (https=) |
| ZA (1) | ZA201408064B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114507157A (zh) * | 2020-11-17 | 2022-05-17 | 沧州维智达美制药有限公司 | 一种利用氯乙腈制备溴乙腈的方法 |
| CN117343000A (zh) * | 2020-07-29 | 2024-01-05 | 上海柯君医药科技有限公司 | 抗血小板药物和其用途 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201407328TA (en) * | 2012-07-03 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of moderate to severe pain |
| CN119019320B (zh) * | 2024-10-29 | 2025-03-11 | 上海柯君医药科技有限公司 | 一种具有抗血小板活性的哌啶类化合物的制备方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004094374A2 (en) * | 2003-04-23 | 2004-11-04 | Rhodia Pharma Solutions Inc. (Formally Rhodia Chirex Inc.) | Preparation of (s)-clopidogrel and related compounds |
| WO2005046575A2 (en) * | 2003-07-29 | 2005-05-26 | Signature R & D Holdings, Lcc | Amino acid prodrugs |
| EP1889835A1 (en) * | 2005-05-27 | 2008-02-20 | Daiichi Sankyo Company, Limited | Cyclic amine derivative having substituted alkyl group |
| EP2298777A2 (en) * | 2008-06-09 | 2011-03-23 | Enzytech, Ltd. | Method for preparing clopidogrel and its derivatives |
| CN102002053A (zh) * | 2009-09-02 | 2011-04-06 | 陕西合成药业有限公司 | 用于治疗的四氢噻吩并吡啶衍生物 |
| CN102336767A (zh) * | 2011-07-11 | 2012-02-01 | 华东理工大学 | 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法 |
| WO2013024376A1 (en) * | 2011-08-16 | 2013-02-21 | Mahesh Kandula | Compositions and methods for the treatment of atherothrombosis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9525998B2 (en) * | 2012-01-06 | 2016-12-20 | Qualcomm Incorporated | Wireless display with multiscreen service |
| JP6097766B2 (ja) * | 2012-01-27 | 2017-03-15 | インターデイジタル パテント ホールディングス インコーポレイテッド | マルチキャリアベースおよび／または疑似照合ネットワークにおいてｅｐｄｃｃｈを提供するためのシステムおよび／または方法 |
| WO2013167985A1 (en) * | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological disorders |
| SG11201407317SA (en) * | 2012-05-08 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for suppression of carbonic anhydrase activity |
| WO2013167987A1 (en) * | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of diabetes |
| JP2015526385A (ja) * | 2012-05-08 | 2015-09-10 | セリックスビオ プライヴェート リミテッド | てんかんの治療のための組成物及び方法 |
| CA2872976A1 (en) * | 2012-05-08 | 2013-11-14 | Cellixbio Private Limited | Compositions and methods for the treatment of neurological disorders |
| SG11201407328TA (en) * | 2012-07-03 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of moderate to severe pain |
-
2013
- 2013-03-24 CN CN201380030644.9A patent/CN104379589A/zh active Pending
- 2013-03-24 SG SG11201407307YA patent/SG11201407307YA/en unknown
- 2013-03-24 AU AU2013257745A patent/AU2013257745A1/en not_active Abandoned
- 2013-03-24 CA CA2873094A patent/CA2873094A1/en not_active Abandoned
- 2013-03-24 EP EP13787471.5A patent/EP2847197A4/en not_active Withdrawn
- 2013-03-24 WO PCT/IB2013/052328 patent/WO2013168024A1/en not_active Ceased
- 2013-03-24 JP JP2015510901A patent/JP2015519334A/ja active Pending
-
2014
- 2014-11-04 ZA ZA2014/08064A patent/ZA201408064B/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004094374A2 (en) * | 2003-04-23 | 2004-11-04 | Rhodia Pharma Solutions Inc. (Formally Rhodia Chirex Inc.) | Preparation of (s)-clopidogrel and related compounds |
| WO2005046575A2 (en) * | 2003-07-29 | 2005-05-26 | Signature R & D Holdings, Lcc | Amino acid prodrugs |
| EP1889835A1 (en) * | 2005-05-27 | 2008-02-20 | Daiichi Sankyo Company, Limited | Cyclic amine derivative having substituted alkyl group |
| EP2298777A2 (en) * | 2008-06-09 | 2011-03-23 | Enzytech, Ltd. | Method for preparing clopidogrel and its derivatives |
| CN102002053A (zh) * | 2009-09-02 | 2011-04-06 | 陕西合成药业有限公司 | 用于治疗的四氢噻吩并吡啶衍生物 |
| CN102336767A (zh) * | 2011-07-11 | 2012-02-01 | 华东理工大学 | 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法 |
| WO2013024376A1 (en) * | 2011-08-16 | 2013-02-21 | Mahesh Kandula | Compositions and methods for the treatment of atherothrombosis |
Non-Patent Citations (6)
| Title |
|---|
| KATRIN SANGKUHL，等: "Clopidogrel pathway", 《PHARMACOGENET GENOMICS》 * |
| MIHO KAZUI，等: "Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite", 《DRUG METABOLISM AND DISPOSITION》 * |
| PATRICK M. DANSETTE，等: "Formation and Fate of a Sulfenic Acid Intermediate in the Metabolic Activation of the Antithrombotic Prodrug Prasugrel", 《CHEM. RES. TOXICOL.》 * |
| 张青山，等: "新型抗血小板药氯吡格雷研究进展", 《化工进展》 * |
| 荆亚萍，等: "新一代血小板抑制剂——普拉格雷", 《国际药学研究杂志》 * |
| 陈继方，等: "氯吡格雷类似物的合成及其抗血小板聚集活性", 《合成化学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117343000A (zh) * | 2020-07-29 | 2024-01-05 | 上海柯君医药科技有限公司 | 抗血小板药物和其用途 |
| CN114507157A (zh) * | 2020-11-17 | 2022-05-17 | 沧州维智达美制药有限公司 | 一种利用氯乙腈制备溴乙腈的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201407307YA (en) | 2014-12-30 |
| AU2013257745A1 (en) | 2014-11-27 |
| JP2015519334A (ja) | 2015-07-09 |
| WO2013168024A1 (en) | 2013-11-14 |
| EP2847197A1 (en) | 2015-03-18 |
| ZA201408064B (en) | 2016-04-28 |
| CA2873094A1 (en) | 2013-11-14 |
| EP2847197A4 (en) | 2015-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150225 |